| HGNC Family | G protein-coupled receptors |
| Name | olfactory receptor, family 4, subfamily C, member 15 |
| Description | Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008] |
| Summary |
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nThe body of research summarized in these abstracts provides extensive insights into the regulation of key biological processes—such as immune responses, cell proliferation, differentiation, apoptosis, metabolism, and vascular as well as neuronal functions—primarily through the actions of various microRNAs (notably miR‐139, its 5p and 3p isoforms, and others). For example, environmental stimuli such as particulate matter and simulated microgravity have been shown to modulate microRNA profiles that in turn influence T lymphocyte polarization, osteoblast differentiation, adipogenesis, and epithelial integrity (see."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "8"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nOther studies expand on the roles of these microRNAs in mediating cell survival and stress responses in diverse contexts such as hepatic gluconeogenesis, cerebral ischemia/reperfusion injury, and depressive states. They also illuminate the involvement of microRNA-regulated pathways—such as NF-κB, Wnt/β-catenin, PI3K/Akt, Notch, and others—in diseases ranging from diabetes and Alzheimer’s disease to various forms of cancer and bone marrow failure (see."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "9", "end_ref": "15"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nFurthermore, a number of these investigations underscore that microRNAs are integral components of multifaceted regulatory networks. They often serve to fine-tune the signaling cascades governing cell fate decisions (including senescence, differentiation, and angiogenic responses) and to modulate the balances between proliferation and apoptosis in both normal development and disease progression. These intricate networks have been elaborated in contexts involving osteogenic differentiation, mesenchymal stem cell function, pancreatic β-cell regulation, and even immunomodulatory responses during infection and inflammatory stress."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "16", "end_ref": "27"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nImportantly, despite the breadth and depth of these studies examining microRNA‐mediated regulation across numerous physiological and pathological systems, none of the examined abstracts address or provide evidence regarding the function or involvement of OR4C15. In other words, while these studies offer rich insights into microRNA networks and their impacts on signaling and cellular behavior, they do not report any findings related to OR4C15. Therefore, based on the current literature provided here, no functional role for OR4C15 can be discerned.\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Tianfang Hou, Jiping Liao, Cheng Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Elevated expression of miR-146, miR-139 and miR-340 involved in regulating Th1/Th2 balance with acute exposure of fine particulate matter in mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int Immunopharmacol (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.intimp.2017.10.003"}], "href": "https://doi.org/10.1016/j.intimp.2017.10.003"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29107863"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29107863"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Yixuan Wang, Ke Wang, Zebing Hu, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "ICL-induced miR139-3p and miR199a-3p have opposite roles in hematopoietic cell expansion and leukemic transformation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Blood (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1182/blood-2014-11-612507"}], "href": "https://doi.org/10.1182/blood-2014-11-612507"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25778535"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25778535"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Larbi Kamal Hasseine, Charlotte Hinault, Patricia Lebrun, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA-139-5p regulates C2C12 cell myogenesis through blocking Wnt/β-catenin signaling pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Cell Biol (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1139/bcb-2014-0079"}], "href": "https://doi.org/10.1139/bcb-2014-0079"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25529604"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25529604"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Yiqin Yao, Sheng Hu, Chunxue Zhang, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA-139-5p regulates proliferation of hematopoietic progenitors and is repressed during BCR-ABL-mediated leukemogenesis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Blood (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1182/blood-2016-02-702464"}], "href": "https://doi.org/10.1182/blood-2016-02-702464"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27605510"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27605510"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Y Tang, J S Bao, J H Su, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA-139 modulates Alzheimer's-associated pathogenesis in SAMP8 mice by targeting cannabinoid receptor type 2."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Genet Mol Res (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4238/gmr16019166"}], "href": "https://doi.org/10.4238/gmr16019166"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28218780"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28218780"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Yu-Fang Luo, Xin-Xing Wan, Li-Ling Zhao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA-139-5p upregulation is associated with diabetic endothelial cell dysfunction by targeting c-jun."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Aging (Albany NY) (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/aging.202257"}], "href": "https://doi.org/10.18632/aging.202257"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33293476"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33293476"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Qing Lu, Hao Qin, Haitao Tan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Senescence Osteoblast-Derived Exosome-Mediated miR-139-5p Regulates Endothelial Cell Functions."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biomed Res Int (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1155/2021/5576023"}], "href": "https://doi.org/10.1155/2021/5576023"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33954179"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33954179"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Meng Xu, Xiaoling Chen, Zhiqing Huang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA-139-5p suppresses myosin heavy chain I and IIa expression via inhibition of the calcineurin/NFAT signaling pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2018.04.202"}], "href": "https://doi.org/10.1016/j.bbrc.2018.04.202"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29705696"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29705696"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Hua Wei, Liwei Huang, Fenghua Wei, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Up-regulation of miR-139-5p protects diabetic mice from liver tissue damage and oxidative stress through inhibiting Notch signaling pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Acta Biochim Biophys Sin (Shanghai) (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/abbs/gmaa008"}], "href": "https://doi.org/10.1093/abbs/gmaa008"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32293663"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32293663"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Haiyan Qiu, Lizhen Ma, Fabo Feng "}, {"type": "b", "children": [{"type": "t", "text": "PICK1 attenuates high glucose-induced pancreatic β-cell death through the PI3K/Akt pathway and is negatively regulated by miR-139-5p."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2019.11.051"}], "href": "https://doi.org/10.1016/j.bbrc.2019.11.051"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31735337"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31735337"}]}, {"type": "r", "ref": 20, "children": [{"type": "t", "text": "Zhongwei Zhang, Caiping Song, Tao Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR-139-5p promotes neovascularization in diabetic retinopathy by regulating the phosphatase and tensin homolog."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Arch Pharm Res (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s12272-021-01308-8"}], "href": "https://doi.org/10.1007/s12272-021-01308-8"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33609236"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33609236"}]}, {"type": "r", "ref": 21, "children": [{"type": "t", "text": "Christiaan J Stavast, Iris van Zuijen, Elena Karkoulia, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The tumor suppressor MIR139 is silenced by POLR2M to promote AML oncogenesis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Leukemia (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41375-021-01461-5"}], "href": "https://doi.org/10.1038/s41375-021-01461-5"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34741119"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34741119"}]}, {"type": "r", "ref": 22, "children": [{"type": "t", "text": "Dongfang Xie, Man Tong, Baolong Xia, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long noncoding RNA "}, {"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "lnc-NAP"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": " sponges mmu-miR-139-5p to modulate "}, {"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "Nanog"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": " functions in mouse ESCs and embryos."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "RNA Biol (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/15476286.2020.1827591"}], "href": "https://doi.org/10.1080/15476286.2020.1827591"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32991228"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32991228"}]}, {"type": "r", "ref": 23, "children": [{"type": "t", "text": "Bing Su, Suohua Cheng, Lei Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA-139-5p acts as a suppressor gene for depression by targeting nuclear receptor subfamily 3, group C, member 1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Bioengineered (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/21655979.2022.2059937"}], "href": "https://doi.org/10.1080/21655979.2022.2059937"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35543383"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35543383"}]}, {"type": "r", "ref": 24, "children": [{"type": "t", "text": "Xiuxiu Zhang, Xin Liu, Rui Chang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR-139-5p protects septic mice with acute lung injury by inhibiting Toll-like receptor 4/Myeloid differentiation factor 88/Nuclear factor-&mac_kgr;B signaling pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Clinics (Sao Paulo) (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.6061/clinics/2021/e2484"}], "href": "https://doi.org/10.6061/clinics/2021/e2484"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33681946"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33681946"}]}, {"type": "r", "ref": 25, "children": [{"type": "t", "text": "Lei Bao, Cecilia S Chau, Zhengdeng Lei, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Dysregulated microRNA expression in IL-4 transgenic mice, an animal model of atopic dermatitis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Arch Dermatol Res (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s00403-020-02176-w"}], "href": "https://doi.org/10.1007/s00403-020-02176-w"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33433718"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33433718"}]}, {"type": "r", "ref": 26, "children": [{"type": "t", "text": "Jennifer L Hope, Manzhi Zhao, Christopher J Stairiker, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA-139 Expression Is Dispensable for the Generation of Influenza-Specific CD8"}, {"type": "a", "children": [{"type": "t", "text": "sup"}], "href": "sup"}, {"type": "t", "text": "+"}, {"type": "a", "children": [{"type": "t", "text": "/sup"}], "href": "/sup"}, {"type": "t", "text": " T Cell Responses."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Immunol (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4049/jimmunol.2000621"}], "href": "https://doi.org/10.4049/jimmunol.2000621"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35022277"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35022277"}]}, {"type": "r", "ref": 27, "children": [{"type": "t", "text": "Xiaohong Xu, Tingyun Ye, Yizhang Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA-139-5p inhibits inflammatory and oxidative stress responses of Salmonella-infected macrophages through modulating TRAF6."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Pathog Dis (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/femspd/ftab018"}], "href": "https://doi.org/10.1093/femspd/ftab018"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33822016"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33822016"}]}]}]}
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| Synonyms | OR11-134, OR11-127 |
| Proteins | OR4CF_HUMAN |
| NCBI Gene ID | 81309 |
| API | |
| Download Associations | |
| Predicted Functions |
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| Co-expressed Genes |
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| Expression in Tissues and Cell Lines |
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OR4C15 has 1,037 functional associations with biological entities spanning 7 categories (molecular profile, functional term, phrase or reference, disease, phenotype or trait, chemical, structural feature, cell line, cell type or tissue, gene, protein or microRNA) extracted from 49 datasets.
Click the + buttons to view associations for OR4C15 from the datasets below.
If available, associations are ranked by standardized value
| Dataset | Summary | |
|---|---|---|
| Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles | tissues with high or low expression of OR4C15 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset. | |
| Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles | tissue samples with high or low expression of OR4C15 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset. | |
| Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray | tissue samples with high or low expression of OR4C15 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset. | |
| Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles | tissues with high or low expression of OR4C15 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset. | |
| CCLE Cell Line Gene CNV Profiles | cell lines with high or low copy number of OR4C15 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset. | |
| ChEA Transcription Factor Binding Site Profiles | transcription factor binding site profiles with transcription factor binding evidence at the promoter of OR4C15 gene from the CHEA Transcription Factor Binding Site Profiles dataset. | |
| ChEA Transcription Factor Targets | transcription factors binding the promoter of OR4C15 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset. | |
| ChEA Transcription Factor Targets 2022 | transcription factors binding the promoter of OR4C15 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset. | |
| COMPARTMENTS Curated Protein Localization Evidence Scores | cellular components containing OR4C15 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset. | |
| COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 | cellular components co-occuring with OR4C15 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset. | |
| COSMIC Cell Line Gene CNV Profiles | cell lines with high or low copy number of OR4C15 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset. | |
| COSMIC Cell Line Gene Mutation Profiles | cell lines with OR4C15 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset. | |
| DepMap CRISPR Gene Dependency | cell lines with fitness changed by OR4C15 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset. | |
| DISEASES Experimental Gene-Disease Association Evidence Scores 2025 | diseases associated with OR4C15 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset. | |
| DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 | diseases co-occuring with OR4C15 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset. | |
| DisGeNET Gene-Phenotype Associations | phenotypes associated with OR4C15 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset. | |
| ENCODE Histone Modification Site Profiles | histone modification site profiles with high histone modification abundance at OR4C15 gene from the ENCODE Histone Modification Site Profiles dataset. | |
| ENCODE Transcription Factor Binding Site Profiles | transcription factor binding site profiles with transcription factor binding evidence at the promoter of OR4C15 gene from the ENCODE Transcription Factor Binding Site Profiles dataset. | |
| ENCODE Transcription Factor Targets | transcription factors binding the promoter of OR4C15 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset. | |
| GeneSigDB Published Gene Signatures | PubMedIDs of publications reporting gene signatures containing OR4C15 from the GeneSigDB Published Gene Signatures dataset. | |
| GEO Signatures of Differentially Expressed Genes for Gene Perturbations | gene perturbations changing expression of OR4C15 gene from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset. | |
| GEO Signatures of Differentially Expressed Genes for Kinase Perturbations | kinase perturbations changing expression of OR4C15 gene from the GEO Signatures of Differentially Expressed Genes for Kinase Perturbations dataset. | |
| GEO Signatures of Differentially Expressed Genes for Small Molecules | small molecule perturbations changing expression of OR4C15 gene from the GEO Signatures of Differentially Expressed Genes for Small Molecules dataset. | |
| GO Biological Process Annotations 2015 | biological processes involving OR4C15 gene from the curated GO Biological Process Annotations 2015 dataset. | |
| GO Cellular Component Annotations 2015 | cellular components containing OR4C15 protein from the curated GO Cellular Component Annotations 2015 dataset. | |
| GO Molecular Function Annotations 2015 | molecular functions performed by OR4C15 gene from the curated GO Molecular Function Annotations 2015 dataset. | |
| GO Molecular Function Annotations 2025 | molecular functions performed by OR4C15 gene from the curated GO Molecular Function Annotations 2025 dataset. | |
| GTEx Tissue Gene Expression Profiles | tissues with high or low expression of OR4C15 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles dataset. | |
| GWAS Catalog SNP-Phenotype Associations 2025 | phenotypes associated with OR4C15 gene in GWAS datasets from the GWAS Catalog SNP-Phenotype Associations 2025 dataset. | |
| GWASdb SNP-Disease Associations | diseases associated with OR4C15 gene in GWAS and other genetic association datasets from the GWASdb SNP-Disease Associations dataset. | |
| GWASdb SNP-Phenotype Associations | phenotypes associated with OR4C15 gene in GWAS datasets from the GWASdb SNP-Phenotype Associations dataset. | |
| Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles | cell lines with high or low expression of OR4C15 gene relative to other cell lines from the Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles dataset. | |
| HPA Tissue Protein Expression Profiles | tissues with high or low expression of OR4C15 protein relative to other tissues from the HPA Tissue Protein Expression Profiles dataset. | |
| InterPro Predicted Protein Domain Annotations | protein domains predicted for OR4C15 protein from the InterPro Predicted Protein Domain Annotations dataset. | |
| JASPAR Predicted Human Transcription Factor Targets 2025 | transcription factors regulating expression of OR4C15 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Human Transcription Factor Targets dataset. | |
| JASPAR Predicted Mouse Transcription Factor Targets 2025 | transcription factors regulating expression of OR4C15 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Mouse Transcription Factor Targets 2025 dataset. | |
| JASPAR Predicted Transcription Factor Targets | transcription factors regulating expression of OR4C15 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset. | |
| KEGG Pathways 2026 | pathways involving OR4C15 protein from the KEGG Pathways 2026 dataset. | |
| Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles | cell lines with high or low copy number of OR4C15 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset. | |
| LOCATE Predicted Protein Localization Annotations | cellular components predicted to contain OR4C15 protein from the LOCATE Predicted Protein Localization Annotations dataset. | |
| MotifMap Predicted Transcription Factor Targets | transcription factors regulating expression of OR4C15 gene predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset. | |
| Reactome Pathways 2014 | pathways involving OR4C15 protein from the Reactome Pathways dataset. | |
| Reactome Pathways 2024 | pathways involving OR4C15 protein from the Reactome Pathways 2024 dataset. | |
| Roadmap Epigenomics Histone Modification Site Profiles | histone modification site profiles with high histone modification abundance at OR4C15 gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset. | |
| Rummagene Transcription Factor Associations 2026 | transcription factors regulating expression of OR4C15 gene from the Rummagene Transcription Factor Associations 2026 dataset. | |
| RummaGEO Gene Perturbation Signatures | gene perturbations changing expression of OR4C15 gene from the RummaGEO Gene Perturbation Signatures dataset. | |
| TCGA Signatures of Differentially Expressed Genes for Tumors | tissue samples with high or low expression of OR4C15 gene relative to other tissue samples from the TCGA Signatures of Differentially Expressed Genes for Tumors dataset. | |
| TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 | tissues with high expression of OR4C15 protein in proteomics datasets from the TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 dataset. | |
| TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 | tissues co-occuring with OR4C15 protein in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 dataset. | |
