| HGNC Family | G protein-coupled receptors |
| Name | olfactory receptor, family 4, subfamily D, member 1 |
| Description | Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008] |
| Summary |
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nInsulin‐like growth factor–binding protein‐5 (IGFBP‐5) is a multifunctional regulator that modulates IGF signaling in a range of developmental and pathological processes. In several studies, IGFBP‐5 has been shown to participate in postnatal tissue growth and differentiation – for example, during mammary gland development and involution it alters cell survival, apoptosis, and differentiation through both IGF‐dependent and independent mechanisms, influencing beta‐cell proliferation as well as epithelial remodeling."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "8"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIGFBP‐5 also plays important roles in the regulation of cell cycle progression and survival in cancer and differentiating muscle. In breast cancer cells, for instance, IGFBP‐5 expression induces G2/M cell cycle arrest and promotes apoptosis – an effect that appears to be mediated via intracellular signaling pathways rather than by simply sequestering IGFs – while in differentiating myoblasts its regulation by microRNAs influences both myogenesis and the senescence of satellite cells."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "9", "end_ref": "15"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn addition, IGFBP‐5 is a key modulator of bone homeostasis and mineral density. Studies in osteoblasts and animal models indicate that IGFBP‐5 can inhibit or stimulate aspects of osteogenic differentiation and mineral deposition depending on the cellular context, often acting by interfering with IGF–IGF receptor interactions. Complementary work has also implicated IGFBP‐5 in regulating extracellular matrix remodeling, coupling osteoblast and osteoclast activities, and even modulating angiogenesis and tissue fibrosis in organs such as the liver and kidney."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}, {"type": "fg_fs", "start_ref": "16", "end_ref": "23"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nMoreover, IGFBP‐5 expression is tightly integrated into broader regulatory networks. It acts as a downstream effector in mTORC1 feedback loops and is subject to regulation by cytokines, growth factors, and noncoding RNAs – including microRNAs and long noncoding RNAs – which modulate its expression during aging, inflammation, and tissue regenerative processes. Such control mechanisms have been implicated in inflammatory diseases, where altered IGFBP‐5 levels can exacerbate fibrosis and organ dysfunction, as well as in the regulation of angiogenesis and immune homeostasis."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "24", "end_ref": "38"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nCollectively, these studies emphasize that IGFBP‐5 is not merely a passive carrier of IGFs but a dynamic modulator of cellular fate and tissue homeostasis. By orchestrating receptor activation, influencing apoptotic and survival pathways, and interacting with components of the extracellular milieu, IGFBP‐5 emerges as a central node in the regulation of growth, differentiation, and repair across organ systems."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "6"}, {"type": "fg_fs", "start_ref": "9", "end_ref": "15"}, {"type": "fg_f", "ref": "7"}, {"type": "fg_f", "ref": "39"}, {"type": "fg_fs", "start_ref": "16", "end_ref": "38"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "M R Schneider, R Zhou, A Hoeflich, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Insulin-like growth factor-binding protein-5 inhibits growth and induces differentiation of mouse osteosarcoma cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2001)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1006/bbrc.2001.5785"}], "href": "https://doi.org/10.1006/bbrc.2001.5785"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "11606061"}], "href": "https://pubmed.ncbi.nlm.nih.gov/11606061"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Elizabeth Tonner, Michael C Barber, Gordon J Allan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Insulin-like growth factor binding protein-5 (IGFBP-5) induces premature cell death in the mammary glands of transgenic mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Development (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1242/dev.129.19.4547"}], "href": "https://doi.org/10.1242/dev.129.19.4547"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12223411"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12223411"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Emma Marshman, Kirsty A Green, David J Flint, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Insulin-like growth factor binding protein 5 and apoptosis in mammary epithelial cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Sci (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1242/jcs.00263"}], "href": "https://doi.org/10.1242/jcs.00263"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12538768"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12538768"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "John H Shand, James Beattie, Hyuk Song, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Specific amino acid substitutions determine the differential contribution of the N- and C-terminal domains of insulin-like growth factor (IGF)-binding protein-5 in binding IGF-I."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M300526200"}], "href": "https://doi.org/10.1074/jbc.M300526200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12626499"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12626499"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Alison J Butt, Kristie A Dickson, Fiona McDougall, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Insulin-like growth factor-binding protein-5 inhibits the growth of human breast cancer cells in vitro and in vivo."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M301965200"}], "href": "https://doi.org/10.1074/jbc.M301965200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12777377"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12777377"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "K Phillips, M A Park, L H Quarrie, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Hormonal control of IGF-binding protein (IGFBP)-5 and IGFBP-2 secretion during differentiation of the HC11 mouse mammary epithelial cell line."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Mol Endocrinol (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1677/jme.0.0310197"}], "href": "https://doi.org/10.1677/jme.0.0310197"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12914536"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12914536"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Yun Ning, Alwin G P Schuller, Sheri Bradshaw, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Diminished growth and enhanced glucose metabolism in triple knockout mice containing mutations of insulin-like growth factor binding protein-3, -4, and -5."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Endocrinol (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1210/me.2005-0196"}], "href": "https://doi.org/10.1210/me.2005-0196"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16675541"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16675541"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "D J Flint, M Boutinaud, C B A Whitelaw, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Prolactin inhibits cell loss and decreases matrix metalloproteinase expression in the involuting mouse mammary gland but fails to prevent cell loss in the mammary glands of mice expressing IGFBP-5 as a mammary transgene."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Mol Endocrinol (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1677/jme.1.01873"}], "href": "https://doi.org/10.1677/jme.1.01873"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16720715"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16720715"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Robert H McCusker, Jan Novakofski "}, {"type": "b", "children": [{"type": "t", "text": "Zinc partitions insulin-like growth factors (IGFs) from soluble IGF binding protein (IGFBP)-5 to the cell surface receptors of BC3H-1 muscle cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Physiol (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jcp.10360"}], "href": "https://doi.org/10.1002/jcp.10360"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "14566968"}], "href": "https://pubmed.ncbi.nlm.nih.gov/14566968"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Laura J Cobb, Dervis A M Salih, Ivelisse Gonzalez, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Partitioning of IGFBP-5 actions in myogenesis: IGF-independent anti-apoptotic function."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Sci (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1242/jcs.01028"}], "href": "https://doi.org/10.1242/jcs.01028"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15075235"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15075235"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Dervis A M Salih, Subburaman Mohan, Yuji Kasukawa, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Insulin-like growth factor-binding protein-5 induces a gender-related decrease in bone mineral density in transgenic mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Endocrinology (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1210/en.2004-0816"}], "href": "https://doi.org/10.1210/en.2004-0816"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15550514"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15550514"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "E Atti, A L Boskey, E Canalis "}, {"type": "b", "children": [{"type": "t", "text": "Overexpression of IGF-binding protein 5 alters mineral and matrix properties in mouse femora: an infrared imaging study."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Calcif Tissue Int (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s00223-004-0076-2"}], "href": "https://doi.org/10.1007/s00223-004-0076-2"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15570402"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15570402"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Thomas Schlake "}, {"type": "b", "children": [{"type": "t", "text": "Segmental Igfbp5 expression is specifically associated with the bent structure of zigzag hairs."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mech Dev (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.mod.2005.04.012"}], "href": "https://doi.org/10.1016/j.mod.2005.04.012"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16024235"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16024235"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Jennifer D Lochrie, Kirsten Phillips, Elizabeth Tonner, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Insulin-like growth factor binding protein (IGFBP)-5 is upregulated during both differentiation and apoptosis in primary cultures of mouse mammary epithelial cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Physiol (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jcp.20587"}], "href": "https://doi.org/10.1002/jcp.20587"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16419030"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16419030"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Alice M Sorrell, John H Shand, Elizabeth Tonner, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Insulin-like growth factor-binding protein-5 activates plasminogen by interaction with tissue plasminogen activator, independently of its ability to bind to plasminogen activator inhibitor-1, insulin-like growth factor-I, or heparin."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M508505200"}], "href": "https://doi.org/10.1074/jbc.M508505200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16505491"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16505491"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Yun Ning, Bao Hoang, Alwin G P Schuller, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Delayed mammary gland involution in mice with mutation of the insulin-like growth factor binding protein 5 gene."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Endocrinology (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1210/en.2006-0041"}], "href": "https://doi.org/10.1210/en.2006-0041"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17255210"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17255210"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Andreas Jurgeit, Chiara Berlato, Peter Obrist, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Insulin-like growth factor-binding protein-5 enters vesicular structures but not the nucleus."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Traffic (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/j.1600-0854.2007.00655.x"}], "href": "https://doi.org/10.1111/j.1600-0854.2007.00655.x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17892529"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17892529"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Aditi Mukherjee, Peter Rotwein "}, {"type": "b", "children": [{"type": "t", "text": "Insulin-like growth factor-binding protein-5 inhibits osteoblast differentiation and skeletal growth by blocking insulin-like growth factor actions."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Endocrinol (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1210/me.2008-0001"}], "href": "https://doi.org/10.1210/me.2008-0001"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18292241"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18292241"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Gyanendra Tripathi, Dervis A M Salih, Anja C Drozd, et al. "}, {"type": "b", "children": [{"type": "t", "text": "IGF-independent effects of insulin-like growth factor binding protein-5 (Igfbp5) in vivo."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "FASEB J (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1096/fj.08-114124"}], "href": "https://doi.org/10.1096/fj.08-114124"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19332648"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19332648"}]}, {"type": "r", "ref": 20, "children": [{"type": "t", "text": "Catherine E Gleason, Yun Ning, Tara P Cominski, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Role of insulin-like growth factor-binding protein 5 (IGFBP5) in organismal and pancreatic beta-cell growth."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Endocrinol (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1210/me.2009-0167"}], "href": "https://doi.org/10.1210/me.2009-0167"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19897600"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19897600"}]}, {"type": "r", "ref": 21, "children": [{"type": "t", "text": "Bo Young Ahn, Adam N Elwi, Byoungchun Lee, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Genetic screen identifies insulin-like growth factor binding protein 5 as a modulator of tamoxifen resistance in breast cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Res (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/0008-5472.CAN-09-3108"}], "href": "https://doi.org/10.1158/0008-5472.CAN-09-3108"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20354179"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20354179"}]}, {"type": "r", "ref": 22, "children": [{"type": "t", "text": "Yukie Yamaguchi, Hidekata Yasuoka, Donna B Stolz, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Decreased caveolin-1 levels contribute to fibrosis and deposition of extracellular IGFBP-5."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Mol Med (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/j.1582-4934.2010.01063.x"}], "href": "https://doi.org/10.1111/j.1582-4934.2010.01063.x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20345844"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20345844"}]}, {"type": "r", "ref": 23, "children": [{"type": "t", "text": "Xiaoliang L Xu, Thomas C Lee, Nneka Offor, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Tumor-associated retinal astrocytes promote retinoblastoma cell proliferation through production of IGFBP-5."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Pathol (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.2353/ajpath.2010.090512"}], "href": "https://doi.org/10.2353/ajpath.2010.090512"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20508032"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20508032"}]}, {"type": "r", "ref": 24, "children": [{"type": "t", "text": "Barbara Peruzzi, Alfredo Cappariello, Andrea Del Fattore, et al. "}, {"type": "b", "children": [{"type": "t", "text": "c-Src and IL-6 inhibit osteoblast differentiation and integrate IGFBP5 signalling."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Commun (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ncomms1651"}], "href": "https://doi.org/10.1038/ncomms1651"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22252554"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22252554"}]}, {"type": "r", "ref": 25, "children": [{"type": "t", "text": "Aleksandar Sokolović, Paula S Montenegro-Miranda, Dirk Rudi de Waart, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Overexpression of insulin like growth factor binding protein 5 reduces liver fibrosis in chronic cholangiopathy."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochim Biophys Acta (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbadis.2012.02.022"}], "href": "https://doi.org/10.1016/j.bbadis.2012.02.022"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22434064"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22434064"}]}, {"type": "r", "ref": 26, "children": [{"type": "t", "text": "Kazuya Fujita, Yuji Taya, Yoshihito Shimazu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Molecular signaling at the fusion stage of the mouse mandibular arch: involvement of insulin-like growth factor family."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Dev Biol (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1387/ijdb.120110ys"}], "href": "https://doi.org/10.1387/ijdb.120110ys"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23584732"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23584732"}]}, {"type": "r", "ref": 27, "children": [{"type": "t", "text": "Takayuki Okano, Matthew W Kelley "}, {"type": "b", "children": [{"type": "t", "text": "Expression of insulin-like growth factor binding proteins during mouse cochlear development."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Dev Dyn (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/dvdy.24005"}], "href": "https://doi.org/10.1002/dvdy.24005"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23813480"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23813480"}]}, {"type": "r", "ref": 28, "children": [{"type": "t", "text": "Christian M Simon, Stefanie Rauskolb, Jennifer M Gunnersen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Dysregulated IGFBP5 expression causes axon degeneration and motoneuron loss in diabetic neuropathy."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Acta Neuropathol (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s00401-015-1446-8"}], "href": "https://doi.org/10.1007/s00401-015-1446-8"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26025657"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26025657"}]}, {"type": "r", "ref": 29, "children": [{"type": "t", "text": "Ana Soriano-Arroquia, Rachel McCormick, Andrew P Molloy, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Age-related changes in miR-143-3p:Igfbp5 interactions affect muscle regeneration."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Aging Cell (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/acel.12442"}], "href": "https://doi.org/10.1111/acel.12442"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26762731"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26762731"}]}, {"type": "r", "ref": 30, "children": [{"type": "t", "text": "Ming Ding, Richard K Bruick, Yonghao Yu "}, {"type": "b", "children": [{"type": "t", "text": "Secreted IGFBP5 mediates mTORC1-dependent feedback inhibition of IGF-1 signalling."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Cell Biol (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ncb3311"}], "href": "https://doi.org/10.1038/ncb3311"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26854565"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26854565"}]}, {"type": "r", "ref": 31, "children": [{"type": "t", "text": "Yufan Chen, Lianyong Li, Enbo Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Abnormal expression of Pappa2 gene may indirectly affect mouse hip development through the IGF signaling pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Endocrine (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s12020-019-01975-0"}], "href": "https://doi.org/10.1007/s12020-019-01975-0"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31168749"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31168749"}]}, {"type": "r", "ref": 32, "children": [{"type": "t", "text": "Zheng Xiao, Yafei Chu, Wangsen Qin "}, {"type": "b", "children": [{"type": "t", "text": "IGFBP5 modulates lipid metabolism and insulin sensitivity through activating AMPK pathway in non-alcoholic fatty liver disease."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Life Sci (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.lfs.2020.117997"}], "href": "https://doi.org/10.1016/j.lfs.2020.117997"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32585242"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32585242"}]}, {"type": "r", "ref": 33, "children": [{"type": "t", "text": "Chengcheng Song, Shuqiang Wang, Zhangning Fu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "IGFBP5 promotes diabetic kidney disease progression by enhancing PFKFB3-mediated endothelial glycolysis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Death Dis (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41419-022-04803-y"}], "href": "https://doi.org/10.1038/s41419-022-04803-y"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35418167"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35418167"}]}, {"type": "r", "ref": 34, "children": [{"type": "t", "text": "Dan Gu, Ting Cao, Shijie Yi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "CCCTC-Binding Factor Mediates the Transcription of Insulin-Like Growth Factor Binding Protein 5 Through EZH2 in Ulcerative Colitis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Dig Dis Sci (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s10620-022-07566-w"}], "href": "https://doi.org/10.1007/s10620-022-07566-w"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35705732"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35705732"}]}, {"type": "r", "ref": 35, "children": [{"type": "t", "text": "Mengyuan Zhu, Han Han, Lei Hu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Insulin-binding protein-5 down-regulates the balance of Th17/Treg."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Front Immunol (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3389/fimmu.2022.1019248"}], "href": "https://doi.org/10.3389/fimmu.2022.1019248"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36389828"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36389828"}]}, {"type": "r", "ref": 36, "children": [{"type": "t", "text": "Bingxin Li, Yaqiong Ye, Longsheng Hong, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Transcriptome analysis reveals a potential regulatory mechanism of the lnc-5423.6/IGFBP5 axis in the early stages of mouse thymic involution."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Acta Biochim Biophys Sin (Shanghai) (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3724/abbs.2023042"}], "href": "https://doi.org/10.3724/abbs.2023042"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "37078747"}], "href": "https://pubmed.ncbi.nlm.nih.gov/37078747"}]}, {"type": "r", "ref": 37, "children": [{"type": "t", "text": "Fei Song, Yu Hu, Yi-Xiang Hong, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Deletion of endothelial IGFBP5 protects against ischaemic hindlimb injury by promoting angiogenesis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Clin Transl Med (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/ctm2.1725"}], "href": "https://doi.org/10.1002/ctm2.1725"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "38886900"}], "href": "https://pubmed.ncbi.nlm.nih.gov/38886900"}]}, {"type": "r", "ref": 38, "children": [{"type": "t", "text": "Junhong Xiao, Yifei Deng, Jirong Xie, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Apoptotic vesicles from macrophages exacerbate periodontal bone resorption in periodontitis via delivering miR-143-3p targeting Igfbp5."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Nanobiotechnology (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12951-024-02934-2"}], "href": "https://doi.org/10.1186/s12951-024-02934-2"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "39456001"}], "href": "https://pubmed.ncbi.nlm.nih.gov/39456001"}]}, {"type": "r", "ref": 39, "children": [{"type": "t", "text": "Basem M Abdallah "}, {"type": "b", "children": [{"type": "t", "text": "Osteoblast differentiation of NIH3T3 fibroblasts is associated with changes in the IGF-I/IGFBP expression pattern."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Mol Biol Lett (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.2478/s11658-006-0038-y"}], "href": "https://doi.org/10.2478/s11658-006-0038-y"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17001448"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17001448"}]}]}]}
|
| Synonyms | TPCR16, OR4D3, OR4D4P |
| Proteins | OR4D1_HUMAN |
| NCBI Gene ID | 26689 |
| API | |
| Download Associations | |
| Predicted Functions |
 |
| Co-expressed Genes |
|
| Expression in Tissues and Cell Lines |
|
OR4D1 has 1,767 functional associations with biological entities spanning 8 categories (molecular profile, organism, functional term, phrase or reference, disease, phenotype or trait, chemical, structural feature, cell line, cell type or tissue, gene, protein or microRNA) extracted from 62 datasets.
Click the + buttons to view associations for OR4D1 from the datasets below.
If available, associations are ranked by standardized value
| Dataset | Summary | |
|---|---|---|
| Achilles Cell Line Gene Essentiality Profiles | cell lines with fitness changed by OR4D1 gene knockdown relative to other cell lines from the Achilles Cell Line Gene Essentiality Profiles dataset. | |
| Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles | tissue samples with high or low expression of OR4D1 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset. | |
| Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray | tissue samples with high or low expression of OR4D1 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset. | |
| BioGPS Human Cell Type and Tissue Gene Expression Profiles | cell types and tissues with high or low expression of OR4D1 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset. | |
| BioGPS Mouse Cell Type and Tissue Gene Expression Profiles | cell types and tissues with high or low expression of OR4D1 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset. | |
| CCLE Cell Line Gene CNV Profiles | cell lines with high or low copy number of OR4D1 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset. | |
| CCLE Cell Line Gene Expression Profiles | cell lines with high or low expression of OR4D1 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset. | |
| ChEA Transcription Factor Binding Site Profiles | transcription factor binding site profiles with transcription factor binding evidence at the promoter of OR4D1 gene from the CHEA Transcription Factor Binding Site Profiles dataset. | |
| ChEA Transcription Factor Targets | transcription factors binding the promoter of OR4D1 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset. | |
| ChEA Transcription Factor Targets 2022 | transcription factors binding the promoter of OR4D1 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset. | |
| CM4AI KOLF21J CRISPRi Gene Perturbation Atlas | gene perturbations changing expression of OR4D1 gene from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas dataset. | |
| COMPARTMENTS Curated Protein Localization Evidence Scores | cellular components containing OR4D1 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset. | |
| COMPARTMENTS Text-mining Protein Localization Evidence Scores | cellular components co-occuring with OR4D1 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset. | |
| COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 | cellular components co-occuring with OR4D1 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset. | |
| COSMIC Cell Line Gene CNV Profiles | cell lines with high or low copy number of OR4D1 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset. | |
| COSMIC Cell Line Gene Mutation Profiles | cell lines with OR4D1 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset. | |
| DepMap CRISPR Gene Dependency | cell lines with fitness changed by OR4D1 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset. | |
| DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 | diseases co-occuring with OR4D1 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset. | |
| DisGeNET Gene-Phenotype Associations | phenotypes associated with OR4D1 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset. | |
| ENCODE Histone Modification Site Profiles | histone modification site profiles with high histone modification abundance at OR4D1 gene from the ENCODE Histone Modification Site Profiles dataset. | |
| ENCODE Transcription Factor Binding Site Profiles | transcription factor binding site profiles with transcription factor binding evidence at the promoter of OR4D1 gene from the ENCODE Transcription Factor Binding Site Profiles dataset. | |
| ENCODE Transcription Factor Targets | transcription factors binding the promoter of OR4D1 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset. | |
| ESCAPE Omics Signatures of Genes and Proteins for Stem Cells | PubMedIDs of publications reporting gene signatures containing OR4D1 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset. | |
| GAD Gene-Disease Associations | diseases associated with OR4D1 gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset. | |
| GAD High Level Gene-Disease Associations | diseases associated with OR4D1 gene in GWAS and other genetic association datasets from the GAD High Level Gene-Disease Associations dataset. | |
| GEO Signatures of Differentially Expressed Genes for Diseases | disease perturbations changing expression of OR4D1 gene from the GEO Signatures of Differentially Expressed Genes for Diseases dataset. | |
| GEO Signatures of Differentially Expressed Genes for Gene Perturbations | gene perturbations changing expression of OR4D1 gene from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset. | |
| GEO Signatures of Differentially Expressed Genes for Small Molecules | small molecule perturbations changing expression of OR4D1 gene from the GEO Signatures of Differentially Expressed Genes for Small Molecules dataset. | |
| GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations | transcription factor perturbations changing expression of OR4D1 gene from the GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations dataset. | |
| GEO Signatures of Differentially Expressed Genes for Viral Infections | virus perturbations changing expression of OR4D1 gene from the GEO Signatures of Differentially Expressed Genes for Viral Infections dataset. | |
| GO Biological Process Annotations 2015 | biological processes involving OR4D1 gene from the curated GO Biological Process Annotations 2015 dataset. | |
| GO Biological Process Annotations 2023 | biological processes involving OR4D1 gene from the curated GO Biological Process Annotations 2023 dataset. | |
| GO Biological Process Annotations 2025 | biological processes involving OR4D1 gene from the curated GO Biological Process Annotations2025 dataset. | |
| GO Cellular Component Annotations 2015 | cellular components containing OR4D1 protein from the curated GO Cellular Component Annotations 2015 dataset. | |
| GO Molecular Function Annotations 2015 | molecular functions performed by OR4D1 gene from the curated GO Molecular Function Annotations 2015 dataset. | |
| GO Molecular Function Annotations 2023 | molecular functions performed by OR4D1 gene from the curated GO Molecular Function Annotations 2023 dataset. | |
| GO Molecular Function Annotations 2025 | molecular functions performed by OR4D1 gene from the curated GO Molecular Function Annotations 2025 dataset. | |
| GTEx Tissue Gene Expression Profiles | tissues with high or low expression of OR4D1 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles dataset. | |
| GTEx Tissue Gene Expression Profiles 2023 | tissues with high or low expression of OR4D1 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles 2023 dataset. | |
| Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles | cell lines with high or low expression of OR4D1 gene relative to other cell lines from the Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles dataset. | |
| HuGE Navigator Gene-Phenotype Associations | phenotypes associated with OR4D1 gene by text-mining GWAS publications from the HuGE Navigator Gene-Phenotype Associations dataset. | |
| InterPro Predicted Protein Domain Annotations | protein domains predicted for OR4D1 protein from the InterPro Predicted Protein Domain Annotations dataset. | |
| JASPAR Predicted Human Transcription Factor Targets 2025 | transcription factors regulating expression of OR4D1 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Human Transcription Factor Targets dataset. | |
| JASPAR Predicted Mouse Transcription Factor Targets 2025 | transcription factors regulating expression of OR4D1 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Mouse Transcription Factor Targets 2025 dataset. | |
| JASPAR Predicted Transcription Factor Targets | transcription factors regulating expression of OR4D1 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset. | |
| KEGG Pathways 2026 | pathways involving OR4D1 protein from the KEGG Pathways 2026 dataset. | |
| Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles | cell lines with high or low copy number of OR4D1 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset. | |
| Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles | cell lines with OR4D1 gene mutations from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles dataset. | |
| KnockTF Gene Expression Profiles with Transcription Factor Perturbations | transcription factor perturbations changing expression of OR4D1 gene from the KnockTF Gene Expression Profiles with Transcription Factor Perturbations dataset. | |
| LOCATE Predicted Protein Localization Annotations | cellular components predicted to contain OR4D1 protein from the LOCATE Predicted Protein Localization Annotations dataset. | |
| MotifMap Predicted Transcription Factor Targets | transcription factors regulating expression of OR4D1 gene predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset. | |
| Reactome Pathways 2014 | pathways involving OR4D1 protein from the Reactome Pathways dataset. | |
| Reactome Pathways 2024 | pathways involving OR4D1 protein from the Reactome Pathways 2024 dataset. | |
| Roadmap Epigenomics Histone Modification Site Profiles | histone modification site profiles with high histone modification abundance at OR4D1 gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset. | |
| Rummagene Transcription Factor Associations 2026 | transcription factors regulating expression of OR4D1 gene from the Rummagene Transcription Factor Associations 2026 dataset. | |
| RummaGEO Drug Perturbation Signatures | drug perturbations changing expression of OR4D1 gene from the RummaGEO Drug Perturbation Signatures dataset. | |
| RummaGEO Gene Perturbation Signatures | gene perturbations changing expression of OR4D1 gene from the RummaGEO Gene Perturbation Signatures dataset. | |
| Tabula Sapiens Gene-Cell Associations | cell types with high or low expression of OR4D1 gene relative to other cell types from the Tabula Sapiens Gene-Cell Associations dataset. | |
| TCGA Signatures of Differentially Expressed Genes for Tumors | tissue samples with high or low expression of OR4D1 gene relative to other tissue samples from the TCGA Signatures of Differentially Expressed Genes for Tumors dataset. | |
| TISSUES Curated Tissue Protein Expression Evidence Scores | tissues with high expression of OR4D1 protein from the TISSUES Curated Tissue Protein Expression Evidence Scores dataset. | |
| TISSUES Curated Tissue Protein Expression Evidence Scores 2025 | tissues with high expression of OR4D1 protein from the TISSUES Curated Tissue Protein Expression Evidence Scores 2025 dataset. | |
| TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 | tissues co-occuring with OR4D1 protein in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 dataset. | |
