| HGNC Family | G protein-coupled receptors |
| Name | olfactory receptor, family 52, subfamily J, member 3 |
| Description | Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008] |
| Summary |
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nMultiple studies have implicated ORMDL3 as a critical mediator of airway inflammation and remodeling in allergic asthma. Increased ORMDL3 expression in response to allergen challenge has been shown to promote airway smooth muscle proliferation, subepithelial fibrosis, and mucus hypersecretion, while simultaneously heightening IgE levels and facilitating eosinophil activation, rolling, and degranulation. These effects suggest that ORMDL3 contributes directly to the development of airway hyperresponsiveness and immune cell recruitment in asthma."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "4"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn addition to its role in airway pathology, ORMDL3 is widely recognized for its regulatory influence on sphingolipid metabolism. As a negative modulator of serine palmitoyltransferase—the rate‐limiting enzyme in de novo sphingolipid synthesis—ORMDL3 has been associated with subtle modifications in cellular ceramide profiles and sphingosine‐1‐phosphate levels, although its overall control of sphingolipid production appears complex and context dependent. Mouse models with altered ORMDL3 expression further underscore how this protein may impact endoplasmic reticulum stress responses and downstream lipid signaling events."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "5", "end_ref": "10"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nORMDL3 also modulates activation of mast cells and the integrity of the airway epithelial barrier. In mast cells, reduced ORMDL3 expression amplifies AKT and NF‑κB signaling, resulting in enhanced degranulation and cytokine production, whereas its overexpression dampens these responses via induction of unfolded protein response effectors and autophagy mediators. Similarly, in airway epithelial cells, altered ORMDL3 levels affect tight junction protein expression and paracellular permeability through the SPHK1/ERK pathway, thereby contributing to epithelial dysfunction observed in asthma. Furthermore, targeted interventions that modify ORMDL3 expression in these cells have been shown to decrease inflammatory cell infiltration and mucus secretion."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "11", "end_ref": "16"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its established roles in asthma, emerging evidence indicates that ORMDL3 functions as a multifaceted regulator in other biological contexts. It appears to affect circadian regulation of immune-related genes and participates in metabolic pathways linked to obesity, insulin resistance, and even β‑cell function. Moreover, ORMDL3 has been implicated in processes such as pyroptosis in obese asthmatic models, modulation of B cell development and survival in autoimmune conditions, and the regulation of ferroptosis in Alzheimer’s disease via endoplasmic reticulum stress pathways. Interactions with other cellular proteins—including those involved in leukotriene synthesis and chromatin modification—suggest that ORMDL3 integrates lipid metabolism, inflammatory signaling, and cell stress responses to influence a broad spectrum of disorders."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "17", "end_ref": "25"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Marina Miller, Peter Rosenthal, Andrew Beppu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "ORMDL3 transgenic mice have increased airway remodeling and airway responsiveness characteristic of asthma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Immunol (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4049/jimmunol.1303047"}], "href": "https://doi.org/10.4049/jimmunol.1303047"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24623133"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24623133"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Clement Oyeniran, Jamie L Sturgill, Nitai C Hait, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Aberrant ORM (yeast)-like protein isoform 3 (ORMDL3) expression dysregulates ceramide homeostasis in cells and ceramide exacerbates allergic asthma in mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Allergy Clin Immunol (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.jaci.2015.02.031"}], "href": "https://doi.org/10.1016/j.jaci.2015.02.031"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25842287"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25842287"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Sung Gil Ha, Xiao Na Ge, Nooshin S Bahaie, et al. "}, {"type": "b", "children": [{"type": "t", "text": "ORMDL3 promotes eosinophil trafficking and activation via regulation of integrins and CD48."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Commun (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ncomms3479"}], "href": "https://doi.org/10.1038/ncomms3479"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24056518"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24056518"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Stephan Löser, Lisa G Gregory, Youming Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Pulmonary ORMDL3 is critical for induction of Alternaria-induced allergic airways disease."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Allergy Clin Immunol (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.jaci.2016.07.033"}], "href": "https://doi.org/10.1016/j.jaci.2016.07.033"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27623174"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27623174"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Deanna Siow, Manjula Sunkara, Teresa M Dunn, et al. "}, {"type": "b", "children": [{"type": "t", "text": "ORMDL/serine palmitoyltransferase stoichiometry determines effects of ORMDL3 expression on sphingolipid biosynthesis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Lipid Res (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1194/jlr.M057539"}], "href": "https://doi.org/10.1194/jlr.M057539"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25691431"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25691431"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Marina Miller, Arvin B Tam, James L Mueller, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Cutting Edge: Targeting Epithelial ORMDL3 Increases, Rather than Reduces, Airway Responsiveness and Is Associated with Increased Sphingosine-1-Phosphate."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Immunol (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4049/jimmunol.1601848"}], "href": "https://doi.org/10.4049/jimmunol.1601848"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28275141"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28275141"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Benjamin A Clarke, Saurav Majumder, Hongling Zhu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The "}, {"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "Ormdl"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": " genes regulate the sphingolipid synthesis pathway to ensure proper myelination and neurologic function in mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Elife (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.7554/eLife.51067"}], "href": "https://doi.org/10.7554/eLife.51067"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31880535"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31880535"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Nincy Debeuf, Assem Zhakupova, Regula Steiner, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The ORMDL3 asthma susceptibility gene regulates systemic ceramide levels without altering key asthma features in mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Allergy Clin Immunol (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.jaci.2019.06.041"}], "href": "https://doi.org/10.1016/j.jaci.2019.06.041"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31330218"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31330218"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Jie Dang, Xianli Bian, Xiaochun Ma, et al. "}, {"type": "b", "children": [{"type": "t", "text": "ORMDL3 Facilitates the Survival of Splenic B Cells via an ATF6α-Endoplasmic Reticulum Stress-Beclin1 Autophagy Regulatory Pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Immunol (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4049/jimmunol.1602124"}], "href": "https://doi.org/10.4049/jimmunol.1602124"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28747345"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28747345"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Assem Zhakupova, Nincy Debeuf, Michiel Krols, et al. "}, {"type": "b", "children": [{"type": "t", "text": "ORMDL3 expression levels have no influence on the activity of serine palmitoyltransferase."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "FASEB J (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1096/fj.201600639R"}], "href": "https://doi.org/10.1096/fj.201600639R"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27645259"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27645259"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Viktor Bugajev, Ivana Halova, Lubica Draberova, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Negative regulatory roles of ORMDL3 in the FcεRI-triggered expression of proinflammatory mediators and chemotactic response in murine mast cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Mol Life Sci (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s00018-015-2047-3"}], "href": "https://doi.org/10.1007/s00018-015-2047-3"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26407610"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26407610"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Fei Yu, Yan Sun, Jiachen Yu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "ORMDL3 is associated with airway remodeling in asthma via the ERK/MMP-9 pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Med Rep (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/mmr.2017.6413"}], "href": "https://doi.org/10.3892/mmr.2017.6413"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28358425"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28358425"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Jia Li, Md Ashik Ullah, Hongping Jin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "ORMDL3 Functions as a Negative Regulator of Antigen-Mediated Mast Cell Activation "}, {"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "via"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": " an ATF6-UPR-Autophagy-Dependent Pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Front Immunol (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3389/fimmu.2021.604974"}], "href": "https://doi.org/10.3389/fimmu.2021.604974"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33679742"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33679742"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Ruixue Yang, Min Tan, Jianya Xu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Investigating the regulatory role of ORMDL3 in airway barrier dysfunction using in vivo and in vitro models."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Mol Med (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/ijmm.2019.4233"}], "href": "https://doi.org/10.3892/ijmm.2019.4233"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31173170"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31173170"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Huan Wang, Ying Liu, Jiang Shi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "ORMDL3 knockdown in the lungs alleviates airway inflammation and airway remodeling in asthmatic mice via JNK1/2-MMP-9 pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2019.06.122"}], "href": "https://doi.org/10.1016/j.bbrc.2019.06.122"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31255288"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31255288"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Li-Li Zhuang, Rui Jin, Liang-Hua Zhu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Promoter characterization and role of cAMP/PKA/CREB in the basal transcription of the mouse ORMDL3 gene."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0060630"}], "href": "https://doi.org/10.1371/journal.pone.0060630"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23577138"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23577138"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Yu Song, Wenying Zan, Liping Qin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Ablation of ORMDL3 impairs adipose tissue thermogenesis and insulin sensitivity by increasing ceramide generation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Metab (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.molmet.2021.101423"}], "href": "https://doi.org/10.1016/j.molmet.2021.101423"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34954108"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34954108"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Viktor Bugajev, Ivana Halova, Livia Demkova, et al. "}, {"type": "b", "children": [{"type": "t", "text": "ORMDL2 Deficiency Potentiates the ORMDL3-Dependent Changes in Mast Cell Signaling."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Front Immunol (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3389/fimmu.2020.591975"}], "href": "https://doi.org/10.3389/fimmu.2020.591975"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33643282"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33643282"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Briana N James, Cynthia Weigel, Christopher D Green, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Neutrophilia in severe asthma is reduced in Ormdl3 overexpressing mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "FASEB J (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1096/fj.202201821R"}], "href": "https://doi.org/10.1096/fj.202201821R"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36753412"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36753412"}]}, {"type": "r", "ref": 20, "children": [{"type": "t", "text": "Viktor Bugajev, Tomas Paulenda, Pavol Utekal, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Crosstalk between ORMDL3, serine palmitoyltransferase, and 5-lipoxygenase in the sphingolipid and eicosanoid metabolic pathways."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Lipid Res (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.jlr.2021.100121"}], "href": "https://doi.org/10.1016/j.jlr.2021.100121"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34560079"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34560079"}]}, {"type": "r", "ref": 21, "children": [{"type": "t", "text": "Yankun Shao, Yilin Xu, Huang Di, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The inhibition of ORMDL3 prevents Alzheimer's disease through ferroptosis by PERK/ATF4/HSPA5 pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "IET Nanobiotechnol (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1049/nbt2.12113"}], "href": "https://doi.org/10.1049/nbt2.12113"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36680386"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36680386"}]}, {"type": "r", "ref": 22, "children": [{"type": "t", "text": "Mina Youssef, Juan B De Sanctis, Juhi Shah, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Treatment of Allergic Asthma with Fenretinide Formulation (LAU-7b) Downregulates ORMDL Sphingolipid Biosynthesis Regulator 3 (Ormdl3) Expression and Normalizes Ceramide Imbalance."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Pharmacol Exp Ther (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1124/jpet.119.263715"}], "href": "https://doi.org/10.1124/jpet.119.263715"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32273303"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32273303"}]}, {"type": "r", "ref": 23, "children": [{"type": "t", "text": "Qi Cheng, Fanghan He, Wenqi Zhao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Histone acetylation regulates ORMDL3 expression-mediated NLRP3 inflammasome overexpression during RSV-allergic exacerbation mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Physiol (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jcp.31141"}], "href": "https://doi.org/10.1002/jcp.31141"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "37877592"}], "href": "https://pubmed.ncbi.nlm.nih.gov/37877592"}]}, {"type": "r", "ref": 24, "children": [{"type": "t", "text": "Huiwen Zhang, Lili Zhuang, Rui Jin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "[Recombinant platanus pollen allergen 2 (rPla a2) up-regulates the expression of ORMDL3 mediated by GATA3 in NIH3T3 cells]."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi (2017)"}]}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28031110"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28031110"}]}, {"type": "r", "ref": 25, "children": [{"type": "t", "text": "Livia Demkova, Viktor Bugajev, Miroslava K Adamcova, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Simultaneous deletion of ORMDL1 and ORMDL3 proteins disrupts immune cell homeostasis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Front Immunol (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3389/fimmu.2024.1376629"}], "href": "https://doi.org/10.3389/fimmu.2024.1376629"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "38715613"}], "href": "https://pubmed.ncbi.nlm.nih.gov/38715613"}]}]}]}
|
| Synonyms | OR11-32 |
| Proteins | O52J3_HUMAN |
| NCBI Gene ID | 119679 |
| API | |
| Download Associations | |
| Predicted Functions |
 |
| Co-expressed Genes |
|
| Expression in Tissues and Cell Lines |
|
OR52J3 has 1,023 functional associations with biological entities spanning 7 categories (molecular profile, functional term, phrase or reference, chemical, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA) extracted from 54 datasets.
Click the + buttons to view associations for OR52J3 from the datasets below.
If available, associations are ranked by standardized value
| Dataset | Summary | |
|---|---|---|
| Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles | tissues with high or low expression of OR52J3 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset. | |
| Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles | tissue samples with high or low expression of OR52J3 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset. | |
| Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray | tissue samples with high or low expression of OR52J3 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset. | |
| BioGPS Human Cell Type and Tissue Gene Expression Profiles | cell types and tissues with high or low expression of OR52J3 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset. | |
| CCLE Cell Line Gene CNV Profiles | cell lines with high or low copy number of OR52J3 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset. | |
| ChEA Transcription Factor Binding Site Profiles | transcription factor binding site profiles with transcription factor binding evidence at the promoter of OR52J3 gene from the CHEA Transcription Factor Binding Site Profiles dataset. | |
| ChEA Transcription Factor Targets | transcription factors binding the promoter of OR52J3 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset. | |
| ChEA Transcription Factor Targets 2022 | transcription factors binding the promoter of OR52J3 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset. | |
| CM4AI KOLF21J CRISPRi Gene Perturbation Atlas | gene perturbations changing expression of OR52J3 gene from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas dataset. | |
| COMPARTMENTS Curated Protein Localization Evidence Scores | cellular components containing OR52J3 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset. | |
| COMPARTMENTS Text-mining Protein Localization Evidence Scores | cellular components co-occuring with OR52J3 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset. | |
| COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 | cellular components co-occuring with OR52J3 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset. | |
| COSMIC Cell Line Gene Mutation Profiles | cell lines with OR52J3 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset. | |
| DepMap CRISPR Gene Dependency | cell lines with fitness changed by OR52J3 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset. | |
| DGIdb Drug Targets 2026 | interacting drugs for OR52J3 protein from the DGIdb Drug Targets 2026 dataset. | |
| DISEASES Experimental Gene-Disease Association Evidence Scores | diseases associated with OR52J3 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores dataset. | |
| DISEASES Text-mining Gene-Disease Association Evidence Scores | diseases co-occuring with OR52J3 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset. | |
| DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 | diseases co-occuring with OR52J3 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset. | |
| ENCODE Histone Modification Site Profiles | histone modification site profiles with high histone modification abundance at OR52J3 gene from the ENCODE Histone Modification Site Profiles dataset. | |
| ENCODE Transcription Factor Binding Site Profiles | transcription factor binding site profiles with transcription factor binding evidence at the promoter of OR52J3 gene from the ENCODE Transcription Factor Binding Site Profiles dataset. | |
| ENCODE Transcription Factor Targets | transcription factors binding the promoter of OR52J3 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset. | |
| GEO Signatures of Differentially Expressed Genes for Diseases | disease perturbations changing expression of OR52J3 gene from the GEO Signatures of Differentially Expressed Genes for Diseases dataset. | |
| GEO Signatures of Differentially Expressed Genes for Gene Perturbations | gene perturbations changing expression of OR52J3 gene from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset. | |
| GEO Signatures of Differentially Expressed Genes for Kinase Perturbations | kinase perturbations changing expression of OR52J3 gene from the GEO Signatures of Differentially Expressed Genes for Kinase Perturbations dataset. | |
| GEO Signatures of Differentially Expressed Genes for Small Molecules | small molecule perturbations changing expression of OR52J3 gene from the GEO Signatures of Differentially Expressed Genes for Small Molecules dataset. | |
| GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations | transcription factor perturbations changing expression of OR52J3 gene from the GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations dataset. | |
| GO Biological Process Annotations 2015 | biological processes involving OR52J3 gene from the curated GO Biological Process Annotations 2015 dataset. | |
| GO Cellular Component Annotations 2015 | cellular components containing OR52J3 protein from the curated GO Cellular Component Annotations 2015 dataset. | |
| GO Molecular Function Annotations 2015 | molecular functions performed by OR52J3 gene from the curated GO Molecular Function Annotations 2015 dataset. | |
| GO Molecular Function Annotations 2023 | molecular functions performed by OR52J3 gene from the curated GO Molecular Function Annotations 2023 dataset. | |
| GO Molecular Function Annotations 2025 | molecular functions performed by OR52J3 gene from the curated GO Molecular Function Annotations 2025 dataset. | |
| GTEx Tissue Gene Expression Profiles | tissues with high or low expression of OR52J3 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles dataset. | |
| GTEx Tissue Gene Expression Profiles 2023 | tissues with high or low expression of OR52J3 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles 2023 dataset. | |
| GWAS Catalog SNP-Phenotype Associations 2025 | phenotypes associated with OR52J3 gene in GWAS datasets from the GWAS Catalog SNP-Phenotype Associations 2025 dataset. | |
| Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles | cell lines with high or low expression of OR52J3 gene relative to other cell lines from the Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles dataset. | |
| HuGE Navigator Gene-Phenotype Associations | phenotypes associated with OR52J3 gene by text-mining GWAS publications from the HuGE Navigator Gene-Phenotype Associations dataset. | |
| InterPro Predicted Protein Domain Annotations | protein domains predicted for OR52J3 protein from the InterPro Predicted Protein Domain Annotations dataset. | |
| JASPAR Predicted Human Transcription Factor Targets 2025 | transcription factors regulating expression of OR52J3 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Human Transcription Factor Targets dataset. | |
| JASPAR Predicted Mouse Transcription Factor Targets 2025 | transcription factors regulating expression of OR52J3 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Mouse Transcription Factor Targets 2025 dataset. | |
| JASPAR Predicted Transcription Factor Targets | transcription factors regulating expression of OR52J3 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset. | |
| KEGG Pathways 2026 | pathways involving OR52J3 protein from the KEGG Pathways 2026 dataset. | |
| Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles | cell lines with high or low copy number of OR52J3 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset. | |
| KnockTF Gene Expression Profiles with Transcription Factor Perturbations | transcription factor perturbations changing expression of OR52J3 gene from the KnockTF Gene Expression Profiles with Transcription Factor Perturbations dataset. | |
| LOCATE Predicted Protein Localization Annotations | cellular components predicted to contain OR52J3 protein from the LOCATE Predicted Protein Localization Annotations dataset. | |
| MotifMap Predicted Transcription Factor Targets | transcription factors regulating expression of OR52J3 gene predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset. | |
| Reactome Pathways 2014 | pathways involving OR52J3 protein from the Reactome Pathways dataset. | |
| Reactome Pathways 2024 | pathways involving OR52J3 protein from the Reactome Pathways 2024 dataset. | |
| Roadmap Epigenomics Histone Modification Site Profiles | histone modification site profiles with high histone modification abundance at OR52J3 gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset. | |
| Rummagene Transcription Factor Associations 2026 | transcription factors regulating expression of OR52J3 gene from the Rummagene Transcription Factor Associations 2026 dataset. | |
| RummaGEO Drug Perturbation Signatures | drug perturbations changing expression of OR52J3 gene from the RummaGEO Drug Perturbation Signatures dataset. | |
| RummaGEO Gene Perturbation Signatures | gene perturbations changing expression of OR52J3 gene from the RummaGEO Gene Perturbation Signatures dataset. | |
| TCGA Signatures of Differentially Expressed Genes for Tumors | tissue samples with high or low expression of OR52J3 gene relative to other tissue samples from the TCGA Signatures of Differentially Expressed Genes for Tumors dataset. | |
| TISSUES Text-mining Tissue Protein Expression Evidence Scores | tissues co-occuring with OR52J3 protein in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores dataset. | |
| TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 | tissues co-occuring with OR52J3 protein in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 dataset. | |
