| HGNC Family | G protein-coupled receptors |
| Name | olfactory receptor, family 52, subfamily L, member 1 |
| Description | Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008] |
| Summary |
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nTrefoil factor 2 (TFF2) is a multifunctional secreted peptide that plays a central role in maintaining gastrointestinal mucosal integrity, promoting epithelial restitution after injury, and modulating tumorigenesis. In the stomach, TFF2 is expressed by progenitor and metaplastic cell populations and is up‐regulated in response to injury or Helicobacter infection, where it protects against inflammation‐associated neoplastic progression. TFF2 transcription is regulated by hormones such as gastrin and can be suppressed by oncogenic signals (e.g., p53), thereby influencing both cell survival and migration. Moreover, altered levels of TFF2 have been linked to the emergence of spasmolytic polypeptide–expressing metaplasia and can modulate intestinal tumor size when dysregulated."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "15"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn the lung and intestine, TFF2 contributes to both the resolution of tissue injury and the regulation of local immune responses. In models of parasitic infection and allergic inflammation, TFF2 promotes epithelial proliferation (often through modulation of CXCR4 and Wnt signaling pathways), facilitates barrier repair, and can attenuate airway remodeling by reducing epithelial thickening, collagen deposition, and goblet cell metaplasia. TFF2 also exerts systemic anti‐inflammatory effects—for example, released by vagally modulated splenic T cells, it limits the expansion of myeloid‐derived suppressor cells. These findings are complemented by reports that emphasize the complex interplay of other inflammatory regulators (such as hnRNP A1) within mucosal networks."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "16", "end_ref": "25"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its well‐established roles in mucosal surfaces, TFF2 functions in the pancreas and liver to mediate intercellular cross talk and maintain organ homeostasis. In the pancreas, exocrine acinar cell–derived TFF2 supports the survival and function of insulin‐producing β‐cells, thereby contributing to endocrine integrity. In the liver, aberrant secretion of TFF2 by injured hepatocytes triggers hepatic stellate cell activation and fibrogenesis, whereas in cholangiocarcinogenesis TFF2 acts as a tumor suppressor by modulating PTEN signaling. Collectively, these diverse functions underscore TFF2’s critical versatility as a protective, reparative, and regulatory factor in multiple organ systems."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "26", "end_ref": "29"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Nikolaos M Nikolaidis, Nives Zimmermann, Nina E King, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Trefoil factor-2 is an allergen-induced gene regulated by Th2 cytokines and STAT6 in the lung."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Respir Cell Mol Biol (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1165/rcmb.2002-0309OC"}], "href": "https://doi.org/10.1165/rcmb.2002-0309OC"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12702542"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12702542"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "P L Beck, J F Wong, Y Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Chemotherapy- and radiotherapy-induced intestinal damage is regulated by intestinal trefoil factor."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Gastroenterology (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1053/j.gastro.2003.12.004"}], "href": "https://doi.org/10.1053/j.gastro.2003.12.004"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "14988834"}], "href": "https://pubmed.ncbi.nlm.nih.gov/14988834"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Sachiyo Nomura, Tammy Baxter, Hirokazu Yamaguchi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Spasmolytic polypeptide expressing metaplasia to preneoplasia in H. felis-infected mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Gastroenterology (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1053/j.gastro.2004.05.029"}], "href": "https://doi.org/10.1053/j.gastro.2004.05.029"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15300590"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15300590"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Nikki Cheng, Neil A Bhowmick, Anna Chytil, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Loss of TGF-beta type II receptor in fibroblasts promotes mammary carcinoma growth and invasion through upregulation of TGF-alpha-, MSP- and HGF-mediated signaling networks."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncogene (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/sj.onc.1208685"}], "href": "https://doi.org/10.1038/sj.onc.1208685"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15856015"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15856015"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Mirela Baus-Loncar, Janinne Schmid, El-Nasir Lalani, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Trefoil factor 2 (TFF2) deficiency in murine digestive tract influences the immune system."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Physiol Biochem (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1159/000087729"}], "href": "https://doi.org/10.1159/000087729"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16121031"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16121031"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Shuiping Tu, Alfred L Chi, Seonhee Lim, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Gastrin regulates the TFF2 promoter through gastrin-responsive cis-acting elements and multiple signaling pathways."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Physiol Gastrointest Liver Physiol (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1152/ajpgi.00348.2006"}], "href": "https://doi.org/10.1152/ajpgi.00348.2006"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17332476"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17332476"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Koustav Ganguly, Tobias Stoeger, Scott C Wesselkamper, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Candidate genes controlling pulmonary function in mice: transcript profiling and predicted protein structure."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Physiol Genomics (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1152/physiolgenomics.00260.2006"}], "href": "https://doi.org/10.1152/physiolgenomics.00260.2006"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17804602"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17804602"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "James G Fox, Arlin B Rogers, Mark T Whary, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Accelerated progression of gastritis to dysplasia in the pyloric antrum of TFF2 -/- C57BL6 x Sv129 Helicobacter pylori-infected mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Pathol (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.2353/ajpath.2007.070249"}], "href": "https://doi.org/10.2353/ajpath.2007.070249"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17982128"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17982128"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Koji Nozaki, Masako Ogawa, Janice A Williams, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A molecular signature of gastric metaplasia arising in response to acute parietal cell loss."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Gastroenterology (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1053/j.gastro.2007.11.058"}], "href": "https://doi.org/10.1053/j.gastro.2007.11.058"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18242217"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18242217"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Zinaida Dubeykovskaya, Alexander Dubeykovskiy, Joel Solal-Cohen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Secreted trefoil factor 2 activates the CXCR4 receptor in epithelial and lymphocytic cancer cell lines."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M804935200"}], "href": "https://doi.org/10.1074/jbc.M804935200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19064997"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19064997"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Shui Ping Tu, Alfred L Chi, Walden Ai, et al. "}, {"type": "b", "children": [{"type": "t", "text": "p53 inhibition of AP1-dependent TFF2 expression induces apoptosis and inhibits cell migration in gastric cancer cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Physiol Gastrointest Liver Physiol (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1152/ajpgi.90620.2008"}], "href": "https://doi.org/10.1152/ajpgi.90620.2008"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19541923"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19541923"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Lin Xue, Eitaro Aihara, Daniel K Podolsky, et al. "}, {"type": "b", "children": [{"type": "t", "text": "In vivo action of trefoil factor 2 (TFF2) to speed gastric repair is independent of cyclooxygenase."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Gut (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1136/gut.2009.205625"}], "href": "https://doi.org/10.1136/gut.2009.205625"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20587547"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20587547"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Michael Quante, Frederic Marrache, James R Goldenring, et al. "}, {"type": "b", "children": [{"type": "t", "text": "TFF2 mRNA transcript expression marks a gland progenitor cell of the gastric oxyntic mucosa."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Gastroenterology (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1053/j.gastro.2010.08.003"}], "href": "https://doi.org/10.1053/j.gastro.2010.08.003"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20708616"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20708616"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Anthony J Peterson, Trevelyan R Menheniott, Louise O'Connor, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Helicobacter pylori infection promotes methylation and silencing of trefoil factor 2, leading to gastric tumor development in mice and humans."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Gastroenterology (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1053/j.gastro.2010.08.043"}], "href": "https://doi.org/10.1053/j.gastro.2010.08.043"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20801119"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20801119"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Kyoko Fujimoto, Gen Fujii, Kenichi Taguchi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Involvement of trefoil factor family 2 in the enlargement of intestinal tumors in Apc(Min/+) mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2015.06.025"}], "href": "https://doi.org/10.1016/j.bbrc.2015.06.025"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26056002"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26056002"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Marsha Wills-Karp, Reena Rani, Krista Dienger, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Trefoil factor 2 rapidly induces interleukin 33 to promote type 2 immunity during allergic asthma and hookworm infection."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Exp Med (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1084/jem.20110079"}], "href": "https://doi.org/10.1084/jem.20110079"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22329990"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22329990"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Simon G Royce, Clarice Lim, Ruth C Muljadi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Trefoil factor-2 reverses airway remodeling changes in allergic airways disease."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Respir Cell Mol Biol (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1165/rcmb.2011-0320OC"}], "href": "https://doi.org/10.1165/rcmb.2011-0320OC"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22652198"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22652198"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Cortez McBerry, Charlotte E Egan, Reena Rani, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Trefoil factor 2 negatively regulates type 1 immunity against Toxoplasma gondii."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Immunol (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4049/jimmunol.1103374"}], "href": "https://doi.org/10.4049/jimmunol.1103374"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22896633"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22896633"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Maria Rita De Giorgio, Mayumi Yoshioka, Isabelle Riedl, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Trefoil factor family member 2 (Tff2) KO mice are protected from high-fat diet-induced obesity."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Obesity (Silver Spring) (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/oby.20165"}], "href": "https://doi.org/10.1002/oby.20165"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23754443"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23754443"}]}, {"type": "r", "ref": 20, "children": [{"type": "t", "text": "Louise M Judd, Heather V Chalinor, Anna Walduck, et al. "}, {"type": "b", "children": [{"type": "t", "text": "TFF2 deficiency exacerbates weight loss and alters immune cell and cytokine profiles in DSS colitis, and this cannot be rescued by wild-type bone marrow."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Physiol Gastrointest Liver Physiol (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1152/ajpgi.00172.2014"}], "href": "https://doi.org/10.1152/ajpgi.00172.2014"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25324506"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25324506"}]}, {"type": "r", "ref": 21, "children": [{"type": "t", "text": "Adnana N Paunel-Görgülü, Andreas G Franke, Friedrich P Paulsen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Trefoil factor family peptide 2 acts pro-proliferative and pro-apoptotic in the murine retina."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Histochem Cell Biol (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s00418-011-0810-6"}], "href": "https://doi.org/10.1007/s00418-011-0810-6"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21512811"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21512811"}]}, {"type": "r", "ref": 22, "children": [{"type": "t", "text": "Zina Dubeykovskaya, Yiling Si, Xiaowei Chen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Neural innervation stimulates splenic TFF2 to arrest myeloid cell expansion and cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Commun (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ncomms10517"}], "href": "https://doi.org/10.1038/ncomms10517"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26841680"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26841680"}]}, {"type": "r", "ref": 23, "children": [{"type": "t", "text": "Li-Yin Hung, Taylor K Oniskey, Debasish Sen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Trefoil Factor 2 Promotes Type 2 Immunity and Lung Repair through Intrinsic Roles in Hematopoietic and Nonhematopoietic Cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Pathol (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ajpath.2018.01.020"}], "href": "https://doi.org/10.1016/j.ajpath.2018.01.020"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29458008"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29458008"}]}, {"type": "r", "ref": 24, "children": [{"type": "t", "text": "Li-Yin Hung, Debasish Sen, Taylor K Oniskey, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Macrophages promote epithelial proliferation following infectious and non-infectious lung injury through a Trefoil factor 2-dependent mechanism."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mucosal Immunol (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41385-018-0096-2"}], "href": "https://doi.org/10.1038/s41385-018-0096-2"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30337651"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30337651"}]}, {"type": "r", "ref": 25, "children": [{"type": "t", "text": "Xianjun Xu, Jinnian Cheng, Shengzheng Luo, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Deoxycholic acid-stimulated macrophage-derived exosomes promote spasmolytic polypeptide-expressing metaplasia in the stomach."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2020.01.159"}], "href": "https://doi.org/10.1016/j.bbrc.2020.01.159"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32033746"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32033746"}]}, {"type": "r", "ref": 26, "children": [{"type": "t", "text": "Bichen Zhang, Kalina Lapenta, Qi Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Trefoil factor 2 secreted from damaged hepatocytes activates hepatic stellate cells to induce fibrogenesis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.jbc.2021.100887"}], "href": "https://doi.org/10.1016/j.jbc.2021.100887"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34146542"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34146542"}]}, {"type": "r", "ref": 27, "children": [{"type": "t", "text": "Keiji Hasebe, Junpei Yamaguchi, Toshio Kokuryo, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Trefoil factor family 2 inhibits cholangiocarcinogenesis by regulating the PTEN pathway in mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Carcinogenesis (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/carcin/bgab093"}], "href": "https://doi.org/10.1093/carcin/bgab093"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34644378"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34644378"}]}, {"type": "r", "ref": 28, "children": [{"type": "t", "text": "Eva B Znalesniak, Aikaterini Laskou, Franz Salm, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The Forms of the Lectin Tff2 Differ in the Murine Stomach and Pancreas: Indications for Different Molecular Functions."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Mol Sci (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3390/ijms24087059"}], "href": "https://doi.org/10.3390/ijms24087059"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "37108221"}], "href": "https://pubmed.ncbi.nlm.nih.gov/37108221"}]}, {"type": "r", "ref": 29, "children": [{"type": "t", "text": "Jose A Ortiz, Nadiah Ghazalli, Kassandra Lopez, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Trefoil Factor 2 Expressed by the Murine Pancreatic Acinar Cells Is Required for the Development of Islets and for β-Cell Function During Aging."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Diabetes (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.2337/db23-0490"}], "href": "https://doi.org/10.2337/db23-0490"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "38905124"}], "href": "https://pubmed.ncbi.nlm.nih.gov/38905124"}]}]}]}
|
| Synonyms | OR11-50 |
| Proteins | O52L1_HUMAN |
| NCBI Gene ID | 338751 |
| API | |
| Download Associations | |
| Predicted Functions |
 |
| Co-expressed Genes |
|
| Expression in Tissues and Cell Lines |
|
OR52L1 has 1,240 functional associations with biological entities spanning 8 categories (molecular profile, organism, functional term, phrase or reference, disease, phenotype or trait, chemical, structural feature, cell line, cell type or tissue, gene, protein or microRNA) extracted from 51 datasets.
Click the + buttons to view associations for OR52L1 from the datasets below.
If available, associations are ranked by standardized value
| Dataset | Summary | |
|---|---|---|
| Achilles Cell Line Gene Essentiality Profiles | cell lines with fitness changed by OR52L1 gene knockdown relative to other cell lines from the Achilles Cell Line Gene Essentiality Profiles dataset. | |
| Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles | tissues with high or low expression of OR52L1 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset. | |
| Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles | tissue samples with high or low expression of OR52L1 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset. | |
| Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray | tissue samples with high or low expression of OR52L1 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset. | |
| Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles | tissues with high or low expression of OR52L1 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset. | |
| BioGPS Mouse Cell Type and Tissue Gene Expression Profiles | cell types and tissues with high or low expression of OR52L1 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset. | |
| CCLE Cell Line Gene CNV Profiles | cell lines with high or low copy number of OR52L1 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset. | |
| ChEA Transcription Factor Targets 2022 | transcription factors binding the promoter of OR52L1 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset. | |
| CM4AI KOLF21J CRISPRi Gene Perturbation Atlas | gene perturbations changing expression of OR52L1 gene from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas dataset. | |
| COMPARTMENTS Curated Protein Localization Evidence Scores | cellular components containing OR52L1 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset. | |
| COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 | cellular components co-occuring with OR52L1 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset. | |
| COSMIC Cell Line Gene Mutation Profiles | cell lines with OR52L1 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset. | |
| dbGAP Gene-Trait Associations | traits associated with OR52L1 gene in GWAS and other genetic association datasets from the dbGAP Gene-Trait Associations dataset. | |
| DepMap CRISPR Gene Dependency | cell lines with fitness changed by OR52L1 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset. | |
| DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 | diseases co-occuring with OR52L1 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset. | |
| ENCODE Histone Modification Site Profiles | histone modification site profiles with high histone modification abundance at OR52L1 gene from the ENCODE Histone Modification Site Profiles dataset. | |
| ENCODE Transcription Factor Binding Site Profiles | transcription factor binding site profiles with transcription factor binding evidence at the promoter of OR52L1 gene from the ENCODE Transcription Factor Binding Site Profiles dataset. | |
| ENCODE Transcription Factor Targets | transcription factors binding the promoter of OR52L1 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset. | |
| GAD Gene-Disease Associations | diseases associated with OR52L1 gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset. | |
| GEO Signatures of Differentially Expressed Genes for Gene Perturbations | gene perturbations changing expression of OR52L1 gene from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset. | |
| GEO Signatures of Differentially Expressed Genes for Kinase Perturbations | kinase perturbations changing expression of OR52L1 gene from the GEO Signatures of Differentially Expressed Genes for Kinase Perturbations dataset. | |
| GEO Signatures of Differentially Expressed Genes for Small Molecules | small molecule perturbations changing expression of OR52L1 gene from the GEO Signatures of Differentially Expressed Genes for Small Molecules dataset. | |
| GEO Signatures of Differentially Expressed Genes for Viral Infections | virus perturbations changing expression of OR52L1 gene from the GEO Signatures of Differentially Expressed Genes for Viral Infections dataset. | |
| GO Biological Process Annotations 2015 | biological processes involving OR52L1 gene from the curated GO Biological Process Annotations 2015 dataset. | |
| GO Cellular Component Annotations 2015 | cellular components containing OR52L1 protein from the curated GO Cellular Component Annotations 2015 dataset. | |
| GO Molecular Function Annotations 2015 | molecular functions performed by OR52L1 gene from the curated GO Molecular Function Annotations 2015 dataset. | |
| GO Molecular Function Annotations 2023 | molecular functions performed by OR52L1 gene from the curated GO Molecular Function Annotations 2023 dataset. | |
| GO Molecular Function Annotations 2025 | molecular functions performed by OR52L1 gene from the curated GO Molecular Function Annotations 2025 dataset. | |
| GTEx Tissue Gene Expression Profiles | tissues with high or low expression of OR52L1 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles dataset. | |
| GTEx Tissue Gene Expression Profiles 2023 | tissues with high or low expression of OR52L1 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles 2023 dataset. | |
| GWAS Catalog SNP-Phenotype Associations 2025 | phenotypes associated with OR52L1 gene in GWAS datasets from the GWAS Catalog SNP-Phenotype Associations 2025 dataset. | |
| GWASdb SNP-Disease Associations | diseases associated with OR52L1 gene in GWAS and other genetic association datasets from the GWASdb SNP-Disease Associations dataset. | |
| GWASdb SNP-Phenotype Associations | phenotypes associated with OR52L1 gene in GWAS datasets from the GWASdb SNP-Phenotype Associations dataset. | |
| Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles | cell lines with high or low expression of OR52L1 gene relative to other cell lines from the Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles dataset. | |
| InterPro Predicted Protein Domain Annotations | protein domains predicted for OR52L1 protein from the InterPro Predicted Protein Domain Annotations dataset. | |
| JASPAR Predicted Human Transcription Factor Targets 2025 | transcription factors regulating expression of OR52L1 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Human Transcription Factor Targets dataset. | |
| JASPAR Predicted Mouse Transcription Factor Targets 2025 | transcription factors regulating expression of OR52L1 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Mouse Transcription Factor Targets 2025 dataset. | |
| JASPAR Predicted Transcription Factor Targets | transcription factors regulating expression of OR52L1 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset. | |
| KEGG Pathways 2026 | pathways involving OR52L1 protein from the KEGG Pathways 2026 dataset. | |
| Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles | cell lines with high or low copy number of OR52L1 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset. | |
| LOCATE Predicted Protein Localization Annotations | cellular components predicted to contain OR52L1 protein from the LOCATE Predicted Protein Localization Annotations dataset. | |
| MotifMap Predicted Transcription Factor Targets | transcription factors regulating expression of OR52L1 gene predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset. | |
| Reactome Pathways 2014 | pathways involving OR52L1 protein from the Reactome Pathways dataset. | |
| Reactome Pathways 2024 | pathways involving OR52L1 protein from the Reactome Pathways 2024 dataset. | |
| Roadmap Epigenomics Histone Modification Site Profiles | histone modification site profiles with high histone modification abundance at OR52L1 gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset. | |
| Rummagene Transcription Factor Associations 2026 | transcription factors regulating expression of OR52L1 gene from the Rummagene Transcription Factor Associations 2026 dataset. | |
| RummaGEO Drug Perturbation Signatures | drug perturbations changing expression of OR52L1 gene from the RummaGEO Drug Perturbation Signatures dataset. | |
| TargetScan Predicted Nonconserved microRNA Targets | microRNAs regulating expression of OR52L1 gene predicted using nonconserved miRNA seed sequences from the TargetScan Predicted Nonconserved microRNA Targets dataset. | |
| TCGA Signatures of Differentially Expressed Genes for Tumors | tissue samples with high or low expression of OR52L1 gene relative to other tissue samples from the TCGA Signatures of Differentially Expressed Genes for Tumors dataset. | |
| TISSUES Text-mining Tissue Protein Expression Evidence Scores | tissues co-occuring with OR52L1 protein in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores dataset. | |
| TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 | tissues co-occuring with OR52L1 protein in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 dataset. | |
