| HGNC Family | G protein-coupled receptors |
| Name | olfactory receptor, family 5, subfamily D, member 18 |
| Description | Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008] |
| Summary |
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nPhospholipid scramblase 1 (PLSCR1) is an integral, Ca²⁺‐dependent membrane protein that facilitates the bidirectional translocation of phospholipids—most notably phosphatidylserine (PS)—across the plasma membrane. This activity is fundamental to maintaining membrane asymmetry and is central to processes such as apoptosis, cellular clearance, and hematopoietic differentiation. In murine and cellular models, modulation of PLSCR1 expression alters cytokine‐dependent granulocyte formation, affects erythroid cell survival, and accelerates apoptotic events in response to stressors such as UV irradiation and hypoxia–reoxygenation, thereby linking abnormal PS exposure to vascular and inflammatory responses."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "4"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its plasma membrane function, PLSCR1 translocates to the nucleus where it directly binds to gene promoter regions—such as that of the inositol 1,4,5‐triphosphate receptor—to enhance gene expression and thereby modulate intracellular calcium signaling. This nuclear activity interweaves with its interactions with other regulatory proteins (for example, onzin) to influence cell proliferation, differentiation, and apoptotic sensitivity. PLSCR1 is further upregulated by proinflammatory cytokines during the acute phase response and is indispensable for growth factor–mediated emergency granulopoiesis, emphasizing its critical role in the dynamic regulation of hematopoietic homeostasis."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "5", "end_ref": "8"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nPLSCR1 also plays a pivotal role in innate immunity and antiviral defense. As an interferon‐inducible protein, it not only amplifies the expression of select antiviral genes but also physically interacts with toll‐like receptor 9 (TLR9) in plasmacytoid dendritic cells to promote type I interferon production. This multifaceted defense extends to direct inhibition of viral entry events—such as impeding spike‐mediated fusion during SARS‑CoV‑2 infection—as well as broader roles in regulating vesicular trafficking, microglial activity, neuronal apoptosis via interaction with ion channels like TRPC5, and even mast cell degranulation. Additionally, by influencing coagulation‐linked inflammatory pathways, PLSCR1 emerges as a critical modulator in conditions ranging from preterm birth to neuropathic pain."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "9", "end_ref": "16"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Quansheng Zhou, Ji Zhao, Therese Wiedmer, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Normal hemostasis but defective hematopoietic response to growth factors in mice deficient in phospholipid scramblase 1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Blood (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1182/blood-2001-12-0271"}], "href": "https://doi.org/10.1182/blood-2001-12-0271"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12010804"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12010804"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Leslie S Kean, Laura E Brown, J Wylie Nichols, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Comparison of mechanisms of anemia in mice with sickle cell disease and beta-thalassemia: peripheral destruction, ineffective erythropoiesis, and phospholipid scramblase-mediated phosphatidylserine exposure."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Exp Hematol (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/s0301-472x(02)00780-4"}], "href": "https://doi.org/10.1016/s0301-472x(02"}, {"type": "t", "text": "00780-4) PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12031645"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12031645"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Anan Yu, Christopher R McMaster, David M Byers, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Stimulation of phosphatidylserine biosynthesis and facilitation of UV-induced apoptosis in Chinese hamster ovary cells overexpressing phospholipid scramblase 1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M204614200"}], "href": "https://doi.org/10.1074/jbc.M204614200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12509439"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12509439"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Emily Archer Slone, Michael R Pope, Sherry D Fleming "}, {"type": "b", "children": [{"type": "t", "text": "Phospholipid scramblase 1 is required for β2-glycoprotein I binding in hypoxia and reoxygenation-induced endothelial inflammation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Leukoc Biol (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1189/jlb.3A1014-480R"}], "href": "https://doi.org/10.1189/jlb.3A1014-480R"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26216936"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26216936"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Quansheng Zhou, Iris Ben-Efraim, Jo-Lawrence Bigcas, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Phospholipid scramblase 1 binds to the promoter region of the inositol 1,4,5-triphosphate receptor type 1 gene to enhance its expression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M504821200"}], "href": "https://doi.org/10.1074/jbc.M504821200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16091359"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16091359"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Youjun Li, Kenneth Rogulski, Quansheng Zhou, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The negative c-Myc target onzin affects proliferation and apoptosis via its obligate interaction with phospholipid scramblase 1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Biol (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/MCB.26.9.3401-3413.2006"}], "href": "https://doi.org/10.1128/MCB.26.9.3401-3413.2006"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16611984"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16611984"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Biao Lu, Peter J Sims, Therese Wiedmer, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Expression of the phospholipid scramblase (PLSCR) gene family during the acute phase response."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochim Biophys Acta (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbalip.2007.05.002"}], "href": "https://doi.org/10.1016/j.bbalip.2007.05.002"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17590392"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17590392"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Chun-Wei Chen, Mark Sowden, Qian Zhao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Nuclear phospholipid scramblase 1 prolongs the mitotic expansion of granulocyte precursors during G-CSF-induced granulopoiesis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Leukoc Biol (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1189/jlb.0111006"}], "href": "https://doi.org/10.1189/jlb.0111006"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21447647"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21447647"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Beihua Dong, Quansheng Zhou, Ji Zhao, et al. 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| Synonyms | OR11-143 |
| Proteins | OR5DI_HUMAN |
| NCBI Gene ID | 219438 |
| API | |
| Download Associations | |
| Predicted Functions |
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| Co-expressed Genes |
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| Expression in Tissues and Cell Lines |
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OR5D18 has 790 functional associations with biological entities spanning 8 categories (molecular profile, organism, functional term, phrase or reference, disease, phenotype or trait, chemical, structural feature, cell line, cell type or tissue, gene, protein or microRNA) extracted from 47 datasets.
Click the + buttons to view associations for OR5D18 from the datasets below.
If available, associations are ranked by standardized value
| Dataset | Summary | |
|---|---|---|
| Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles | tissue samples with high or low expression of OR5D18 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset. | |
| BioGPS Human Cell Type and Tissue Gene Expression Profiles | cell types and tissues with high or low expression of OR5D18 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset. | |
| BioGPS Mouse Cell Type and Tissue Gene Expression Profiles | cell types and tissues with high or low expression of OR5D18 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset. | |
| CCLE Cell Line Gene CNV Profiles | cell lines with high or low copy number of OR5D18 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset. | |
| ChEA Transcription Factor Binding Site Profiles | transcription factor binding site profiles with transcription factor binding evidence at the promoter of OR5D18 gene from the CHEA Transcription Factor Binding Site Profiles dataset. | |
| ChEA Transcription Factor Targets | transcription factors binding the promoter of OR5D18 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset. | |
| ChEA Transcription Factor Targets 2022 | transcription factors binding the promoter of OR5D18 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset. | |
| COMPARTMENTS Curated Protein Localization Evidence Scores | cellular components containing OR5D18 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset. | |
| COMPARTMENTS Curated Protein Localization Evidence Scores 2025 | cellular components containing OR5D18 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset. | |
| COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 | cellular components co-occuring with OR5D18 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset. | |
| COSMIC Cell Line Gene CNV Profiles | cell lines with high or low copy number of OR5D18 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset. | |
| COSMIC Cell Line Gene Mutation Profiles | cell lines with OR5D18 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset. | |
| DepMap CRISPR Gene Dependency | cell lines with fitness changed by OR5D18 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset. | |
| DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 | diseases co-occuring with OR5D18 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset. | |
| ENCODE Histone Modification Site Profiles | histone modification site profiles with high histone modification abundance at OR5D18 gene from the ENCODE Histone Modification Site Profiles dataset. | |
| ENCODE Transcription Factor Binding Site Profiles | transcription factor binding site profiles with transcription factor binding evidence at the promoter of OR5D18 gene from the ENCODE Transcription Factor Binding Site Profiles dataset. | |
| ENCODE Transcription Factor Targets | transcription factors binding the promoter of OR5D18 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset. | |
| GeneSigDB Published Gene Signatures | PubMedIDs of publications reporting gene signatures containing OR5D18 from the GeneSigDB Published Gene Signatures dataset. | |
| GEO Signatures of Differentially Expressed Genes for Diseases | disease perturbations changing expression of OR5D18 gene from the GEO Signatures of Differentially Expressed Genes for Diseases dataset. | |
| GEO Signatures of Differentially Expressed Genes for Gene Perturbations | gene perturbations changing expression of OR5D18 gene from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset. | |
| GEO Signatures of Differentially Expressed Genes for Kinase Perturbations | kinase perturbations changing expression of OR5D18 gene from the GEO Signatures of Differentially Expressed Genes for Kinase Perturbations dataset. | |
| GEO Signatures of Differentially Expressed Genes for Small Molecules | small molecule perturbations changing expression of OR5D18 gene from the GEO Signatures of Differentially Expressed Genes for Small Molecules dataset. | |
| GEO Signatures of Differentially Expressed Genes for Viral Infections | virus perturbations changing expression of OR5D18 gene from the GEO Signatures of Differentially Expressed Genes for Viral Infections dataset. | |
| GO Biological Process Annotations 2015 | biological processes involving OR5D18 gene from the curated GO Biological Process Annotations 2015 dataset. | |
| GO Biological Process Annotations 2023 | biological processes involving OR5D18 gene from the curated GO Biological Process Annotations 2023 dataset. | |
| GO Biological Process Annotations 2025 | biological processes involving OR5D18 gene from the curated GO Biological Process Annotations2025 dataset. | |
| GO Cellular Component Annotations 2015 | cellular components containing OR5D18 protein from the curated GO Cellular Component Annotations 2015 dataset. | |
| GO Molecular Function Annotations 2015 | molecular functions performed by OR5D18 gene from the curated GO Molecular Function Annotations 2015 dataset. | |
| GO Molecular Function Annotations 2023 | molecular functions performed by OR5D18 gene from the curated GO Molecular Function Annotations 2023 dataset. | |
| GO Molecular Function Annotations 2025 | molecular functions performed by OR5D18 gene from the curated GO Molecular Function Annotations 2025 dataset. | |
| GTEx Tissue Gene Expression Profiles | tissues with high or low expression of OR5D18 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles dataset. | |
| GTEx Tissue Gene Expression Profiles 2023 | tissues with high or low expression of OR5D18 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles 2023 dataset. | |
| Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles | cell lines with high or low expression of OR5D18 gene relative to other cell lines from the Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles dataset. | |
| InterPro Predicted Protein Domain Annotations | protein domains predicted for OR5D18 protein from the InterPro Predicted Protein Domain Annotations dataset. | |
| JASPAR Predicted Human Transcription Factor Targets 2025 | transcription factors regulating expression of OR5D18 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Human Transcription Factor Targets dataset. | |
| JASPAR Predicted Mouse Transcription Factor Targets 2025 | transcription factors regulating expression of OR5D18 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Mouse Transcription Factor Targets 2025 dataset. | |
| JASPAR Predicted Transcription Factor Targets | transcription factors regulating expression of OR5D18 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset. | |
| KEGG Pathways 2026 | pathways involving OR5D18 protein from the KEGG Pathways 2026 dataset. | |
| Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles | cell lines with high or low copy number of OR5D18 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset. | |
| LOCATE Predicted Protein Localization Annotations | cellular components predicted to contain OR5D18 protein from the LOCATE Predicted Protein Localization Annotations dataset. | |
| MotifMap Predicted Transcription Factor Targets | transcription factors regulating expression of OR5D18 gene predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset. | |
| Reactome Pathways 2014 | pathways involving OR5D18 protein from the Reactome Pathways dataset. | |
| Reactome Pathways 2024 | pathways involving OR5D18 protein from the Reactome Pathways 2024 dataset. | |
| Roadmap Epigenomics Histone Modification Site Profiles | histone modification site profiles with high histone modification abundance at OR5D18 gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset. | |
| Rummagene Transcription Factor Associations 2026 | transcription factors regulating expression of OR5D18 gene from the Rummagene Transcription Factor Associations 2026 dataset. | |
| TCGA Signatures of Differentially Expressed Genes for Tumors | tissue samples with high or low expression of OR5D18 gene relative to other tissue samples from the TCGA Signatures of Differentially Expressed Genes for Tumors dataset. | |
| TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 | tissues co-occuring with OR5D18 protein in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 dataset. | |
