| HGNC Family | G protein-coupled receptors |
| Name | olfactory receptor, family 5, subfamily M, member 9 |
| Description | Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008] |
| Summary |
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nAlthough the query mentions “OR5M9,” the provided literature focuses on D‐aspartate oxidase (DDO)—a flavoprotein enzyme that selectively degrades the atypical amino acid D‐aspartate, thereby modulating NMDA receptor activation. In the embryonic brain, D‐aspartate is abundant and acts as an endogenous agonist for NMDA receptors, but its levels decline sharply after birth as DDO expression ramps up. This increase in enzyme activity has been linked to epigenetic events, such as promoter demethylation, which ensure that extracellular D‐aspartate levels remain within a physiologically safe range. In DDO-deficient models, persistent elevation of D‐aspartate leads to neuronal stress, including microglial dystrophy, caspase-3 activation, and cell death, underscoring DDO’s protective role against excitotoxic damage."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nAlterations in DDO expression are also implicated in neurodevelopmental and psychiatric conditions. For instance, increased DDO mRNA levels have been observed in the prefrontal cortex of schizophrenic patients, suggesting that dysregulation of D‐aspartate turnover may contribute to NMDA receptor hypofunction in schizophrenia. Complementary studies in animal models demonstrate that both DDO deficiency and premature enzyme expression (via knockin or knockout strategies) modify brain circuitry, affecting interneuron composition, sensorimotor gating, and performance in behavioral tasks related to memory and social recognition. These observations indicate that proper regulation of D‐aspartate by DDO is crucial for establishing functional neuronal networks."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nAt the molecular level, structural and mutational analyses have revealed that specific residues within DDO are essential for substrate recognition and catalytic efficiency. Substitutions at key arginine sites can dramatically alter substrate specificity, broadening the range of D-amino acids oxidized while reducing activity toward acidic substrates. Furthermore, ultra-deep single-molecule methylation studies during neural differentiation have uncovered complex, cell type–specific epiallele patterns at the DDO promoter, highlighting an additional layer of regulation during brain development. Finally, distinct behavioral phenotypes—including deficits in motor coordination, sensorimotor gating, and alterations in affective responses—observed in both DDO knockout and overexpression models underscore the enzyme’s multifaceted role in neurodevelopment and overall brain function."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "5", "end_ref": "7"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Zachary M Weil, Alex S Huang, Anne Beigneux, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Behavioural alterations in male mice lacking the gene for D-aspartate oxidase."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Behav Brain Res (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbr.2006.04.008"}], "href": "https://doi.org/10.1016/j.bbr.2006.04.008"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16725213"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16725213"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Daniela Punzo, Francesco Errico, Luigia Cristino, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Age-Related Changes in D-Aspartate Oxidase Promoter Methylation Control Extracellular D-Aspartate Levels and Prevent Precocious Cell Death during Brain Aging."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Neurosci (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1523/JNEUROSCI.3881-15.2016"}], "href": "https://doi.org/10.1523/JNEUROSCI.3881-15.2016"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26961959"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26961959"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "F Errico, V D'Argenio, F Sforazzini, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A role for D-aspartate oxidase in schizophrenia and in schizophrenia-related symptoms induced by phencyclidine in mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Transl Psychiatry (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/tp.2015.2"}], "href": "https://doi.org/10.1038/tp.2015.2"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25689573"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25689573"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Barbara Lombardo, Marco Pagani, Arianna De Rosa, et al. "}, {"type": "b", "children": [{"type": "t", "text": "D-aspartate oxidase gene duplication induces social recognition memory deficit in mice and intellectual disabilities in humans."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Transl Psychiatry (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41398-022-02088-5"}], "href": "https://doi.org/10.1038/s41398-022-02088-5"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35915065"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35915065"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Masumi Katane, Yasuaki Saitoh, Kazuhiro Maeda, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Role of the active site residues arginine-216 and arginine-237 in the substrate specificity of mammalian D-aspartate oxidase."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Amino Acids (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s00726-010-0658-4"}], "href": "https://doi.org/10.1007/s00726-010-0658-4"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20567862"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20567862"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Ermanno Florio, Simona Keller, Lorena Coretti, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Tracking the evolution of epialleles during neural differentiation and brain development: D-Aspartate oxidase as a model gene."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Epigenetics (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/15592294.2016.1260211"}], "href": "https://doi.org/10.1080/15592294.2016.1260211"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27858532"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27858532"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Arianna De Rosa, Francesca Mastrostefano, Anna Di Maio, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Prenatal expression of D-aspartate oxidase causes early cerebral D-aspartate depletion and influences brain morphology and cognitive functions at adulthood."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Amino Acids (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s00726-020-02839-y"}], "href": "https://doi.org/10.1007/s00726-020-02839-y"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32185508"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32185508"}]}]}]}
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| Synonyms | OR11-190 |
| Proteins | OR5M9_HUMAN |
| NCBI Gene ID | 390162 |
| API | |
| Download Associations | |
| Predicted Functions |
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| Co-expressed Genes |
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| Expression in Tissues and Cell Lines |
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OR5M9 has 846 functional associations with biological entities spanning 6 categories (molecular profile, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA) extracted from 44 datasets.
Click the + buttons to view associations for OR5M9 from the datasets below.
If available, associations are ranked by standardized value
| Dataset | Summary | |
|---|---|---|
| Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles | tissues with high or low expression of OR5M9 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset. | |
| Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles | tissue samples with high or low expression of OR5M9 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset. | |
| Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray | tissue samples with high or low expression of OR5M9 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset. | |
| Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles | tissues with high or low expression of OR5M9 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset. | |
| CCLE Cell Line Gene CNV Profiles | cell lines with high or low copy number of OR5M9 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset. | |
| ChEA Transcription Factor Binding Site Profiles | transcription factor binding site profiles with transcription factor binding evidence at the promoter of OR5M9 gene from the CHEA Transcription Factor Binding Site Profiles dataset. | |
| ChEA Transcription Factor Targets | transcription factors binding the promoter of OR5M9 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset. | |
| ChEA Transcription Factor Targets 2022 | transcription factors binding the promoter of OR5M9 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset. | |
| CM4AI KOLF21J CRISPRi Gene Perturbation Atlas | gene perturbations changing expression of OR5M9 gene from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas dataset. | |
| COMPARTMENTS Curated Protein Localization Evidence Scores | cellular components containing OR5M9 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset. | |
| COMPARTMENTS Curated Protein Localization Evidence Scores 2025 | cellular components containing OR5M9 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset. | |
| COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 | cellular components co-occuring with OR5M9 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset. | |
| COSMIC Cell Line Gene CNV Profiles | cell lines with high or low copy number of OR5M9 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset. | |
| COSMIC Cell Line Gene Mutation Profiles | cell lines with OR5M9 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset. | |
| DepMap CRISPR Gene Dependency | cell lines with fitness changed by OR5M9 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset. | |
| DISEASES Experimental Gene-Disease Association Evidence Scores 2025 | diseases associated with OR5M9 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset. | |
| ENCODE Histone Modification Site Profiles | histone modification site profiles with high histone modification abundance at OR5M9 gene from the ENCODE Histone Modification Site Profiles dataset. | |
| ENCODE Transcription Factor Binding Site Profiles | transcription factor binding site profiles with transcription factor binding evidence at the promoter of OR5M9 gene from the ENCODE Transcription Factor Binding Site Profiles dataset. | |
| ENCODE Transcription Factor Targets | transcription factors binding the promoter of OR5M9 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset. | |
| ESCAPE Omics Signatures of Genes and Proteins for Stem Cells | PubMedIDs of publications reporting gene signatures containing OR5M9 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset. | |
| GO Biological Process Annotations 2015 | biological processes involving OR5M9 gene from the curated GO Biological Process Annotations 2015 dataset. | |
| GO Biological Process Annotations 2023 | biological processes involving OR5M9 gene from the curated GO Biological Process Annotations 2023 dataset. | |
| GO Biological Process Annotations 2025 | biological processes involving OR5M9 gene from the curated GO Biological Process Annotations2025 dataset. | |
| GO Cellular Component Annotations 2015 | cellular components containing OR5M9 protein from the curated GO Cellular Component Annotations 2015 dataset. | |
| GO Molecular Function Annotations 2015 | molecular functions performed by OR5M9 gene from the curated GO Molecular Function Annotations 2015 dataset. | |
| GO Molecular Function Annotations 2023 | molecular functions performed by OR5M9 gene from the curated GO Molecular Function Annotations 2023 dataset. | |
| GO Molecular Function Annotations 2025 | molecular functions performed by OR5M9 gene from the curated GO Molecular Function Annotations 2025 dataset. | |
| GTEx Tissue Gene Expression Profiles | tissues with high or low expression of OR5M9 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles dataset. | |
| Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles | cell lines with high or low expression of OR5M9 gene relative to other cell lines from the Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles dataset. | |
| InterPro Predicted Protein Domain Annotations | protein domains predicted for OR5M9 protein from the InterPro Predicted Protein Domain Annotations dataset. | |
| JASPAR Predicted Human Transcription Factor Targets 2025 | transcription factors regulating expression of OR5M9 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Human Transcription Factor Targets dataset. | |
| JASPAR Predicted Mouse Transcription Factor Targets 2025 | transcription factors regulating expression of OR5M9 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Mouse Transcription Factor Targets 2025 dataset. | |
| JASPAR Predicted Transcription Factor Targets | transcription factors regulating expression of OR5M9 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset. | |
| KEGG Pathways 2026 | pathways involving OR5M9 protein from the KEGG Pathways 2026 dataset. | |
| Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles | cell lines with high or low copy number of OR5M9 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset. | |
| KnockTF Gene Expression Profiles with Transcription Factor Perturbations | transcription factor perturbations changing expression of OR5M9 gene from the KnockTF Gene Expression Profiles with Transcription Factor Perturbations dataset. | |
| LOCATE Predicted Protein Localization Annotations | cellular components predicted to contain OR5M9 protein from the LOCATE Predicted Protein Localization Annotations dataset. | |
| MotifMap Predicted Transcription Factor Targets | transcription factors regulating expression of OR5M9 gene predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset. | |
| Reactome Pathways 2014 | pathways involving OR5M9 protein from the Reactome Pathways dataset. | |
| Reactome Pathways 2024 | pathways involving OR5M9 protein from the Reactome Pathways 2024 dataset. | |
| Roadmap Epigenomics Histone Modification Site Profiles | histone modification site profiles with high histone modification abundance at OR5M9 gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset. | |
| Rummagene Transcription Factor Associations 2026 | transcription factors regulating expression of OR5M9 gene from the Rummagene Transcription Factor Associations 2026 dataset. | |
| TCGA Signatures of Differentially Expressed Genes for Tumors | tissue samples with high or low expression of OR5M9 gene relative to other tissue samples from the TCGA Signatures of Differentially Expressed Genes for Tumors dataset. | |
| TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 | tissues co-occuring with OR5M9 protein in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 dataset. | |
