| HGNC Family | G protein-coupled receptors |
| Name | olfactory receptor, family 6, subfamily C, member 76 |
| Description | Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008] |
| Summary |
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nLymphocyte activation gene‑3 (LAG‑3) is an inhibitory receptor expressed primarily on activated T cells—including conventional CD4⁺ and CD8⁺ T cells—as well as on regulatory T cells, activated B cells, and even certain dendritic cell subsets. Its engagement with MHC class II molecules (often in complex with specific peptides) results in negative regulation of T‐cell expansion, cytokine secretion, and effector function. In various experimental systems, LAG‑3 has been shown to restrain T‐cell proliferation and to calibrate the size of the memory and effector T‐cell pools, thereby contributing to self‐tolerance and dampening immune responses in settings such as autoimmunity and chronic infections."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "9"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nAt the molecular level, LAG‑3 transduces its inhibitory signals via a distinct cytoplasmic domain that contains conserved motifs essential for binding downstream signaling molecules. Structural studies have revealed that LAG‑3, although related to the co‑receptor CD4, recognizes only a subset of stable peptide–MHC class II complexes and interacts with other ligands such as fibrinogen‑like protein 1 (FGL1). In addition, LAG‑3 is subject to proteolytic cleavage by metalloproteases (e.g., ADAM10 and ADAM17), a regulatory step necessary for full T‑cell activation. Moreover, LAG‑3 can physically associate with other inhibitory receptors like PD‑1, and this cooperation—mediated by overlapping signaling motifs—further reinforces inhibitory signals in T cells."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "10", "end_ref": "18"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nPreclinical studies have underscored the therapeutic potential of modulating LAG‑3 activity. In diverse models—including autoimmunity, infectious diseases, and cancer—LAG‑3 blockade (often in combination with PD‑1 inhibition) has been shown to reinvigorate exhausted T cells, enhance effector functions, and promote tumor clearance. LAG‑3 deficiency or inhibition leads to altered cellular metabolism and enhanced downstream signaling (for example, via STAT5), rendering T cells less susceptible to regulatory cell–mediated suppression and more proficient at cytokine production. The broad impact of these regulatory effects has prompted exploration of LAG‑3 as a target for cancer immunotherapy as well as for interventions aimed at modulating autoimmunity, viral infections, and even inflammatory responses in the context of other diseases."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "19", "end_ref": "34"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Creg J Workman, Kari J Dugger, Dario A A Vignali "}, {"type": "b", "children": [{"type": "t", "text": "Cutting edge: molecular analysis of the negative regulatory function of lymphocyte activation gene-3."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Immunol (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4049/jimmunol.169.10.5392"}], "href": "https://doi.org/10.4049/jimmunol.169.10.5392"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12421911"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12421911"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Creg J Workman, Dario A A Vignali "}, {"type": "b", "children": [{"type": "t", "text": "The CD4-related molecule, LAG-3 (CD223), regulates the expansion of activated T cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur J Immunol (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/eji.200323382"}], "href": "https://doi.org/10.1002/eji.200323382"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12672063"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12672063"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Frédéric Triebel "}, {"type": "b", "children": [{"type": "t", "text": "LAG-3: a regulator of T-cell and DC responses and its use in therapeutic vaccination."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Trends Immunol (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.it.2003.10.001"}], "href": "https://doi.org/10.1016/j.it.2003.10.001"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "14644131"}], "href": "https://pubmed.ncbi.nlm.nih.gov/14644131"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Creg J Workman, Linda S Cauley, In-Jeong Kim, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Lymphocyte activation gene-3 (CD223) regulates the size of the expanding T cell population following antigen activation in vivo."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Immunol (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4049/jimmunol.172.9.5450"}], "href": "https://doi.org/10.4049/jimmunol.172.9.5450"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15100286"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15100286"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Ching-Tai Huang, Creg J Workman, Dallas Flies, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Role of LAG-3 in regulatory T cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Immunity (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.immuni.2004.08.010"}], "href": "https://doi.org/10.1016/j.immuni.2004.08.010"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15485628"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15485628"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Creg J Workman, Dario A A Vignali "}, {"type": "b", "children": [{"type": "t", "text": "Negative regulation of T cell homeostasis by lymphocyte activation gene-3 (CD223)."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Immunol (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4049/jimmunol.174.2.688"}], "href": "https://doi.org/10.4049/jimmunol.174.2.688"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15634887"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15634887"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Malgorzata Kisielow, Jan Kisielow, Giuseppina Capoferri-Sollami, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Expression of lymphocyte activation gene 3 (LAG-3) on B cells is induced by T cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur J Immunol (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/eji.200526090"}], "href": "https://doi.org/10.1002/eji.200526090"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15971272"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15971272"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Nianyu Li, Yao Wang, Karen Forbes, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Metalloproteases regulate T-cell proliferation and effector function via LAG-3."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "EMBO J (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/sj.emboj.7601520"}], "href": "https://doi.org/10.1038/sj.emboj.7601520"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17245433"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17245433"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Joseph F Grosso, Cristin C Kelleher, Timothy J Harris, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LAG-3 regulates CD8+ T cell accumulation and effector function in murine self- and tumor-tolerance systems."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Clin Invest (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1172/JCI31184"}], "href": "https://doi.org/10.1172/JCI31184"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17932562"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17932562"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Bitao Liang, Craig Workman, Janine Lee, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Regulatory T cells inhibit dendritic cells by lymphocyte activation gene-3 engagement of MHC class II."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Immunol (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4049/jimmunol.180.9.5916"}], "href": "https://doi.org/10.4049/jimmunol.180.9.5916"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18424711"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18424711"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Creg J Workman, Yao Wang, Karim C El Kasmi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LAG-3 regulates plasmacytoid dendritic cell homeostasis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Immunol (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4049/jimmunol.0800185"}], "href": "https://doi.org/10.4049/jimmunol.0800185"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19201841"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19201841"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Joseph F Grosso, Monica V Goldberg, Derese Getnet, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Functionally distinct LAG-3 and PD-1 subsets on activated and chronically stimulated CD8 T cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Immunol (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4049/jimmunol.0804211"}], "href": "https://doi.org/10.4049/jimmunol.0804211"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19454660"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19454660"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Tomohisa Okamura, Keishi Fujio, Mihoko Shibuya, et al. "}, {"type": "b", "children": [{"type": "t", "text": "CD4+CD25-LAG3+ regulatory T cells controlled by the transcription factor Egr-2."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.0906872106"}], "href": "https://doi.org/10.1073/pnas.0906872106"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19666526"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19666526"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Seng-Ryong Woo, Nianyu Li, Tullia C Bruno, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Differential subcellular localization of the regulatory T-cell protein LAG-3 and the coreceptor CD4."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur J Immunol (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/eji.200939874"}], "href": "https://doi.org/10.1002/eji.200939874"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20391435"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20391435"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Taku Okazaki, Il-mi Okazaki, Jian Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "PD-1 and LAG-3 inhibitory co-receptors act synergistically to prevent autoimmunity in mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Exp Med (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1084/jem.20100466"}], "href": "https://doi.org/10.1084/jem.20100466"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21300912"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21300912"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Carrie L Lucas, Creg J Workman, Semir Beyaz, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LAG-3, TGF-β, and cell-intrinsic PD-1 inhibitory pathways contribute to CD8 but not CD4 T-cell tolerance induced by allogeneic BMT with anti-CD40L."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Blood (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1182/blood-2010-11-318675"}], "href": "https://doi.org/10.1182/blood-2010-11-318675"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21422469"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21422469"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Maria Bettini, Andrea L Szymczak-Workman, Karen Forbes, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Cutting edge: accelerated autoimmune diabetes in the absence of LAG-3."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Immunol (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4049/jimmunol.1100714"}], "href": "https://doi.org/10.4049/jimmunol.1100714"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21873518"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21873518"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Seng-Ryong Woo, Meghan E Turnis, Monica V Goldberg, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Immune inhibitory molecules LAG-3 and PD-1 synergistically regulate T-cell function to promote tumoral immune escape."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Res (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/0008-5472.CAN-11-1620"}], "href": "https://doi.org/10.1158/0008-5472.CAN-11-1620"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22186141"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22186141"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Vibha Jha, Creg J Workman, Tracy L McGaha, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Lymphocyte Activation Gene-3 (LAG-3) negatively regulates environmentally-induced autoimmunity."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0104484"}], "href": "https://doi.org/10.1371/journal.pone.0104484"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25122007"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25122007"}]}, {"type": "r", "ref": 20, "children": [{"type": "t", "text": "Nicholas M Durham, Christopher J Nirschl, Christopher M Jackson, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Lymphocyte Activation Gene 3 (LAG-3) modulates the ability of CD4 T-cells to be suppressed in vivo."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0109080"}], "href": "https://doi.org/10.1371/journal.pone.0109080"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25372844"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25372844"}]}, {"type": "r", "ref": 21, "children": [{"type": "t", "text": "Sherin J Rouhani, Jacob D Eccles, Priscila Riccardi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Roles of lymphatic endothelial cells expressing peripheral tissue antigens in CD4 T-cell tolerance induction."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Commun (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ncomms7771"}], "href": "https://doi.org/10.1038/ncomms7771"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25857745"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25857745"}]}, {"type": "r", "ref": 22, "children": [{"type": "t", "text": "J-S Do, A Visperas, Y O Sanogo, et al. "}, {"type": "b", "children": [{"type": "t", "text": "An IL-27/Lag3 axis enhances Foxp3+ regulatory T cell-suppressive function and therapeutic efficacy."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mucosal Immunol (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/mi.2015.45"}], "href": "https://doi.org/10.1038/mi.2015.45"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26013006"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26013006"}]}, {"type": "r", "ref": 23, "children": [{"type": "t", "text": "Ruea-Yea Huang, Cheryl Eppolito, Shashikant Lele, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LAG3 and PD1 co-inhibitory molecules collaborate to limit CD8+ T cell signaling and dampen antitumor immunity in a murine ovarian cancer model."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncotarget (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/oncotarget.4751"}], "href": "https://doi.org/10.18632/oncotarget.4751"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26318293"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26318293"}]}, {"type": "r", "ref": 24, "children": [{"type": "t", "text": "Andreia C Lino, Van Duc Dang, Vicky Lampropoulou, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LAG-3 Inhibitory Receptor Expression Identifies Immunosuppressive Natural Regulatory Plasma Cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Immunity (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.immuni.2018.06.007"}], "href": "https://doi.org/10.1016/j.immuni.2018.06.007"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30005826"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30005826"}]}, {"type": "r", "ref": 25, "children": [{"type": "t", "text": "Takumi Maruhashi, Il-Mi Okazaki, Daisuke Sugiura, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LAG-3 inhibits the activation of CD4"}, {"type": "a", "children": [{"type": "t", "text": "sup"}], "href": "sup"}, {"type": "t", "text": "+"}, {"type": "a", "children": [{"type": "t", "text": "/sup"}], "href": "/sup"}, {"type": "t", "text": " T cells that recognize stable pMHCII through its conformation-dependent recognition of pMHCII."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Immunol (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41590-018-0217-9"}], "href": "https://doi.org/10.1038/s41590-018-0217-9"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30349037"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30349037"}]}, {"type": "r", "ref": 26, "children": [{"type": "t", "text": "Takeo K Maeda, Daisuke Sugiura, Il-Mi Okazaki, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Atypical motifs in the cytoplasmic region of the inhibitory immune co-receptor LAG-3 inhibit T cell activation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.RA119.007455"}], "href": "https://doi.org/10.1074/jbc.RA119.007455"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30760527"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30760527"}]}, {"type": "r", "ref": 27, "children": [{"type": "t", "text": "Dan Tian, Lu Yang, Song Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Double negative T cells mediate Lag3-dependent antigen-specific protection in allergic asthma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Commun (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41467-019-12243-0"}], "href": "https://doi.org/10.1038/s41467-019-12243-0"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31534137"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31534137"}]}, {"type": "r", "ref": 28, "children": [{"type": "t", "text": "Shengnan Zhang, Yu-Qing Liu, Chunyu Jia, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Mechanistic basis for receptor-mediated pathological α-synuclein fibril cell-to-cell transmission in Parkinson's disease."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.2011196118"}], "href": "https://doi.org/10.1073/pnas.2011196118"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34172566"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34172566"}]}, {"type": "r", "ref": 29, "children": [{"type": "t", "text": "Johannes Brandi, Cari Lehmann, Lea-Christina Kaminski, et al. "}, {"type": "b", "children": [{"type": "t", "text": "T cells expressing multiple co-inhibitory molecules in acute malaria are not exhausted but exert a suppressive function in mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur J Immunol (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/eji.202149424"}], "href": "https://doi.org/10.1002/eji.202149424"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34752634"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34752634"}]}, {"type": "r", "ref": 30, "children": [{"type": "t", "text": "Qianqian Ming, Daiana P Celias, Chao Wu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LAG3 ectodomain structure reveals functional interfaces for ligand and antibody recognition."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Immunol (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41590-022-01238-7"}], "href": "https://doi.org/10.1038/s41590-022-01238-7"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35761082"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35761082"}]}, {"type": "r", "ref": 31, "children": [{"type": "t", "text": "Qingxi Zhang, Qingrui Duan, Yuyuan Gao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Cerebral Microvascular Injury Induced by Lag3-Dependent α-Synuclein Fibril Endocytosis Exacerbates Cognitive Impairment in a Mouse Model of α-Synucleinopathies."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Adv Sci (Weinh) (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/advs.202301903"}], "href": "https://doi.org/10.1002/advs.202301903"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "37381656"}], "href": "https://pubmed.ncbi.nlm.nih.gov/37381656"}]}, {"type": "r", "ref": 32, "children": [{"type": "t", "text": "Chan Chen, Ramhari Kumbhar, Hu Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Lymphocyte-Activation Gene 3 Facilitates Pathological Tau Neuron-to-Neuron Transmission."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Adv Sci (Weinh) (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/advs.202303775"}], "href": "https://doi.org/10.1002/advs.202303775"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "38327094"}], "href": "https://pubmed.ncbi.nlm.nih.gov/38327094"}]}, {"type": "r", "ref": 33, "children": [{"type": "t", "text": "John L Silberstein, Jasper Du, Kun-Wei Chan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Structural insights reveal interplay between LAG-3 homodimerization, ligand binding, and function."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.2310866121"}], "href": "https://doi.org/10.1073/pnas.2310866121"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "38483996"}], "href": "https://pubmed.ncbi.nlm.nih.gov/38483996"}]}, {"type": "r", "ref": 34, "children": [{"type": "t", "text": "R Zibigu, A Abidan, D Adilai, et al. "}, {"type": "b", "children": [{"type": "t", "text": "[Effect of LAG3 deficiency on natural killer cell function and hepatic fibrosis in mice infected with "}, {"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "Echinococcus multilocularis"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": "]."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.16250/j.32.1374.2024013"}], "href": "https://doi.org/10.16250/j.32.1374.2024013"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "38604686"}], "href": "https://pubmed.ncbi.nlm.nih.gov/38604686"}]}]}]}
|
| Proteins | O6C76_HUMAN |
| NCBI Gene ID | 390326 |
| API | |
| Download Associations | |
| Predicted Functions |
 |
| Co-expressed Genes |
|
| Expression in Tissues and Cell Lines |
|
OR6C76 has 943 functional associations with biological entities spanning 7 categories (molecular profile, functional term, phrase or reference, disease, phenotype or trait, chemical, structural feature, cell line, cell type or tissue, gene, protein or microRNA) extracted from 46 datasets.
Click the + buttons to view associations for OR6C76 from the datasets below.
If available, associations are ranked by standardized value
| Dataset | Summary | |
|---|---|---|
| Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles | tissues with high or low expression of OR6C76 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset. | |
| Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles | tissue samples with high or low expression of OR6C76 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset. | |
| Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray | tissue samples with high or low expression of OR6C76 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset. | |
| Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles | tissues with high or low expression of OR6C76 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset. | |
| BioGPS Mouse Cell Type and Tissue Gene Expression Profiles | cell types and tissues with high or low expression of OR6C76 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset. | |
| CCLE Cell Line Gene CNV Profiles | cell lines with high or low copy number of OR6C76 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset. | |
| ChEA Transcription Factor Binding Site Profiles | transcription factor binding site profiles with transcription factor binding evidence at the promoter of OR6C76 gene from the CHEA Transcription Factor Binding Site Profiles dataset. | |
| ChEA Transcription Factor Targets | transcription factors binding the promoter of OR6C76 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset. | |
| ChEA Transcription Factor Targets 2022 | transcription factors binding the promoter of OR6C76 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset. | |
| CM4AI KOLF21J CRISPRi Gene Perturbation Atlas | gene perturbations changing expression of OR6C76 gene from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas dataset. | |
| COMPARTMENTS Curated Protein Localization Evidence Scores | cellular components containing OR6C76 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset. | |
| COMPARTMENTS Curated Protein Localization Evidence Scores 2025 | cellular components containing OR6C76 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset. | |
| COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 | cellular components co-occuring with OR6C76 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset. | |
| COSMIC Cell Line Gene Mutation Profiles | cell lines with OR6C76 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset. | |
| DepMap CRISPR Gene Dependency | cell lines with fitness changed by OR6C76 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset. | |
| DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 | diseases co-occuring with OR6C76 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset. | |
| ENCODE Transcription Factor Binding Site Profiles | transcription factor binding site profiles with transcription factor binding evidence at the promoter of OR6C76 gene from the ENCODE Transcription Factor Binding Site Profiles dataset. | |
| ENCODE Transcription Factor Targets | transcription factors binding the promoter of OR6C76 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset. | |
| ESCAPE Omics Signatures of Genes and Proteins for Stem Cells | PubMedIDs of publications reporting gene signatures containing OR6C76 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset. | |
| GEO Signatures of Differentially Expressed Genes for Gene Perturbations | gene perturbations changing expression of OR6C76 gene from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset. | |
| GEO Signatures of Differentially Expressed Genes for Kinase Perturbations | kinase perturbations changing expression of OR6C76 gene from the GEO Signatures of Differentially Expressed Genes for Kinase Perturbations dataset. | |
| GEO Signatures of Differentially Expressed Genes for Small Molecules | small molecule perturbations changing expression of OR6C76 gene from the GEO Signatures of Differentially Expressed Genes for Small Molecules dataset. | |
| GO Biological Process Annotations 2015 | biological processes involving OR6C76 gene from the curated GO Biological Process Annotations 2015 dataset. | |
| GO Cellular Component Annotations 2015 | cellular components containing OR6C76 protein from the curated GO Cellular Component Annotations 2015 dataset. | |
| GO Molecular Function Annotations 2015 | molecular functions performed by OR6C76 gene from the curated GO Molecular Function Annotations 2015 dataset. | |
| GO Molecular Function Annotations 2023 | molecular functions performed by OR6C76 gene from the curated GO Molecular Function Annotations 2023 dataset. | |
| GO Molecular Function Annotations 2025 | molecular functions performed by OR6C76 gene from the curated GO Molecular Function Annotations 2025 dataset. | |
| GTEx Tissue Gene Expression Profiles | tissues with high or low expression of OR6C76 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles dataset. | |
| GWAS Catalog SNP-Phenotype Associations 2025 | phenotypes associated with OR6C76 gene in GWAS datasets from the GWAS Catalog SNP-Phenotype Associations 2025 dataset. | |
| Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles | cell lines with high or low expression of OR6C76 gene relative to other cell lines from the Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles dataset. | |
| InterPro Predicted Protein Domain Annotations | protein domains predicted for OR6C76 protein from the InterPro Predicted Protein Domain Annotations dataset. | |
| JASPAR Predicted Human Transcription Factor Targets 2025 | transcription factors regulating expression of OR6C76 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Human Transcription Factor Targets dataset. | |
| JASPAR Predicted Mouse Transcription Factor Targets 2025 | transcription factors regulating expression of OR6C76 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Mouse Transcription Factor Targets 2025 dataset. | |
| JASPAR Predicted Transcription Factor Targets | transcription factors regulating expression of OR6C76 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset. | |
| KEGG Pathways 2026 | pathways involving OR6C76 protein from the KEGG Pathways 2026 dataset. | |
| Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles | cell lines with high or low copy number of OR6C76 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset. | |
| KnockTF Gene Expression Profiles with Transcription Factor Perturbations | transcription factor perturbations changing expression of OR6C76 gene from the KnockTF Gene Expression Profiles with Transcription Factor Perturbations dataset. | |
| LOCATE Predicted Protein Localization Annotations | cellular components predicted to contain OR6C76 protein from the LOCATE Predicted Protein Localization Annotations dataset. | |
| MotifMap Predicted Transcription Factor Targets | transcription factors regulating expression of OR6C76 gene predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset. | |
| Reactome Pathways 2014 | pathways involving OR6C76 protein from the Reactome Pathways dataset. | |
| Reactome Pathways 2024 | pathways involving OR6C76 protein from the Reactome Pathways 2024 dataset. | |
| Rummagene Transcription Factor Associations 2026 | transcription factors regulating expression of OR6C76 gene from the Rummagene Transcription Factor Associations 2026 dataset. | |
| RummaGEO Drug Perturbation Signatures | drug perturbations changing expression of OR6C76 gene from the RummaGEO Drug Perturbation Signatures dataset. | |
| RummaGEO Gene Perturbation Signatures | gene perturbations changing expression of OR6C76 gene from the RummaGEO Gene Perturbation Signatures dataset. | |
| TCGA Signatures of Differentially Expressed Genes for Tumors | tissue samples with high or low expression of OR6C76 gene relative to other tissue samples from the TCGA Signatures of Differentially Expressed Genes for Tumors dataset. | |
| TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 | tissues co-occuring with OR6C76 protein in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 dataset. | |
