| HGNC Family | G protein-coupled receptors |
| Name | olfactory receptor, family 6, subfamily X, member 1 |
| Description | Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008] |
| Summary |
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRecent studies have demonstrated that the heterodimeric receptor complex, most commonly known as T1R1 + T1R3, functions as a broadly tuned sensor for L‐amino acids—mediating the umami taste in mammals. These receptors enable animals not only to discriminate nutritional amino acids from less desirable compounds but also to integrate species‐specific differences in ligand selectivity. Experiments employing knockout models, chimeric receptor constructs, and behavioral assessments have confirmed that an intact T1R1/T1R3 complex is essential for normal detection of amino acid stimuli, as well as for synergistic interactions with umami enhancers such as inosine 5′‐monophosphate. In addition, mapping studies of receptor expression in taste buds have revealed region‐specific co-expression with downstream signaling proteins, underscoring their central role in gustatory perception."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "7"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond their classical role in taste perception, these amino acid–sensing receptors are expressed in a range of extraoral tissues, where they contribute to diverse cellular processes. In pancreatic β‐cells, for instance, activation of the T1R1/T1R3 complex by amino acids such as L‐glutamate and L‐arginine elevates intracellular levels of inositol-1,4,5-triphosphate and Ca²⁺ to promote insulin secretion. Similar mechanisms have been implicated in the regulation of autophagy via mTOR complex 1 activation, in the control of milk protein synthesis in the mammary gland, and even in reproductive cells, where taste receptor expression in sperm suggests a role in chemosensory signaling. Additional findings indicate that in neuronal and other non‐gustatory cells, these receptors help coordinate nutrient-sensing pathways that modulate cellular morphology and gene transcription."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "8", "end_ref": "14"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn addition to their chemosensory and metabolic regulatory roles, these receptors partake in broader aspects of physiological regulation. Studies in pancreatic tissue have linked T1R3 to proper islet morphology and insulin production, while investigations in skeletal muscle cells have elucidated transcriptional regulatory mechanisms for Tas1r1 expression. Moreover, expression in hepatic natural killer cells has been shown to enhance tumoricidal activity via activation of Akt/mTOR signaling pathways, and genetic ablation of Tas1r1 in mice is associated with reduced adiposity and altered lipid metabolism. Finally, comparisons of extraoral expression profiles suggest that receptor functions observed in rodent models may not fully recapitulate human physiology, prompting further evaluation of their roles in cardiometabolic regulation."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "15", "end_ref": "19"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Greg Nelson, Jayaram Chandrashekar, Mark A Hoon, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "The receptors for mammalian sweet and umami taste."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/s0092-8674(03)00844-4"}], "href": "https://doi.org/10.1016/s0092-8674(03"}, {"type": "t", "text": "00844-4) PMID: "}, {"type": "a", "children": [{"type": "t", "text": "14636554"}], "href": "https://pubmed.ncbi.nlm.nih.gov/14636554"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Mi-Ryung Kim, Yuko Kusakabe, Hirohito Miura, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "Two distinct determinants of ligand specificity in T1R1/T1R3 (the umami taste receptor)."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M113.494443"}], "href": "https://doi.org/10.1074/jbc.M113.494443"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24214976"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24214976"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Keiko Yasumatsu, Tomohiro Manabe, Ryusuke Yoshida, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Involvement of multiple taste receptors in umami taste: analysis of gustatory nerve responses in metabotropic glutamate receptor 4 knockout mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Physiol (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1113/jphysiol.2014.284703"}], "href": "https://doi.org/10.1113/jphysiol.2014.284703"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25529865"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25529865"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Anja Voigt, Juliane Bojahr, Masataka Narukawa, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Transsynaptic Tracing from Taste Receptor Cells Reveals Local Taste Receptor Gene Expression in Gustatory Ganglia and Brain."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Neurosci (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1523/JNEUROSCI.0381-15.2015"}], "href": "https://doi.org/10.1523/JNEUROSCI.0381-15.2015"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26134654"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26134654"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Ginger D Blonde, Susan P Travers, Alan C Spector "}, {"type": "b", "children": [{"type": "t", "text": "Taste sensitivity to a mixture of monosodium glutamate and inosine 5'-monophosphate by mice lacking both subunits of the T1R1+T1R3 amino acid receptor."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Physiol Regul Integr Comp Physiol (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1152/ajpregu.00352.2017"}], "href": "https://doi.org/10.1152/ajpregu.00352.2017"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29443544"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29443544"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Manami Oya, Hideyuki Suzuki, Yuichiro Watanabe, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "Expression of Tas1 taste receptors in mammalian spermatozoa: functional role of Tas1r1 in regulating basal Ca²⁺ and cAMP concentrations in spermatozoa."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0032354"}], "href": "https://doi.org/10.1371/journal.pone.0032354"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22427794"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22427794"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Eric M Wauson, Elma Zaganjor, Melanie H Cobb "}, {"type": "b", "children": [{"type": "t", "text": "Amino acid regulation of autophagy through the GPCR TAS1R1-TAS1R3."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Autophagy (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4161/auto.22911"}], "href": "https://doi.org/10.4161/auto.22911"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23222068"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23222068"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Eric M Wauson, Marcy L Guerra, Julia Dyachok, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "Milk protein synthesis is regulated by T1R1/T1R3, a G protein-coupled taste receptor, through the mTOR pathway in the mouse mammary gland."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Nutr Food Res (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/mnfr.201601017"}], "href": "https://doi.org/10.1002/mnfr.201601017"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28497545"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28497545"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "V O Murovets, E A Sozontov, T G Zachepilo "}, {"type": "b", "children": [{"type": "t", "text": "The Effect of the Taste Receptor Protein T1R3 on the Development of Islet Tissue of the Murine Pancreas."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Dokl Biol Sci (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1134/S0012496619010010"}], "href": "https://doi.org/10.1134/S0012496619010010"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31016494"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31016494"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Yuki Hirata, Takashi Toyono, Shoichiro Kokabu, et al. 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| Synonyms | OR11-270 |
| Proteins | OR6X1_HUMAN |
| NCBI Gene ID | 390260 |
| API | |
| Download Associations | |
| Predicted Functions |
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| Co-expressed Genes |
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| Expression in Tissues and Cell Lines |
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OR6X1 has 977 functional associations with biological entities spanning 8 categories (molecular profile, organism, functional term, phrase or reference, disease, phenotype or trait, chemical, structural feature, cell line, cell type or tissue, gene, protein or microRNA) extracted from 56 datasets.
Click the + buttons to view associations for OR6X1 from the datasets below.
If available, associations are ranked by standardized value
| Dataset | Summary | |
|---|---|---|
| Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles | tissues with high or low expression of OR6X1 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset. | |
| Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles | tissue samples with high or low expression of OR6X1 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset. | |
| Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray | tissue samples with high or low expression of OR6X1 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset. | |
| Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles | tissues with high or low expression of OR6X1 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset. | |
| BioGPS Human Cell Type and Tissue Gene Expression Profiles | cell types and tissues with high or low expression of OR6X1 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset. | |
| BioGPS Mouse Cell Type and Tissue Gene Expression Profiles | cell types and tissues with high or low expression of OR6X1 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset. | |
| CCLE Cell Line Gene CNV Profiles | cell lines with high or low copy number of OR6X1 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset. | |
| ChEA Transcription Factor Binding Site Profiles | transcription factor binding site profiles with transcription factor binding evidence at the promoter of OR6X1 gene from the CHEA Transcription Factor Binding Site Profiles dataset. | |
| ChEA Transcription Factor Targets | transcription factors binding the promoter of OR6X1 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset. | |
| ChEA Transcription Factor Targets 2022 | transcription factors binding the promoter of OR6X1 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset. | |
| CM4AI KOLF21J CRISPRi Gene Perturbation Atlas | gene perturbations changing expression of OR6X1 gene from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas dataset. | |
| COMPARTMENTS Curated Protein Localization Evidence Scores | cellular components containing OR6X1 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset. | |
| COMPARTMENTS Curated Protein Localization Evidence Scores 2025 | cellular components containing OR6X1 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset. | |
| COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 | cellular components co-occuring with OR6X1 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset. | |
| COSMIC Cell Line Gene CNV Profiles | cell lines with high or low copy number of OR6X1 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset. | |
| COSMIC Cell Line Gene Mutation Profiles | cell lines with OR6X1 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset. | |
| dbGAP Gene-Trait Associations | traits associated with OR6X1 gene in GWAS and other genetic association datasets from the dbGAP Gene-Trait Associations dataset. | |
| DepMap CRISPR Gene Dependency | cell lines with fitness changed by OR6X1 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset. | |
| DISEASES Text-mining Gene-Disease Association Evidence Scores | diseases co-occuring with OR6X1 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset. | |
| DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 | diseases co-occuring with OR6X1 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset. | |
| ENCODE Histone Modification Site Profiles | histone modification site profiles with high histone modification abundance at OR6X1 gene from the ENCODE Histone Modification Site Profiles dataset. | |
| ENCODE Transcription Factor Binding Site Profiles | transcription factor binding site profiles with transcription factor binding evidence at the promoter of OR6X1 gene from the ENCODE Transcription Factor Binding Site Profiles dataset. | |
| ENCODE Transcription Factor Targets | transcription factors binding the promoter of OR6X1 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset. | |
| ESCAPE Omics Signatures of Genes and Proteins for Stem Cells | PubMedIDs of publications reporting gene signatures containing OR6X1 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset. | |
| GAD Gene-Disease Associations | diseases associated with OR6X1 gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset. | |
| GEO Signatures of Differentially Expressed Genes for Gene Perturbations | gene perturbations changing expression of OR6X1 gene from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset. | |
| GEO Signatures of Differentially Expressed Genes for Small Molecules | small molecule perturbations changing expression of OR6X1 gene from the GEO Signatures of Differentially Expressed Genes for Small Molecules dataset. | |
| GEO Signatures of Differentially Expressed Genes for Viral Infections | virus perturbations changing expression of OR6X1 gene from the GEO Signatures of Differentially Expressed Genes for Viral Infections dataset. | |
| GO Biological Process Annotations 2015 | biological processes involving OR6X1 gene from the curated GO Biological Process Annotations 2015 dataset. | |
| GO Cellular Component Annotations 2015 | cellular components containing OR6X1 protein from the curated GO Cellular Component Annotations 2015 dataset. | |
| GO Molecular Function Annotations 2015 | molecular functions performed by OR6X1 gene from the curated GO Molecular Function Annotations 2015 dataset. | |
| GO Molecular Function Annotations 2023 | molecular functions performed by OR6X1 gene from the curated GO Molecular Function Annotations 2023 dataset. | |
| GO Molecular Function Annotations 2025 | molecular functions performed by OR6X1 gene from the curated GO Molecular Function Annotations 2025 dataset. | |
| GTEx Tissue Gene Expression Profiles | tissues with high or low expression of OR6X1 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles dataset. | |
| GTEx Tissue Gene Expression Profiles 2023 | tissues with high or low expression of OR6X1 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles 2023 dataset. | |
| GWAS Catalog SNP-Phenotype Associations 2025 | phenotypes associated with OR6X1 gene in GWAS datasets from the GWAS Catalog SNP-Phenotype Associations 2025 dataset. | |
| GWASdb SNP-Disease Associations | diseases associated with OR6X1 gene in GWAS and other genetic association datasets from the GWASdb SNP-Disease Associations dataset. | |
| GWASdb SNP-Phenotype Associations | phenotypes associated with OR6X1 gene in GWAS datasets from the GWASdb SNP-Phenotype Associations dataset. | |
| InterPro Predicted Protein Domain Annotations | protein domains predicted for OR6X1 protein from the InterPro Predicted Protein Domain Annotations dataset. | |
| JASPAR Predicted Human Transcription Factor Targets 2025 | transcription factors regulating expression of OR6X1 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Human Transcription Factor Targets dataset. | |
| JASPAR Predicted Mouse Transcription Factor Targets 2025 | transcription factors regulating expression of OR6X1 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Mouse Transcription Factor Targets 2025 dataset. | |
| JASPAR Predicted Transcription Factor Targets | transcription factors regulating expression of OR6X1 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset. | |
| KEGG Pathways 2026 | pathways involving OR6X1 protein from the KEGG Pathways 2026 dataset. | |
| Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles | cell lines with high or low copy number of OR6X1 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset. | |
| LOCATE Predicted Protein Localization Annotations | cellular components predicted to contain OR6X1 protein from the LOCATE Predicted Protein Localization Annotations dataset. | |
| MotifMap Predicted Transcription Factor Targets | transcription factors regulating expression of OR6X1 gene predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset. | |
| Reactome Pathways 2014 | pathways involving OR6X1 protein from the Reactome Pathways dataset. | |
| Reactome Pathways 2024 | pathways involving OR6X1 protein from the Reactome Pathways 2024 dataset. | |
| Roadmap Epigenomics Histone Modification Site Profiles | histone modification site profiles with high histone modification abundance at OR6X1 gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset. | |
| Rummagene Transcription Factor Associations 2026 | transcription factors regulating expression of OR6X1 gene from the Rummagene Transcription Factor Associations 2026 dataset. | |
| RummaGEO Drug Perturbation Signatures | drug perturbations changing expression of OR6X1 gene from the RummaGEO Drug Perturbation Signatures dataset. | |
| TCGA Signatures of Differentially Expressed Genes for Tumors | tissue samples with high or low expression of OR6X1 gene relative to other tissue samples from the TCGA Signatures of Differentially Expressed Genes for Tumors dataset. | |
| TISSUES Curated Tissue Protein Expression Evidence Scores | tissues with high expression of OR6X1 protein from the TISSUES Curated Tissue Protein Expression Evidence Scores dataset. | |
| TISSUES Curated Tissue Protein Expression Evidence Scores 2025 | tissues with high expression of OR6X1 protein from the TISSUES Curated Tissue Protein Expression Evidence Scores 2025 dataset. | |
| TISSUES Text-mining Tissue Protein Expression Evidence Scores | tissues co-occuring with OR6X1 protein in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores dataset. | |
| TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 | tissues co-occuring with OR6X1 protein in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 dataset. | |
