{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nA broad survey of the provided literature reveals detailed investigations into epigenetic and post‐transcriptional regulatory mechanisms in diverse contexts including cancer stem cell metabolism, T cell differentiation, tissue-specific gene silencing, and metabolic as well as developmental control. Many of these studies focus on key regulators such as the IGF2 mRNA‐binding protein IMP2 and the family of methyl–CpG–binding domain proteins (e.g., MBD2, MBD3, MeCP2) that govern processes ranging from oxidative phosphorylation and tumorigenesis"}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "4"}]}, {"type": "t", "text": "to immune modulation and stem cell function."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "5", "end_ref": "8"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nDespite the extensive functional analyses described in these abstracts—with studies addressing aspects of gene silencing in erythroid differentiation"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "9"}]}, {"type": "t", "text": ", mechanisms controlling hepatocellular carcinoma"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "10"}]}, {"type": "t", "text": ", regulation of immune cell polarization"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "11"}]}, {"type": "t", "text": ", and even neural or stem cell regulatory pathways"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "12"}]}, {"type": "t", "text": "—none of these works address the olfactory receptor OR8J2. In fact, information about OR8J2’s expression, signaling mechanisms, or physiological roles is entirely absent from the collected studies."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "14", "end_ref": "17"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn summary, while the referenced abstracts"}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "18", "end_ref": "39"}]}, {"type": "t", "text": "collectively advance our understanding of complex gene‐regulatory networks. However, because none of these studies mention OR8J2, its function remains uncharacterized and warrants dedicated investigation to determine whether it plays a role analogous to other G–protein coupled receptors in sensory or even non–sensory tissues.\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Anne S Hutchins, Alan C Mullen, Hubert W Lee, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Gene silencing quantitatively controls the function of a developmental trans-activator."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/s1097-2765(02)00564-6"}], "href": "https://doi.org/10.1016/s1097-2765(02"}, {"type": "t", "text": "00564-6) PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12150909"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12150909"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Owen J Sansom, Jennifer Berger, Stefan M Bishop, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Deficiency of Mbd2 suppresses intestinal tumorigenesis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Genet (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ng1155"}], "href": "https://doi.org/10.1038/ng1155"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12730693"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12730693"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Guilin Wang, Li-Na Wei, Horace H Loh "}, {"type": "b", "children": [{"type": "t", "text": "Transcriptional regulation of mouse delta-opioid receptor gene by CpG methylation: involvement of Sp3 and a methyl-CpG-binding protein, MBD2, in transcriptional repression of mouse delta-opioid receptor gene in Neuro2A cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M302879200"}], "href": "https://doi.org/10.1074/jbc.M302879200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12890683"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12890683"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Kalpana Ghoshal, Sarmila Majumder, Jharna Datta, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Role of human ribosomal RNA (rRNA) promoter methylation and of methyl-CpG-binding protein MBD2 in the suppression of rRNA gene expression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M309393200"}], "href": "https://doi.org/10.1074/jbc.M309393200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "14610093"}], "href": "https://pubmed.ncbi.nlm.nih.gov/14610093"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Chun-Ling Jiang, Seung-Gi Jin, Gerd P Pfeifer "}, {"type": "b", "children": [{"type": "t", "text": "MBD3L1 is a transcriptional repressor that interacts with methyl-CpG-binding protein 2 (MBD2) and components of the NuRD complex."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M409149200"}], "href": "https://doi.org/10.1074/jbc.M409149200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15456747"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15456747"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Seung-Gi Jin, Chun-Ling Jiang, Tibor Rauch, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MBD3L2 interacts with MBD3 and components of the NuRD complex and can oppose MBD2-MeCP1-mediated methylation silencing."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M413492200"}], "href": "https://doi.org/10.1074/jbc.M413492200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15701600"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15701600"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Owen James Sansom, Stefan Mark Bishop, Adrian Bird, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MBD2 deficiency does not accelerate p53 mediated lymphomagenesis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncogene (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/sj.onc.1208166"}], "href": "https://doi.org/10.1038/sj.onc.1208166"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15735763"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15735763"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Alessandro Brero, Hariharan P Easwaran, Danny Nowak, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Methyl CpG-binding proteins induce large-scale chromatin reorganization during terminal differentiation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Biol (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1083/jcb.200502062"}], "href": "https://doi.org/10.1083/jcb.200502062"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15939760"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15939760"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Jeremy W Rupon, Shou Zhen Wang, Karin Gaensler, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Methyl binding domain protein 2 mediates gamma-globin gene silencing in adult human betaYAC transgenic mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.0509322103"}], "href": "https://doi.org/10.1073/pnas.0509322103"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16608912"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16608912"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Jennifer Berger, Owen Sansom, Alan Clarke, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MBD2 is required for correct spatial gene expression in the gut."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Biol (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/MCB.02023-06"}], "href": "https://doi.org/10.1128/MCB.02023-06"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17353267"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17353267"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Toby J Phesse, Lee Parry, Karen R Reed, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Deficiency of Mbd2 attenuates Wnt signaling."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Biol (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/MCB.00539-08"}], "href": "https://doi.org/10.1128/MCB.00539-08"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18644872"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18644872"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Isabel Martín Caballero, Janne Hansen, Donna Leaford, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The methyl-CpG binding proteins Mecp2, Mbd2 and Kaiso are dispensable for mouse embryogenesis, but play a redundant function in neural differentiation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0004315"}], "href": "https://doi.org/10.1371/journal.pone.0004315"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19177165"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19177165"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Jessica L Macdonald, Adrian Verster, Anthony Berndt, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MBD2 and MeCP2 regulate distinct transitions in the stage-specific differentiation of olfactory receptor neurons."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Neurosci (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.mcn.2010.02.003"}], "href": "https://doi.org/10.1016/j.mcn.2010.02.003"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20188178"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20188178"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Andrea Fuso, Vincenzina Nicolia, Rosaria A Cavallaro, et al. "}, {"type": "b", "children": [{"type": "t", "text": "DNA methylase and demethylase activities are modulated by one-carbon metabolism in Alzheimer's disease models."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Nutr Biochem (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.jnutbio.2010.01.010"}], "href": "https://doi.org/10.1016/j.jnutbio.2010.01.010"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20573497"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20573497"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Ning Dai, Joseph Rapley, Matthew Angel, et al. "}, {"type": "b", "children": [{"type": "t", "text": "mTOR phosphorylates IMP2 to promote IGF2 mRNA translation by internal ribosomal entry."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Genes Dev (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1101/gad.2042311"}], "href": "https://doi.org/10.1101/gad.2042311"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21576258"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21576258"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Michalina Janiszewska, Mario L Suvà, Nicolo Riggi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Imp2 controls oxidative phosphorylation and is crucial for preserving glioblastoma cancer stem cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Genes Dev (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1101/gad.188292.112"}], "href": "https://doi.org/10.1101/gad.188292.112"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22899010"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22899010"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Zhizhong Li, Jason A Gilbert, Yunyu Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "An HMGA2-IGF2BP2 axis regulates myoblast proliferation and myogenesis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Dev Cell (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.devcel.2012.10.019"}], "href": "https://doi.org/10.1016/j.devcel.2012.10.019"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23177649"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23177649"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Stephan Laggai, Sonja M Kessler, Stefan Boettcher, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The IGF2 mRNA binding protein p62/IGF2BP2-2 induces fatty acid elongation as a critical feature of steatosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Lipid Res (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1194/jlr.M045500"}], "href": "https://doi.org/10.1194/jlr.M045500"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24755648"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24755648"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Hai-Jun Li, Rui-Ping Wan, Ling-Jia Tang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Alteration of Scn3a expression is mediated via CpG methylation and MBD2 in mouse hippocampus during postnatal development and seizure condition."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochim Biophys Acta (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbagrm.2014.11.004"}], "href": "https://doi.org/10.1016/j.bbagrm.2014.11.004"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25459751"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25459751"}]}, {"type": "r", "ref": 20, "children": [{"type": "t", "text": "Yang Cao, Wen-Ting Guo, Shengya Tian, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR-290/371-Mbd2-Myc circuit regulates glycolytic metabolism to promote pluripotency."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "EMBO J (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.15252/embj.201490441"}], "href": "https://doi.org/10.15252/embj.201490441"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25603933"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25603933"}]}, {"type": "r", "ref": 21, "children": [{"type": "t", "text": "Megha A Desai, Heather D Webb, Leander M Sinanan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "An intrinsically disordered region of methyl-CpG binding domain protein 2 (MBD2) recruits the histone deacetylase core of the NuRD complex."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nucleic Acids Res (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/nar/gkv168"}], "href": "https://doi.org/10.1093/nar/gkv168"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25753662"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25753662"}]}, {"type": "r", "ref": 22, "children": [{"type": "t", "text": "Dhaval Varshney, Jana Vavrova-Anderson, Andrew J Oler, et al. "}, {"type": "b", "children": [{"type": "t", "text": "SINE transcription by RNA polymerase III is suppressed by histone methylation but not by DNA methylation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Commun (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ncomms7569"}], "href": "https://doi.org/10.1038/ncomms7569"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25798578"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25798578"}]}, {"type": "r", "ref": 23, "children": [{"type": "t", "text": "Ning Dai, Liping Zhao, Diedra Wrighting, et al. "}, {"type": "b", "children": [{"type": "t", "text": "IGF2BP2/IMP2-Deficient mice resist obesity through enhanced translation of Ucp1 mRNA and Other mRNAs encoding mitochondrial proteins."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Metab (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.cmet.2015.03.006"}], "href": "https://doi.org/10.1016/j.cmet.2015.03.006"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25863250"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25863250"}]}, {"type": "r", "ref": 24, "children": [{"type": "t", "text": "Peter C Cook, Heather Owen, Aimée M Deaton, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A dominant role for the methyl-CpG-binding protein Mbd2 in controlling Th2 induction by dendritic cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Commun (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ncomms7920"}], "href": "https://doi.org/10.1038/ncomms7920"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25908537"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25908537"}]}, {"type": "r", "ref": 25, "children": [{"type": "t", "text": "S M Kessler, S Laggai, A Barghash, et al. "}, {"type": "b", "children": [{"type": "t", "text": "IMP2/p62 induces genomic instability and an aggressive hepatocellular carcinoma phenotype."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Death Dis (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/cddis.2015.241"}], "href": "https://doi.org/10.1038/cddis.2015.241"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26426686"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26426686"}]}, {"type": "r", "ref": 26, "children": [{"type": "t", "text": "Jia Cheng, Jia Song, Xiaoyu He, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Loss of Mbd2 Protects Mice Against High-Fat Diet-Induced Obesity and Insulin Resistance by Regulating the Homeostasis of Energy Storage and Expenditure."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Diabetes (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.2337/db16-0151"}], "href": "https://doi.org/10.2337/db16-0151"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27554473"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27554473"}]}, {"type": "r", "ref": 27, "children": [{"type": "t", "text": "C Stirzaker, J Z Song, W Ng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Methyl-CpG-binding protein MBD2 plays a key role in maintenance and spread of DNA methylation at CpG islands and shores in cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncogene (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/onc.2016.297"}], "href": "https://doi.org/10.1038/onc.2016.297"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27593931"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27593931"}]}, {"type": "r", "ref": 28, "children": [{"type": "t", "text": "Xingyu Zhou, Mingsen Li, Huaxing Huang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "HMGB2 regulates satellite-cell-mediated skeletal muscle regeneration through IGF2BP2."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Sci (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1242/jcs.189944"}], "href": "https://doi.org/10.1242/jcs.189944"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27672022"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27672022"}]}, {"type": "r", "ref": 29, "children": [{"type": "t", "text": "Sarah J Hainer, Kurtis N McCannell, Jun Yu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "DNA methylation directs genomic localization of Mbd2 and Mbd3 in embryonic stem cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Elife (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.7554/eLife.21964"}], "href": "https://doi.org/10.7554/eLife.21964"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27849519"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27849519"}]}, {"type": "r", "ref": 30, "children": [{"type": "t", "text": "Aijun Jia, Yueling Wang, Wenjin Sun, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MBD2 Regulates Th17 Cell Differentiation and Experimental Severe Asthma by Affecting IRF4 Expression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mediators Inflamm (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1155/2017/6249685"}], "href": "https://doi.org/10.1155/2017/6249685"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28808358"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28808358"}]}, {"type": "r", "ref": 31, "children": [{"type": "t", "text": "William W Greenwald, Joshua Chiou, Jian Yan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Pancreatic islet chromatin accessibility and conformation reveals distal enhancer networks of type 2 diabetes risk."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Commun (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41467-019-09975-4"}], "href": "https://doi.org/10.1038/s41467-019-09975-4"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31064983"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31064983"}]}, {"type": "r", "ref": 32, "children": [{"type": "t", "text": "Laura Regué, Liliana Minichiello, Joseph Avruch, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Liver-specific deletion of IGF2 mRNA binding protein-2/IMP2 reduces hepatic fatty acid oxidation and increases hepatic triglyceride accumulation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.RA119.008778"}], "href": "https://doi.org/10.1074/jbc.RA119.008778"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31209109"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31209109"}]}, {"type": "r", "ref": 33, "children": [{"type": "t", "text": "Xinzhou Zhu, Jingyi Yan, Catherine Bregere, et al. "}, {"type": "b", "children": [{"type": "t", "text": "RBM3 promotes neurogenesis in a niche-dependent manner via IMP2-IGF2 signaling pathway after hypoxic-ischemic brain injury."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Commun (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41467-019-11870-x"}], "href": "https://doi.org/10.1038/s41467-019-11870-x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31484925"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31484925"}]}, {"type": "r", "ref": 34, "children": [{"type": "t", "text": "Rui Cai, Que Zhang, Yingqian Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Lnc-ORA interacts with microRNA-532-3p and IGF2BP2 to inhibit skeletal muscle myogenesis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.jbc.2021.100376"}], "href": "https://doi.org/10.1016/j.jbc.2021.100376"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33548229"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33548229"}]}, {"type": "r", "ref": 35, "children": [{"type": "t", "text": "Laura Regué, Liping Zhao, Fei Ji, et al. "}, {"type": "b", "children": [{"type": "t", "text": "RNA m6A reader IMP2/IGF2BP2 promotes pancreatic β-cell proliferation and insulin secretion by enhancing PDX1 expression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Metab (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.molmet.2021.101209"}], "href": "https://doi.org/10.1016/j.molmet.2021.101209"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33705986"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33705986"}]}, {"type": "r", "ref": 36, "children": [{"type": "t", "text": "Rami Bechara, Nilesh Amatya, Rachel D Bailey, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The m"}, {"type": "a", "children": [{"type": "t", "text": "sup"}], "href": "sup"}, {"type": "t", "text": "6"}, {"type": "a", "children": [{"type": "t", "text": "/sup"}], "href": "/sup"}, {"type": "t", "text": "A reader IMP2 directs autoimmune inflammation through an IL-17- and TNFα-dependent C/EBP transcription factor axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Immunol (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1126/sciimmunol.abd1287"}], "href": "https://doi.org/10.1126/sciimmunol.abd1287"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34215679"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34215679"}]}, {"type": "r", "ref": 37, "children": [{"type": "t", "text": "Xia Wang, Yuge Ji, Panpan Feng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The m6A Reader IGF2BP2 Regulates Macrophage Phenotypic Activation and Inflammatory Diseases by Stabilizing TSC1 and PPAR"}, {"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "γ"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": "."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Adv Sci (Weinh) (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/advs.202100209"}], "href": "https://doi.org/10.1002/advs.202100209"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34258163"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34258163"}]}, {"type": "r", "ref": 38, "children": [{"type": "t", "text": "Tiantian Yue, Fei Sun, Faxi Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MBD2 acts as a repressor to maintain the homeostasis of the Th1 program in type 1 diabetes by regulating the STAT1-IFN-γ axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Death Differ (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41418-021-00852-6"}], "href": "https://doi.org/10.1038/s41418-021-00852-6"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34420035"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34420035"}]}, {"type": "r", "ref": 39, "children": [{"type": "t", "text": "Miaomiao Suo, Megan K Rommelfanger, Yulin Chen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Age-dependent effects of Igf2bp2 on gene regulation, function, and aging of hematopoietic stem cells in mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Blood (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1182/blood.2021012197"}], "href": "https://doi.org/10.1182/blood.2021012197"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35231105"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35231105"}]}]}]}