OR8U3 Gene

Name olfactory receptor family 8 subfamily U member 3
Description Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. This olfactory receptor gene is a segregating pseudogene, where some individuals have an allele that encodes a functional olfactory receptor, while other individuals have an allele encoding a protein that is predicted to be non-functional. [provided by RefSeq, Jun 2015]
Summary
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These studies consistently demonstrate that Cav1.4 is critical for sustaining Ca²⁺ influx at photoreceptor terminals, thereby facilitating graded neurotransmitter release at ribbon synapses and ensuring accurate retinal neural transmission."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "5"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nMechanistic investigations in mutant mouse models reveal that both loss-of-function and gain-of-function alterations in Cav1.4 disrupt synaptic transmission between photoreceptors and second-order neurons, leading to clinical phenotypes such as congenital stationary night blindness. Several reports highlight that perturbations in Cav1.4 not only impair Ca²⁺ influx but also affect the proper assembly, maturation, and maintenance of photoreceptor ribbon synapses. Furthermore, interactions with modulatory proteins (for example, CaBP4) and auxiliary subunits, along with the precise regulation of synaptic proteins like RIM2 and filamin, are essential for stabilizing active zone architecture."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "6", "end_ref": "11"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nCollectively, these studies emphasize that the finely tuned regulation of Cav1.4 channel activity and its interactions with a network of synaptic proteins is fundamental for normal retinal function. The detailed characterization of Cav1.4 underscores its role in synapse formation, maintenance, and adaptive remodeling under varying light conditions, which ultimately governs the fidelity of visual signal processing. In contrast, because none of the abstracts provide any evidence or analysis regarding OR8U3, its function remains undefined in the context of retinal neurotransmission explored herein."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "12", "end_ref": "24"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Amy Berntson, W Rowland Taylor, Catherine W Morgans "}, {"type": "b", "children": [{"type": "t", "text": "Molecular identity, synaptic localization, and physiology of calcium channels in retinal bipolar cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Neurosci Res (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jnr.10459"}], "href": "https://doi.org/10.1002/jnr.10459"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12478624"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12478624"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Fiona Mansergh, Noelle C Orton, John P Vessey, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "Structural insights into activation of the retinal L-type Ca²⁺ channel (Cav1.4) by Ca²⁺-binding protein 4 (CaBP4)."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M114.604439"}], "href": "https://doi.org/10.1074/jbc.M114.604439"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25258313"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25258313"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Amy Lee, Shiyi Wang, Brittany Williams, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "Cone dystrophy and ectopic synaptogenesis in a Cacna1f loss of function model of congenital stationary night blindness (CSNB2A)."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Channels (Austin) (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/19336950.2017.1401688"}], "href": "https://doi.org/10.1080/19336950.2017.1401688"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29179637"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29179637"}]}, {"type": "r", "ref": 21, "children": [{"type": "t", "text": "Xufeng Dai, Shiyi Pang, Jieping Wang, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "A dual role for Ca"}, {"type": "a", "children": [{"type": "t", "text": "sub"}], "href": "sub"}, {"type": "t", "text": "v"}, {"type": "a", "children": [{"type": "t", "text": "/sub"}], "href": "/sub"}, {"type": "t", "text": "1.4 Ca"}, {"type": "a", "children": [{"type": "t", "text": "sup"}], "href": "sup"}, {"type": "t", "text": "2+"}, {"type": "a", "children": [{"type": "t", "text": "/sup"}], "href": "/sup"}, {"type": "t", "text": " channels in the molecular and structural organization of the rod photoreceptor synapse."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Elife (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.7554/eLife.62184"}], "href": "https://doi.org/10.7554/eLife.62184"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32940604"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32940604"}]}, {"type": "r", "ref": 24, "children": [{"type": "t", "text": "Lucia Zanetti, Irem Kilicarslan, Michael Netzer, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Function of cone and cone-related pathways in Ca"}, {"type": "a", "children": [{"type": "t", "text": "sub"}], "href": "sub"}, {"type": "t", "text": "V"}, {"type": "a", "children": [{"type": "t", "text": "/sub"}], "href": "/sub"}, {"type": "t", "text": "1.4 IT mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41598-021-82210-7"}], "href": "https://doi.org/10.1038/s41598-021-82210-7"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33526839"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33526839"}]}]}]}
NCBI Gene ID 219479
API
Download Associations
Predicted Functions View OR8U3's ARCHS4 Predicted Functions.
Co-expressed Genes View OR8U3's ARCHS4 Predicted Functions.
Expression in Tissues and Cell Lines View OR8U3's ARCHS4 Predicted Functions.

Functional Associations

OR8U3 has 288 functional associations with biological entities spanning 4 categories (functional term, phrase or reference, disease, phenotype or trait, cell line, cell type or tissue, gene, protein or microRNA) extracted from 12 datasets.

Click the + buttons to view associations for OR8U3 from the datasets below.

If available, associations are ranked by standardized value

Dataset Summary
Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles tissue samples with high or low expression of OR8U3 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
COMPARTMENTS Curated Protein Localization Evidence Scores 2025 cellular components containing OR8U3 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 cellular components co-occuring with OR8U3 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
GWAS Catalog SNP-Phenotype Associations 2025 phenotypes associated with OR8U3 gene in GWAS datasets from the GWAS Catalog SNP-Phenotype Associations 2025 dataset.
JASPAR Predicted Human Transcription Factor Targets 2025 transcription factors regulating expression of OR8U3 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Human Transcription Factor Targets dataset.
JASPAR Predicted Mouse Transcription Factor Targets 2025 transcription factors regulating expression of OR8U3 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Mouse Transcription Factor Targets 2025 dataset.
KEGG Pathways 2026 pathways involving OR8U3 protein from the KEGG Pathways 2026 dataset.
Reactome Pathways 2024 pathways involving OR8U3 protein from the Reactome Pathways 2024 dataset.
Rummagene Transcription Factor Associations 2026 transcription factors regulating expression of OR8U3 gene from the Rummagene Transcription Factor Associations 2026 dataset.
RummaGEO Gene Perturbation Signatures gene perturbations changing expression of OR8U3 gene from the RummaGEO Gene Perturbation Signatures dataset.
TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 tissues with high expression of OR8U3 protein in proteomics datasets from the TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 dataset.
TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 tissues co-occuring with OR8U3 protein in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 dataset.