| HGNC Family | G protein-coupled receptors |
| Name | olfactory receptor, family 9, subfamily G, member 1 |
| Description | Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008] |
| Summary |
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nThe collection of abstracts provides a broad overview of the critical roles played by stress‐response proteins and transcription factors—such as HSPA4L and KLF12—in a variety of tissues and biological processes ranging from spermatogenesis and kidney maturation to immune regulation and neural development. For example, some studies describe how HSPA4L is indispensable for proper sperm development and osmotolerance and how KLF12 regulates key genes involved in kidney function and innate immunity. Notably, however, none of these abstracts include any information regarding the function of OR9G1, leaving its role uncharacterized in the contexts presented."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}, {"type": "p", "children": [{"type": "t", "text": "\nOther reports in this collection focus on intricate molecular mechanisms—such as the chaperone activity of HSPA4L in enabling proper chromatin maturation of sperm and its role in lung development, and the transcriptional control exerted by KLF12 in modulating cellular proliferation, apoptosis, and tumor immune evasion. These findings underscore the importance of stress proteins and transcription factors in mediating cellular adaptations to physiological stress and developmental cues while simultaneously highlighting that no analyses or functional assessments of OR9G1 are provided within these studies."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "3", "end_ref": "5"}]}, {"type": "t", "text": ""}, {"type": "p", "children": [{"type": "t", "text": "\nAdditional investigations detailed in these abstracts explore the impact of altered microRNA expression on KLF12 in cystogenesis, as well as how dysregulated KLF12 expression contributes to aberrant developmental outcomes such as neural tube defects and impaired immune responses. Although these studies advance our understanding of cellular stress responses, developmental regulation, and disease states such as polycystic kidney disease and cancer, they do not shed any light on OR9G1. Overall, while the assembled abstracts significantly enhance our insights into the role of HSPA4L and KLF12 in various biological settings, the function of OR9G1 remains unexplored and represents a gap in the current literature."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "6", "end_ref": "11"}]}, {"type": "t", "text": ""}]}]}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Shin Suda, Tatemitsu Rai, Eisei Sohara, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Postnatal expression of KLF12 in the inner medullary collecting ducts of kidney and its trans-activation of UT-A1 urea transporter promoter."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2006.03.138"}], "href": "https://doi.org/10.1016/j.bbrc.2006.03.138"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16615998"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16615998"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Torsten Held, Ilona Paprotta, Janchiv Khulan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Hspa4l-deficient mice display increased incidence of male infertility and hydronephrosis development."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Biol (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/MCB.01332-06"}], "href": "https://doi.org/10.1128/MCB.01332-06"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16923965"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16923965"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Chang-Hee Kim, Young Chul Kim, Byung Yoon Choi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Expression of osmotic stress protein 94 in murine endolymphatic hydrops model."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Acta Otolaryngol (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3109/00016489.2012.666804"}], "href": "https://doi.org/10.3109/00016489.2012.666804"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22582773"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22582773"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Florian Kern, Ruslan I Stanika, Bettina Sarg, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Nogo-A couples with Apg-1 through interaction and co-ordinate expression under hypoxic and oxidative stress."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem J (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1042/BJ20130579"}], "href": "https://doi.org/10.1042/BJ20130579"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23909438"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23909438"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Belal A Mohamed, Amal Z Barakat, Torsten Held, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Respiratory distress and early neonatal lethality in Hspa4l/Hspa4 double-mutant mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Respir Cell Mol Biol (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1165/rcmb.2013-0132OC"}], "href": "https://doi.org/10.1165/rcmb.2013-0132OC"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23980576"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23980576"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Yubin Shin, Do Yeon Kim, Je Yeong Ko, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Regulation of KLF12 by microRNA-20b and microRNA-106a in cystogenesis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "FASEB J (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1096/fj.201700923R"}], "href": "https://doi.org/10.1096/fj.201700923R"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29475398"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29475398"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Katsuhiko Itoh, Gen Kondoh, Hitoshi Miyachi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Dephosphorylation of protamine 2 at serine 56 is crucial for murine sperm maturation in vivo."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Signal (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1126/scisignal.aao7232"}], "href": "https://doi.org/10.1126/scisignal.aao7232"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30914484"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30914484"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Viola C Lam, Lasse Folkersen, Oscar A Aguilar, et al. "}, {"type": "b", "children": [{"type": "t", "text": "KLF12 Regulates Mouse NK Cell Proliferation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Immunol (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4049/jimmunol.1900396"}], "href": "https://doi.org/10.4049/jimmunol.1900396"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31300511"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31300511"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Kenta Nagahori, Shuichi Hirai, Naoyuki Hatayama, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Heat shock protein A4L is a potent autoantigen for testicular autoimmunity in mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Reprod Immunol (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.jri.2021.103318"}], "href": "https://doi.org/10.1016/j.jri.2021.103318"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33894646"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33894646"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Yang Liu, Qiong Yuan, Zhilong Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A high level of KLF12 causes folic acid-resistant neural tube defects by activating the Shh signaling pathway in mice†."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biol Reprod (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/biolre/ioab111"}], "href": "https://doi.org/10.1093/biolre/ioab111"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34104947"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34104947"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Xiaohui Pan, Wenxin Zhang, Longsheng Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "KLF12 transcriptionally regulates PD-L1 expression in non-small cell lung cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Oncol (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/1878-0261.13512"}], "href": "https://doi.org/10.1002/1878-0261.13512"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "37606530"}], "href": "https://pubmed.ncbi.nlm.nih.gov/37606530"}]}]}]}
|
| Synonyms | OR9G5 |
| Proteins | OR9G1_HUMAN |
| NCBI Gene ID | 390174 |
| API | |
| Download Associations | |
| Predicted Functions |
![]() |
| Co-expressed Genes |
![]() |
| Expression in Tissues and Cell Lines |
![]() |
OR9G1 has 718 functional associations with biological entities spanning 7 categories (molecular profile, functional term, phrase or reference, disease, phenotype or trait, chemical, structural feature, cell line, cell type or tissue, gene, protein or microRNA) extracted from 41 datasets.
Click the + buttons to view associations for OR9G1 from the datasets below.
If available, associations are ranked by standardized value
| Dataset | Summary | |
|---|---|---|
| Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray | tissue samples with high or low expression of OR9G1 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset. | |
| Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles | tissues with high or low expression of OR9G1 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset. | |
| BioGPS Mouse Cell Type and Tissue Gene Expression Profiles | cell types and tissues with high or low expression of OR9G1 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset. | |
| CCLE Cell Line Gene CNV Profiles | cell lines with high or low copy number of OR9G1 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset. | |
| ChEA Transcription Factor Binding Site Profiles | transcription factor binding site profiles with transcription factor binding evidence at the promoter of OR9G1 gene from the CHEA Transcription Factor Binding Site Profiles dataset. | |
| ChEA Transcription Factor Targets | transcription factors binding the promoter of OR9G1 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset. | |
| ChEA Transcription Factor Targets 2022 | transcription factors binding the promoter of OR9G1 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset. | |
| CM4AI KOLF21J CRISPRi Gene Perturbation Atlas | gene perturbations changing expression of OR9G1 gene from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas dataset. | |
| COMPARTMENTS Curated Protein Localization Evidence Scores | cellular components containing OR9G1 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset. | |
| COSMIC Cell Line Gene Mutation Profiles | cell lines with OR9G1 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset. | |
| CTD Gene-Disease Associations | diseases associated with OR9G1 gene/protein from the curated CTD Gene-Disease Associations dataset. | |
| dbGAP Gene-Trait Associations | traits associated with OR9G1 gene in GWAS and other genetic association datasets from the dbGAP Gene-Trait Associations dataset. | |
| DepMap CRISPR Gene Dependency | cell lines with fitness changed by OR9G1 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset. | |
| DISEASES Experimental Gene-Disease Association Evidence Scores | diseases associated with OR9G1 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores dataset. | |
| DISEASES Experimental Gene-Disease Association Evidence Scores 2025 | diseases associated with OR9G1 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset. | |
| DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 | diseases co-occuring with OR9G1 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset. | |
| ENCODE Histone Modification Site Profiles | histone modification site profiles with high histone modification abundance at OR9G1 gene from the ENCODE Histone Modification Site Profiles dataset. | |
| ENCODE Transcription Factor Binding Site Profiles | transcription factor binding site profiles with transcription factor binding evidence at the promoter of OR9G1 gene from the ENCODE Transcription Factor Binding Site Profiles dataset. | |
| ENCODE Transcription Factor Targets | transcription factors binding the promoter of OR9G1 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset. | |
| GAD Gene-Disease Associations | diseases associated with OR9G1 gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset. | |
| GEO Signatures of Differentially Expressed Genes for Gene Perturbations | gene perturbations changing expression of OR9G1 gene from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset. | |
| GEO Signatures of Differentially Expressed Genes for Kinase Perturbations | kinase perturbations changing expression of OR9G1 gene from the GEO Signatures of Differentially Expressed Genes for Kinase Perturbations dataset. | |
| GEO Signatures of Differentially Expressed Genes for Small Molecules | small molecule perturbations changing expression of OR9G1 gene from the GEO Signatures of Differentially Expressed Genes for Small Molecules dataset. | |
| GO Biological Process Annotations 2015 | biological processes involving OR9G1 gene from the curated GO Biological Process Annotations 2015 dataset. | |
| GO Cellular Component Annotations 2015 | cellular components containing OR9G1 protein from the curated GO Cellular Component Annotations 2015 dataset. | |
| GO Molecular Function Annotations 2015 | molecular functions performed by OR9G1 gene from the curated GO Molecular Function Annotations 2015 dataset. | |
| GTEx Tissue Gene Expression Profiles | tissues with high or low expression of OR9G1 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles dataset. | |
| GWAS Catalog SNP-Phenotype Associations | phenotypes associated with OR9G1 gene in GWAS datasets from the GWAS Catalog SNP-Phenotype Associations dataset. | |
| GWASdb SNP-Disease Associations | diseases associated with OR9G1 gene in GWAS and other genetic association datasets from the GWASdb SNP-Disease Associations dataset. | |
| GWASdb SNP-Phenotype Associations | phenotypes associated with OR9G1 gene in GWAS datasets from the GWASdb SNP-Phenotype Associations dataset. | |
| Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles | cell lines with high or low expression of OR9G1 gene relative to other cell lines from the Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles dataset. | |
| InterPro Predicted Protein Domain Annotations | protein domains predicted for OR9G1 protein from the InterPro Predicted Protein Domain Annotations dataset. | |
| JASPAR Predicted Transcription Factor Targets | transcription factors regulating expression of OR9G1 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset. | |
| Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles | cell lines with high or low copy number of OR9G1 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset. | |
| KnockTF Gene Expression Profiles with Transcription Factor Perturbations | transcription factor perturbations changing expression of OR9G1 gene from the KnockTF Gene Expression Profiles with Transcription Factor Perturbations dataset. | |
| LOCATE Curated Protein Localization Annotations | cellular components containing OR9G1 protein in low- or high-throughput protein localization assays from the LOCATE Curated Protein Localization Annotations dataset. | |
| LOCATE Predicted Protein Localization Annotations | cellular components predicted to contain OR9G1 protein from the LOCATE Predicted Protein Localization Annotations dataset. | |
| Reactome Pathways 2014 | pathways involving OR9G1 protein from the Reactome Pathways dataset. | |
| Reactome Pathways 2024 | pathways involving OR9G1 protein from the Reactome Pathways 2024 dataset. | |
| Roadmap Epigenomics Histone Modification Site Profiles | histone modification site profiles with high histone modification abundance at OR9G1 gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset. | |
| Rummagene Transcription Factor Associations 2026 | transcription factors regulating expression of OR9G1 gene from the Rummagene Transcription Factor Associations 2026 dataset. | |