{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRecent bioinformatics analyses have identified lncRNA OXCT1‐AS1 as a promising therapeutic target in glioblastoma, underscoring its potential involvement in glioma pathogenesis through altered ceRNA network regulation. These findings suggest that modulation of OXCT1‐AS1 could affect key oncogenic processes in glioma cells."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn non‐small‐cell lung cancer (NSCLC), OXCT1‐AS1 is markedly upregulated and plays a critical role in promoting metastasis. Functional assays demonstrated that silencing this lncRNA impairs cell invasion and migration, while mechanistic studies revealed that OXCT1‐AS1 directly interacts with lymphoid enhancer factor 1 (LEF1) to maintain its stability by counteracting NARF‐mediated ubiquitination—thereby facilitating metastatic dissemination."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nMoreover, in osteosarcoma, OXCT1‐AS1 contributes to tumor progression by suppressing the maturation of microRNA‐886. The direct interaction between OXCT1‐AS1 and miR‐886 results in decreased levels of mature miR‐886, which in turn promotes cancer cell proliferation without altering epithelial–mesenchymal transition markers."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Chen Zhong, Qian Yu, Yucong Peng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Novel LncRNA OXCT1-AS1 indicates poor prognosis and contributes to tumorigenesis by regulating miR-195/CDC25A axis in glioblastoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Exp Clin Cancer Res (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s13046-021-01928-4"}], "href": "https://doi.org/10.1186/s13046-021-01928-4"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33832517"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33832517"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Binru Li, Libo Zhu, Linlin Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "lncRNA OXCT1-AS1 Promotes Metastasis in Non-Small-Cell Lung Cancer by Stabilizing LEF1, "}, {"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "In Vitro"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": " and "}, {"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "In Vivo"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": "."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biomed Res Int (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1155/2021/4959381"}], "href": "https://doi.org/10.1155/2021/4959381"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34337014"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34337014"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Wen Dai, Han Liu "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA-886 suppresses osteosarcoma cell proliferation and its maturation is suppressed by long non-coding RNA OXCT1-AS1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Bioengineered (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/21655979.2022.2031669"}], "href": "https://doi.org/10.1080/21655979.2022.2031669"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35191809"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35191809"}]}]}]}