P2RY1 Gene

HGNC Family	Purinergic receptors (P2R), G protein-coupled receptors
Name	purinergic receptor P2Y, G-protein coupled, 1
Description	The product of this gene belongs to the family of G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor functions as a receptor for extracellular ATP and ADP. In platelets binding to ADP leads to mobilization of intracellular calcium ions via activation of phospholipase C, a change in platelet shape, and probably to platelet aggregation. [provided by RefSeq, Jul 2008]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nThe P2Y1 receptor is a critical mediator of adenosine diphosphate (ADP)‐induced responses in platelets. Structural studies have revealed its unique ligand‐binding mode that underlies ADP recognition and its role in promoting platelet aggregation, making it an attractive antithrombotic target."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In platelets, ADP activation of P2Y1 triggers rapid intracellular calcium mobilization and shape change, events that initiate adhesion and aggregation; these early responses are distinct from the slower, kinase‐regulated desensitization pathways evident in P2Y12."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " Genetic studies and pharmacological inhibition further underscore that both P2Y1 and P2Y12 function in concert to sustain effective platelet responses—evidence emphasized by the blockade of P2Y1 (using selective antagonists) leading to diminished platelet adhesion, reduced secondary accumulation under flow, attenuated VEGF release, and altered microparticle formation."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "4", "end_ref": "9"}]}, {"type": "t", "text": " Moreover, emerging dual antagonists that target both P2Y1 and P2Y12 receptors have been proposed as promising candidates for antithrombotic therapy."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "10"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its central role in platelet activation, the P2Y1 receptor is subject to tightly regulated internalization and trafficking that determine the duration and intensity of its signaling. Studies using heterologous systems have demonstrated that P2Y1 can form hetero‐oligomers—for example, with the P2Y11 receptor—thereby influencing receptor internalization following agonist stimulation."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "11"}]}, {"type": "t", "text": " In both platelets and transfected cell models, agonist-induced activation leads to rapid, clathrin-dependent internalization of P2Y1, a process that contrasts with the minimal internalization seen with its P2Y12 counterpart."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "12"}]}, {"type": "t", "text": " Furthermore, protein kinase C isoforms modulate P2Y1 signaling and receptor trafficking"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "13"}]}, {"type": "t", "text": ", while sorting nexin-1 (SNX1) regulates a slower recycling pathway for P2Y1 that is independent of the classical retromer complex."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "14"}]}, {"type": "t", "text": " In parallel, a novel lysosomal sorting pathway mediated by the adaptor protein ALIX, via a YPX₃L motif in the receptor’s intracellular loop, leads to ubiquitin-independent degradation of activated P2Y1 receptors."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "15"}]}, {"type": "t", "text": " In addition, agonist exposure has been shown to promote receptor dimerization—a reversible process necessary for efficient internalization."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "16"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn various non‐platelet tissues, P2Y1 receptor activation similarly initiates key intracellular signaling cascades. In human skin, while P2Y1 is largely expressed in the tumor stroma, studies in keratinocytes have revealed that its activation leads to calcium transients and contributes to cell proliferation and wound healing."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "17"}]}, {"type": "t", "text": " In endothelial cells, selective P2Y1 stimulation activates mitogen-activated protein kinase pathways that promote migration, suggesting an important role in reendothelialization and angiogenesis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "19"}]}, {"type": "t", "text": " Neuronal studies indicate that P2Y1 activation enhances axonal elongation and contributes to calcium-dependent signaling in astrocytes, a process further supported by its involvement in olfactory nerve-stimulated calcium responses."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "20", "end_ref": "22"}]}, {"type": "t", "text": " Moreover, in human periodontal ligament cells, stress-induced ATP release acts via P2Y1 to upregulate osteopontin expression through the Rho kinase pathway"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "23"}]}, {"type": "t", "text": ", and in epithelial cells, P2Y1 activation transactivates the epidermal growth factor receptor, stimulating mitogenic signals."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "24"}]}, {"type": "t", "text": " Finally, directional expression of P2Y1 in human placental tissues—with its co-localization in endothelial caveolae—and studies in erythrocytes, where it contributes to autocrine signaling and regulation of osmolyte permeability, further underscore the receptor’s widely distributed functional roles."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "25"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Dandan Zhang, Zhan-Guo Gao, Kaihua Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Two disparate ligand-binding sites in the human P2Y1 receptor."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nature (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/nature14287"}], "href": "https://doi.org/10.1038/nature14287"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25822790"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25822790"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Adam R Hardy, Pamela B Conley, Jiansong Luo, et al. "}, {"type": "b", "children": [{"type": "t", "text": "P2Y1 and P2Y12 receptors for ADP desensitize by distinct kinase-dependent mechanisms."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Blood (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1182/blood-2004-07-2893"}], "href": "https://doi.org/10.1182/blood-2004-07-2893"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15665114"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15665114"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Adam R Hardy, Matthew L Jones, Stuart J Mundell, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Reciprocal cross-talk between P2Y1 and P2Y12 receptors at the level of calcium signaling in human platelets."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Blood (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1182/blood-2004-02-0534"}], "href": "https://doi.org/10.1182/blood-2004-02-0534"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15187029"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15187029"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Simon L Hetherington, Ravi K Singh, David Lodwick, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Dimorphism in the P2Y1 ADP receptor gene is associated with increased platelet activation response to ADP."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Arterioscler Thromb Vasc Biol (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1161/01.ATV.0000148708.44691.27"}], "href": "https://doi.org/10.1161/01.ATV.0000148708.44691.27"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15514209"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15514209"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "S F Maloney, Lawrence F Brass, S L Diamond "}, {"type": "b", "children": [{"type": "t", "text": "P2Y12 or P2Y1 inhibitors reduce platelet deposition in a microfluidic model of thrombosis while apyrase lacks efficacy under flow conditions."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Integr Biol (Camb) (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1039/b919728a"}], "href": "https://doi.org/10.1039/b919728a"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20473398"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20473398"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Nadia M Bambace, Jamie E Levis, Chris E Holmes "}, {"type": "b", "children": [{"type": "t", "text": "The effect of P2Y-mediated platelet activation on the release of VEGF and endostatin from platelets."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Platelets (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3109/09537100903470298"}], "href": "https://doi.org/10.3109/09537100903470298"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20063989"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20063989"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Mario Mazzucato, Maria Rita Cozzi, Paola Pradella, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Distinct roles of ADP receptors in von Willebrand factor-mediated platelet signaling and activation under high flow."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Blood (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1182/blood-2004-03-1145"}], "href": "https://doi.org/10.1182/blood-2004-03-1145"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15284110"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15284110"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Katsuhiro Takano, Naoki Asazuma, Kaneo Satoh, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Collagen-induced generation of platelet-derived microparticles in whole blood is dependent on ADP released from red blood cells and calcium ions."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Platelets (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/09537100410001682797"}], "href": "https://doi.org/10.1080/09537100410001682797"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15203713"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15203713"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Sayuri Sukigara, Hongmei Dai, Shin Nabatame, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Expression of astrocyte-related receptors in cortical dysplasia with intractable epilepsy."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Neuropathol Exp Neurol (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1097/NEN.0000000000000099"}], "href": "https://doi.org/10.1097/NEN.0000000000000099"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25003238"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25003238"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Thomas Gremmel, Ivan B Yanachkov, Milka I Yanachkova, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Synergistic Inhibition of Both P2Y1 and P2Y12 Adenosine Diphosphate Receptors As Novel Approach to Rapidly Attenuate Platelet-Mediated Thrombosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Arterioscler Thromb Vasc Biol (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1161/ATVBAHA.115.306885"}], "href": "https://doi.org/10.1161/ATVBAHA.115.306885"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26743169"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26743169"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Denise Ecke, Theodor Hanck, Mohan E Tulapurkar, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Hetero-oligomerization of the P2Y11 receptor with the P2Y1 receptor controls the internalization and ligand selectivity of the P2Y11 receptor."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem J (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1042/BJ20070671"}], "href": "https://doi.org/10.1042/BJ20070671"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17824841"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17824841"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Anthony Baurand, Anita Eckly, Béatrice Hechler, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Differential regulation and relocalization of the platelet P2Y receptors after activation: a way to avoid loss of hemostatic properties?"}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Pharmacol (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1124/mol.104.004846"}], "href": "https://doi.org/10.1124/mol.104.004846"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15602005"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15602005"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Stuart J Mundell, Matthew L Jones, Adam R Hardy, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Distinct roles for protein kinase C isoforms in regulating platelet purinergic receptor function."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Pharmacol (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1124/mol.106.023549"}], "href": "https://doi.org/10.1124/mol.106.023549"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16804093"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16804093"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Shaista Nisar, Eamonn Kelly, Pete J Cullen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Regulation of P2Y1 receptor traffic by sorting Nexin 1 is retromer independent."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Traffic (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/j.1600-0854.2010.01035.x"}], "href": "https://doi.org/10.1111/j.1600-0854.2010.01035.x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20070609"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20070609"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Michael R Dores, Neil J Grimsey, Francisco Mendez, et al. "}, {"type": "b", "children": [{"type": "t", "text": "ALIX Regulates the Ubiquitin-Independent Lysosomal Sorting of the P2Y1 Purinergic Receptor via a YPX3L Motif."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0157587"}], "href": "https://doi.org/10.1371/journal.pone.0157587"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27301021"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27301021"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Roy C Y Choi, Joseph Simon, Karl W K Tsim, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Constitutive and agonist-induced dimerizations of the P2Y1 receptor: relationship to internalization and scaffolding."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M709266200"}], "href": "https://doi.org/10.1074/jbc.M709266200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18270199"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18270199"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Aina V H Greig, Claire Linge, Vourneen Healy, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Expression of purinergic receptors in non-melanoma skin cancers and their functional roles in A431 cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Invest Dermatol (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1046/j.1523-1747.2003.12379.x"}], "href": "https://doi.org/10.1046/j.1523-1747.2003.12379.x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12880424"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12880424"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Aina V H Greig, Claire Linge, Giorgio Terenghi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Purinergic receptors are part of a functional signaling system for proliferation and differentiation of human epidermal keratinocytes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Invest Dermatol (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1046/j.1523-1747.2003.12261.x"}], "href": "https://doi.org/10.1046/j.1523-1747.2003.12261.x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12787128"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12787128"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Jianzhong Shen, Paul E DiCorleto "}, {"type": "b", "children": [{"type": "t", "text": "ADP stimulates human endothelial cell migration via P2Y1 nucleotide receptor-mediated mitogen-activated protein kinase pathways."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Circ Res (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1161/CIRCRESAHA.107.165795"}], "href": "https://doi.org/10.1161/CIRCRESAHA.107.165795"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18174464"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18174464"}]}, {"type": "r", "ref": 20, "children": [{"type": "t", "text": "Ana del Puerto, Juan-Ignacio Díaz-Hernández, Mónica Tapia, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Adenylate cyclase 5 coordinates the action of ADP, P2Y1, P2Y13 and ATP-gated P2X7 receptors on axonal elongation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Sci (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1242/jcs.091736"}], "href": "https://doi.org/10.1242/jcs.091736"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22250198"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22250198"}]}, {"type": "r", "ref": 21, "children": [{"type": "t", "text": "Helen E Burrell, Wayne B Bowler, James A Gallagher, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Human keratinocytes express multiple P2Y-receptors: evidence for functional P2Y1, P2Y2, and P2Y4 receptors."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Invest Dermatol (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1046/j.1523-1747.2003.12050.x"}], "href": "https://doi.org/10.1046/j.1523-1747.2003.12050.x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12603858"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12603858"}]}, {"type": "r", "ref": 22, "children": [{"type": "t", "text": "Michael Doengi, Joachim W Deitmer, Christian Lohr "}, {"type": "b", "children": [{"type": "t", "text": "New evidence for purinergic signaling in the olfactory bulb: A2A and P2Y1 receptors mediate intracellular calcium release in astrocytes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "FASEB J (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1096/fj.07-101782"}], "href": "https://doi.org/10.1096/fj.07-101782"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18310463"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18310463"}]}, {"type": "r", "ref": 23, "children": [{"type": "t", "text": "S Wongkhantee, T Yongchaitrakul, P Pavasant "}, {"type": "b", "children": [{"type": "t", "text": "Mechanical stress induces osteopontin via ATP/P2Y1 in periodontal cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Dent Res (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1177/154405910808700601"}], "href": "https://doi.org/10.1177/154405910808700601"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18502966"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18502966"}]}, {"type": "r", "ref": 24, "children": [{"type": "t", "text": "Sonja Buvinic, Marcela Bravo-Zehnder, José Luis Boyer, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Nucleotide P2Y1 receptor regulates EGF receptor mitogenic signaling and expression in epithelial cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Sci (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1242/jcs.03490"}], "href": "https://doi.org/10.1242/jcs.03490"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18057028"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18057028"}]}, {"type": "r", "ref": 25, "children": [{"type": "t", "text": "A Kittel, Z S Csapó, E Csizmadia, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Co-localization of P2Y1 receptor and NTPDase1/CD39 within caveolae in human placenta."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur J Histochem (2004)"}]}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15590415"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15590415"}]}, {"type": "r", "ref": 26, "children": [{"type": "t", "text": "Valérie Tanneur, Christophe Duranton, Verena B Brand, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Purinoceptors are involved in the induction of an osmolyte permeability in malaria-infected and oxidized human erythrocytes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "FASEB J (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1096/fj.04-3371fje"}], "href": "https://doi.org/10.1096/fj.04-3371fje"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16267125"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16267125"}]}]}]}
Synonyms	SARCC, P2Y1
Proteins	P2RY1_HUMAN
NCBI Gene ID	5028
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

P2RY1 has 6,166 functional associations with biological entities spanning 9 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 115 datasets.

Click the + buttons to view associations for P2RY1 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

P2RY1 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of P2RY1 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of P2RY1 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of P2RY1 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of P2RY1 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of P2RY1 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of P2RY1 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of P2RY1 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of P2RY1 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of P2RY1 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of P2RY1 gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of P2RY1 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of P2RY1 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with P2RY1 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of P2RY1 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of P2RY1 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of P2RY1 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of P2RY1 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing P2RY1 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing P2RY1 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with P2RY1 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with P2RY1 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of P2RY1 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with P2RY1 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with P2RY1 gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with P2RY1 gene/protein from the curated CTD Gene-Disease Associations dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by P2RY1 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with P2RY1 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with P2RY1 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with P2RY1 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with P2RY1 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at P2RY1 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of P2RY1 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of P2RY1 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing P2RY1 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GAD Gene-Disease Associations	diseases associated with P2RY1 gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.
	GAD High Level Gene-Disease Associations	diseases associated with P2RY1 gene in GWAS and other genetic association datasets from the GAD High Level Gene-Disease Associations dataset.
	GDSC Cell Line Gene Expression Profiles	cell lines with high or low expression of P2RY1 gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset.
	GeneRIF Biological Term Annotations	biological terms co-occuring with P2RY1 gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.
	GeneSigDB Published Gene Signatures	PubMedIDs of publications reporting gene signatures containing P2RY1 from the GeneSigDB Published Gene Signatures dataset.
	GEO Signatures of Differentially Expressed Genes for Diseases	disease perturbations changing expression of P2RY1 gene from the GEO Signatures of Differentially Expressed Genes for Diseases dataset.