| HGNC Family | G protein-coupled receptors, Purinergic receptors (P2R) |
| Name | purinergic receptor P2Y, G-protein coupled, 11 |
| Description | The product of this gene belongs to the family of G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor is coupled to the stimulation of the phosphoinositide and adenylyl cyclase pathways and behaves as a selective purinoceptor. Naturally occuring read-through transcripts, resulting from intergenic splicing between this gene and an immediately upstream gene (PPAN, encoding peter pan homolog), have been found. The PPAN-P2RY11 read-through mRNA is ubiquitously expressed and encodes a fusion protein that shares identity with each individual gene product. [provided by RefSeq, Jul 2008] |
| Summary |
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Structural and computational modeling studies have further delineated critical residues for nucleotide recognition, while hetero‐oligomerization with receptors such as P2Y1 contributes to agonist-induced internalization, emphasizing the complexity of purinergic cross-talk."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "7"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn the immune system, P2Y11 signaling has emerged as a key regulator of inflammatory and autoimmune responses. Genetic association studies have linked polymorphisms and rare missense mutations in the P2RY11 gene with disorders such as narcolepsy, suggesting that diminished receptor function contributes to autoimmunity. In human dendritic cells and T lymphocytes, aberrant extracellular ATP levels engage P2Y11 to suppress pro-inflammatory cytokine production and impair T cell activation, thereby contributing to immunosuppressive states observed in sepsis. In IL-10–polarized M2 macrophages and fibroblast-like synoviocytes, P2Y11 activation interfaces with IL-1 receptor pathways and modulates downstream effectors—including upregulation of anti-inflammatory and pro-angiogenic mediators as well as chemokine receptor expression—thus shaping both innate and adaptive immune responses."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "8", "end_ref": "17"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond immune cell regulation, P2Y11 signaling has significant implications in tissue homeostasis and repair. In tumor-derived endothelial cells, activation of P2Y11 by high extracellular ATP levels contributes to anti-migratory effects and cytoskeletal remodeling, actions that can normalize aberrant vessel permeability. Similarly, in airway epithelial cells, P2Y11 underlies ATP-dependent mechanisms that increase airway surface liquid height and promote epithelial repair, thereby representing potential therapeutic targets in inflammatory and ischemia/reperfusion injury settings."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "18", "end_ref": "20"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Iliana Moreschi, Santina Bruzzone, Robert A Nicholas, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Extracellular NAD+ is an agonist of the human P2Y11 purinergic receptor in human granulocytes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M606625200"}], "href": "https://doi.org/10.1074/jbc.M606625200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16926152"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16926152"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Stefan Amisten, Olle Melander, Anna-Karin Wihlborg, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Increased risk of acute myocardial infarction and elevated levels of C-reactive protein in carriers of the Thr-87 variant of the ATP receptor P2Y11."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur Heart J (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/eurheartj/ehl410"}], "href": "https://doi.org/10.1093/eurheartj/ehl410"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17135283"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17135283"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Jacques Zylberg, Denise Ecke, Bilha Fischer, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Structure and ligand-binding site characteristics of the human P2Y11 nucleotide receptor deduced from computational modelling and mutational analysis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem J (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1042/BJ20061728"}], "href": "https://doi.org/10.1042/BJ20061728"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17338680"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17338680"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Iliana Moreschi, Santina Bruzzone, Nicoletta Bodrato, et al. "}, {"type": "b", "children": [{"type": "t", "text": "NAADP+ is an agonist of the human P2Y11 purinergic receptor."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Calcium (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ceca.2007.06.006"}], "href": "https://doi.org/10.1016/j.ceca.2007.06.006"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17707504"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17707504"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Denise Ecke, Theodor Hanck, Mohan E Tulapurkar, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Hetero-oligomerization of the P2Y11 receptor with the P2Y1 receptor controls the internalization and ligand selectivity of the P2Y11 receptor."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem J (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1042/BJ20070671"}], "href": "https://doi.org/10.1042/BJ20070671"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17824841"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17824841"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Kathryn R Vaughan, Leanne Stokes, Lynne R Prince, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Inhibition of neutrophil apoptosis by ATP is mediated by the P2Y11 receptor."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Immunol (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4049/jimmunol.179.12.8544"}], "href": "https://doi.org/10.4049/jimmunol.179.12.8544"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18056402"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18056402"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Floriana Fruscione, Sonia Scarfì, Chiara Ferraris, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Regulation of human mesenchymal stem cell functions by an autocrine loop involving NAD+ release and P2Y11-mediated signaling."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Stem Cells Dev (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1089/scd.2010.0295"}], "href": "https://doi.org/10.1089/scd.2010.0295"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20964598"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20964598"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Birgitte R Kornum, Minae Kawashima, Juliette Faraco, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Common variants in P2RY11 are associated with narcolepsy."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Genet (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ng.734"}], "href": "https://doi.org/10.1038/ng.734"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21170044"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21170044"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Fang Han, Ling Lin, Jing Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "TCRA, P2RY11, and CPT1B/CHKB associations in Chinese narcolepsy."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sleep Med (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.sleep.2011.06.020"}], "href": "https://doi.org/10.1016/j.sleep.2011.06.020"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22177342"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22177342"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Stéphanie Chadet, Fabrice Ivanes, Lauriane Benoist, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Hypoxia/Reoxygenation Inhibits P2Y11 Receptor Expression and Its Immunosuppressive Activity in Human Dendritic Cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Immunol (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4049/jimmunol.1500197"}], "href": "https://doi.org/10.4049/jimmunol.1500197"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26078273"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26078273"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Yan Zhou, Xiao Leng, Yan He, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Loss of "}, {"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "Perp"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": " in T Cells Promotes Resistance to Apoptosis of T Helper 17 Cells and Exacerbates the Development of Experimental Autoimmune Encephalomyelitis in Mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Front Immunol (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3389/fimmu.2018.00842"}], "href": "https://doi.org/10.3389/fimmu.2018.00842"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29740445"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29740445"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Koichiro Sueyoshi, Carola Ledderose, Yong Shen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Lipopolysaccharide suppresses T cells by generating extracellular ATP that impairs their mitochondrial function via P2Y11 receptors."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.RA118.007188"}], "href": "https://doi.org/10.1074/jbc.RA118.007188"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30787105"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30787105"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Maja Wallentin Dommer, Karin Dreisig, Birgitte Rahbek Kornum "}, {"type": "b", "children": [{"type": "t", "text": "Altered surface expression of P2Y11 receptor with narcolepsy-associated mutations."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Pharmacol Rep (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.pharep.2019.05.005"}], "href": "https://doi.org/10.1016/j.pharep.2019.05.005"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31450027"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31450027"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Nisha Patel, Salim Alkeraye, Eman Alobeid, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Confirming the recessive inheritance of PERP-related erythrokeratoderma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Clin Genet (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/cge.13699"}], "href": "https://doi.org/10.1111/cge.13699"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31898316"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31898316"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Dominik Klaver, Hubert Gander, Gabriele Dobler, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The P2Y"}, {"type": "a", "children": [{"type": "t", "text": "sub"}], "href": "sub"}, {"type": "t", "text": "11"}, {"type": "a", "children": [{"type": "t", "text": "/sub"}], "href": "/sub"}, {"type": "t", "text": " receptor of human M2 macrophages activates canonical and IL-1 receptor signaling to translate the extracellular danger signal ATP into anti-inflammatory and pro-angiogenic responses."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Mol Life Sci (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s00018-022-04548-z"}], "href": "https://doi.org/10.1007/s00018-022-04548-z"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36107259"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36107259"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Line Lykke Andersen, Yiqi Huang, Christian Urban, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Systematic P2Y receptor survey identifies P2Y11 as modulator of immune responses and virus replication in macrophages."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "EMBO J (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.15252/embj.2022113279"}], "href": "https://doi.org/10.15252/embj.2022113279"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "37881155"}], "href": "https://pubmed.ncbi.nlm.nih.gov/37881155"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Dominik Klaver, Hubert Gander, Beatrice Frena, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "Activation of P2X7 and P2Y11 purinergic receptors inhibits migration and normalizes tumor-derived endothelial cells via cAMP signaling."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/srep32602"}], "href": "https://doi.org/10.1038/srep32602"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27586846"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27586846"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Madiha Khalid, Lucie Brisson, Menahil Tariq, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Carcinoma-specific expression of P2Y11 receptor and its contribution in ATP-induced purinergic signalling and cell migration in human hepatocellular carcinoma cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncotarget (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/oncotarget.16191"}], "href": "https://doi.org/10.18632/oncotarget.16191"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28418839"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28418839"}]}, {"type": "r", "ref": 20, "children": [{"type": "t", "text": "Matilda Degn, Yves Dauvilliers, Karin Dreisig, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Rare missense mutations in P2RY11 in narcolepsy with cataplexy."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Brain (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/brain/awx093"}], "href": "https://doi.org/10.1093/brain/awx093"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28460015"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28460015"}]}]}]}
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| Synonyms | P2Y11 |
| Proteins | P2Y11_HUMAN |
| NCBI Gene ID | 5032 |
| API | |
| Download Associations | |
| Predicted Functions |
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| Co-expressed Genes |
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| Expression in Tissues and Cell Lines |
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P2RY11 has 3,521 functional associations with biological entities spanning 8 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA) extracted from 80 datasets.
Click the + buttons to view associations for P2RY11 from the datasets below.
If available, associations are ranked by standardized value
| Dataset | Summary | |
|---|---|---|
| Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles | tissues with high or low expression of P2RY11 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset. | |
| Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray | tissue samples with high or low expression of P2RY11 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset. | |
| Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq | tissue samples with high or low expression of P2RY11 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset. | |
| Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles | tissues with high or low expression of P2RY11 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset. | |
| CCLE Cell Line Gene CNV Profiles | cell lines with high or low copy number of P2RY11 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset. | |
| ChEA Transcription Factor Binding Site Profiles | transcription factor binding site profiles with transcription factor binding evidence at the promoter of P2RY11 gene from the CHEA Transcription Factor Binding Site Profiles dataset. | |
| ChEA Transcription Factor Targets | transcription factors binding the promoter of P2RY11 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset. | |
| ChEA Transcription Factor Targets 2022 | transcription factors binding the promoter of P2RY11 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset. | |
| CMAP Signatures of Differentially Expressed Genes for Small Molecules | small molecule perturbations changing expression of P2RY11 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset. | |
| COMPARTMENTS Curated Protein Localization Evidence Scores | cellular components containing P2RY11 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset. | |
| COMPARTMENTS Experimental Protein Localization Evidence Scores | cellular components containing P2RY11 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores dataset. | |
| COMPARTMENTS Text-mining Protein Localization Evidence Scores | cellular components co-occuring with P2RY11 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset. | |
| COSMIC Cell Line Gene CNV Profiles | cell lines with high or low copy number of P2RY11 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset. | |
| COSMIC Cell Line Gene Mutation Profiles | cell lines with P2RY11 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset. | |
| CTD Gene-Chemical Interactions | chemicals interacting with P2RY11 gene/protein from the curated CTD Gene-Chemical Interactions dataset. | |
| CTD Gene-Disease Associations | diseases associated with P2RY11 gene/protein from the curated CTD Gene-Disease Associations dataset. | |
| DepMap CRISPR Gene Dependency | cell lines with fitness changed by P2RY11 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset. | |
| DISEASES Curated Gene-Disease Association Evidence Scores 2025 | diseases involving P2RY11 gene from the DISEASES Curated Gene-Disease Association Evidence Scores 2025 dataset. | |
| DISEASES Text-mining Gene-Disease Association Evidence Scores | diseases co-occuring with P2RY11 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset. | |
| DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 | diseases co-occuring with P2RY11 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset. | |
| DisGeNET Gene-Disease Associations | diseases associated with P2RY11 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset. | |
| DisGeNET Gene-Phenotype Associations | phenotypes associated with P2RY11 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset. | |
| ENCODE Histone Modification Site Profiles | histone modification site profiles with high histone modification abundance at P2RY11 gene from the ENCODE Histone Modification Site Profiles dataset. | |
| ENCODE Transcription Factor Binding Site Profiles | transcription factor binding site profiles with transcription factor binding evidence at the promoter of P2RY11 gene from the ENCODE Transcription Factor Binding Site Profiles dataset. | |
| ENCODE Transcription Factor Targets | transcription factors binding the promoter of P2RY11 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset. | |
| GAD Gene-Disease Associations | diseases associated with P2RY11 gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset. | |
| GAD High Level Gene-Disease Associations | diseases associated with P2RY11 gene in GWAS and other genetic association datasets from the GAD High Level Gene-Disease Associations dataset. | |
| GDSC Cell Line Gene Expression Profiles | cell lines with high or low expression of P2RY11 gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset. | |
| GeneRIF Biological Term Annotations | biological terms co-occuring with P2RY11 gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset. | |
| GeneSigDB Published Gene Signatures | PubMedIDs of publications reporting gene signatures containing P2RY11 from the GeneSigDB Published Gene Signatures dataset. | |
| GEO Signatures of Differentially Expressed Genes for Diseases | disease perturbations changing expression of P2RY11 gene from the GEO Signatures of Differentially Expressed Genes for Diseases dataset. | |
| GEO Signatures of Differentially Expressed Genes for Kinase Perturbations | kinase perturbations changing expression of P2RY11 gene from the GEO Signatures of Differentially Expressed Genes for Kinase Perturbations dataset. | |
| GEO Signatures of Differentially Expressed Genes for Small Molecules | small molecule perturbations changing expression of P2RY11 gene from the GEO Signatures of Differentially Expressed Genes for Small Molecules dataset. | |
| GEO Signatures of Differentially Expressed Genes for Viral Infections | virus perturbations changing expression of P2RY11 gene from the GEO Signatures of Differentially Expressed Genes for Viral Infections dataset. | |
| GO Biological Process Annotations 2015 | biological processes involving P2RY11 gene from the curated GO Biological Process Annotations 2015 dataset. | |
| GO Biological Process Annotations 2023 | biological processes involving P2RY11 gene from the curated GO Biological Process Annotations 2023 dataset. | |
| GO Cellular Component Annotations 2015 | cellular components containing P2RY11 protein from the curated GO Cellular Component Annotations 2015 dataset. | |
| GO Molecular Function Annotations 2015 | molecular functions performed by P2RY11 gene from the curated GO Molecular Function Annotations 2015 dataset. | |
| GO Molecular Function Annotations 2023 | molecular functions performed by P2RY11 gene from the curated GO Molecular Function Annotations 2023 dataset. | |
| GTEx Tissue Gene Expression Profiles | tissues with high or low expression of P2RY11 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles dataset. | |
| GTEx Tissue Gene Expression Profiles 2023 | tissues with high or low expression of P2RY11 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles 2023 dataset. | |
| GTEx Tissue Sample Gene Expression Profiles | tissue samples with high or low expression of P2RY11 gene relative to other tissue samples from the GTEx Tissue Sample Gene Expression Profiles dataset. | |
| Guide to Pharmacology Chemical Ligands of Receptors | ligands (chemical) binding P2RY11 receptor from the curated Guide to Pharmacology Chemical Ligands of Receptors dataset. | |
| Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles | cell lines with high or low expression of P2RY11 gene relative to other cell lines from the Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles dataset. | |
| HMDB Metabolites of Enzymes | interacting metabolites for P2RY11 protein from the curated HMDB Metabolites of Enzymes dataset. | |
| HPA Cell Line Gene Expression Profiles | cell lines with high or low expression of P2RY11 gene relative to other cell lines from the HPA Cell Line Gene Expression Profiles dataset. | |
| HPA Tissue Gene Expression Profiles | tissues with high or low expression of P2RY11 gene relative to other tissues from the HPA Tissue Gene Expression Profiles dataset. | |
| HPA Tissue Protein Expression Profiles | tissues with high or low expression of P2RY11 protein relative to other tissues from the HPA Tissue Protein Expression Profiles dataset. | |
| HPA Tissue Sample Gene Expression Profiles | tissue samples with high or low expression of P2RY11 gene relative to other tissue samples from the HPA Tissue Sample Gene Expression Profiles dataset. | |
| HPO Gene-Disease Associations | phenotypes associated with P2RY11 gene by mapping known disease genes to disease phenotypes from the HPO Gene-Disease Associations dataset. | |
| HuGE Navigator Gene-Phenotype Associations | phenotypes associated with P2RY11 gene by text-mining GWAS publications from the HuGE Navigator Gene-Phenotype Associations dataset. | |
| InterPro Predicted Protein Domain Annotations | protein domains predicted for P2RY11 protein from the InterPro Predicted Protein Domain Annotations dataset. | |
| JASPAR Predicted Transcription Factor Targets | transcription factors regulating expression of P2RY11 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset. | |
| KEGG Pathways | pathways involving P2RY11 protein from the KEGG Pathways dataset. | |
| Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles | cell lines with high or low copy number of P2RY11 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset. | |
| Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles | cell lines with high or low expression of P2RY11 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles dataset. | |
| Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles | cell lines with P2RY11 gene mutations from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles dataset. | |
| KnockTF Gene Expression Profiles with Transcription Factor Perturbations | transcription factor perturbations changing expression of P2RY11 gene from the KnockTF Gene Expression Profiles with Transcription Factor Perturbations dataset. | |
| LOCATE Curated Protein Localization Annotations | cellular components containing P2RY11 protein in low- or high-throughput protein localization assays from the LOCATE Curated Protein Localization Annotations dataset. | |
| LOCATE Predicted Protein Localization Annotations | cellular components predicted to contain P2RY11 protein from the LOCATE Predicted Protein Localization Annotations dataset. | |
| MiRTarBase microRNA Targets | microRNAs targeting P2RY11 gene in low- or high-throughput microRNA targeting studies from the MiRTarBase microRNA Targets dataset. | |
| MotifMap Predicted Transcription Factor Targets | transcription factors regulating expression of P2RY11 gene predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset. | |
| MSigDB Cancer Gene Co-expression Modules | co-expressed genes for P2RY11 from the MSigDB Cancer Gene Co-expression Modules dataset. | |
| MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations | gene perturbations changing expression of P2RY11 gene from the MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations dataset. | |
| Pathway Commons Protein-Protein Interactions | interacting proteins for P2RY11 from the Pathway Commons Protein-Protein Interactions dataset. | |
| PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations | gene perturbations changing expression of P2RY11 gene from the PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations dataset. | |
| PFOCR Pathway Figure Associations 2023 | pathways involving P2RY11 protein from the PFOCR Pathway Figure Associations 2023 dataset. | |
| PFOCR Pathway Figure Associations 2024 | pathways involving P2RY11 protein from the Wikipathways PFOCR 2024 dataset. | |
| Reactome Pathways 2014 | pathways involving P2RY11 protein from the Reactome Pathways dataset. | |
| Reactome Pathways 2024 | pathways involving P2RY11 protein from the Reactome Pathways 2024 dataset. | |
| Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles | cell types and tissues with high or low DNA methylation of P2RY11 gene relative to other cell types and tissues from the Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles dataset. | |
| Roadmap Epigenomics Cell and Tissue Gene Expression Profiles | cell types and tissues with high or low expression of P2RY11 gene relative to other cell types and tissues from the Roadmap Epigenomics Cell and Tissue Gene Expression Profiles dataset. | |
| Roadmap Epigenomics Histone Modification Site Profiles | histone modification site profiles with high histone modification abundance at P2RY11 gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset. | |
| TargetScan Predicted Nonconserved microRNA Targets | microRNAs regulating expression of P2RY11 gene predicted using nonconserved miRNA seed sequences from the TargetScan Predicted Nonconserved microRNA Targets dataset. | |
| TCGA Signatures of Differentially Expressed Genes for Tumors | tissue samples with high or low expression of P2RY11 gene relative to other tissue samples from the TCGA Signatures of Differentially Expressed Genes for Tumors dataset. | |
| TISSUES Curated Tissue Protein Expression Evidence Scores | tissues with high expression of P2RY11 protein from the TISSUES Curated Tissue Protein Expression Evidence Scores dataset. | |
| TISSUES Experimental Tissue Protein Expression Evidence Scores | tissues with high expression of P2RY11 protein in proteomics datasets from the TISSUES Experimental Tissue Protein Expression Evidence Scores dataset. | |
| TISSUES Text-mining Tissue Protein Expression Evidence Scores | tissues co-occuring with P2RY11 protein in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores dataset. | |
| WikiPathways Pathways 2014 | pathways involving P2RY11 protein from the Wikipathways Pathways 2014 dataset. | |
| WikiPathways Pathways 2024 | pathways involving P2RY11 protein from the WikiPathways Pathways 2024 dataset. | |
