{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nLong noncoding RNAs (lncRNAs) have emerged as key regulators in tumor progression. Several studies have demonstrated that lncRNA POU3F3 and its isoforms serve oncogenic functions in multiple malignancies—promoting cell migration, invasion, and proliferation in esophageal squamous cell carcinoma, hepatocellular carcinoma, non‐small cell lung cancer, glioma, colorectal cancer, and renal cell carcinoma ["}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "4"}]}, {"type": "t", "text": "].\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn contrast, a novel lncRNA, PANTR1, has been identified in hepatocellular carcinoma (HCC) as a potent tumor promoter. PANTR1 is significantly upregulated in HCC tumor tissues and cell lines; its knockdown not only inhibits cell proliferation, migration, and invasion, and promotes apoptosis in vitro, but also suppresses tumor growth in vivo. Notably, reducing PANTR1 levels attenuates the Warburg effect in HCC cells, indicating its role in metabolic reprogramming. Mechanistic studies reveal that PANTR1 functions as a competitive endogenous RNA by sponging miR-587, thereby downregulating miR-587 and relieving its repression on BCL2A1—a direct miR-587 target—which ultimately promotes HCC progression. These findings highlight PANTR1 as a potential therapeutic target for HCC management ["}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": "].\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Yichun Li, Yannan Li, Dan Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Linc-POU3F3 is overexpressed in hepatocellular carcinoma and regulates cell proliferation, migration and invasion."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biomed Pharmacother (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.biopha.2018.06.006"}], "href": "https://doi.org/10.1016/j.biopha.2018.06.006"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29906746"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29906746"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Wei Li, Xingyu Wu, Wensheng She "}, {"type": "b", "children": [{"type": "t", "text": "LncRNA POU3F3 promotes cancer cell migration and invasion in nasopharyngeal carcinoma by up-regulating TGF-β1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biosci Rep (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1042/BSR20181632"}], "href": "https://doi.org/10.1042/BSR20181632"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30602452"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30602452"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Qigang Zeng, Yong Dai, Chenxia Duan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long noncoding RNA POU3F3 enhances cancer cell proliferation, migration and invasion in non-small cell lung cancer (adenocarcinoma) by downregulating microRNA-30d-5p."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "BMC Pulm Med (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12890-020-01218-3"}], "href": "https://doi.org/10.1186/s12890-020-01218-3"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32615948"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32615948"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Lei Zhang, Cezheng Wang, Min Ma "}, {"type": "b", "children": [{"type": "t", "text": "LncRNA POU3F3 Promotes Cancer Cell Proliferation, Migration, and Invasion in Renal Cell Carcinoma by Downregulating LncRNA GAS5."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Kidney Blood Press Res (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1159/000511174"}], "href": "https://doi.org/10.1159/000511174"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34352801"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34352801"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Xirui Ma, Ziming Mao, Jing Zhu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "lncRNA PANTR1 Upregulates BCL2A1 Expression to Promote Tumorigenesis and Warburg Effect of Hepatocellular Carcinoma through Restraining miR-587."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Immunol Res (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1155/2021/1736819"}], "href": "https://doi.org/10.1155/2021/1736819"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34423048"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34423048"}]}]}]}