{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRecent evidence suggests that PARAIL plays a regulatory role in mediating post‐transcriptional events that promote the metabolic reprogramming seen in cancer cells. In the context of gastric cancer, the mechanism appears to involve the recognition of m6A-methylated transcripts, particularly c-MYC mRNA, by LIN28B. LIN28B, a protein known to be critical in driving the Warburg effect, is proposed to cooperate with factors such as IGF2BP3—an m6A reader—to support this recognition process, thereby potentially acting through a PARAIL-dependent mechanism."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n \nIn this proposed model, PARAIL is envisioned as a bridging component that facilitates the interaction between methylated mRNA substrates and the machinery required for their stabilization and enhanced translation. By enabling LIN28B to effectively recognize m6A modifications on c-MYC transcripts, PARAIL may help sustain the high glycolytic flux characteristic of the Warburg effect, ultimately fuelling tumor progression and providing a survival advantage to gastric cancer cells."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n\nCollectively, these findings underscore the potential of PARAIL as a pivotal mediator linking RNA methylation to oncogenic metabolic pathways. The involvement of PARAIL in the stabilization and translation of key transcripts such as c-MYC positions it as a promising target for therapeutic intervention in cancers that depend on dysregulated metabolic reprogramming for growth and survival."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Tong-Peng Xu, Tao Yu, Meng-Yan Xie, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LOC101929709 promotes gastric cancer progression by aiding LIN28B to stabilize c-MYC mRNA."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Gastric Cancer (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s10120-022-01348-z"}], "href": "https://doi.org/10.1007/s10120-022-01348-z"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36284068"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36284068"}]}]}]}