{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRecent computational and epigenomic analyses have identified PARD6G‑AS1 as a candidate imprinted differentially methylated region (iDMR) that carries a gametic, maternally derived 5mCpG imprint. Intriguingly, despite this maternal methyl mark, PARD6G‑AS1 is expressed biallelically across multiple tissues, indicating that its imprint does not translate into classical monoallelic expression. Instead, the region exhibits a dynamic chromatin segmentation state—alternating between activation and repression—suggesting that PARD6G‑AS1 may function as a regulatory non‐coding element involved in long‐range gene regulation. Moreover, the maternal 5mCpG imprint at this locus is perturbed in several hematopoietic cancers, implying that dysregulation of this epigenetic mark might contribute to disease pathogenesis. Overall, these findings highlight a nuanced role for PARD6G‑AS1 in epigenetic regulation, where its imprinted mark provides an additional layer of context‐dependent control that, rather than dictating allelic silencing, may influence chromatin states and gene expression patterns over broad genomic distances."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Graziela de Sá Machado Araújo, Ronaldo da Silva Francisco Junior, Cristina Dos Santos Ferreira, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Maternal 5"}, {"type": "a", "children": [{"type": "t", "text": "sup"}], "href": "sup"}, {"type": "t", "text": "m"}, {"type": "a", "children": [{"type": "t", "text": "/sup"}], "href": "/sup"}, {"type": "t", "text": "CpG Imprints at the "}, {"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "PARD6G-AS1"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": " and "}, {"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "GCSAML"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": " Differentially Methylated Regions Are Decoupled From Parent-of-Origin Expression Effects in Multiple Human Tissues."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Front Genet (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3389/fgene.2018.00036"}], "href": "https://doi.org/10.3389/fgene.2018.00036"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29545821"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29545821"}]}]}]}