{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nlncRNA PAUPAR has emerged as an important tumor‐suppressive regulator in cancer. In uveal melanoma, PAUPAR is expressed at low levels, and its ectopic re‐expression silences HES1 by inhibiting histone H3K4 methylation, a process that markedly reduces tumor metastasis. Similarly, in colorectal cancer, diminished PAUPAR correlates with enhanced proliferation, migration, and invasion, while its overexpression suppresses malignant features by modulating the miR‑17‑5p/ZNF750 axis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn the context of neural development, PAUPAR plays a critical role in cortical differentiation. Located adjacent to the PAX6 gene, PAUPAR interacts directly with PAX6 to secure appropriate binding to regulatory regions of numerous neural genes. This interaction facilitates the recruitment of the histone methyltransferase NSD1, driving H3K36 methylation and thereby orchestrating the epigenetic programs essential for proper cortical lineage specification."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nCollectively, these studies reveal that PAUPAR exerts multifaceted regulatory functions through epigenetic modulation. Whether by restraining oncogenic processes in uveal melanoma and colorectal cancer or by guiding neural gene expression during cortical differentiation, PAUPAR represents an intrinsic regulatory node with significant potential as a therapeutic target in both oncology and neurodevelopment."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}, {"type": "fg_f", "ref": "3"}, {"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Xia Ding, Xi Wang, Ming Lin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "PAUPAR lncRNA suppresses tumourigenesis by H3K4 demethylation in uveal melanoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "FEBS Lett (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/1873-3468.12220"}], "href": "https://doi.org/10.1002/1873-3468.12220"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27214741"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27214741"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Ruhui Wen, Chao Chen, Xiaohua Zhong, et al. "}, {"type": "b", "children": [{"type": "t", "text": "PAX6 upstream antisense RNA (PAUPAR) inhibits colorectal cancer progression through modulation of the microRNA (miR)-17-5p / zinc finger protein 750 (ZNF750) axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Bioengineered (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/21655979.2021.1940071"}], "href": "https://doi.org/10.1080/21655979.2021.1940071"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34288812"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34288812"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Yanxin Xu, Jiajie Xi, Guiying Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "PAUPAR and PAX6 sequentially regulate human embryonic stem cell cortical differentiation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nucleic Acids Res (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/nar/gkab030"}], "href": "https://doi.org/10.1093/nar/gkab030"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33544864"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33544864"}]}]}]}