{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nThe study described in this abstract (PMID:"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "primarily investigates the role of SAYSVFN domain‐containing protein 1 (SAYSD1) in translocation‐associated quality control (TAQC) during protein synthesis and sperm production in mice. SAYSD1, a conserved membrane protein that becomes conjugated with UFM1 and associates with ribosomes, is predominantly expressed in round and elongating spermatids where it localizes to the endoplasmic reticulum. Although mice lacking SAYSD1 exhibit a modest reduction in sperm count within the cauda epididymis, they display normal sperm morphology, motility, and overall fertility, and the ER stress markers remain unchanged. It is important to note that this abstract does not address or provide any functional insights regarding PAXBP1‑AS1."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Lei Chang, Wataru Fujii, Keiichiro Yogo "}, {"type": "b", "children": [{"type": "t", "text": "The UFMylated ribosome-recognition protein SAYSD1 is predominantly expressed in spermatids but is dispensable for fertility in mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2023.06.085"}], "href": "https://doi.org/10.1016/j.bbrc.2023.06.085"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "37419030"}], "href": "https://pubmed.ncbi.nlm.nih.gov/37419030"}]}]}]}