{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRecent investigations have shown that the long non‐coding RNA PCAT18 is markedly down‐regulated in gastrointestinal cancers, such as gastric cancer, suggesting that it may function as a tumor suppressor. In particular, transcriptome analyses and network studies demonstrated that reduced PCAT18 levels in gastric and other gastrointestinal tissues are associated with dysregulation of metabolic pathways and networks involved in gastrointestinal disease, supporting its potential role in mitigating carcinogenesis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn the context of gastric cancer, where tumor growth and metastasis are critically influenced by long non‐coding RNAs, understanding the mechanistic roles of such transcripts, including PCAT18, is of paramount importance. The emphasis on lncRNAs in cancer development underscores the impetus to explore their regulatory functions comprehensively, thereby refining the landscape of diagnostic and therapeutic targets."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond solid tumors, PCAT18 has also been investigated in hematological malignancies. In adult acute myeloid leukemia, emerging evidence points to an aberrant expression of PCAT18, suggesting a potential utility for this lncRNA in the clinical diagnosis and prognostication of AML patients. Although the mechanistic details remain to be fully clarified, altered PCAT18 expression may reflect underlying molecular disturbances that contribute to leukemogenesis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nFurthermore, in triple‐negative breast cancer (TNBC), low levels of PCAT18 are associated with poor clinical outcomes, including an increased rate of lymph node metastasis. Functional studies revealed that PCAT18 can act as a molecular sponge for miR-103a-3p, thereby relieving inhibitory pressure on the transcription factor ATF7. The resulting upregulation of ATF7 contributes to the suppression of cell migration and metastatic spread, highlighting the prognostic significance of PCAT18 as well as its potential as a therapeutic target for preventing TNBC metastasis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Kobra Foroughi, Mohammad Amini, Amir Atashi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Tissue-Specific Down-Regulation of the Long Non-Coding RNAs PCAT18 and LINC01133 in Gastric Cancer Development."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Mol Sci (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3390/ijms19123881"}], "href": "https://doi.org/10.3390/ijms19123881"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30518158"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30518158"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Xiao-Zhan Zhang, Hong-Li Mao, Shi-Jie Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "lncRNA PCAT18 inhibits proliferation, migration and invasion of gastric cancer cells through miR-135b suppression to promote CLDN11 expression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Life Sci (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.lfs.2020.117478"}], "href": "https://doi.org/10.1016/j.lfs.2020.117478"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32119960"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32119960"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Jihong Zhang, Henan Zhang, Xiaohui Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "PCAT18, as a novel differentially regulated long noncoding RNA in adult acute myeloid leukemia patients revealed by next-generation sequencing."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Lab Hematol (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/ijlh.13305"}], "href": "https://doi.org/10.1111/ijlh.13305"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33006448"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33006448"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Jinfeng Zhang, Donghua Liu, Guoming Deng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "lncRNA prostate cancer-associated transcript 18 upregulates activating transcription factor 7 to prevent metastasis of triple-negative breast cancer via sponging miR-103a-3p."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Bioengineered (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/21655979.2021.2003928"}], "href": "https://doi.org/10.1080/21655979.2021.2003928"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34787047"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34787047"}]}]}]}