{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nPCAT7 is a long noncoding RNA that plays a pivotal role in prostate cancer bone metastasis. In prostate cancer, PCAT7 is elevated in primary tissues with bone metastasis and is associated with poor prognosis. Mechanistically, it acts as a competing endogenous RNA by sponging miR‑324‑5p, leading to upregulation of TGFBR1 and constitutive activation of TGF‑β/SMAD signaling. This, in turn, fuels cancer cell migration, invasion, and epithelial‑to‑mesenchymal transition, thereby promoting bone metastasis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn addition to its role in prostate cancer, PCAT7 has been implicated in the progression of other malignancies. In nasopharyngeal carcinoma, PCAT7 overexpression facilitates tumor cell proliferation by functioning as a ceRNA that sequesters miR‑134‑5p, leading to dysregulation of the ELF2 signaling pathway. Similarly, in non‑small cell lung cancer, PCAT7 promotes tumor cell proliferation, inhibits apoptosis, and encourages metastasis and EMT by targeting miR‑134‑5p. Together, these findings highlight PCAT7’s oncogenic role in modulating microRNA activity to drive tumor aggressiveness."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nMoreover, in breast cancer, PCAT7 is highly expressed and contributes to tumor progression by activating key oncogenic signaling pathways. Specifically, PCAT7 stimulates the ErbB/PI3K/Akt pathway, which enhances cell proliferation, migration, and invasion while suppressing apoptosis, further facilitating malignant transformation."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Chuandong Lang, Yuhu Dai, Zhengquan Wu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "SMAD3/SP1 complex-mediated constitutive active loop between lncRNA PCAT7 and TGF-β signaling promotes prostate cancer bone metastasis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Oncol (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/1878-0261.12634"}], "href": "https://doi.org/10.1002/1878-0261.12634"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31925912"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31925912"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Yejun Liu, Zezhang Tao, Jining Qu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long non-coding RNA PCAT7 regulates ELF2 signaling through inhibition of miR-134-5p in nasopharyngeal carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2017.07.093"}], "href": "https://doi.org/10.1016/j.bbrc.2017.07.093"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28728844"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28728844"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Qiongliang Liu, Yingying Wu, Jie Xiao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long Non-Coding RNA Prostate Cancer-Associated Transcript 7 (PCAT7) Induces Poor Prognosis and Promotes Tumorigenesis by Inhibiting mir-134-5p in Non-Small-Cell Lung (NSCLC)."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Med Sci Monit (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.12659/msm.907904"}], "href": "https://doi.org/10.12659/msm.907904"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29275424"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29275424"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Jiaoqun Zhou, Shiwei Zhang, Mingyuan Luo "}, {"type": "b", "children": [{"type": "t", "text": "LncRNA "}, {"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "PCAT7"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": " promotes the malignant progression of breast cancer by regulating ErbB/PI3K/Akt pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Future Oncol (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.2217/fon-2020-0273"}], "href": "https://doi.org/10.2217/fon-2020-0273"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33401925"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33401925"}]}]}]}