{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRecent studies have identified the long noncoding RNA PCBP2‐OT1—also known as TUC338 or uc.338—as a critical oncogenic regulator in tumorigenesis. In tongue squamous cell carcinoma, for example, PCBP2‐OT1 has been shown to influence key cellular processes that drive malignant transformation and progression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn hepatocellular carcinoma, elevated levels of TUC338 enhance tumor proliferation and invasion by directly targeting the 3′‐untranslated region of RASAL1. This interaction suppresses the tumor‐suppressive RASAL1 pathway, which not only promotes oncogenic gene expression but also contributes to resistance against sorafenib, a commonly used chemotherapeutic agent."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nInvestigations in colorectal cancer have revealed that upregulation of TUC338 correlates with lymph node metastasis. Mechanistically, TUC338 reduces the expression of TIMP‐1 at the posttranscriptional level, leading to the activation of matrix metalloproteinases such as MMP9 and thus facilitating increased cancer cell migration and invasion."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn lung cancer, particularly in studies focusing on tumor heterogeneity and metastasis, TUC338 has been implicated in activating the MAPK signaling pathway. This activation supports the invasive phenotype of lung cancer cells, thereby contributing to the aggressive behavior observed in these tumors."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nFurther supporting its oncogenic role, work on non‐small cell lung cancer implicates TUC338 (uc.338) as a promoter of tumorigenic processes, although the detailed molecular mechanisms in this context remain under ongoing investigation."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn prostate carcinoma, high expression of TUC338 in both tumor tissues and plasma is associated with unfavorable clinical outcomes. The oncogenic effects in these tumors are mediated, in part, through the downregulation of miR‐466, which normally functions to restrain cancer cell migration and invasion."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nSimilarly, in bladder cancer, elevated TUC338 levels correlate with increased expression of miR‐10b, together promoting enhanced invasion and migration of cancer cells. Notably, reductions in plasma TUC338 levels following surgical tumor resection underscore its potential utility as an early diagnostic biomarker."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Ke-Xiong Ouyang, Rui Zou, Jun Liang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "TUC338 Overexpression Leads to Enhanced Proliferation and Reduced Apoptosis in Tongue Squamous Cell Carcinoma Cells In Vitro."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Oral Maxillofac Surg (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.joms.2016.08.009"}], "href": "https://doi.org/10.1016/j.joms.2016.08.009"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27637778"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27637778"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Weidong Jin, Lei Chen, Xun Cai, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long non-coding RNA TUC338 is functionally involved in sorafenib-sensitized hepatocarcinoma cells by targeting RASAL1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncol Rep (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/or.2016.5248"}], "href": "https://doi.org/10.3892/or.2016.5248"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27878301"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27878301"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Chenghai Wang, Zheng Wang, Jie Zhou, et al. "}, {"type": "b", "children": [{"type": "t", "text": "TUC.338 promotes invasion and metastasis in colorectal cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Cancer (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/ijc.30542"}], "href": "https://doi.org/10.1002/ijc.30542"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27914101"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27914101"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Y-X Zhang, J Yuan, Z-M Gao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LncRNA TUC338 promotes invasion of lung cancer by activating MAPK pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur Rev Med Pharmacol Sci (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.26355/eurrev_201801_14193"}], "href": "https://doi.org/10.26355/eurrev_201801_14193"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29424901"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29424901"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Yu Tian, Yun Feng "}, {"type": "b", "children": [{"type": "t", "text": "Up-regulation of long noncoding RNA uc.338 predicts poor survival in non-small cell lung cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Biomark (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3233/CBM-181331"}], "href": "https://doi.org/10.3233/CBM-181331"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29843223"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29843223"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Gang Li, Yang Zhang, Jing Mao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LncRNA TUC338 is overexpressed in prostate carcinoma and downregulates miR-466."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Gene (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.gene.2019.05.026"}], "href": "https://doi.org/10.1016/j.gene.2019.05.026"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31085276"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31085276"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Gang Li, Yang Zhang, Jing Mao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "lncRNA TUC338 is a potential diagnostic biomarker for bladder cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Biochem (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jcb.29104"}], "href": "https://doi.org/10.1002/jcb.29104"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31162712"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31162712"}]}]}]}