| HGNC Family | Cadherins |
| Name | protocadherin alpha cluster, complex locus |
| Description | The protocadherin alpha gene cluster is one of three related clusters tandemly linked on chromosome five. The clusters have a genomic organization similar to that of B-cell and T-cell receptor gene clusters. The alpha gene cluster is composed of 15 genes and 1 pseudogene, which are members of the cadherin superfamily and related to the mouse CNR genes. The sequence of the 13 upstream genes and the pseudogene are highly similar to one another, while a subfamily (C) contains two more distantly related coding sequences. The alpha cluster genes are organized in a tandem array of 15 large, variable region exons followed by a constant region, which contains 3 exons shared by all genes in the cluster. Each variable region exon encodes an extracellular domain comprised of 6 cadherin ectodomains and a transmembrane region. The constant region exons encode a common cytoplasmic tail. These neural adhesion proteins most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been described for the alpha cluster genes. [provided by RefSeq, Jul 2008] |
| Synonyms | CNRS1, CNR1 |
| NCBI Gene ID | 56117 |
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PCDHA@ has 20 functional associations with biological entities spanning 2 categories (disease, phenotype or trait, functional term, phrase or reference) extracted from 4 datasets.
Click the + buttons to view associations for PCDHA@ from the datasets below.
If available, associations are ranked by standardized value
| Dataset | Summary | |
|---|---|---|
| GAD Gene-Disease Associations | diseases associated with PCDHA@ gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset. | |
| GeneRIF Biological Term Annotations | biological terms co-occuring with PCDHA@ gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset. | |
| HuGE Navigator Gene-Phenotype Associations | phenotypes associated with PCDHA@ gene by text-mining GWAS publications from the HuGE Navigator Gene-Phenotype Associations dataset. | |
| PFOCR Pathway Figure Associations 2023 | pathways involving PCDHA@ protein from the PFOCR Pathway Figure Associations 2023 dataset. | |
