| HGNC Family | Cadherins |
| Name | protocadherin beta 10 |
| Description | This gene is a member of the protocadherin beta gene cluster, one of three related gene clusters tandemly linked on chromosome five. The gene clusters demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The beta cluster contains 16 genes and 3 pseudogenes, each encoding 6 extracellular cadherin domains and a cytoplasmic tail that deviates from others in the cadherin superfamily. The extracellular domains interact in a homophilic manner to specify differential cell-cell connections. Unlike the alpha and gamma clusters, the transcripts from these genes are made up of only one large exon, not sharing common 3' exons as expected. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins. Their specific functions are unknown but they most likely play a critical role in the establishment and function of specific cell-cell neural connections. [provided by RefSeq, Jul 2008] |
| Summary |
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nWWP2 is a versatile HECT‐type E3 ubiquitin ligase that plays pivotal roles during development by precisely regulating key transcription factors and signaling molecules. In cartilage and craniofacial tissues, WWP2 is transcriptionally induced by Sox9 and modulates chondrogenesis and palatogenesis through interactions with Med25 and by controlling miR‑140 expression, while also regulating craniofacial patterning via mono‑ubiquitination of transcription factors such as Goosecoid, RUNX2, and KLF5 to promote osteogenesis and odontoblast differentiation. Its deficiency or mutant activity can lead to aberrant skeletal patterning and aggravated osteoarthritis, underscoring its importance in developmental processes and tissue homeostasis."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "7"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its developmental roles, WWP2 orchestrates multiple signaling pathways by targeting a diverse array of substrates for ubiquitination. It regulates iron homeostasis via DMT1, modulates RNA processing through the degradation of ADAR2, and curbs innate immune responses by mediating the K48‑linked ubiquitination of TRIF. Moreover, WWP2 controls the steady state of the RNA polymerase II subunit Rpb1 and governs cardiac remodeling by promoting the proteasomal degradation of PARP1. In tumor and metabolic contexts, WWP2 facilitates PTEN degradation—thereby enhancing PI3K–AKT signaling—and modulates differentiation through non‑proteolytic K63‑linked ubiquitination of Oct4, while also affecting vascular smooth muscle cell function via SIRT1–STAT3 pathway regulation."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "8", "end_ref": "17"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn addition to its roles in development and cellular signaling, WWP2 is an important regulator in immune, neuronal, and chromatin‐remodeling processes. It achieves this through cooperation with other E3 ligases such as Itch to fine‑tune T‑cell receptor signaling, and in neurons, along with its homolog WWP1 and intronic miRNA (miR‑140), it contributes to the acquisition of proper axon–dendrite polarity. WWP2 further regulates the stability of chromatin remodeling complexes by ubiquitinating scaffold proteins like SRG3 and interfaces with long non‑coding RNAs (for example, LINC01588) to support cardiomyocyte function, while studies of miRNA regulation also underscore its multifaceted impact on cellular homeostasis."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "18", "end_ref": "23"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Yukio Nakamura, Koji Yamamoto, Xinjun He, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Wwp2 is essential for palatogenesis mediated by the interaction between Sox9 and mediator subunit 25."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Commun (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ncomms1242"}], "href": "https://doi.org/10.1038/ncomms1242"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21427722"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21427722"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Jun Yang, Shengying Qin, Chengqing Yi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MiR-140 is co-expressed with Wwp2-C transcript and activated by Sox9 to target Sp1 in maintaining the chondrocyte proliferation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "FEBS Lett (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.febslet.2011.08.013"}], "href": "https://doi.org/10.1016/j.febslet.2011.08.013"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21872590"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21872590"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Weiguo Zou, Xi Chen, Jae-Hyuck Shim, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The E3 ubiquitin ligase Wwp2 regulates craniofacial development through mono-ubiquitylation of Goosecoid."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Cell Biol (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ncb2134"}], "href": "https://doi.org/10.1038/ncb2134"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21170031"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21170031"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Wei Zhu, Xinyu He, Yue Hua, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The E3 ubiquitin ligase WWP2 facilitates RUNX2 protein transactivation in a mono-ubiquitination manner during osteogenic differentiation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M116.772277"}], "href": "https://doi.org/10.1074/jbc.M116.772277"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28500134"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28500134"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "J Fu, H Zheng, Y Xue, et al. "}, {"type": "b", "children": [{"type": "t", "text": "WWP2 Promotes Odontoblastic Differentiation by Monoubiquitinating KLF5."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Dent Res (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1177/0022034520970866"}], "href": "https://doi.org/10.1177/0022034520970866"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33164644"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33164644"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Jing Fu, Xiaobo Zhang, Huiwen Zheng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A WWP2-PTEN-KLF5 signaling axis regulates odontoblast differentiation and dentinogenesis in mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.jbc.2022.102220"}], "href": "https://doi.org/10.1016/j.jbc.2022.102220"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35780838"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35780838"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Sho Mokuda, Ryo Nakamichi, Tokio Matsuzaki, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Wwp2 maintains cartilage homeostasis through regulation of Adamts5."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Commun (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41467-019-10177-1"}], "href": "https://doi.org/10.1038/s41467-019-10177-1"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31160553"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31160553"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Natalie J Foot, Hazel E Dalton, Linda M Shearwin-Whyatt, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Regulation of the divalent metal ion transporter DMT1 and iron homeostasis by a ubiquitin-dependent mechanism involving Ndfips and WWP2."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Blood (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1182/blood-2008-04-150953"}], "href": "https://doi.org/10.1182/blood-2008-04-150953"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18776082"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18776082"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Roberto Marcucci, James Brindle, Simona Paro, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Pin1 and WWP2 regulate GluR2 Q/R site RNA editing by ADAR2 with opposing effects."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "EMBO J (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/emboj.2011.303"}], "href": "https://doi.org/10.1038/emboj.2011.303"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21847096"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21847096"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Yan Yang, Bing Liao, Suyun Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "E3 ligase WWP2 negatively regulates TLR3-mediated innate immune response by targeting TRIF for ubiquitination and degradation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.1220271110"}], "href": "https://doi.org/10.1073/pnas.1220271110"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23479606"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23479606"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Hui Li, Zhihong Zhang, Beibei Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Wwp2-mediated ubiquitination of the RNA polymerase II large subunit in mouse embryonic pluripotent stem cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Biol (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/MCB.01667-06"}], "href": "https://doi.org/10.1128/MCB.01667-06"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17526739"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17526739"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Naijin Zhang, Ying Zhang, Hao Qian, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Selective targeting of ubiquitination and degradation of PARP1 by E3 ubiquitin ligase WWP2 regulates isoproterenol-induced cardiac remodeling."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Death Differ (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41418-020-0523-2"}], "href": "https://doi.org/10.1038/s41418-020-0523-2"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32139900"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32139900"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Hongchang Li, Pengfei Zhang, Qiuyue Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "WWP2 is a physiological ubiquitin ligase for phosphatase and tensin homolog (PTEN) in mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.RA117.001060"}], "href": "https://doi.org/10.1074/jbc.RA117.001060"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29685889"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29685889"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Ke Wang, Jun Liu, Xinhui Zhao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "WWP2 regulates proliferation of gastric cancer cells in a PTEN-dependent manner."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2019.10.179"}], "href": "https://doi.org/10.1016/j.bbrc.2019.10.179"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31677789"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31677789"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Bing Liao, Ying Jin "}, {"type": "b", "children": [{"type": "t", "text": "Wwp2 mediates Oct4 ubiquitination and its own auto-ubiquitination in a dosage-dependent manner."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Res (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/cr.2009.136"}], "href": "https://doi.org/10.1038/cr.2009.136"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19997087"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19997087"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Ying Zhang, Shilong You, Yichen Tian, et al. "}, {"type": "b", "children": [{"type": "t", "text": "WWP2 regulates SIRT1-STAT3 acetylation and phosphorylation involved in hypertensive angiopathy."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Mol Med (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/jcmm.15538"}], "href": "https://doi.org/10.1111/jcmm.15538"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32627301"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32627301"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Xiuyu Wang, Na Gui, Xing Ma, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Proliferation, migration and phenotypic transformation of VSMC induced via Hcy related to up-expression of WWP2 and p-STAT3."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0296359"}], "href": "https://doi.org/10.1371/journal.pone.0296359"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "38166045"}], "href": "https://pubmed.ncbi.nlm.nih.gov/38166045"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "An Chen, Beixue Gao, Jingping Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The HECT-type E3 ubiquitin ligase AIP2 inhibits activation-induced T-cell death by catalyzing EGR2 ubiquitination."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Biol (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/MCB.00407-09"}], "href": "https://doi.org/10.1128/MCB.00407-09"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19651900"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19651900"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Dong Lu, Matthew P A Davis, Cei Abreu-Goodger, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MiR-25 regulates Wwp2 and Fbxw7 and promotes reprogramming of mouse fibroblast cells to iPSCs."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0040938"}], "href": "https://doi.org/10.1371/journal.pone.0040938"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22912667"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22912667"}]}, {"type": "r", "ref": 20, "children": [{"type": "t", "text": "Mateusz C Ambrozkiewicz, Manuela Schwark, Mika Kishimoto-Suga, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Polarity Acquisition in Cortical Neurons Is Driven by Synergistic Action of Sox9-Regulated Wwp1 and Wwp2 E3 Ubiquitin Ligases and Intronic miR-140."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Neuron (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.neuron.2018.10.008"}], "href": "https://doi.org/10.1016/j.neuron.2018.10.008"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30392800"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30392800"}]}, {"type": "r", "ref": 21, "children": [{"type": "t", "text": "Daisuke Aki, Hui Li, Wen Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The E3 ligases Itch and WWP2 cooperate to limit T"}, {"type": "a", "children": [{"type": "t", "text": "sub"}], "href": "sub"}, {"type": "t", "text": "H"}, {"type": "a", "children": [{"type": "t", "text": "/sub"}], "href": "/sub"}, {"type": "t", "text": "2 differentiation by enhancing signaling through the TCR."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Immunol (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41590-018-0137-8"}], "href": "https://doi.org/10.1038/s41590-018-0137-8"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29925997"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29925997"}]}, {"type": "r", "ref": 22, "children": [{"type": "t", "text": "Xinlong Luo, Beibei Wang, Fan Tang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Wwp2 targets SRG3, a scaffold protein of the SWI/SNF-like BAF complex, for ubiquitination and degradation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2013.12.089"}], "href": "https://doi.org/10.1016/j.bbrc.2013.12.089"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24365151"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24365151"}]}, {"type": "r", "ref": 23, "children": [{"type": "t", "text": "Yanbin Song, Xiaoyue Ren, Feng Gao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LINC01588 regulates WWP2-mediated cardiomyocyte injury by interacting with HNRNPL."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Environ Toxicol (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/tox.23512"}], "href": "https://doi.org/10.1002/tox.23512"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35258167"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35258167"}]}]}]}
|
| Synonyms | PCDH-BETA10, PCHB10 |
| Proteins | PCDBA_HUMAN |
| NCBI Gene ID | 56126 |
| API | |
| Download Associations | |
| Predicted Functions |
 |
| Co-expressed Genes |
|
| Expression in Tissues and Cell Lines |
|
PCDHB10 has 2,630 functional associations with biological entities spanning 9 categories (molecular profile, organism, functional term, phrase or reference, chemical, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 70 datasets.
Click the + buttons to view associations for PCDHB10 from the datasets below.
If available, associations are ranked by standardized value
| Dataset | Summary | |
|---|---|---|
| Achilles Cell Line Gene Essentiality Profiles | cell lines with fitness changed by PCDHB10 gene knockdown relative to other cell lines from the Achilles Cell Line Gene Essentiality Profiles dataset. | |
| Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles | tissues with high or low expression of PCDHB10 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset. | |
| Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles | tissue samples with high or low expression of PCDHB10 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset. | |
| Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray | tissue samples with high or low expression of PCDHB10 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset. | |
| Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq | tissue samples with high or low expression of PCDHB10 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset. | |
| Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles | tissues with high or low expression of PCDHB10 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset. | |
| CCLE Cell Line Gene CNV Profiles | cell lines with high or low copy number of PCDHB10 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset. | |
| CCLE Cell Line Gene Expression Profiles | cell lines with high or low expression of PCDHB10 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset. | |
| ChEA Transcription Factor Binding Site Profiles | transcription factor binding site profiles with transcription factor binding evidence at the promoter of PCDHB10 gene from the CHEA Transcription Factor Binding Site Profiles dataset. | |
| ChEA Transcription Factor Targets | transcription factors binding the promoter of PCDHB10 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset. | |
| ChEA Transcription Factor Targets 2022 | transcription factors binding the promoter of PCDHB10 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset. | |
| COMPARTMENTS Curated Protein Localization Evidence Scores | cellular components containing PCDHB10 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset. | |
| COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 | cellular components co-occuring with PCDHB10 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset. | |
| COSMIC Cell Line Gene CNV Profiles | cell lines with high or low copy number of PCDHB10 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset. | |
| COSMIC Cell Line Gene Mutation Profiles | cell lines with PCDHB10 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset. | |
| CTD Gene-Chemical Interactions | chemicals interacting with PCDHB10 gene/protein from the curated CTD Gene-Chemical Interactions dataset. | |
| DepMap CRISPR Gene Dependency | cell lines with fitness changed by PCDHB10 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset. | |
| DISEASES Text-mining Gene-Disease Association Evidence Scores | diseases co-occuring with PCDHB10 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset. | |
| DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 | diseases co-occuring with PCDHB10 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset. | |
| ENCODE Histone Modification Site Profiles | histone modification site profiles with high histone modification abundance at PCDHB10 gene from the ENCODE Histone Modification Site Profiles dataset. | |
| ENCODE Transcription Factor Binding Site Profiles | transcription factor binding site profiles with transcription factor binding evidence at the promoter of PCDHB10 gene from the ENCODE Transcription Factor Binding Site Profiles dataset. | |
| ENCODE Transcription Factor Targets | transcription factors binding the promoter of PCDHB10 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset. | |
| ESCAPE Omics Signatures of Genes and Proteins for Stem Cells | PubMedIDs of publications reporting gene signatures containing PCDHB10 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset. | |
| GeneSigDB Published Gene Signatures | PubMedIDs of publications reporting gene signatures containing PCDHB10 from the GeneSigDB Published Gene Signatures dataset. | |
| GEO Signatures of Differentially Expressed Genes for Gene Perturbations | gene perturbations changing expression of PCDHB10 gene from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset. | |
| GEO Signatures of Differentially Expressed Genes for Kinase Perturbations | kinase perturbations changing expression of PCDHB10 gene from the GEO Signatures of Differentially Expressed Genes for Kinase Perturbations dataset. | |
| GEO Signatures of Differentially Expressed Genes for Small Molecules | small molecule perturbations changing expression of PCDHB10 gene from the GEO Signatures of Differentially Expressed Genes for Small Molecules dataset. | |
| GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations | transcription factor perturbations changing expression of PCDHB10 gene from the GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations dataset. | |
| GEO Signatures of Differentially Expressed Genes for Viral Infections | virus perturbations changing expression of PCDHB10 gene from the GEO Signatures of Differentially Expressed Genes for Viral Infections dataset. | |
| GlyGen Glycosylated Proteins | ligands (chemical) binding PCDHB10 protein from the GlyGen Glycosylated Proteins dataset. | |
| GO Biological Process Annotations 2015 | biological processes involving PCDHB10 gene from the curated GO Biological Process Annotations 2015 dataset. | |
| GO Biological Process Annotations 2023 | biological processes involving PCDHB10 gene from the curated GO Biological Process Annotations 2023 dataset. | |
| GO Biological Process Annotations 2025 | biological processes involving PCDHB10 gene from the curated GO Biological Process Annotations2025 dataset. | |
| GO Cellular Component Annotations 2015 | cellular components containing PCDHB10 protein from the curated GO Cellular Component Annotations 2015 dataset. | |
| GO Molecular Function Annotations 2015 | molecular functions performed by PCDHB10 gene from the curated GO Molecular Function Annotations 2015 dataset. | |
| GTEx eQTL 2025 | SNPs regulating expression of PCDHB10 gene from the GTEx eQTL 2025 dataset. | |
| GTEx Tissue Gene Expression Profiles | tissues with high or low expression of PCDHB10 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles dataset. | |
| GTEx Tissue Gene Expression Profiles 2023 | tissues with high or low expression of PCDHB10 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles 2023 dataset. | |
| GTEx Tissue Sample Gene Expression Profiles | tissue samples with high or low expression of PCDHB10 gene relative to other tissue samples from the GTEx Tissue Sample Gene Expression Profiles dataset. | |
| GTEx Tissue-Specific Aging Signatures | tissue samples with high or low expression of PCDHB10 gene relative to other tissue samples from the GTEx Tissue-Specific Aging Signatures dataset. | |
| Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles | cell lines with high or low expression of PCDHB10 gene relative to other cell lines from the Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles dataset. | |
| HMDB Metabolites of Enzymes | interacting metabolites for PCDHB10 protein from the curated HMDB Metabolites of Enzymes dataset. | |
| HPA Cell Line Gene Expression Profiles | cell lines with high or low expression of PCDHB10 gene relative to other cell lines from the HPA Cell Line Gene Expression Profiles dataset. | |
| HPA Tissue Gene Expression Profiles | tissues with high or low expression of PCDHB10 gene relative to other tissues from the HPA Tissue Gene Expression Profiles dataset. | |
| HPA Tissue Protein Expression Profiles | tissues with high or low expression of PCDHB10 protein relative to other tissues from the HPA Tissue Protein Expression Profiles dataset. | |
| HPA Tissue Sample Gene Expression Profiles | tissue samples with high or low expression of PCDHB10 gene relative to other tissue samples from the HPA Tissue Sample Gene Expression Profiles dataset. | |
| InterPro Predicted Protein Domain Annotations | protein domains predicted for PCDHB10 protein from the InterPro Predicted Protein Domain Annotations dataset. | |
| JASPAR Predicted Human Transcription Factor Targets 2025 | transcription factors regulating expression of PCDHB10 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Human Transcription Factor Targets dataset. | |
| JASPAR Predicted Transcription Factor Targets | transcription factors regulating expression of PCDHB10 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset. | |
| Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles | cell lines with high or low copy number of PCDHB10 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset. | |
| Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles | cell lines with high or low expression of PCDHB10 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles dataset. | |
| Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles | cell lines with PCDHB10 gene mutations from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles dataset. | |
| KnockTF Gene Expression Profiles with Transcription Factor Perturbations | transcription factor perturbations changing expression of PCDHB10 gene from the KnockTF Gene Expression Profiles with Transcription Factor Perturbations dataset. | |
| MiRTarBase microRNA Targets | microRNAs targeting PCDHB10 gene in low- or high-throughput microRNA targeting studies from the MiRTarBase microRNA Targets dataset. | |
| NURSA Protein Complexes | protein complexs containing PCDHB10 protein recovered by IP-MS from the NURSA Protein Complexes dataset. | |
| PANTHER Pathways | pathways involving PCDHB10 protein from the PANTHER Pathways dataset. | |
| Pathway Commons Protein-Protein Interactions | interacting proteins for PCDHB10 from the Pathway Commons Protein-Protein Interactions dataset. | |
| PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations | gene perturbations changing expression of PCDHB10 gene from the PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations dataset. | |
| Roadmap Epigenomics Histone Modification Site Profiles | histone modification site profiles with high histone modification abundance at PCDHB10 gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset. | |
| RummaGEO Drug Perturbation Signatures | drug perturbations changing expression of PCDHB10 gene from the RummaGEO Drug Perturbation Signatures dataset. | |
| RummaGEO Gene Perturbation Signatures | gene perturbations changing expression of PCDHB10 gene from the RummaGEO Gene Perturbation Signatures dataset. | |
| TargetScan Predicted Conserved microRNA Targets | microRNAs regulating expression of PCDHB10 gene predicted using conserved miRNA seed sequences from the TargetScan Predicted Conserved microRNA Targets dataset. | |
| TargetScan Predicted Nonconserved microRNA Targets | microRNAs regulating expression of PCDHB10 gene predicted using nonconserved miRNA seed sequences from the TargetScan Predicted Nonconserved microRNA Targets dataset. | |
| TCGA Signatures of Differentially Expressed Genes for Tumors | tissue samples with high or low expression of PCDHB10 gene relative to other tissue samples from the TCGA Signatures of Differentially Expressed Genes for Tumors dataset. | |
| TISSUES Curated Tissue Protein Expression Evidence Scores | tissues with high expression of PCDHB10 protein from the TISSUES Curated Tissue Protein Expression Evidence Scores dataset. | |
| TISSUES Curated Tissue Protein Expression Evidence Scores 2025 | tissues with high expression of PCDHB10 protein from the TISSUES Curated Tissue Protein Expression Evidence Scores 2025 dataset. | |
| TISSUES Experimental Tissue Protein Expression Evidence Scores | tissues with high expression of PCDHB10 protein in proteomics datasets from the TISSUES Experimental Tissue Protein Expression Evidence Scores dataset. | |
| TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 | tissues with high expression of PCDHB10 protein in proteomics datasets from the TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 dataset. | |
| TISSUES Text-mining Tissue Protein Expression Evidence Scores | tissues co-occuring with PCDHB10 protein in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores dataset. | |
| TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 | tissues co-occuring with PCDHB10 protein in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 dataset. | |
