| HGNC Family | Cadherins |
| Name | protocadherin gamma subfamily C, 5 |
| Description | This gene is a member of the protocadherin gamma gene cluster, one of three related clusters tandemly linked on chromosome five. These gene clusters have an immunoglobulin-like organization, suggesting that a novel mechanism may be involved in their regulation and expression. The gamma gene cluster includes 22 genes divided into 3 subfamilies. Subfamily A contains 12 genes, subfamily B contains 7 genes and 2 pseudogenes, and the more distantly related subfamily C contains 3 genes. The tandem array of 22 large, variable region exons are followed by a constant region, containing 3 exons shared by all genes in the cluster. Each variable region exon encodes the extracellular region, which includes 6 cadherin ectodomains and a transmembrane region. The constant region exons encode the common cytoplasmic region. These neural cadherin-like cell adhesion proteins most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been described for the gamma cluster genes. [provided by RefSeq, Jul 2008] |
| Summary |
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRegulator of G‐protein signaling 5 (RGS5) is a critical modulator of vascular development and remodeling. It is highly expressed in pericytes and vascular smooth muscle cells where it attenuates GPCR‐mediated signals, thereby regulating vessel tone, pericyte attachment, and angiogenesis. In developmental models, RGS5 is abundant in arterial walls and pericytes, and its expression correlates with key signaling pathways such as those mediated by PDGFR‐β. In pathological settings, loss of RGS5 improves the normalization of aberrant tumor vasculature—reducing hypoxia and leakiness—and influences pericyte coverage in conditions such as stroke, highlighting its essential role in vascular homeostasis."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "8"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn the heart and large conductance arteries, RGS5 governs cardiomyocyte and vascular smooth muscle cell functions that impact cardiac remodeling, contraction, and electrophysiological properties. Robust evidence indicates that altered RGS5 expression modifies pathways that control hypertrophy, arrhythmogenic repolarization, and cell survival during ischemia–reperfusion injury. Deficiency of RGS5 has been associated with dysregulated K⁺ currents and enhanced pro‐hypertrophic as well as arrhythmogenic signaling, while its proper modulation preserves cardiac contractility and limits inflammatory remodeling after myocardial insult."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "9", "end_ref": "18"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its vascular and cardiac roles, RGS5 influences diverse pathophysiological processes including metabolic regulation, atherosclerosis, pulmonary inflammation, and neurovascular protection. In models of asthma and lung injury, altered RGS5 levels modulate airway smooth muscle reactivity and inflammatory cell recruitment. Similarly, RGS5 deficiency affects metabolic parameters such as obesity and insulin resistance, and in the context of preeclampsia and uterine vascular remodeling, its absence results in exaggerated vasoconstriction and impaired arterial adaptation. Moreover, RGS5 contributes to the maintenance of blood–brain barrier integrity and neuroprotection during cerebral ischemia, underscoring its multifaceted role in modulating GPCR‐driven signaling in various cell types."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "19", "end_ref": "29"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nAt the molecular level, RGS5 functions as an inhibitor of G‐protein signaling by accelerating the GTPase activity of Galpha subunits, thereby fine‐tuning responses downstream of GPCR activation. Its regulation is further modulated by proteolytic pathways—as demonstrated by ATE1-mediated arginylation—and it intersects with signaling cascades such as hedgehog, which influences osteogenesis and neural differentiation. These findings not only position RGS5 as a central node in the integration of diverse extracellular signals but also point to its potential as a therapeutic target in conditions ranging from fibrotic disease to neurodegeneration."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "30", "end_ref": "33"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Hyeseon Cho, Tohru Kozasa, Cecilia Bondjers, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Pericyte-specific expression of Rgs5: implications for PDGF and EDG receptor signaling during vascular maturation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "FASEB J (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1096/fj.02-0340fje"}], "href": "https://doi.org/10.1096/fj.02-0340fje"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12514120"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12514120"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Tracy S Mitchell, John Bradley, Gregory S Robinson, et al. "}, {"type": "b", "children": [{"type": "t", "text": "RGS5 expression is a quantitative measure of pericyte coverage of blood vessels."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Angiogenesis (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s10456-007-9085-x"}], "href": "https://doi.org/10.1007/s10456-007-9085-x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18038251"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18038251"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Maya H Nisancioglu, William M Mahoney, Dara D Kimmel, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Generation and characterization of rgs5 mutant mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Biol (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/MCB.01252-07"}], "href": "https://doi.org/10.1128/MCB.01252-07"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18212066"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18212066"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Hyeseon Cho, Chung Park, Il-Young Hwang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Rgs5 targeting leads to chronic low blood pressure and a lean body habitus."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Biol (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/MCB.01889-07"}], "href": "https://doi.org/10.1128/MCB.01889-07"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18268011"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18268011"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Kerry Hannon "}, {"type": "b", "children": [{"type": "t", "text": "Stitching together a new life. Here's a yarn: a former nurse finds focus in a knitting business."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "US News World Rep (2008)"}]}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18318378"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18318378"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Vasyl Holobotovskyy, Mitali Manzur, Marianne Tare, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Regulator of G-protein signaling 5 controls blood pressure homeostasis and vessel wall remodeling."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Circ Res (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1161/CIRCRESAHA.111.300142"}], "href": "https://doi.org/10.1161/CIRCRESAHA.111.300142"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23303165"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23303165"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Caroline Arnold, Anja Feldner, Larissa Pfisterer, et al. "}, {"type": "b", "children": [{"type": "t", "text": "RGS5 promotes arterial growth during arteriogenesis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "EMBO Mol Med (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.15252/emmm.201403864"}], "href": "https://doi.org/10.15252/emmm.201403864"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24972930"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24972930"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Ilknur Özen, Michaela Roth, Marco Barbariga, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Loss of Regulator of G-Protein Signaling 5 Leads to Neurovascular Protection in Stroke."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Stroke (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1161/STROKEAHA.118.020124"}], "href": "https://doi.org/10.1161/STROKEAHA.118.020124"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30354999"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30354999"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Hongliang Li, Chengwei He, Jinhua Feng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Regulator of G protein signaling 5 protects against cardiac hypertrophy and fibrosis during biomechanical stress of pressure overload."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.1008397107"}], "href": "https://doi.org/10.1073/pnas.1008397107"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20643937"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20643937"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Hangjun Zhang, Steven Gu, Basil Al-Sabeq, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Origin-specific epigenetic program correlates with vascular bed-specific differences in Rgs5 expression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "FASEB J (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1096/fj.11-185454"}], "href": "https://doi.org/10.1096/fj.11-185454"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21965603"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21965603"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Mu Qin, He Huang, Teng Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Atrial tachyarrhythmia in Rgs5-null mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0046856"}], "href": "https://doi.org/10.1371/journal.pone.0046856"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23144791"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23144791"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Jan-Marcus Daniel, André Prock, Jochen Dutzmann, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Regulator of G-Protein Signaling 5 Prevents Smooth Muscle Cell Proliferation and Attenuates Neointima Formation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Arterioscler Thromb Vasc Biol (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1161/ATVBAHA.115.305974"}], "href": "https://doi.org/10.1161/ATVBAHA.115.305974"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26663397"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26663397"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Zhiqiang Wang, He Huang, Wangwei He, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Regulator of G-protein signaling 5 protects cardiomyocytes against apoptosis during in vitro cardiac ischemia-reperfusion in mice by inhibiting both JNK1/2 and P38 signaling pathways."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2016.03.114"}], "href": "https://doi.org/10.1016/j.bbrc.2016.03.114"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27021681"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27021681"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Caroline Arnold, Eda Demirel, Anja Feldner, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Hypertension-evoked RhoA activity in vascular smooth muscle cells requires RGS5."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "FASEB J (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1096/fj.201700384RR"}], "href": "https://doi.org/10.1096/fj.201700384RR"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29208700"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29208700"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Nariman Balenga, James Koh, Pedram Azimzadeh, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Parathyroid-Targeted Overexpression of Regulator of G-Protein Signaling 5 (RGS5) Causes Hyperparathyroidism in Transgenic Mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Bone Miner Res (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jbmr.3674"}], "href": "https://doi.org/10.1002/jbmr.3674"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30690792"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30690792"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Michaela Roth, Abderahim Gaceb, Andreas Enström, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Regulator of G-protein signaling 5 regulates the shift from perivascular to parenchymal pericytes in the chronic phase after stroke."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "FASEB J (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1096/fj.201900153R"}], "href": "https://doi.org/10.1096/fj.201900153R"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31039042"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31039042"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Eda Demirel, Caroline Arnold, Jaspal Garg, et al. "}, {"type": "b", "children": [{"type": "t", "text": "RGS5 Attenuates Baseline Activity of ERK1/2 and Promotes Growth Arrest of Vascular Smooth Muscle Cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cells (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3390/cells10071748"}], "href": "https://doi.org/10.3390/cells10071748"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34359918"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34359918"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Shelby A Dahlen, Tyler F Bernadyn, Alethia J Dixon, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Dual loss of regulator of G protein signaling 2 and 5 exacerbates ventricular myocyte arrhythmias and disrupts the fine-tuning of G"}, {"type": "a", "children": [{"type": "t", "text": "sub"}], "href": "sub"}, {"type": "t", "text": "i/o"}, {"type": "a", "children": [{"type": "t", "text": "/sub"}], "href": "/sub"}, {"type": "t", "text": " signaling."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Mol Cell Cardiol (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.yjmcc.2022.05.009"}], "href": "https://doi.org/10.1016/j.yjmcc.2022.05.009"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35661621"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35661621"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Zhao Yang, Philip R Cooper, Gautam Damera, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Beta-agonist-associated reduction in RGS5 expression promotes airway smooth muscle hyper-responsiveness."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M110.212480"}], "href": "https://doi.org/10.1074/jbc.M110.212480"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21278382"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21278382"}]}, {"type": "r", "ref": 20, "children": [{"type": "t", "text": "Wei Deng, Xinan Wang, Jinfeng Xiao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Loss of regulator of G protein signaling 5 exacerbates obesity, hepatic steatosis, inflammation and insulin resistance."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0030256"}], "href": "https://doi.org/10.1371/journal.pone.0030256"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22272317"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22272317"}]}, {"type": "r", "ref": 21, "children": [{"type": "t", "text": "Pimonrat Ketsawatsomkron, Ramón A Lorca, Henry L Keen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "PPARγ regulates resistance vessel tone through a mechanism involving RGS5-mediated control of protein kinase C and BKCa channel activity."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Circ Res (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1161/CIRCRESAHA.112.271577"}], "href": "https://doi.org/10.1161/CIRCRESAHA.112.271577"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22962432"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22962432"}]}, {"type": "r", "ref": 22, "children": [{"type": "t", "text": "Nariman A Balenga, William Jester, Meiqi Jiang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Loss of regulator of G protein signaling 5 promotes airway hyperresponsiveness in the absence of allergic inflammation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Allergy Clin Immunol (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.jaci.2014.01.019"}], "href": "https://doi.org/10.1016/j.jaci.2014.01.019"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24666695"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24666695"}]}, {"type": "r", "ref": 23, "children": [{"type": "t", "text": "Arya J Bahrami, Jagadambika J Gunaje, Brian J Hayes, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Regulator of G-protein signaling-5 is a marker of hepatic stellate cells and expression mediates response to liver injury."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0108505"}], "href": "https://doi.org/10.1371/journal.pone.0108505"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25290689"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25290689"}]}, {"type": "r", "ref": 24, "children": [{"type": "t", "text": "Wen-Lin Cheng, Pi-Xiao Wang, Tao Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Regulator of G-protein signalling 5 protects against atherosclerosis in apolipoprotein E-deficient mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Br J Pharmacol (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/bph.12991"}], "href": "https://doi.org/10.1111/bph.12991"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25363362"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25363362"}]}, {"type": "r", "ref": 25, "children": [{"type": "t", "text": "Vasyl Holobotovskyy, Yee Seng Chong, Jennifer Burchell, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Regulator of G protein signaling 5 is a determinant of gestational hypertension and preeclampsia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Transl Med (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1126/scitranslmed.aaa5038"}], "href": "https://doi.org/10.1126/scitranslmed.aaa5038"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26041705"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26041705"}]}, {"type": "r", "ref": 26, "children": [{"type": "t", "text": "Jennifer N Koch, Shelby A Dahlen, Elizabeth A Owens, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Regulator of G Protein Signaling 2 Facilitates Uterine Artery Adaptation During Pregnancy in Mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Am Heart Assoc (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1161/JAHA.118.010917"}], "href": "https://doi.org/10.1161/JAHA.118.010917"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31030617"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31030617"}]}, {"type": "r", "ref": 27, "children": [{"type": "t", "text": "Nikola Sladojevic, Brian Yu, James K Liao "}, {"type": "b", "children": [{"type": "t", "text": "Regulator of G-Protein Signaling 5 Maintains Brain Endothelial Cell Function in Focal Cerebral Ischemia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Am Heart Assoc (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1161/JAHA.120.017533"}], "href": "https://doi.org/10.1161/JAHA.120.017533"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32875943"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32875943"}]}, {"type": "r", "ref": 28, "children": [{"type": "t", "text": "Neha Sharma, Chandran Nagaraj, Bence M Nagy, et al. "}, {"type": "b", "children": [{"type": "t", "text": "RGS5 Determines Neutrophil Migration in the Acute Inflammatory Phase of Bleomycin-Induced Lung Injury."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Mol Sci (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3390/ijms22179342"}], "href": "https://doi.org/10.3390/ijms22179342"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34502263"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34502263"}]}, {"type": "r", "ref": 29, "children": [{"type": "t", "text": "Manoranjan S D'Souza, Anh N Luu, Trevor C Guisinger, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Regulator of G-Protein Signaling 5 Protein Deficiency Differentially Influences Blood Pressure, Vascular and Behavioral Effects in Aged Male Mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cardiovasc Pharmacol (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1097/FJC.0000000000001272"}], "href": "https://doi.org/10.1097/FJC.0000000000001272"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35384894"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35384894"}]}, {"type": "r", "ref": 30, "children": [{"type": "t", "text": "Min Jae Lee, Takafumi Tasaki, Kayoko Moroi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "RGS4 and RGS5 are in vivo substrates of the N-end rule pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.0507533102"}], "href": "https://doi.org/10.1073/pnas.0507533102"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16217033"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16217033"}]}, {"type": "r", "ref": 31, "children": [{"type": "t", "text": "Nadiya M Teplyuk, Mario Galindo, Viktor I Teplyuk, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Runx2 regulates G protein-coupled signaling pathways to control growth of osteoblast progenitors."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M802453200"}], "href": "https://doi.org/10.1074/jbc.M802453200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18625716"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18625716"}]}, {"type": "r", "ref": 32, "children": [{"type": "t", "text": "William M Mahoney, Jagadambika Gunaje, Guenter Daum, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Regulator of G-protein signaling - 5 (RGS5) is a novel repressor of hedgehog signaling."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0061421"}], "href": "https://doi.org/10.1371/journal.pone.0061421"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23637832"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23637832"}]}, {"type": "r", "ref": 33, "children": [{"type": "t", "text": "Chuanliang Liu, Qiongqiong Hu, Jia Jing, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Regulator of G protein signaling 5 (RGS5) inhibits sonic hedgehog function in mouse cortical neurons."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Neurosci (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.mcn.2017.06.005"}], "href": "https://doi.org/10.1016/j.mcn.2017.06.005"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28684360"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28684360"}]}]}]}
|
| Synonyms | PCDH-GAMMA-C5 |
| Proteins | PCDGM_HUMAN |
| NCBI Gene ID | 56097 |
| API | |
| Download Associations | |
| Predicted Functions |
 |
| Co-expressed Genes |
|
| Expression in Tissues and Cell Lines |
|
PCDHGC5 has 2,641 functional associations with biological entities spanning 8 categories (molecular profile, organism, functional term, phrase or reference, disease, phenotype or trait, chemical, structural feature, cell line, cell type or tissue, gene, protein or microRNA) extracted from 67 datasets.
Click the + buttons to view associations for PCDHGC5 from the datasets below.
If available, associations are ranked by standardized value
| Dataset | Summary | |
|---|---|---|
| Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles | tissues with high or low expression of PCDHGC5 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset. | |
| Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles | tissues with high or low expression of PCDHGC5 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset. | |
| Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles | tissue samples with high or low expression of PCDHGC5 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset. | |
| Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray | tissue samples with high or low expression of PCDHGC5 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset. | |
| Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq | tissue samples with high or low expression of PCDHGC5 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset. | |
| Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles | tissues with high or low expression of PCDHGC5 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset. | |
| CCLE Cell Line Gene CNV Profiles | cell lines with high or low copy number of PCDHGC5 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset. | |
| CCLE Cell Line Gene Expression Profiles | cell lines with high or low expression of PCDHGC5 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset. | |
| ChEA Transcription Factor Binding Site Profiles | transcription factor binding site profiles with transcription factor binding evidence at the promoter of PCDHGC5 gene from the CHEA Transcription Factor Binding Site Profiles dataset. | |
| ChEA Transcription Factor Targets | transcription factors binding the promoter of PCDHGC5 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset. | |
| ChEA Transcription Factor Targets 2022 | transcription factors binding the promoter of PCDHGC5 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset. | |
| COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 | cellular components co-occuring with PCDHGC5 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset. | |
| COSMIC Cell Line Gene CNV Profiles | cell lines with high or low copy number of PCDHGC5 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset. | |
| COSMIC Cell Line Gene Mutation Profiles | cell lines with PCDHGC5 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset. | |
| dbGAP Gene-Trait Associations | traits associated with PCDHGC5 gene in GWAS and other genetic association datasets from the dbGAP Gene-Trait Associations dataset. | |
| DepMap CRISPR Gene Dependency | cell lines with fitness changed by PCDHGC5 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset. | |
| DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 | diseases co-occuring with PCDHGC5 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset. | |
| ENCODE Histone Modification Site Profiles | histone modification site profiles with high histone modification abundance at PCDHGC5 gene from the ENCODE Histone Modification Site Profiles dataset. | |
| ENCODE Transcription Factor Binding Site Profiles | transcription factor binding site profiles with transcription factor binding evidence at the promoter of PCDHGC5 gene from the ENCODE Transcription Factor Binding Site Profiles dataset. | |
| ENCODE Transcription Factor Targets | transcription factors binding the promoter of PCDHGC5 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset. | |
| ESCAPE Omics Signatures of Genes and Proteins for Stem Cells | PubMedIDs of publications reporting gene signatures containing PCDHGC5 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset. | |
| GAD Gene-Disease Associations | diseases associated with PCDHGC5 gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset. | |
| GeneSigDB Published Gene Signatures | PubMedIDs of publications reporting gene signatures containing PCDHGC5 from the GeneSigDB Published Gene Signatures dataset. | |
| GEO Signatures of Differentially Expressed Genes for Diseases | disease perturbations changing expression of PCDHGC5 gene from the GEO Signatures of Differentially Expressed Genes for Diseases dataset. | |
| GEO Signatures of Differentially Expressed Genes for Kinase Perturbations | kinase perturbations changing expression of PCDHGC5 gene from the GEO Signatures of Differentially Expressed Genes for Kinase Perturbations dataset. | |
| GEO Signatures of Differentially Expressed Genes for Small Molecules | small molecule perturbations changing expression of PCDHGC5 gene from the GEO Signatures of Differentially Expressed Genes for Small Molecules dataset. | |
| GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations | transcription factor perturbations changing expression of PCDHGC5 gene from the GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations dataset. | |
| GEO Signatures of Differentially Expressed Genes for Viral Infections | virus perturbations changing expression of PCDHGC5 gene from the GEO Signatures of Differentially Expressed Genes for Viral Infections dataset. | |
| GO Biological Process Annotations 2015 | biological processes involving PCDHGC5 gene from the curated GO Biological Process Annotations 2015 dataset. | |
| GO Cellular Component Annotations 2015 | cellular components containing PCDHGC5 protein from the curated GO Cellular Component Annotations 2015 dataset. | |
| GO Molecular Function Annotations 2015 | molecular functions performed by PCDHGC5 gene from the curated GO Molecular Function Annotations 2015 dataset. | |
| GTEx Tissue Gene Expression Profiles | tissues with high or low expression of PCDHGC5 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles dataset. | |
| GTEx Tissue Gene Expression Profiles 2023 | tissues with high or low expression of PCDHGC5 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles 2023 dataset. | |
| GTEx Tissue Sample Gene Expression Profiles | tissue samples with high or low expression of PCDHGC5 gene relative to other tissue samples from the GTEx Tissue Sample Gene Expression Profiles dataset. | |
| GTEx Tissue-Specific Aging Signatures | tissue samples with high or low expression of PCDHGC5 gene relative to other tissue samples from the GTEx Tissue-Specific Aging Signatures dataset. | |
| GWAS Catalog SNP-Phenotype Associations 2025 | phenotypes associated with PCDHGC5 gene in GWAS datasets from the GWAS Catalog SNP-Phenotype Associations 2025 dataset. | |
| HMDB Metabolites of Enzymes | interacting metabolites for PCDHGC5 protein from the curated HMDB Metabolites of Enzymes dataset. | |
| HPA Cell Line Gene Expression Profiles | cell lines with high or low expression of PCDHGC5 gene relative to other cell lines from the HPA Cell Line Gene Expression Profiles dataset. | |
| HPA Tissue Gene Expression Profiles | tissues with high or low expression of PCDHGC5 gene relative to other tissues from the HPA Tissue Gene Expression Profiles dataset. | |
| HPA Tissue Protein Expression Profiles | tissues with high or low expression of PCDHGC5 protein relative to other tissues from the HPA Tissue Protein Expression Profiles dataset. | |
| HPA Tissue Sample Gene Expression Profiles | tissue samples with high or low expression of PCDHGC5 gene relative to other tissue samples from the HPA Tissue Sample Gene Expression Profiles dataset. | |
| InterPro Predicted Protein Domain Annotations | protein domains predicted for PCDHGC5 protein from the InterPro Predicted Protein Domain Annotations dataset. | |
| JASPAR Predicted Human Transcription Factor Targets 2025 | transcription factors regulating expression of PCDHGC5 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Human Transcription Factor Targets dataset. | |
| JASPAR Predicted Mouse Transcription Factor Targets 2025 | transcription factors regulating expression of PCDHGC5 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Mouse Transcription Factor Targets 2025 dataset. | |
| JASPAR Predicted Transcription Factor Targets | transcription factors regulating expression of PCDHGC5 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset. | |
| Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles | cell lines with high or low copy number of PCDHGC5 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset. | |
| Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles | cell lines with high or low expression of PCDHGC5 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles dataset. | |
| Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles | cell lines with PCDHGC5 gene mutations from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles dataset. | |
| KnockTF Gene Expression Profiles with Transcription Factor Perturbations | transcription factor perturbations changing expression of PCDHGC5 gene from the KnockTF Gene Expression Profiles with Transcription Factor Perturbations dataset. | |
| LOCATE Predicted Protein Localization Annotations | cellular components predicted to contain PCDHGC5 protein from the LOCATE Predicted Protein Localization Annotations dataset. | |
| MiRTarBase microRNA Targets | microRNAs targeting PCDHGC5 gene in low- or high-throughput microRNA targeting studies from the MiRTarBase microRNA Targets dataset. | |
| MotifMap Predicted Transcription Factor Targets | transcription factors regulating expression of PCDHGC5 gene predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset. | |
| NURSA Protein Complexes | protein complexs containing PCDHGC5 protein recovered by IP-MS from the NURSA Protein Complexes dataset. | |
| PANTHER Pathways | pathways involving PCDHGC5 protein from the PANTHER Pathways dataset. | |
| Pathway Commons Protein-Protein Interactions | interacting proteins for PCDHGC5 from the Pathway Commons Protein-Protein Interactions dataset. | |
| PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations | gene perturbations changing expression of PCDHGC5 gene from the PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations dataset. | |
| PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations | gene perturbations changing expression of PCDHGC5 gene from the PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations dataset. | |
| Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles | cell types and tissues with high or low DNA methylation of PCDHGC5 gene relative to other cell types and tissues from the Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles dataset. | |
| Roadmap Epigenomics Cell and Tissue Gene Expression Profiles | cell types and tissues with high or low expression of PCDHGC5 gene relative to other cell types and tissues from the Roadmap Epigenomics Cell and Tissue Gene Expression Profiles dataset. | |
| Roadmap Epigenomics Histone Modification Site Profiles | histone modification site profiles with high histone modification abundance at PCDHGC5 gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset. | |
| RummaGEO Drug Perturbation Signatures | drug perturbations changing expression of PCDHGC5 gene from the RummaGEO Drug Perturbation Signatures dataset. | |
| RummaGEO Gene Perturbation Signatures | gene perturbations changing expression of PCDHGC5 gene from the RummaGEO Gene Perturbation Signatures dataset. | |
| TargetScan Predicted Conserved microRNA Targets | microRNAs regulating expression of PCDHGC5 gene predicted using conserved miRNA seed sequences from the TargetScan Predicted Conserved microRNA Targets dataset. | |
| TargetScan Predicted Nonconserved microRNA Targets | microRNAs regulating expression of PCDHGC5 gene predicted using nonconserved miRNA seed sequences from the TargetScan Predicted Nonconserved microRNA Targets dataset. | |
| TCGA Signatures of Differentially Expressed Genes for Tumors | tissue samples with high or low expression of PCDHGC5 gene relative to other tissue samples from the TCGA Signatures of Differentially Expressed Genes for Tumors dataset. | |
| TISSUES Curated Tissue Protein Expression Evidence Scores 2025 | tissues with high expression of PCDHGC5 protein from the TISSUES Curated Tissue Protein Expression Evidence Scores 2025 dataset. | |
| TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 | tissues co-occuring with PCDHGC5 protein in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 dataset. | |
