{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nIn glioma, PCED1B‑AS1 acts as an oncogenic long noncoding RNA that modulates tumor progression. Localized mainly in the cytoplasm, it forms a competing endogenous RNA network by sponging miR‑194‑5p, thereby relieving its suppression on PCED1B. This molecular interaction promotes cell proliferation and inhibits apoptosis, suggesting that PCED1B‑AS1 is essential for glioma cell survival and proliferation."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn pancreatic ductal adenocarcinoma (PDAC) and gastric cancer (GC), PCED1B‑AS1 is significantly upregulated and contributes to more aggressive tumor characteristics. In PDAC, its overexpression is correlated with advanced clinical stage and lymph node metastasis; mechanistic studies reveal that PCED1B‑AS1 sponges miR‑411‑3p, leading to the upregulation of hypoxia inducible factor‑1α which in turn enhances cell proliferation, invasion, and epithelial–mesenchymal transition. Similarly, in GC, PCED1B‑AS1 promotes cell proliferation, migration, invasion, and EMT by binding to miR‑215‑3p and upregulating CXCR1 expression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn hepatocellular carcinoma (HCC), increased PCED1B‑AS1 expression is associated with poor patient survival. Here, PCED1B‑AS1 decreases miR‑10a levels, resulting in the enhanced expression of BCL6 and subsequent promotion of cell proliferation. Additionally, preliminary research in osteosarcoma implies a tumor‑promoting role for PCED1B‑AS1, while its diagnostic potential has been explored in proliferative diabetic retinopathy. Together, these findings underscore the multifaceted functions of PCED1B‑AS1 in oncogenesis and suggest its utility both as a prognostic biomarker and as a potential therapeutic target in a range of human cancers."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "4", "end_ref": "7"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Jinghui Yang, Duo Yu, Xueshibojie Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LncRNA PCED1B-AS1 activates the proliferation and restricts the apoptosis of glioma through cooperating with miR-194-5p/PCED1B axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Biochem (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jcb.29417"}], "href": "https://doi.org/10.1002/jcb.29417"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31680313"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31680313"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Yi Zhang, Huan Ma, Chang Chen "}, {"type": "b", "children": [{"type": "t", "text": "Long non‑coding RNA PCED1B‑AS1 promotes pancreatic ductal adenocarcinoma progression by regulating the miR‑411‑3p/HIF‑1α axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncol Rep (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/or.2021.8085"}], "href": "https://doi.org/10.3892/or.2021.8085"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34036383"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34036383"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Junyu Ren, Ning Xu, Ruize Zhou, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long non-coding RNA PCED1B antisense RNA 1 promotes gastric cancer progression via modulating microRNA-215-3p / C-X-C motif chemokine receptor 1 axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Bioengineered (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/21655979.2021.1971503"}], "href": "https://doi.org/10.1080/21655979.2021.1971503"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34516330"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34516330"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Haitao Ding, Juan He, Weili Xiao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LncRNA PCED1B-AS1 Upregulation in Hepatocellular Carcinoma and Regulation of the miR-10a/BCL6 Axis to Promote Cell Proliferation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Crit Rev Eukaryot Gene Expr (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1615/CritRevEukaryotGeneExpr.2022039954"}], "href": "https://doi.org/10.1615/CritRevEukaryotGeneExpr.2022039954"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35997114"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35997114"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Bing Wang, Li Yao, Yuefu Dong, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LncRNA PCED1B-AS1 knockdown inhibits osteosarcoma via methylation-mediated miR-10a downregulation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Orthop Surg Res (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s13018-022-03284-1"}], "href": "https://doi.org/10.1186/s13018-022-03284-1"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36274134"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36274134"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Xuyang Wang, Wangling Chen, Wei Lao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Upregulation of PCED1B-AS1 in proliferative diabetic retinopathy and its involvement in retinal vascular endothelial cell proliferation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "BMC Ophthalmol (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12886-022-02683-6"}], "href": "https://doi.org/10.1186/s12886-022-02683-6"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36418980"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36418980"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Jian-Gang Bi, Qi Li, Yu-Sheng Guo, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long Non-coding RNA PCED1B Antisense RNA 1 Promotes Cell Proliferation and Invasion in Hepatocellular Carcinoma by Regulating the MicroRNA-34a/CD44 Axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Curr Med Sci (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s11596-023-2823-5"}], "href": "https://doi.org/10.1007/s11596-023-2823-5"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "38748366"}], "href": "https://pubmed.ncbi.nlm.nih.gov/38748366"}]}]}]}