PDGFA-DT Gene

Name PDGFA divergent transcript
Summary
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nThe provided abstract (PubMed:"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "does not report any details regarding PDGFA‐DT. Rather, it focuses on Clptm1 – a protein identified via tandem affinity purification from tagged GABAAR‐subunit γ2 transgenic mice – and its role in governing inhibitory neurotransmission. The study demonstrates that Clptm1 interacts with all tested GABAAR subunits and limits their trafficking from the endoplasmic reticulum to the cell surface, leading to reduced GABAAR‐mediated currents. Overexpression of Clptm1 diminished inhibitory responses while its knockdown enhanced both phasic and tonic inhibitory transmission, indicating its pivotal involvement in inhibitory homeostatic plasticity. As a result, although the abstract provides valuable insights into mechanisms modulating GABAAR forward trafficking and synaptic scaling, it does not include any functional characterization or mention of PDGFA‐DT.\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Yuan Ge, Yunhee Kang, Robert M Cassidy, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Clptm1 Limits Forward Trafficking of GABA"}, {"type": "a", "children": [{"type": "t", "text": "sub"}], "href": "sub"}, {"type": "t", "text": "A"}, {"type": "a", "children": [{"type": "t", "text": "/sub"}], "href": "/sub"}, {"type": "t", "text": " Receptors to Scale Inhibitory Synaptic Strength."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Neuron (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.neuron.2017.12.038"}], "href": "https://doi.org/10.1016/j.neuron.2017.12.038"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29395912"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29395912"}]}]}]}
NCBI Gene ID 441307
API
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Predicted Functions View PDGFA-DT's ARCHS4 Predicted Functions.
Co-expressed Genes View PDGFA-DT's ARCHS4 Predicted Functions.
Expression in Tissues and Cell Lines View PDGFA-DT's ARCHS4 Predicted Functions.

Functional Associations

PDGFA-DT has 2 functional associations with biological entities spanning 1 categories (cell line, cell type or tissue) extracted from 1 datasets.

Click the + buttons to view associations for PDGFA-DT from the datasets below.

If available, associations are ranked by standardized value

Dataset Summary
GTEx Tissue-Specific Aging Signatures tissue samples with high or low expression of PDGFA-DT gene relative to other tissue samples from the GTEx Tissue-Specific Aging Signatures dataset.