Name | pseudopodium-enriched atypical kinase 1 |
Description | This gene encodes a non-receptor tyrosine kinase that is a member of the new kinase family three (NFK3) family. In migrating cells, the encoded protein is associated with the actin cytoskeleton and focal adhesions and promotes developing focal adhesion elongation. This protein may play a role in the regulation of cell migration, proliferation and cancer metastasis. [provided by RefSeq, Mar 2014] |
Summary |
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nPEAK1, a pseudopodium‐enriched atypical non–receptor tyrosine kinase, has emerged as a pivotal signaling hub in cancer. Initially identified through large‐scale kinome analyses"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ", subsequent studies demonstrated that PEAK1 is upregulated in several malignancies—including pancreatic ductal adenocarcinoma (PDAC), basal breast cancers, neuroblastoma, lung cancer, and melanoma—where it drives tumor growth, metastasis, and therapy resistance."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "2", "end_ref": "4"}]}, {"type": "t", "text": " In vivo and in vitro experiments have revealed that by modulating key processes such as epithelial–mesenchymal transition (EMT) and focal adhesion dynamics, PEAK1 facilitates rapid cell migration and invasion."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "5", "end_ref": "7"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nMechanistically, PEAK1 functions as an adaptor and scaffold that integrates signals from multiple oncogenic pathways. For instance, in PDAC, oncogenic KRas and the translation activator eIF5A stimulate PEAK1 expression, which in turn participates in a feed‐forward loop that enhances KRas protein synthesis and activates downstream effectors such as YAP/TAZ."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "8"}]}, {"type": "t", "text": " In breast cancer, elevated PEAK1 cooperates with TGFβ in a fibronectin‐dependent manner to switch signaling from canonical Smad pathways toward non–canonical Src and MAPK cascades, promoting EMT and metastasis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "10"}]}, {"type": "t", "text": " Furthermore, evidence in colorectal and gastric cancers indicates context‐dependent roles—while some studies show that EGFR/KRas signaling induces PEAK1 to drive tumor progression"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "11"}]}, {"type": "t", "text": ", others report that loss of PEAK1 correlates with enhanced EMT and poorer clinical outcomes."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "12"}]}, {"type": "t", "text": " In non–small cell lung cancer, noncoding RNA networks (e.g., lncRNA NORAD sponging miR-363-3p) upregulate PEAK1 to promote invasion and EMT"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "14"}]}, {"type": "t", "text": ", and in neuroblastoma, activated ALK signaling recruits PEAK1 as part of its intracellular interactome."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "15"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nStructurally, PEAK1 harbors a unique split helical dimerization (SHED) region that distinguishes it from typical kinases and underlies its function as a molecular scaffold. Its ability to form both homo- and heterodimeric complexes—most notably with the related pseudokinase SgK223—enables the assembly of diverse signaling complexes that modulate pathways such as Stat3, ERK, JAK/STAT, PI3K/Akt, and integrin-mediated responses."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "16", "end_ref": "18"}]}, {"type": "t", "text": " In melanoma and breast cancer models, overexpression of PEAK1 enhances tumorigenesis, chemoresistance, and metastatic behavior, whereas its inhibition disrupts these oncogenic processes."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "19"}]}, {"type": "t", "text": " Collectively, these findings position PEAK1 as both a critical biomarker and a promising therapeutic target, with its multifaceted roles reflecting the complexity of cancer signaling networks."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "8"}, {"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "G Manning, D B Whyte, R Martinez, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "KRas induces a Src/PEAK1/ErbB2 kinase amplification loop that drives metastatic growth and therapy resistance in pancreatic cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Res (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/0008-5472.CAN-11-3552"}], "href": "https://doi.org/10.1158/0008-5472.CAN-11-3552"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22589274"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22589274"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "David R Croucher, Falko Hochgräfe, Luxi Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Involvement of Lyn and the atypical kinase SgK269/PEAK1 in a basal breast cancer signaling pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Res (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/0008-5472.CAN-12-1472"}], "href": "https://doi.org/10.1158/0008-5472.CAN-12-1472"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23378338"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23378338"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Ken Fujimura, Tracy Wright, Jan Strnadel, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A hypusine-eIF5A-PEAK1 switch regulates the pathogenesis of pancreatic cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Res (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/0008-5472.CAN-14-1031"}], "href": "https://doi.org/10.1158/0008-5472.CAN-14-1031"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25261239"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25261239"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Afnan Abu-Thuraia, Marie-Anne Goyette, Jonathan Boulais, et al. "}, {"type": "b", "children": [{"type": "t", "text": "AXL confers cell migration and invasion by hijacking a PEAK1-regulated focal adhesion protein network."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Commun (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41467-020-17415-x"}], "href": "https://doi.org/10.1038/s41467-020-17415-x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32681075"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32681075"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Min Pan, Xiaohui Yin, Yi-Chuan Huang "}, {"type": "b", "children": [{"type": "t", "text": "Pseudopodium enriched atypical kinase 1(PEAK1) promotes invasion and of melanoma cells by activating JAK/STAT3 signals."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Bioengineered (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/21655979.2021.1961661"}], "href": "https://doi.org/10.1080/21655979.2021.1961661"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34365903"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34365903"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Jun Zhu, Fudong Wang, Yuan Weng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Exosome-delivered circSATB2 targets the miR-330-5p/PEAK1 axis to regulate proliferation, migration and invasion of lung cancer cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Thorac Cancer (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/1759-7714.14652"}], "href": "https://doi.org/10.1111/1759-7714.14652"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36148757"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36148757"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Ken Fujimura, Huawei Wang, Felicia Watson, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "PEAK1, acting as a tumor promoter in colorectal cancer, is regulated by the EGFR/KRas signaling axis and miR-181d."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Death Dis (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41419-018-0320-8"}], "href": "https://doi.org/10.1038/s41419-018-0320-8"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29449544"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29449544"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Qingqu Guo, Wenjie Qin, Baozhong Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Analysis of a cytoskeleton-associated kinase PEAK1 and E-cadherin in gastric cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Pathol Res Pract (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.prp.2014.09.013"}], "href": "https://doi.org/10.1016/j.prp.2014.09.013"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25445115"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25445115"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Chenbo Ding, Wendong Tang, Hailu Wu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The PEAK1-PPP1R12B axis inhibits tumor growth and metastasis by regulating Grb2/PI3K/Akt signalling in colorectal cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Lett (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.canlet.2018.11.014"}], "href": "https://doi.org/10.1016/j.canlet.2018.11.014"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30472186"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30472186"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Qianqian Geng, Zhubin Li, Xintao Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LncRNA NORAD, sponging miR-363-3p, promotes invasion and EMT by upregulating PEAK1 and activating the ERK signaling pathway in NSCLC cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Bioenerg Biomembr (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s10863-021-09892-6"}], "href": "https://doi.org/10.1007/s10863-021-09892-6"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33742335"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33742335"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Ezgi Uçkun, Joachim T Siaw, Jikui Guan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "BioID-Screening Identifies PEAK1 and SHP2 as Components of the ALK Proximitome in Neuroblastoma Cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Mol Biol (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.jmb.2021.167158"}], "href": "https://doi.org/10.1016/j.jmb.2021.167158"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34273398"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34273398"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Ling Liu, Yu Wei Phua, Rachel S Lee, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Homo- and Heterotypic Association Regulates Signaling by the SgK269/PEAK1 and SgK223 Pseudokinases."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M116.748897"}], "href": "https://doi.org/10.1074/jbc.M116.748897"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27531744"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27531744"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Chenbo Ding, Wendong Tang, Xiaobo Fan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Overexpression of PEAK1 contributes to epithelial-mesenchymal transition and tumor metastasis in lung cancer through modulating ERK1/2 and JAK2 signaling."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Death Dis (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41419-018-0817-1"}], "href": "https://doi.org/10.1038/s41419-018-0817-1"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30038287"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30038287"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Alba Zuidema, Paul Atherton, Maaike Kreft, et al. "}, {"type": "b", "children": [{"type": "t", "text": "PEAK1 Y635 phosphorylation regulates cell migration through association with Tensin3 and integrins."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Biol (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1083/jcb.202108027"}], "href": "https://doi.org/10.1083/jcb.202108027"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35687021"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35687021"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Xingang Wang, Yan Zheng, Yu Wang "}, {"type": "b", "children": [{"type": "t", "text": "PEAK1 promotes invasion and metastasis and confers drug resistance in breast cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Clin Exp Med (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s10238-021-00761-5"}], "href": "https://doi.org/10.1007/s10238-021-00761-5"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34554318"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34554318"}]}]}]}
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Synonyms | SGK269 |
Proteins | PEAK1_HUMAN |
NCBI Gene ID | 79834 |
API | |
Download Associations | |
Predicted Functions |
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Co-expressed Genes |
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Expression in Tissues and Cell Lines |
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PEAK1 has 5,800 functional associations with biological entities spanning 9 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 109 datasets.
Click the + buttons to view associations for PEAK1 from the datasets below.
If available, associations are ranked by standardized value
Dataset | Summary | |
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Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles | tissues with high or low expression of PEAK1 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset. | |
Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles | tissues with high or low expression of PEAK1 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset. | |
Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq | tissue samples with high or low expression of PEAK1 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset. | |
Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles | tissues with high or low expression of PEAK1 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset. | |
BioGPS Cell Line Gene Expression Profiles | cell lines with high or low expression of PEAK1 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset. | |
BioGPS Human Cell Type and Tissue Gene Expression Profiles | cell types and tissues with high or low expression of PEAK1 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset. | |
BioGPS Mouse Cell Type and Tissue Gene Expression Profiles | cell types and tissues with high or low expression of PEAK1 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset. | |
CCLE Cell Line Gene CNV Profiles | cell lines with high or low copy number of PEAK1 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset. | |
CCLE Cell Line Gene Expression Profiles | cell lines with high or low expression of PEAK1 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset. | |
CCLE Cell Line Gene Mutation Profiles | cell lines with PEAK1 gene mutations from the CCLE Cell Line Gene Mutation Profiles dataset. | |
CCLE Cell Line Proteomics | Cell lines associated with PEAK1 protein from the CCLE Cell Line Proteomics dataset. | |
CellMarker Gene-Cell Type Associations | cell types associated with PEAK1 gene from the CellMarker Gene-Cell Type Associations dataset. | |
ChEA Transcription Factor Binding Site Profiles | transcription factor binding site profiles with transcription factor binding evidence at the promoter of PEAK1 gene from the CHEA Transcription Factor Binding Site Profiles dataset. | |
ChEA Transcription Factor Targets | transcription factors binding the promoter of PEAK1 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset. | |
ChEA Transcription Factor Targets 2022 | transcription factors binding the promoter of PEAK1 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset. | |
CMAP Signatures of Differentially Expressed Genes for Small Molecules | small molecule perturbations changing expression of PEAK1 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset. | |
COMPARTMENTS Curated Protein Localization Evidence Scores | cellular components containing PEAK1 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset. | |
COMPARTMENTS Curated Protein Localization Evidence Scores 2025 | cellular components containing PEAK1 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset. | |
COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 | cellular components containing PEAK1 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 dataset. | |
COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 | cellular components co-occuring with PEAK1 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset. | |
COSMIC Cell Line Gene Mutation Profiles | cell lines with PEAK1 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset. | |
CTD Gene-Disease Associations | diseases associated with PEAK1 gene/protein from the curated CTD Gene-Disease Associations dataset. | |
DeepCoverMOA Drug Mechanisms of Action | small molecule perturbations with high or low expression of PEAK1 protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset. | |
DepMap CRISPR Gene Dependency | cell lines with fitness changed by PEAK1 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset. | |
DISEASES Experimental Gene-Disease Association Evidence Scores 2025 | diseases associated with PEAK1 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset. | |
DISEASES Text-mining Gene-Disease Association Evidence Scores | diseases co-occuring with PEAK1 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset. | |
DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 | diseases co-occuring with PEAK1 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset. | |
DisGeNET Gene-Disease Associations | diseases associated with PEAK1 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset. | |
DisGeNET Gene-Phenotype Associations | phenotypes associated with PEAK1 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset. | |
ENCODE Histone Modification Site Profiles | histone modification site profiles with high histone modification abundance at PEAK1 gene from the ENCODE Histone Modification Site Profiles dataset. | |
ENCODE Transcription Factor Binding Site Profiles | transcription factor binding site profiles with transcription factor binding evidence at the promoter of PEAK1 gene from the ENCODE Transcription Factor Binding Site Profiles dataset. | |
ENCODE Transcription Factor Targets | transcription factors binding the promoter of PEAK1 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset. | |
ESCAPE Omics Signatures of Genes and Proteins for Stem Cells | PubMedIDs of publications reporting gene signatures containing PEAK1 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset. | |
GAD Gene-Disease Associations | diseases associated with PEAK1 gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset. | |
GeneRIF Biological Term Annotations | biological terms co-occuring with PEAK1 gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset. | |
GeneSigDB Published Gene Signatures | PubMedIDs of publications reporting gene signatures containing PEAK1 from the GeneSigDB Published Gene Signatures dataset. | |
GEO Signatures of Differentially Expressed Genes for Kinase Perturbations | kinase perturbations changing expression of PEAK1 gene from the GEO Signatures of Differentially Expressed Genes for Kinase Perturbations dataset. | |
GEO Signatures of Differentially Expressed Genes for Small Molecules | small molecule perturbations changing expression of PEAK1 gene from the GEO Signatures of Differentially Expressed Genes for Small Molecules dataset. | |
GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations | transcription factor perturbations changing expression of PEAK1 gene from the GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations dataset. | |
GEO Signatures of Differentially Expressed Genes for Viral Infections | virus perturbations changing expression of PEAK1 gene from the GEO Signatures of Differentially Expressed Genes for Viral Infections dataset. | |
GlyGen Glycosylated Proteins | ligands (chemical) binding PEAK1 protein from the GlyGen Glycosylated Proteins dataset. | |
GO Biological Process Annotations 2015 | biological processes involving PEAK1 gene from the curated GO Biological Process Annotations 2015 dataset. | |
GO Biological Process Annotations 2023 | biological processes involving PEAK1 gene from the curated GO Biological Process Annotations 2023 dataset. | |
GO Biological Process Annotations 2025 | biological processes involving PEAK1 gene from the curated GO Biological Process Annotations2025 dataset. | |
GO Cellular Component Annotations 2015 | cellular components containing PEAK1 protein from the curated GO Cellular Component Annotations 2015 dataset. | |
GO Cellular Component Annotations 2023 | cellular components containing PEAK1 protein from the curated GO Cellular Component Annotations 2023 dataset. | |
GO Cellular Component Annotations 2025 | cellular components containing PEAK1 protein from the curated GO Cellular Component Annotations 2025 dataset. | |
GO Molecular Function Annotations 2015 | molecular functions performed by PEAK1 gene from the curated GO Molecular Function Annotations 2015 dataset. | |
GO Molecular Function Annotations 2023 | molecular functions performed by PEAK1 gene from the curated GO Molecular Function Annotations 2023 dataset. | |
GO Molecular Function Annotations 2025 | molecular functions performed by PEAK1 gene from the curated GO Molecular Function Annotations 2025 dataset. | |
GTEx eQTL 2025 | SNPs regulating expression of PEAK1 gene from the GTEx eQTL 2025 dataset. | |
GTEx Tissue Gene Expression Profiles | tissues with high or low expression of PEAK1 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles dataset. | |
GTEx Tissue Gene Expression Profiles 2023 | tissues with high or low expression of PEAK1 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles 2023 dataset. | |
GTEx Tissue Sample Gene Expression Profiles | tissue samples with high or low expression of PEAK1 gene relative to other tissue samples from the GTEx Tissue Sample Gene Expression Profiles dataset. | |
GWASdb SNP-Disease Associations | diseases associated with PEAK1 gene in GWAS and other genetic association datasets from the GWASdb SNP-Disease Associations dataset. | |
GWASdb SNP-Phenotype Associations | phenotypes associated with PEAK1 gene in GWAS datasets from the GWASdb SNP-Phenotype Associations dataset. | |
HPA Cell Line Gene Expression Profiles | cell lines with high or low expression of PEAK1 gene relative to other cell lines from the HPA Cell Line Gene Expression Profiles dataset. | |
HPA Tissue Gene Expression Profiles | tissues with high or low expression of PEAK1 gene relative to other tissues from the HPA Tissue Gene Expression Profiles dataset. | |
HPA Tissue Protein Expression Profiles | tissues with high or low expression of PEAK1 protein relative to other tissues from the HPA Tissue Protein Expression Profiles dataset. | |
HPA Tissue Sample Gene Expression Profiles | tissue samples with high or low expression of PEAK1 gene relative to other tissue samples from the HPA Tissue Sample Gene Expression Profiles dataset. | |
Hub Proteins Protein-Protein Interactions | interacting hub proteins for PEAK1 from the curated Hub Proteins Protein-Protein Interactions dataset. | |
HuGE Navigator Gene-Phenotype Associations | phenotypes associated with PEAK1 gene by text-mining GWAS publications from the HuGE Navigator Gene-Phenotype Associations dataset. | |
IMPC Knockout Mouse Phenotypes | phenotypes of mice caused by PEAK1 gene knockout from the IMPC Knockout Mouse Phenotypes dataset. | |
InterPro Predicted Protein Domain Annotations | protein domains predicted for PEAK1 protein from the InterPro Predicted Protein Domain Annotations dataset. | |
JASPAR Predicted Transcription Factor Targets | transcription factors regulating expression of PEAK1 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset. | |
KEA Substrates of Kinases | kinases that phosphorylate PEAK1 protein from the curated KEA Substrates of Kinases dataset. | |
Kinase Library Serine Threonine Kinome Atlas | kinases that phosphorylate PEAK1 protein from the Kinase Library Serine Threonine Atlas dataset. | |
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles | cell lines with high or low copy number of PEAK1 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset. | |
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles | cell lines with high or low expression of PEAK1 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles dataset. | |
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles | cell lines with PEAK1 gene mutations from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles dataset. | |
KnockTF Gene Expression Profiles with Transcription Factor Perturbations | transcription factor perturbations changing expression of PEAK1 gene from the KnockTF Gene Expression Profiles with Transcription Factor Perturbations dataset. | |
LINCS L1000 CMAP Chemical Perturbation Consensus Signatures | small molecule perturbations changing expression of PEAK1 gene from the LINCS L1000 CMAP Chemical Perturbations Consensus Signatures dataset. | |
LINCS L1000 CMAP CRISPR Knockout Consensus Signatures | gene perturbations changing expression of PEAK1 gene from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset. | |
LOCATE Predicted Protein Localization Annotations | cellular components predicted to contain PEAK1 protein from the LOCATE Predicted Protein Localization Annotations dataset. | |
MGI Mouse Phenotype Associations 2023 | phenotypes of transgenic mice caused by PEAK1 gene mutations from the MGI Mouse Phenotype Associations 2023 dataset. | |
MiRTarBase microRNA Targets | microRNAs targeting PEAK1 gene in low- or high-throughput microRNA targeting studies from the MiRTarBase microRNA Targets dataset. | |
MotifMap Predicted Transcription Factor Targets | transcription factors regulating expression of PEAK1 gene predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset. | |
MoTrPAC Rat Endurance Exercise Training | tissue samples with high or low expression of PEAK1 gene relative to other tissue samples from the MoTrPAC Rat Endurance Exercise Training dataset. | |
MSigDB Cancer Gene Co-expression Modules | co-expressed genes for PEAK1 from the MSigDB Cancer Gene Co-expression Modules dataset. | |
MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations | gene perturbations changing expression of PEAK1 gene from the MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations dataset. | |
NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles | drug perturbations changing expression of PEAK1 gene from the NIBR DRUG-seq U2OS MoA Box dataset. | |
NURSA Protein Complexes | protein complexs containing PEAK1 protein recovered by IP-MS from the NURSA Protein Complexes dataset. | |
PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations | gene perturbations changing expression of PEAK1 gene from the PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations dataset. | |
PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations | gene perturbations changing expression of PEAK1 gene from the PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations dataset. | |
PFOCR Pathway Figure Associations 2023 | pathways involving PEAK1 protein from the PFOCR Pathway Figure Associations 2023 dataset. | |
PFOCR Pathway Figure Associations 2024 | pathways involving PEAK1 protein from the Wikipathways PFOCR 2024 dataset. | |
Phosphosite Textmining Biological Term Annotations | biological terms co-occuring with PEAK1 protein in abstracts of publications describing phosphosites from the Phosphosite Textmining Biological Term Annotations dataset. | |
PhosphoSitePlus Substrates of Kinases | kinases that phosphorylate PEAK1 protein from the curated PhosphoSitePlus Substrates of Kinases dataset. | |
Reactome Pathways 2024 | pathways involving PEAK1 protein from the Reactome Pathways 2024 dataset. | |
Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures | gene perturbations changing expression of PEAK1 gene from the Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures dataset. | |
Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures | gene perturbations changing expression of PEAK1 gene from the Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures dataset. | |
Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures | gene perturbations changing expression of PEAK1 gene from the Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures dataset. | |
Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles | cell types and tissues with high or low DNA methylation of PEAK1 gene relative to other cell types and tissues from the Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles dataset. | |
Roadmap Epigenomics Histone Modification Site Profiles | histone modification site profiles with high histone modification abundance at PEAK1 gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset. | |
RummaGEO Drug Perturbation Signatures | drug perturbations changing expression of PEAK1 gene from the RummaGEO Drug Perturbation Signatures dataset. | |
RummaGEO Gene Perturbation Signatures | gene perturbations changing expression of PEAK1 gene from the RummaGEO Gene Perturbation Signatures dataset. | |
SILAC Phosphoproteomics Signatures of Differentially Phosphorylated Proteins for Drugs | drug perturbations changing phosphorylation of PEAK1 protein from the SILAC Phosphoproteomics Signatures of Differentially Phosphorylated Proteins for Drugs dataset. | |
SILAC Phosphoproteomics Signatures of Differentially Phosphorylated Proteins for Gene Perturbations | gene perturbations changing phosphorylation of PEAK1 protein from the SILAC Phosphoproteomics Signatures of Differentially Phosphorylated Proteins for Gene Perturbations dataset. | |
SILAC Phosphoproteomics Signatures of Differentially Phosphorylated Proteins for Protein Ligands | ligand (protein) perturbations changing phosphorylation of PEAK1 protein from the SILAC Phosphoproteomics Signatures of Differentially Phosphorylated Proteins for Protein Ligands dataset. | |
Tabula Sapiens Gene-Cell Associations | cell types with high or low expression of PEAK1 gene relative to other cell types from the Tabula Sapiens Gene-Cell Associations dataset. | |
TargetScan Predicted Conserved microRNA Targets | microRNAs regulating expression of PEAK1 gene predicted using conserved miRNA seed sequences from the TargetScan Predicted Conserved microRNA Targets dataset. | |
TargetScan Predicted Nonconserved microRNA Targets | microRNAs regulating expression of PEAK1 gene predicted using nonconserved miRNA seed sequences from the TargetScan Predicted Nonconserved microRNA Targets dataset. | |
TCGA Signatures of Differentially Expressed Genes for Tumors | tissue samples with high or low expression of PEAK1 gene relative to other tissue samples from the TCGA Signatures of Differentially Expressed Genes for Tumors dataset. | |
TISSUES Curated Tissue Protein Expression Evidence Scores | tissues with high expression of PEAK1 protein from the TISSUES Curated Tissue Protein Expression Evidence Scores dataset. | |
TISSUES Curated Tissue Protein Expression Evidence Scores 2025 | tissues with high expression of PEAK1 protein from the TISSUES Curated Tissue Protein Expression Evidence Scores 2025 dataset. | |
TISSUES Experimental Tissue Protein Expression Evidence Scores | tissues with high expression of PEAK1 protein in proteomics datasets from the TISSUES Experimental Tissue Protein Expression Evidence Scores dataset. | |
TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 | tissues with high expression of PEAK1 protein in proteomics datasets from the TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 dataset. | |
TISSUES Text-mining Tissue Protein Expression Evidence Scores | tissues co-occuring with PEAK1 protein in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores dataset. | |
TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 | tissues co-occuring with PEAK1 protein in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 dataset. | |