PEAK1 Gene

Name	pseudopodium-enriched atypical kinase 1
Description	This gene encodes a non-receptor tyrosine kinase that is a member of the new kinase family three (NFK3) family. In migrating cells, the encoded protein is associated with the actin cytoskeleton and focal adhesions and promotes developing focal adhesion elongation. This protein may play a role in the regulation of cell migration, proliferation and cancer metastasis. [provided by RefSeq, Mar 2014]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nPEAK1, a pseudopodium‐enriched atypical non–receptor tyrosine kinase, has emerged as a pivotal signaling hub in cancer. Initially identified through large‐scale kinome analyses"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ", subsequent studies demonstrated that PEAK1 is upregulated in several malignancies—including pancreatic ductal adenocarcinoma (PDAC), basal breast cancers, neuroblastoma, lung cancer, and melanoma—where it drives tumor growth, metastasis, and therapy resistance."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "2", "end_ref": "4"}]}, {"type": "t", "text": " In vivo and in vitro experiments have revealed that by modulating key processes such as epithelial–mesenchymal transition (EMT) and focal adhesion dynamics, PEAK1 facilitates rapid cell migration and invasion."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "5", "end_ref": "7"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nMechanistically, PEAK1 functions as an adaptor and scaffold that integrates signals from multiple oncogenic pathways. For instance, in PDAC, oncogenic KRas and the translation activator eIF5A stimulate PEAK1 expression, which in turn participates in a feed‐forward loop that enhances KRas protein synthesis and activates downstream effectors such as YAP/TAZ."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "8"}]}, {"type": "t", "text": " In breast cancer, elevated PEAK1 cooperates with TGFβ in a fibronectin‐dependent manner to switch signaling from canonical Smad pathways toward non–canonical Src and MAPK cascades, promoting EMT and metastasis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "10"}]}, {"type": "t", "text": " Furthermore, evidence in colorectal and gastric cancers indicates context‐dependent roles—while some studies show that EGFR/KRas signaling induces PEAK1 to drive tumor progression"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "11"}]}, {"type": "t", "text": ", others report that loss of PEAK1 correlates with enhanced EMT and poorer clinical outcomes."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "12"}]}, {"type": "t", "text": " In non–small cell lung cancer, noncoding RNA networks (e.g., lncRNA NORAD sponging miR-363-3p) upregulate PEAK1 to promote invasion and EMT"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "14"}]}, {"type": "t", "text": ", and in neuroblastoma, activated ALK signaling recruits PEAK1 as part of its intracellular interactome."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "15"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nStructurally, PEAK1 harbors a unique split helical dimerization (SHED) region that distinguishes it from typical kinases and underlies its function as a molecular scaffold. Its ability to form both homo- and heterodimeric complexes—most notably with the related pseudokinase SgK223—enables the assembly of diverse signaling complexes that modulate pathways such as Stat3, ERK, JAK/STAT, PI3K/Akt, and integrin-mediated responses."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "16", "end_ref": "18"}]}, {"type": "t", "text": " In melanoma and breast cancer models, overexpression of PEAK1 enhances tumorigenesis, chemoresistance, and metastatic behavior, whereas its inhibition disrupts these oncogenic processes."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "19"}]}, {"type": "t", "text": " Collectively, these findings position PEAK1 as both a critical biomarker and a promising therapeutic target, with its multifaceted roles reflecting the complexity of cancer signaling networks."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "8"}, {"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "G Manning, D B Whyte, R Martinez, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The protein kinase complement of the human genome."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Science (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1126/science.1075762"}], "href": "https://doi.org/10.1126/science.1075762"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12471243"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12471243"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Jonathan A Kelber, Theresa Reno, Sharmeela Kaushal, et al. "}, {"type": "b", "children": [{"type": "t", "text": "KRas induces a Src/PEAK1/ErbB2 kinase amplification loop that drives metastatic growth and therapy resistance in pancreatic cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Res (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/0008-5472.CAN-11-3552"}], "href": "https://doi.org/10.1158/0008-5472.CAN-11-3552"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22589274"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22589274"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "David R Croucher, Falko Hochgräfe, Luxi Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Involvement of Lyn and the atypical kinase SgK269/PEAK1 in a basal breast cancer signaling pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Res (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/0008-5472.CAN-12-1472"}], "href": "https://doi.org/10.1158/0008-5472.CAN-12-1472"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23378338"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23378338"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Ken Fujimura, Tracy Wright, Jan Strnadel, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A hypusine-eIF5A-PEAK1 switch regulates the pathogenesis of pancreatic cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Res (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/0008-5472.CAN-14-1031"}], "href": "https://doi.org/10.1158/0008-5472.CAN-14-1031"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25261239"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25261239"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Afnan Abu-Thuraia, Marie-Anne Goyette, Jonathan Boulais, et al. "}, {"type": "b", "children": [{"type": "t", "text": "AXL confers cell migration and invasion by hijacking a PEAK1-regulated focal adhesion protein network."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Commun (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41467-020-17415-x"}], "href": "https://doi.org/10.1038/s41467-020-17415-x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32681075"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32681075"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Min Pan, Xiaohui Yin, Yi-Chuan Huang "}, {"type": "b", "children": [{"type": "t", "text": "Pseudopodium enriched atypical kinase 1(PEAK1) promotes invasion and of melanoma cells by activating JAK/STAT3 signals."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Bioengineered (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/21655979.2021.1961661"}], "href": "https://doi.org/10.1080/21655979.2021.1961661"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34365903"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34365903"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Jun Zhu, Fudong Wang, Yuan Weng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Exosome-delivered circSATB2 targets the miR-330-5p/PEAK1 axis to regulate proliferation, migration and invasion of lung cancer cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Thorac Cancer (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/1759-7714.14652"}], "href": "https://doi.org/10.1111/1759-7714.14652"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36148757"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36148757"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Ken Fujimura, Huawei Wang, Felicia Watson, et al. "}, {"type": "b", "children": [{"type": "t", "text": "KRAS Oncoprotein Expression Is Regulated by a Self-Governing eIF5A-PEAK1 Feed-Forward Regulatory Loop."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Res (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/0008-5472.CAN-17-2873"}], "href": "https://doi.org/10.1158/0008-5472.CAN-17-2873"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29321164"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29321164"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Jan Strnadel, Sunkyu Choi, Ken Fujimura, et al. "}, {"type": "b", "children": [{"type": "t", "text": "eIF5A-PEAK1 Signaling Regulates YAP1/TAZ Protein Expression and Pancreatic Cancer Cell Growth."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Res (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/0008-5472.CAN-16-2594"}], "href": "https://doi.org/10.1158/0008-5472.CAN-16-2594"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28381547"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28381547"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Megan Agajanian, Anaamika Campeau, Malachia Hoover, et al. "}, {"type": "b", "children": [{"type": "t", "text": "PEAK1 Acts as a Molecular Switch to Regulate Context-Dependent TGFβ Responses in Breast Cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0135748"}], "href": "https://doi.org/10.1371/journal.pone.0135748"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26267863"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26267863"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Lanlan Huang, Chuangyu Wen, Xiangling Yang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "PEAK1, acting as a tumor promoter in colorectal cancer, is regulated by the EGFR/KRas signaling axis and miR-181d."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Death Dis (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41419-018-0320-8"}], "href": "https://doi.org/10.1038/s41419-018-0320-8"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29449544"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29449544"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Qingqu Guo, Wenjie Qin, Baozhong Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Analysis of a cytoskeleton-associated kinase PEAK1 and E-cadherin in gastric cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Pathol Res Pract (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.prp.2014.09.013"}], "href": "https://doi.org/10.1016/j.prp.2014.09.013"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25445115"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25445115"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Chenbo Ding, Wendong Tang, Hailu Wu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The PEAK1-PPP1R12B axis inhibits tumor growth and metastasis by regulating Grb2/PI3K/Akt signalling in colorectal cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Lett (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.canlet.2018.11.014"}], "href": "https://doi.org/10.1016/j.canlet.2018.11.014"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30472186"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30472186"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Qianqian Geng, Zhubin Li, Xintao Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LncRNA NORAD, sponging miR-363-3p, promotes invasion and EMT by upregulating PEAK1 and activating the ERK signaling pathway in NSCLC cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Bioenerg Biomembr (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s10863-021-09892-6"}], "href": "https://doi.org/10.1007/s10863-021-09892-6"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33742335"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33742335"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Ezgi Uçkun, Joachim T Siaw, Jikui Guan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "BioID-Screening Identifies PEAK1 and SHP2 as Components of the ALK Proximitome in Neuroblastoma Cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Mol Biol (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.jmb.2021.167158"}], "href": "https://doi.org/10.1016/j.jmb.2021.167158"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34273398"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34273398"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Ling Liu, Yu Wei Phua, Rachel S Lee, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Homo- and Heterotypic Association Regulates Signaling by the SgK269/PEAK1 and SgK223 Pseudokinases."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M116.748897"}], "href": "https://doi.org/10.1074/jbc.M116.748897"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27531744"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27531744"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Chenbo Ding, Wendong Tang, Xiaobo Fan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Overexpression of PEAK1 contributes to epithelial-mesenchymal transition and tumor metastasis in lung cancer through modulating ERK1/2 and JAK2 signaling."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Death Dis (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41419-018-0817-1"}], "href": "https://doi.org/10.1038/s41419-018-0817-1"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30038287"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30038287"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Alba Zuidema, Paul Atherton, Maaike Kreft, et al. "}, {"type": "b", "children": [{"type": "t", "text": "PEAK1 Y635 phosphorylation regulates cell migration through association with Tensin3 and integrins."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Biol (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1083/jcb.202108027"}], "href": "https://doi.org/10.1083/jcb.202108027"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35687021"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35687021"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Xingang Wang, Yan Zheng, Yu Wang "}, {"type": "b", "children": [{"type": "t", "text": "PEAK1 promotes invasion and metastasis and confers drug resistance in breast cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Clin Exp Med (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s10238-021-00761-5"}], "href": "https://doi.org/10.1007/s10238-021-00761-5"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34554318"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34554318"}]}]}]}
Synonyms	SGK269
Proteins	PEAK1_HUMAN
NCBI Gene ID	79834
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

PEAK1 has 5,800 functional associations with biological entities spanning 9 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 109 datasets.

Click the + buttons to view associations for PEAK1 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

PEAK1 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of PEAK1 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of PEAK1 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of PEAK1 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of PEAK1 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of PEAK1 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of PEAK1 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of PEAK1 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of PEAK1 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of PEAK1 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Gene Mutation Profiles	cell lines with PEAK1 gene mutations from the CCLE Cell Line Gene Mutation Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with PEAK1 protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with PEAK1 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of PEAK1 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of PEAK1 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of PEAK1 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of PEAK1 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing PEAK1 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing PEAK1 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	cellular components containing PEAK1 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with PEAK1 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with PEAK1 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Disease Associations	diseases associated with PEAK1 gene/protein from the curated CTD Gene-Disease Associations dataset.
	DeepCoverMOA Drug Mechanisms of Action	small molecule perturbations with high or low expression of PEAK1 protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by PEAK1 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with PEAK1 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with PEAK1 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with PEAK1 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with PEAK1 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with PEAK1 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at PEAK1 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of PEAK1 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of PEAK1 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing PEAK1 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GAD Gene-Disease Associations	diseases associated with PEAK1 gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.
	GeneRIF Biological Term Annotations	biological terms co-occuring with PEAK1 gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.
	GeneSigDB Published Gene Signatures	PubMedIDs of publications reporting gene signatures containing PEAK1 from the GeneSigDB Published Gene Signatures dataset.
	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	kinase perturbations changing expression of PEAK1 gene from the GEO Signatures of Differentially Expressed Genes for Kinase Perturbations dataset.
	GEO Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of PEAK1 gene from the GEO Signatures of Differentially Expressed Genes for Small Molecules dataset.
	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	transcription factor perturbations changing expression of PEAK1 gene from the GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations dataset.
	GEO Signatures of Differentially Expressed Genes for Viral Infections	virus perturbations changing expression of PEAK1 gene from the GEO Signatures of Differentially Expressed Genes for Viral Infections dataset.