| Name | phosphatidylethanolamine-binding protein 4 |
| Description | The phosphatidylethanolamine (PE)-binding proteins, including PEBP4, are an evolutionarily conserved family of proteins with pivotal biologic functions, such as lipid binding and inhibition of serine proteases (Wang et al., 2004 [PubMed 15302887]).[supplied by OMIM, Dec 2008] |
| Summary |
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nHuman phosphatidylethanolamine‐binding protein 4 (PEBP4) functions as a multifaceted regulator in cancer biology. Several studies have demonstrated that PEBP4 confers resistance to apoptosis and chemotherapeutic agents. In lung adenocarcinoma, upregulation of microRNAs (miR‐15b and miR‐34a) downregulates PEBP4 expression, thereby affecting cisplatin sensitivity and modulating p53‐dependent cell death, while in ovarian cancer cells, endogenous PEBP4 impedes TRAIL‐induced apoptosis by interacting with Raf-1/MEK1 and attenuating MAPK activation. Moreover, in B-cell lymphomas, overexpression of PEBP4 diminishes rituximab-mediated cytotoxicity, pointing to its role as an anti-apoptotic molecule."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "4"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its modulation of cell death, PEBP4 acts as a scaffold protein that orchestrates key signaling pathways involved in cell proliferation, differentiation, and metastasis. In myoblasts, for example, PEBP4 facilitates the formation of ternary complexes with RAF1 and MEK, thereby modulating ERK activation and promoting differentiation. In various carcinomas—including lung (NSCLC), breast, colorectal, pancreatic, and prostate cancers—overexpressed PEBP4 enhances cell proliferation, migration, invasion, and epithelial-to-mesenchymal transition (EMT) through activation of pathways such as Akt, Shh, and PI3K/Akt/mTOR. Furthermore, a secreted form of PEBP4 has been identified, and its processing (via glycosylation and signal peptide cleavage) appears to be essential for certain signaling effects, although it does not impact ERK activation. These mechanistic insights collectively suggest that PEBP4 facilitates tumor progression and metastasis."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "5", "end_ref": "14"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn addition to its intracellular activities, aberrant PEBP4 expression has emerged as a potential prognostic and diagnostic marker in diverse clinical settings. In gliomas, elevated PEBP4 levels not only correlate with high tumor grade and poor patient prognosis but also affect tumor cell proliferation, invasion, and apoptotic resistance. Similarly, increased PEBP4 expression has been observed in rectal cancer, endometrial carcinoma, and meningioma, with implications for treatment response and outcome. Its detection in body fluids further underscores its utility as a marker in kidney diseases such as IgA nephropathy and chronic kidney disease."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "15", "end_ref": "21"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nCollectively, these findings establish PEBP4 as a multifunctional protein that not only modulates critical intracellular signaling networks—affecting apoptosis, proliferation, and EMT—but also serves as an emerging biomarker for tumor progression and therapeutic responsiveness across a spectrum of malignancies and other pathological states.\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Peng Li, Xiaojian Wang, Nan Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Anti-apoptotic hPEBP4 silencing promotes TRAIL-induced apoptosis of human ovarian cancer cells by activating ERK and JNK pathways."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Mol Med (2006)"}]}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16865237"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16865237"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Guiping Yu, Ning Zhong, Guoqiang Chen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Downregulation of PEBP4, a target of miR-34a, sensitizes drug-resistant lung cancer cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Tumour Biol (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s13277-014-2284-3"}], "href": "https://doi.org/10.1007/s13277-014-2284-3"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25038915"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25038915"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Z Zhao, L Zhang, Q Yao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR-15b regulates cisplatin resistance and metastasis by targeting PEBP4 in human lung adenocarcinoma cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Gene Ther (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/cgt.2014.73"}], "href": "https://doi.org/10.1038/cgt.2014.73"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25721211"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25721211"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Kai Wang, Yu Jiang, Weiyan Zheng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Silencing of human phosphatidylethanolamine-binding protein 4 enhances rituximab-induced death and chemosensitization in B-cell lymphoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0056829"}], "href": "https://doi.org/10.1371/journal.pone.0056829"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23451095"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23451095"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Reynaldo Garcia, Joan Grindlay, Oliver Rath, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Regulation of human myoblast differentiation by PEBP4."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "EMBO Rep (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/embor.2009.4"}], "href": "https://doi.org/10.1038/embor.2009.4"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19197339"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19197339"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Gui-Ping Yu, Guo-Qiang Chen, Song Wu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The expression of PEBP4 protein in lung squamous cell carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Tumour Biol (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s13277-011-0230-1"}], "href": "https://doi.org/10.1007/s13277-011-0230-1"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21887552"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21887552"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Gui-Ping Yu, Bin Huang, Guo-Qiang Chen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "PEBP4 gene expression and its significance in invasion and metastasis of non-small cell lung cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Tumour Biol (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s13277-011-0265-3"}], "href": "https://doi.org/10.1007/s13277-011-0265-3"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22076923"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22076923"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Hongyi Liu, Qingling Kong, Bing Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Expression of PEBP4 protein correlates with the invasion and metastasis of colorectal cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Tumour Biol (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s13277-011-0279-x"}], "href": "https://doi.org/10.1007/s13277-011-0279-x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22125029"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22125029"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "H Li, F Huang, L Fan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Phosphatidylethanolamine-binding protein 4 is associated with breast cancer metastasis through Src-mediated Akt tyrosine phosphorylation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncogene (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/onc.2013.408"}], "href": "https://doi.org/10.1038/onc.2013.408"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24276246"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24276246"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Huan He, Dan Liu, Hui Lin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Phosphatidylethanolamine binding protein 4 (PEBP4) is a secreted protein and has multiple functions."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochim Biophys Acta (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbamcr.2016.03.022"}], "href": "https://doi.org/10.1016/j.bbamcr.2016.03.022"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27033522"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27033522"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Dexiang Zhang, Yuedi Dai, Yuankun Cai, et al. "}, {"type": "b", "children": [{"type": "t", "text": "PEBP4 promoted the growth and migration of cancer cells in pancreatic ductal adenocarcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Tumour Biol (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s13277-015-3906-0"}], "href": "https://doi.org/10.1007/s13277-015-3906-0"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26311050"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26311050"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Weiping Li, Yongchao Dong, Bin Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "PEBP4 silencing inhibits hypoxia-induced epithelial-to-mesenchymal transition in prostate cancer cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biomed Pharmacother (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.biopha.2016.03.030"}], "href": "https://doi.org/10.1016/j.biopha.2016.03.030"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27261570"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27261570"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Zijian Wu, Bin Liu, Xuemin Zheng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Role of the PEBP4 protein in the development and metastasis of gastric cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncotarget (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/oncotarget.15255"}], "href": "https://doi.org/10.18632/oncotarget.15255"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28193908"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28193908"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Wen Jian, Yinlan Bai, Xin Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Phosphatidylethanolamine-binding protein 4 promotes the epithelial-to-mesenchymal transition in non-small cell lung cancer cells by activating the sonic hedgehog signaling pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Biochem (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jcb.27817"}], "href": "https://doi.org/10.1002/jcb.27817"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30367510"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30367510"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Jianming Qiu, Guangen Yang, Zhong Shen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "hPEBP4 as a predictive marker for the pathological response of rectal cancer to preoperative radiotherapy."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Colorectal Dis (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s00384-012-1534-3"}], "href": "https://doi.org/10.1007/s00384-012-1534-3"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22801881"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22801881"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Ting Guo, Bin Li, Chao Gu "}, {"type": "b", "children": [{"type": "t", "text": "Expression of hPEBP4 negatively correlates with estrogen and progesterone receptors in endometrial carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J BUON (2013)"}]}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23818363"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23818363"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Ren-qiang Huang, Dong-liang Shi, Wei Huang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Increased expression of phosphatidylethanolamine-binding protein 4 (PEBP4) strongly associates with human gliomas grade."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Neurooncol (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s11060-015-2040-6"}], "href": "https://doi.org/10.1007/s11060-015-2040-6"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26725095"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26725095"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Ren-Qiang Huang, Song-Qing Wang, Qing-Bao Zhu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Knockdown of PEBP4 inhibits human glioma cell growth and invasive potential via ERK1/2 signaling pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Carcinog (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/mc.22915"}], "href": "https://doi.org/10.1002/mc.22915"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30255656"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30255656"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Scott Taylor, Kyriaki Pieri, Paolo Nanni, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Phosphatidylethanolamine binding protein-4 (PEBP4) is increased in IgA nephropathy and is associated with IgA-positive B-cells in affected kidneys."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Autoimmun (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.jaut.2019.102309"}], "href": "https://doi.org/10.1016/j.jaut.2019.102309"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31402200"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31402200"}]}, {"type": "r", "ref": 20, "children": [{"type": "t", "text": "Peipei He, Congli Zhou, Huajuan Shen "}, {"type": "b", "children": [{"type": "t", "text": "Diagnostic value of phosphatidylethanolamine binding protein 4 levels in patients receiving nursing interventions for advanced chronic kidney disease."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Int Med Res (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1177/0300060521996179"}], "href": "https://doi.org/10.1177/0300060521996179"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33752499"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33752499"}]}, {"type": "r", "ref": 21, "children": [{"type": "t", "text": "Ren-Qiang Huang, Feng Chen, Ying-Bo Jiang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Overexpression of phosphatidylethanolamine-binding protein 4 (PEBP4) associates with recurrence of meningiomas."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Clin Neurol Neurosurg (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.clineuro.2022.107148"}], "href": "https://doi.org/10.1016/j.clineuro.2022.107148"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35158167"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35158167"}]}]}]}
|
| Synonyms | HPEBP4, GWTM1933, CORK-1, PEBP-4, HEL-S-300, PRO4408, CORK1 |
| Proteins | PEBP4_HUMAN |
| NCBI Gene ID | 157310 |
| API | |
| Download Associations | |
| Predicted Functions |
 |
| Co-expressed Genes |
|
| Expression in Tissues and Cell Lines |
|
PEBP4 has 5,526 functional associations with biological entities spanning 9 categories (molecular profile, organism, functional term, phrase or reference, disease, phenotype or trait, chemical, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 91 datasets.
Click the + buttons to view associations for PEBP4 from the datasets below.
If available, associations are ranked by standardized value
| Dataset | Summary | |
|---|---|---|
| Achilles Cell Line Gene Essentiality Profiles | cell lines with fitness changed by PEBP4 gene knockdown relative to other cell lines from the Achilles Cell Line Gene Essentiality Profiles dataset. | |
| Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles | tissues with high or low expression of PEBP4 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset. | |
| Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles | tissues with high or low expression of PEBP4 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset. | |
| Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles | tissue samples with high or low expression of PEBP4 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset. | |
| Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray | tissue samples with high or low expression of PEBP4 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset. | |
| Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq | tissue samples with high or low expression of PEBP4 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset. | |
| Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles | tissues with high or low expression of PEBP4 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset. | |
| BioGPS Human Cell Type and Tissue Gene Expression Profiles | cell types and tissues with high or low expression of PEBP4 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset. | |
| CCLE Cell Line Gene CNV Profiles | cell lines with high or low copy number of PEBP4 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset. | |
| CCLE Cell Line Gene Expression Profiles | cell lines with high or low expression of PEBP4 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset. | |
| ChEA Transcription Factor Binding Site Profiles | transcription factor binding site profiles with transcription factor binding evidence at the promoter of PEBP4 gene from the CHEA Transcription Factor Binding Site Profiles dataset. | |
| ChEA Transcription Factor Targets | transcription factors binding the promoter of PEBP4 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset. | |
| ChEA Transcription Factor Targets 2022 | transcription factors binding the promoter of PEBP4 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset. | |
| CM4AI KOLF21J CRISPRi Gene Perturbation Atlas | gene perturbations changing expression of PEBP4 gene from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas dataset. | |
| COMPARTMENTS Curated Protein Localization Evidence Scores | cellular components containing PEBP4 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset. | |
| COMPARTMENTS Text-mining Protein Localization Evidence Scores | cellular components co-occuring with PEBP4 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset. | |
| COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 | cellular components co-occuring with PEBP4 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset. | |
| COSMIC Cell Line Gene CNV Profiles | cell lines with high or low copy number of PEBP4 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset. | |
| COSMIC Cell Line Gene Mutation Profiles | cell lines with PEBP4 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset. | |
| dbGAP Gene-Trait Associations | traits associated with PEBP4 gene in GWAS and other genetic association datasets from the dbGAP Gene-Trait Associations dataset. | |
| DepMap CRISPR Gene Dependency | cell lines with fitness changed by PEBP4 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset. | |
| DGIdb Drug Targets 2026 | interacting drugs for PEBP4 protein from the DGIdb Drug Targets 2026 dataset. | |
| DISEASES Experimental Gene-Disease Association Evidence Scores | diseases associated with PEBP4 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores dataset. | |
| DISEASES Experimental Gene-Disease Association Evidence Scores 2025 | diseases associated with PEBP4 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset. | |
| DISEASES Text-mining Gene-Disease Association Evidence Scores | diseases co-occuring with PEBP4 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset. | |
| DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 | diseases co-occuring with PEBP4 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset. | |
| DisGeNET Gene-Disease Associations | diseases associated with PEBP4 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset. | |
| DisGeNET Gene-Phenotype Associations | phenotypes associated with PEBP4 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset. | |
| ENCODE Histone Modification Site Profiles | histone modification site profiles with high histone modification abundance at PEBP4 gene from the ENCODE Histone Modification Site Profiles dataset. | |
| ENCODE Transcription Factor Binding Site Profiles | transcription factor binding site profiles with transcription factor binding evidence at the promoter of PEBP4 gene from the ENCODE Transcription Factor Binding Site Profiles dataset. | |
| ENCODE Transcription Factor Targets | transcription factors binding the promoter of PEBP4 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset. | |
| GAD Gene-Disease Associations | diseases associated with PEBP4 gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset. | |
| GeneRIF Biological Term Annotations | biological terms co-occuring with PEBP4 gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset. | |
| GeneSigDB Published Gene Signatures | PubMedIDs of publications reporting gene signatures containing PEBP4 from the GeneSigDB Published Gene Signatures dataset. | |
| GEO Signatures of Differentially Expressed Genes for Diseases | disease perturbations changing expression of PEBP4 gene from the GEO Signatures of Differentially Expressed Genes for Diseases dataset. | |
| GEO Signatures of Differentially Expressed Genes for Gene Perturbations | gene perturbations changing expression of PEBP4 gene from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset. | |
| GEO Signatures of Differentially Expressed Genes for Kinase Perturbations | kinase perturbations changing expression of PEBP4 gene from the GEO Signatures of Differentially Expressed Genes for Kinase Perturbations dataset. | |
| GEO Signatures of Differentially Expressed Genes for Small Molecules | small molecule perturbations changing expression of PEBP4 gene from the GEO Signatures of Differentially Expressed Genes for Small Molecules dataset. | |
| GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations | transcription factor perturbations changing expression of PEBP4 gene from the GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations dataset. | |
| GEO Signatures of Differentially Expressed Genes for Viral Infections | virus perturbations changing expression of PEBP4 gene from the GEO Signatures of Differentially Expressed Genes for Viral Infections dataset. | |
| GO Cellular Component Annotations 2015 | cellular components containing PEBP4 protein from the curated GO Cellular Component Annotations 2015 dataset. | |
| GO Molecular Function Annotations 2015 | molecular functions performed by PEBP4 gene from the curated GO Molecular Function Annotations 2015 dataset. | |
| GTEx eQTL 2025 | SNPs regulating expression of PEBP4 gene from the GTEx eQTL 2025 dataset. | |
| GTEx Tissue Gene Expression Profiles | tissues with high or low expression of PEBP4 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles dataset. | |
| GTEx Tissue Gene Expression Profiles 2023 | tissues with high or low expression of PEBP4 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles 2023 dataset. | |
| GTEx Tissue Sample Gene Expression Profiles | tissue samples with high or low expression of PEBP4 gene relative to other tissue samples from the GTEx Tissue Sample Gene Expression Profiles dataset. | |
| GTEx Tissue-Specific Aging Signatures | tissue samples with high or low expression of PEBP4 gene relative to other tissue samples from the GTEx Tissue-Specific Aging Signatures dataset. | |
| GWAS Catalog SNP-Phenotype Associations | phenotypes associated with PEBP4 gene in GWAS datasets from the GWAS Catalog SNP-Phenotype Associations dataset. | |
| GWAS Catalog SNP-Phenotype Associations 2025 | phenotypes associated with PEBP4 gene in GWAS datasets from the GWAS Catalog SNP-Phenotype Associations 2025 dataset. | |
| GWASdb SNP-Disease Associations | diseases associated with PEBP4 gene in GWAS and other genetic association datasets from the GWASdb SNP-Disease Associations dataset. | |
| GWASdb SNP-Phenotype Associations | phenotypes associated with PEBP4 gene in GWAS datasets from the GWASdb SNP-Phenotype Associations dataset. | |
| HMDB Metabolites of Enzymes | interacting metabolites for PEBP4 protein from the curated HMDB Metabolites of Enzymes dataset. | |
| HPA Tissue Gene Expression Profiles | tissues with high or low expression of PEBP4 gene relative to other tissues from the HPA Tissue Gene Expression Profiles dataset. | |
| HPA Tissue Protein Expression Profiles | tissues with high or low expression of PEBP4 protein relative to other tissues from the HPA Tissue Protein Expression Profiles dataset. | |
| HPA Tissue Sample Gene Expression Profiles | tissue samples with high or low expression of PEBP4 gene relative to other tissue samples from the HPA Tissue Sample Gene Expression Profiles dataset. | |
| Hub Proteins Protein-Protein Interactions | interacting hub proteins for PEBP4 from the curated Hub Proteins Protein-Protein Interactions dataset. | |
| HuBMAP Azimuth Cell Type Annotations | cell types associated with PEBP4 gene from the HuBMAP Azimuth Cell Type Annotations dataset. | |
| HuGE Navigator Gene-Phenotype Associations | phenotypes associated with PEBP4 gene by text-mining GWAS publications from the HuGE Navigator Gene-Phenotype Associations dataset. | |
| InterPro Predicted Protein Domain Annotations | protein domains predicted for PEBP4 protein from the InterPro Predicted Protein Domain Annotations dataset. | |
| JASPAR Predicted Human Transcription Factor Targets 2025 | transcription factors regulating expression of PEBP4 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Human Transcription Factor Targets dataset. | |
| JASPAR Predicted Mouse Transcription Factor Targets 2025 | transcription factors regulating expression of PEBP4 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Mouse Transcription Factor Targets 2025 dataset. | |
| JASPAR Predicted Transcription Factor Targets | transcription factors regulating expression of PEBP4 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset. | |
| Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles | cell lines with high or low copy number of PEBP4 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset. | |
| KnockTF Gene Expression Profiles with Transcription Factor Perturbations | transcription factor perturbations changing expression of PEBP4 gene from the KnockTF Gene Expression Profiles with Transcription Factor Perturbations dataset. | |
| LOCATE Curated Protein Localization Annotations | cellular components containing PEBP4 protein in low- or high-throughput protein localization assays from the LOCATE Curated Protein Localization Annotations dataset. | |
| LOCATE Predicted Protein Localization Annotations | cellular components predicted to contain PEBP4 protein from the LOCATE Predicted Protein Localization Annotations dataset. | |
| MiRTarBase microRNA Targets | microRNAs targeting PEBP4 gene in low- or high-throughput microRNA targeting studies from the MiRTarBase microRNA Targets dataset. | |
| MotifMap Predicted Transcription Factor Targets | transcription factors regulating expression of PEBP4 gene predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset. | |
| NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles | drug perturbations changing expression of PEBP4 gene from the NIBR DRUG-seq U2OS MoA Box dataset. | |
| PANTHER Pathways | pathways involving PEBP4 protein from the PANTHER Pathways dataset. | |
| Pathway Commons Protein-Protein Interactions | interacting proteins for PEBP4 from the Pathway Commons Protein-Protein Interactions dataset. | |
| PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations | gene perturbations changing expression of PEBP4 gene from the PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations dataset. | |
| PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations | gene perturbations changing expression of PEBP4 gene from the PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations dataset. | |
| PFOCR Pathway Figure Associations 2023 | pathways involving PEBP4 protein from the PFOCR Pathway Figure Associations 2023 dataset. | |
| PFOCR Pathway Figure Associations 2024 | pathways involving PEBP4 protein from the Wikipathways PFOCR 2024 dataset. | |
| Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles | cell types and tissues with high or low DNA methylation of PEBP4 gene relative to other cell types and tissues from the Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles dataset. | |
| Roadmap Epigenomics Cell and Tissue Gene Expression Profiles | cell types and tissues with high or low expression of PEBP4 gene relative to other cell types and tissues from the Roadmap Epigenomics Cell and Tissue Gene Expression Profiles dataset. | |
| Roadmap Epigenomics Histone Modification Site Profiles | histone modification site profiles with high histone modification abundance at PEBP4 gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset. | |
| Rummagene Transcription Factor Associations 2026 | transcription factors regulating expression of PEBP4 gene from the Rummagene Transcription Factor Associations 2026 dataset. | |
| RummaGEO Drug Perturbation Signatures | drug perturbations changing expression of PEBP4 gene from the RummaGEO Drug Perturbation Signatures dataset. | |
| RummaGEO Gene Perturbation Signatures | gene perturbations changing expression of PEBP4 gene from the RummaGEO Gene Perturbation Signatures dataset. | |
| Tabula Sapiens Gene-Cell Associations | cell types with high or low expression of PEBP4 gene relative to other cell types from the Tabula Sapiens Gene-Cell Associations dataset. | |
| TargetScan Predicted Conserved microRNA Targets | microRNAs regulating expression of PEBP4 gene predicted using conserved miRNA seed sequences from the TargetScan Predicted Conserved microRNA Targets dataset. | |
| TargetScan Predicted Nonconserved microRNA Targets | microRNAs regulating expression of PEBP4 gene predicted using nonconserved miRNA seed sequences from the TargetScan Predicted Nonconserved microRNA Targets dataset. | |
| TCGA Signatures of Differentially Expressed Genes for Tumors | tissue samples with high or low expression of PEBP4 gene relative to other tissue samples from the TCGA Signatures of Differentially Expressed Genes for Tumors dataset. | |
| TISSUES Curated Tissue Protein Expression Evidence Scores | tissues with high expression of PEBP4 protein from the TISSUES Curated Tissue Protein Expression Evidence Scores dataset. | |
| TISSUES Curated Tissue Protein Expression Evidence Scores 2025 | tissues with high expression of PEBP4 protein from the TISSUES Curated Tissue Protein Expression Evidence Scores 2025 dataset. | |
| TISSUES Experimental Tissue Protein Expression Evidence Scores | tissues with high expression of PEBP4 protein in proteomics datasets from the TISSUES Experimental Tissue Protein Expression Evidence Scores dataset. | |
| TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 | tissues with high expression of PEBP4 protein in proteomics datasets from the TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 dataset. | |
| TISSUES Text-mining Tissue Protein Expression Evidence Scores | tissues co-occuring with PEBP4 protein in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores dataset. | |
| TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 | tissues co-occuring with PEBP4 protein in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 dataset. | |
