{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRecent studies have identified the long noncoding RNA LINC01272 as an important regulator in inflammatory conditions. Initially, its dysregulation was noted in inflammatory bowel disease and pediatric Crohn’s disease, suggesting diagnostic potential in these disorders. This emerging evidence led to the re‐designation of LINC01272 as “PELATON” (plaque enriched long noncoding RNA in atherosclerotic and inflammatory bowel macrophage regulation), highlighting its possible role in inflammatory pathways."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn the context of atherosclerosis, PELATON has been shown to be highly specific to monocytes and macrophages and is predominantly localized in the nucleus. It is enriched in inflamed regions of atherosclerotic plaques—colocalizing with macrophages—and functionally contributes to key cellular processes such as phagocytosis, lipid uptake, and reactive oxygen species production. Mechanistic studies further revealed that knockdown of PELATON significantly reduces these macrophage activities, in part by diminishing the expression of the oxLDL receptor CD36."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nComplementary investigations into competitive endogenous RNA networks in inflammatory conditions such as endometriosis have underscored the broader impact of long noncoding RNAs in modulating immune responses. Although not exclusively focused on PELATON, these studies lend support to the concept that similar transcripts exert regulatory control over inflammatory pathways, reinforcing the significance of PELATON in disease contexts."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nFurther extending its impact, research in oncologic and cardiovascular settings has implicated PELATON (in its original designation as LINC01272) in diverse cellular functions. In lung cancer models, for instance, PELATON modulates cell viability, proliferation, and apoptosis via the miR-7-5p/CRLS1 axis. In parallel, clinical studies in acute coronary syndromes have found elevated serum levels of PELATON to correlate with increased markers of myocardial injury and inflammation, ultimately associating with a poorer prognosis. Additionally, in colorectal cancer, concurrent upregulation of PELATON with key mediators of the TGF-β pathway (e.g. INHBA) emphasizes its potential utility as both a diagnostic and prognostic biomarker."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "5", "end_ref": "7"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Sen Wang, Yong Hou, Weiping Chen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "KIF9‑AS1, LINC01272 and DIO3OS lncRNAs as novel biomarkers for inflammatory bowel disease."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Med Rep (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/mmr.2017.8118"}], "href": "https://doi.org/10.3892/mmr.2017.8118"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29207070"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29207070"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Yael Haberman, Marina BenShoshan, Ayelet Di Segni, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long ncRNA Landscape in the Ileum of Treatment-Naive Early-Onset Crohn Disease."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Inflamm Bowel Dis (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/ibd/izx013"}], "href": "https://doi.org/10.1093/ibd/izx013"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29361088"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29361088"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "John Hung, Jessica P Scanlon, Amira D Mahmoud, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Novel Plaque Enriched Long Noncoding RNA in Atherosclerotic Macrophage Regulation (PELATON)."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Arterioscler Thromb Vasc Biol (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1161/ATVBAHA.119.313430"}], "href": "https://doi.org/10.1161/ATVBAHA.119.313430"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31826651"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31826651"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Li Jiang, Mengmeng Zhang, Sixue Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LINC01018 and SMIM25 sponged miR-182-5p in endometriosis revealed by the ceRNA network construction."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Immunopathol Pharmacol (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1177/2058738420976309"}], "href": "https://doi.org/10.1177/2058738420976309"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33237828"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33237828"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Xuan Ma, Yang Liu, Hao Tian, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LINC01272 Suppressed Cell Multiplication and Induced Apoptosis Via Regulating MiR-7-5p/CRLS1 Axis in Lung Cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Microbiol Biotechnol (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4014/jmb.2102.02010"}], "href": "https://doi.org/10.4014/jmb.2102.02010"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34099597"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34099597"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Linmu Chen, Yunxiu Huang "}, {"type": "b", "children": [{"type": "t", "text": "High expression of lncRNA PELATON serves as a risk factor for the incidence and prognosis of acute coronary syndrome."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41598-022-11260-2"}], "href": "https://doi.org/10.1038/s41598-022-11260-2"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35577857"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35577857"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Maryam Abutalebi, Dabing Li, Waqar Ahmad, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Discovery of PELATON links to the INHBA gene in the TGF-β pathway in colorectal cancer using a combination of bioinformatics and experimental investigations."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Biol Macromol (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ijbiomac.2024.132239"}], "href": "https://doi.org/10.1016/j.ijbiomac.2024.132239"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "38735606"}], "href": "https://pubmed.ncbi.nlm.nih.gov/38735606"}]}]}]}