PES1 Gene

Name	pescadillo ribosomal biogenesis factor 1
Description	This gene encodes a nuclear protein that contains a breast cancer associated gene 1 (BRCA1) C-terminal interaction domain. The encoded protein interacts with BOP1 and WDR12 to form the PeBoW complex, which plays a critical role in cell proliferation via pre-rRNA processing and 60S ribosomal subunit maturation. Expression of this gene may play an important role in breast cancer proliferation and tumorigenicity. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. Pseudogenes of this gene are located on the long arm of chromosome 4 and the short arm of chromosome 9. [provided by RefSeq, Aug 2011]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nPescadillo (PES1) is a nucleolar protein that plays a central role in ribosome biogenesis by forming part of the PeBoW complex together with BOP1 and WDR12. This complex is essential for processing precursor ribosomal RNA (rRNA) and for proper 60S ribosomal subunit maturation, thereby supporting cell cycle progression and proliferation. Furthermore, PES1 is evolutionarily conserved in its function, as studies in both yeast and mammalian systems have demonstrated its critical involvement in DNA replication and S phase entry, highlighting its importance in maintaining cellular homeostasis."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "4"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn the context of cancer biology, PES1 acts as a potent oncogene whose overexpression has been reported in a wide spectrum of malignancies, including breast, ovarian, colon, gastric, hepatocellular, and pancreatic cancers. Elevated PES1 levels have been shown to enhance oncogenic phenotypes by modulating key cell cycle regulators—such as cyclin D1 and p27—and by rebalancing estrogen receptor (ER) activities, notably promoting ERα while suppressing ERβ, thus favoring tumor growth and progression. Moreover, PES1 contributes to telomerase assembly by directly interacting with TERT and the telomerase RNA component, which supports telomere maintenance and inhibits cellular senescence. These findings, together with evidence that PES1 sustains cancer stem cell traits in liver tumors, underscore its multifaceted role in promoting proliferation, invasion, and chemoresistance."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "5", "end_ref": "14"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its direct roles in ribosome production and tumor cell proliferation, PES1 is subject to sophisticated regulatory mechanisms that fine-tune its function. It interacts with the nucleolar hub protein B23 to ensure proper subcellular localization and partners with additional factors—such as the DEAD-box helicase DDX27—to aid in rRNA processing. Posttranslational modifications, including SUMOylation at a critical lysine residue, stabilize PES1 by inhibiting its ubiquitination and thereby enhance its capacity to modulate estrogen signaling and cell cycle transitions. Furthermore, depletion of PES1 has been linked to impaired DNA damage repair and increased sensitivity to chemotherapeutic agents, implicating it in the regulation of genomic integrity and chemoresistance."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "15", "end_ref": "18"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nRecent investigations have further expanded the oncogenic spectrum of PES1, implicating it in the pathogenesis of diverse tumor types beyond those initially described. Elevated levels of PES1 have been observed in prostate and head and neck squamous cell carcinomas, where they correlate with aggressive tumor behavior and poor prognosis. In addition, studies in obese models suggest that hepatic overexpression of PES1 disrupts lipid homeostasis through the inhibition of autophagy, thereby linking metabolic dysregulation with tumorigenesis. These findings collectively support the candidacy of PES1 as a promising molecular target for therapeutic intervention across a broad range of cancer types."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "19", "end_ref": "22"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Arianna Maiorana, Xiao Tu, Guanjun Cheng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Role of pescadillo in the transformation and immortalization of mammalian cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncogene (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/sj.onc.1207916"}], "href": "https://doi.org/10.1038/sj.onc.1207916"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15273728"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15273728"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Audrey Killian, Nathalie Le Meur, Richard Sesboüé, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Inactivation of the RRB1-Pescadillo pathway involved in ribosome biogenesis induces chromosomal instability."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncogene (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/sj.onc.1207845"}], "href": "https://doi.org/10.1038/sj.onc.1207845"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15467761"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15467761"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Michael Hölzel, Michaela Rohrmoser, Martin Schlee, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Mammalian WDR12 is a novel member of the Pes1-Bop1 complex and is required for ribosome biogenesis and cell proliferation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Biol (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1083/jcb.200501141"}], "href": "https://doi.org/10.1083/jcb.200501141"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16043514"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16043514"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Michaela Rohrmoser, Michael Hölzel, Thomas Grimm, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Interdependence of Pes1, Bop1, and WDR12 controls nucleolar localization and assembly of the PeBoW complex required for maturation of the 60S ribosomal subunit."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Biol (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/MCB.00172-07"}], "href": "https://doi.org/10.1128/MCB.00172-07"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17353269"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17353269"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Jun Li, Liang Yu, Huizhong Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Down-regulation of pescadillo inhibits proliferation and tumorigenicity of breast cancer cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Sci (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/j.1349-7006.2009.01325.x"}], "href": "https://doi.org/10.1111/j.1349-7006.2009.01325.x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19764998"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19764998"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Long Cheng, Jieping Li, Yongjian Han, et al. "}, {"type": "b", "children": [{"type": "t", "text": "PES1 promotes breast cancer by differentially regulating ERα and ERβ."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Clin Invest (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1172/JCI62676"}], "href": "https://doi.org/10.1172/JCI62676"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22820289"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22820289"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Wei Xie, Qin Feng, Yahui Su, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Transcriptional regulation of PES1 expression by c-Jun in colon cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0042253"}], "href": "https://doi.org/10.1371/journal.pone.0042253"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22860098"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22860098"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Jieping Li, Qinren Zhuang, Xiaopeng Lan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "PES1 differentially regulates the expression of ERα and ERβ in ovarian cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "IUBMB Life (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/iub.1228"}], "href": "https://doi.org/10.1002/iub.1228"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24376209"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24376209"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Jieping Li, Xiaodong Zhou, Xiaopeng Lan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Repression of PES1 expression inhibits growth of gastric cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Tumour Biol (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s13277-015-4069-8"}], "href": "https://doi.org/10.1007/s13277-015-4069-8"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26423399"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26423399"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Ping Fan, Bo Wang, Zibo Meng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "PES1 is transcriptionally regulated by BRD4 and promotes cell proliferation and glycolysis in hepatocellular carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Biochem Cell Biol (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.biocel.2018.08.014"}], "href": "https://doi.org/10.1016/j.biocel.2018.08.014"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30172011"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30172011"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Yi-Bo Qiu, Ling-Yao Liao, Rong Jiang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "PES1 promotes the occurrence and development of papillary thyroid cancer by upregulating the ERα/ERβ protein ratio."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41598-018-37648-7"}], "href": "https://doi.org/10.1038/s41598-018-37648-7"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30705367"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30705367"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Long Cheng, Bin Yuan, Sunyang Ying, et al. "}, {"type": "b", "children": [{"type": "t", "text": "PES1 is a critical component of telomerase assembly and regulates cellular senescence."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Adv (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1126/sciadv.aav1090"}], "href": "https://doi.org/10.1126/sciadv.aav1090"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31106266"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31106266"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Shiruo Wei, Kaiyu Liu, Qihua He, et al. "}, {"type": "b", "children": [{"type": "t", "text": "PES1 is regulated by CD44 in liver cancer stem cells via miR-105-5p."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "FEBS Lett (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/1873-3468.13459"}], "href": "https://doi.org/10.1002/1873-3468.13459"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31127852"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31127852"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Xin Jin, Rui Fang, Ping Fan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "PES1 promotes BET inhibitors resistance and cells proliferation through increasing c-Myc expression in pancreatic cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Exp Clin Cancer Res (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s13046-019-1466-7"}], "href": "https://doi.org/10.1186/s13046-019-1466-7"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31718704"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31718704"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Jianhua Zhang, Ying Yang, Jiarui Wu "}, {"type": "b", "children": [{"type": "t", "text": "B23 interacts with PES1 and is involved in nucleolar localization of PES1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Acta Biochim Biophys Sin (Shanghai) (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/abbs/gmp096"}], "href": "https://doi.org/10.1093/abbs/gmp096"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20011973"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20011973"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Wei Xie, Like Qu, Lin Meng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "PES1 regulates sensitivity of colorectal cancer cells to anticancer drugs."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2012.12.145"}], "href": "https://doi.org/10.1016/j.bbrc.2012.12.145"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23333390"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23333390"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Markus Kellner, Michaela Rohrmoser, Ignasi Forné, et al. "}, {"type": "b", "children": [{"type": "t", "text": "DEAD-box helicase DDX27 regulates 3' end formation of ribosomal 47S RNA and stably associates with the PeBoW-complex."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Exp Cell Res (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.yexcr.2015.03.017"}], "href": "https://doi.org/10.1016/j.yexcr.2015.03.017"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25825154"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25825154"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Shujing Li, Miao Wang, Xinjian Qu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "SUMOylation of PES1 upregulates its stability and function via inhibiting its ubiquitination."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncotarget (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/oncotarget.10494"}], "href": "https://doi.org/10.18632/oncotarget.10494"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27409667"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27409667"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Zhenming Jiang, Yuxi Zhang, Xi Chen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "microRNA-1271 impedes the development of prostate cancer by downregulating PES1 and upregulating ERβ."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Transl Med (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12967-020-02349-1"}], "href": "https://doi.org/10.1186/s12967-020-02349-1"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32448371"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32448371"}]}, {"type": "r", "ref": 20, "children": [{"type": "t", "text": "Dapeng Li, Changyu Yao, Zhao Ding, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Pescadillo ribosomal biogenesis factor 1 reduction suppresses tumour growth and renders chemosensitivity of head and neck squamous cell carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Med (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/cam4.5315"}], "href": "https://doi.org/10.1002/cam4.5315"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36217758"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36217758"}]}, {"type": "r", "ref": 21, "children": [{"type": "t", "text": "Jielin Zhou, Yao Lu, Yan Lin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Overexpression of hepatic pescadillo 1 in obesity induces lipid dysregulation by inhibiting autophagy."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Transl Res (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.trsl.2023.02.003"}], "href": "https://doi.org/10.1016/j.trsl.2023.02.003"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36775058"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36775058"}]}, {"type": "r", "ref": 22, "children": [{"type": "t", "text": "Yaodong He, Junwei Xiang, Yunshan Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "PES1 is a biomarker of head and neck squamous cell carcinoma and is associated with the tumor microenvironment."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Med (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/cam4.5948"}], "href": "https://doi.org/10.1002/cam4.5948"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "37076985"}], "href": "https://pubmed.ncbi.nlm.nih.gov/37076985"}]}]}]}
Synonyms	NOP7, PES
Proteins	PESC_HUMAN
NCBI Gene ID	23481
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

PES1 has 7,912 functional associations with biological entities spanning 9 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 120 datasets.

Click the + buttons to view associations for PES1 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

PES1 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of PES1 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of PES1 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of PES1 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of PES1 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of PES1 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of PES1 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of PES1 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of PES1 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of PES1 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of PES1 gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of PES1 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of PES1 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with PES1 protein from the CCLE Cell Line Proteomics dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of PES1 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of PES1 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of PES1 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	gene perturbations changing expression of PES1 gene from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas dataset.
	CM4AI U2OS Cell Map Protein Localization Assemblies	assemblies containing PES1 protein from integrated AP-MS and IF data from the CM4AI U2OS Cell Map Protein Localization Assemblies dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of PES1 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing PES1 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing PES1 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores	cellular components containing PES1 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	cellular components containing PES1 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with PES1 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with PES1 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	CORUM Protein Complexes	protein complexs containing PES1 protein from the CORUM Protein Complexes dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of PES1 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with PES1 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Disease Associations	diseases associated with PES1 gene/protein from the curated CTD Gene-Disease Associations dataset.
	DeepCoverMOA Drug Mechanisms of Action	small molecule perturbations with high or low expression of PES1 protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with PES1 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with PES1 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with PES1 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with PES1 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with PES1 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at PES1 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of PES1 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of PES1 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing PES1 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GDSC Cell Line Gene Expression Profiles	cell lines with high or low expression of PES1 gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset.