{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRecent investigations have identified Homo sapiens PGM5 antisense RNA 1 (PGM5‐AS1) as a novel long non‐coding RNA that functions as a tumor suppressor in esophageal squamous cell carcinoma (ESCC). PGM5‐AS1 is markedly downregulated in ESCC tissues, plasma, and cell lines; its low expression correlates with poor differentiation, advanced tumor node metastasis stage, and lymph node metastasis. Functional experiments demonstrated that restoration of PGM5‐AS1 significantly suppresses cell proliferation, migration, and invasion in vitro, as well as tumor growth in vivo. Mechanistically, PGM5‐AS1 is transcriptionally activated by p53 and exerts its tumor‐suppressive effects by directly binding to and sequestering miR‐466, which in turn elevates PTEN expression and thereby inhibits ESCC progression. These findings suggest that PGM5‐AS1 not only serves as an effective diagnostic and prognostic biomarker for ESCC but also represents a promising therapeutic target for the treatment of this malignancy."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Zhao Zhihua, Wang Weiwei, Niu Lihua, et al. "}, {"type": "b", "children": [{"type": "t", "text": "p53-induced long non-coding RNA PGM5-AS1 inhibits the progression of esophageal squamous cell carcinoma through regulating miR-466/PTEN axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "IUBMB Life (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/iub.2069"}], "href": "https://doi.org/10.1002/iub.2069"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31185143"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31185143"}]}]}]}