{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRecent studies have demonstrated that the long non‐coding RNA (lncRNA) PGM5P3‐AS1 is significantly down‐regulated in triple‐negative breast cancer (TNBC) cells. Experimental investigations suggest that this lncRNA may serve as a tumor suppressor in TNBC by promoting cell ferroptosis—a regulated form of cell death that TNBC cells are particularly sensitive to. These findings indicate that restoring or enhancing PGM5P3‐AS1 expression could inhibit TNBC progression through the induction of ferroptosis, thereby offering a new potential strategy for therapeutic intervention against this aggressive breast cancer subtype."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn a related exploration of lncRNAs in breast cancer, another study characterized lncRNA AY343892, which is also markedly down‐regulated in breast cancer tissues and cells. Overexpression of AY343892 was shown to inhibit cell proliferation and induce apoptosis through a mechanism that involves the upregulation of tumor suppressors BRCA1 and PTEN. This complementary evidence underscores the broader significance of lncRNAs in the pathogenesis and progression of breast cancer, suggesting that these non-coding transcripts may function through diverse pathways, including regulation of cell death modalities such as ferroptosis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Liqiang Qi, Bo Sun, Beibei Yang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "PGM5P3-AS1 regulates MAP1LC3C to promote cell ferroptosis and thus inhibiting the malignant progression of triple-negative breast cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Breast Cancer Res Treat (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s10549-021-06501-3"}], "href": "https://doi.org/10.1007/s10549-021-06501-3"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35325342"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35325342"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Yan Li, Miao Zhang, Fan Li "}, {"type": "b", "children": [{"type": "t", "text": "LncRNA AY343892 inhibits breast cancer development by positively regulating BRCA1-mediated transcription of PTEN."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Histol Histopathol (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.14670/HH-18-245"}], "href": "https://doi.org/10.14670/HH-18-245"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32754899"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32754899"}]}]}]}