PHF10 Gene

HGNC Family	Zinc fingers
Name	PHD finger protein 10
Description	This gene contains a predicted ORF that encodes a protein with two zinc finger domains. The function of the encoded protein is not known. Sequence analysis suggests that multiple alternatively spliced transcript variants are derived from this gene but the full-length nature of only two of them is known. These two splice variants encode different isoforms. A pseudogene for this gene is located on Xq28. [provided by RefSeq, Jul 2008]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nPHF10 is an essential subunit of the PBAF chromatin‐remodeling complex that plays a pivotal role in regulating gene transcription. It is expressed as multiple evolutionarily conserved isoforms that are incorporated into PBAF in a mutually exclusive manner. These isoforms differ in their C‐terminal domains – one group harbors tandem PHD fingers while the other contains a phosphorylation‐dependent SUMO1 conjugation motif – and this structural variation enables them to modulate promoter recruitment of RNA polymerase II and influence transcription outcomes in a context‐dependent manner, including roles in brain development and c‐MYC–dependent cell proliferation."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "3"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nThe balance of PHF10 protein levels is tightly controlled through post‐translational mechanisms. PHF10 isoforms undergo extensive phosphorylation that is cell type–dependent, and these modifications regulate their stability via non‐canonical degradation signals. In particular, phosphorylation events mediated by CK‐1 can stabilize certain PHF10 isoforms by preventing their recognition and degradation by the β‐TrCP ubiquitin ligase complex. Detailed mapping of phosphorylated serine clusters (the “X‐cluster”) in PHF10 lacking PHD domains has shed light on how such phosphorylation events modulate its half‐life and, consequently, the incorporation of PHF10 into functional PBAF complexes."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "4", "end_ref": "6"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its classical roles in chromatin remodeling and transcription regulation, PHF10 has emerged as a key mediator of cellular proliferation and genomic maintenance. In transformed human fibroblasts, proper PHF10 function is essential for cell growth, with both its overexpression in truncated forms and its knockdown leading to impaired proliferation. In various cancer contexts, including gastric cancer and melanoma, PHF10 supports tumor cell proliferation by acting as a transcriptional repressor of apoptotic mediators like caspase‐3 and by cooperating with oncogenes such as MYC. In addition, recent work reveals a novel function for PHF10 in the DNA damage response where its loss‐of‐function heightens the recruitment of damage markers (γH2AX, RAD51, 53BP1) at double‐strand break sites and diminishes homologous recombination repair efficiency. Furthermore, expression of PHF10 correlates with that of metastasis‐associated genes such as S100A4, underscoring its multifaceted role in cancer biology."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "7", "end_ref": "11"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Alexander V Brechalov, Sofia G Georgieva, Nataliya V Soshnikova "}, {"type": "b", "children": [{"type": "t", "text": "Mammalian cells contain two functionally distinct PBAF complexes incorporating different isoforms of PHF10 signature subunit."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Cycle (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4161/cc.28922"}], "href": "https://doi.org/10.4161/cc.28922"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24763304"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24763304"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Eu V Tatarskiy, G P Georgiev, N V Soshnikova "}, {"type": "b", "children": [{"type": "t", "text": "Oncogene c-MYC Controls the Expression of PHF10 Subunit of PBAF Chromatin Remodeling Complex in SW620 Cell Line."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Dokl Biochem Biophys (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1134/S1607672919010204"}], "href": "https://doi.org/10.1134/S1607672919010204"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31012017"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31012017"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "D O Bayramova, A M Azieva, A V Feoktistov, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Neuronal and Muscle Differentiation of Mammalian Cells Is Accompanied by a Change in PHF10 Isoform Expression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Dokl Biochem Biophys (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1134/S1607672923700643"}], "href": "https://doi.org/10.1134/S1607672923700643"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "38189889"}], "href": "https://pubmed.ncbi.nlm.nih.gov/38189889"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "A V Brechalov, M E Valieva, S G Georgieva, et al. "}, {"type": "b", "children": [{"type": "t", "text": "[PHF10 isoforms are phosphorylated in the PBAF mammalian chromatin remodeling complex]."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Biol (Mosk) (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.7868/S0026898416010031"}], "href": "https://doi.org/10.7868/S0026898416010031"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27239853"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27239853"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Victor V Tatarskiy, Yuriy P Simonov, Dmitrii S Shcherbinin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Stability of the PHF10 subunit of PBAF signature module is regulated by phosphorylation: role of β-TrCP."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41598-017-05944-3"}], "href": "https://doi.org/10.1038/s41598-017-05944-3"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28717195"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28717195"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Andrey A Sheynov, Victor V Tatarskiy, Eugene V Tatarskiy, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The sequential phosphorylation of PHF10 subunit of the PBAF chromatin-remodeling complex determines different properties of the PHF10 isoforms."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biol Open (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1242/bio.043943"}], "href": "https://doi.org/10.1242/bio.043943"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31911482"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31911482"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "S S Banga, L Peng, T Dasgupta, et al. "}, {"type": "b", "children": [{"type": "t", "text": "PHF10 is required for cell proliferation in normal and SV40-immortalized human fibroblast cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cytogenet Genome Res (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1159/000251960"}], "href": "https://doi.org/10.1159/000251960"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20068294"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20068294"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Min Wei, Bingya Liu, Liping Su, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A novel plant homeodomain finger 10-mediated antiapoptotic mechanism involving repression of caspase-3 in gastric cancer cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cancer Ther (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/1535-7163.MCT-09-1162"}], "href": "https://doi.org/10.1158/1535-7163.MCT-09-1162"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20530714"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20530714"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "N V Soshnikova, Yu P Simonov, A V Brechalov, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The level of the Phf10 protein, a PBAF chromatin-remodeling complex subunit, correlates with the Mts1/S100A4 expression in human cancer cell lines."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Dokl Biochem Biophys (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1134/S1607672916020228"}], "href": "https://doi.org/10.1134/S1607672916020228"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27193724"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27193724"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "N V Soshnikova, E V Tatarskiy, V V Tatarskiy, et al. "}, {"type": "b", "children": [{"type": "t", "text": "PHF10 subunit of PBAF complex mediates transcriptional activation by MYC."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncogene (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41388-021-01994-0"}], "href": "https://doi.org/10.1038/s41388-021-01994-0"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34465901"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34465901"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Chaojie Huang, Senhao Zhou, Chaolei Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "ZC3H13-mediated N6-methyladenosine modification of PHF10 is impaired by fisetin which inhibits the DNA damage response in pancreatic cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Lett (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.canlet.2022.01.013"}], "href": "https://doi.org/10.1016/j.canlet.2022.01.013"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35033590"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35033590"}]}]}]}
Synonyms	BAF45A, XAP135
Proteins	PHF10_HUMAN
NCBI Gene ID	55274
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

PHF10 has 6,104 functional associations with biological entities spanning 9 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 120 datasets.

Click the + buttons to view associations for PHF10 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

PHF10 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of PHF10 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of PHF10 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of PHF10 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of PHF10 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of PHF10 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of PHF10 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of PHF10 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of PHF10 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of PHF10 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of PHF10 gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of PHF10 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of PHF10 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with PHF10 protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with PHF10 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of PHF10 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of PHF10 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of PHF10 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CM4AI U2OS Cell Map Protein Localization Assemblies	assemblies containing PHF10 protein from integrated AP-MS and IF data from the CM4AI U2OS Cell Map Protein Localization Assemblies dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of PHF10 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing PHF10 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing PHF10 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with PHF10 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with PHF10 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of PHF10 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with PHF10 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with PHF10 gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with PHF10 gene/protein from the curated CTD Gene-Disease Associations dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by PHF10 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with PHF10 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with PHF10 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with PHF10 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with PHF10 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at PHF10 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of PHF10 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of PHF10 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing PHF10 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GDSC Cell Line Gene Expression Profiles	cell lines with high or low expression of PHF10 gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset.
	GeneRIF Biological Term Annotations	biological terms co-occuring with PHF10 gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.
	GeneSigDB Published Gene Signatures	PubMedIDs of publications reporting gene signatures containing PHF10 from the GeneSigDB Published Gene Signatures dataset.
	GEO Signatures of Differentially Expressed Genes for Diseases	disease perturbations changing expression of PHF10 gene from the GEO Signatures of Differentially Expressed Genes for Diseases dataset.