PHF14 Gene

HGNC Family	Zinc fingers
Name	PHD finger protein 14
Description	Enables histone binding activity. Predicted to be involved in several processes, including germinal center B cell differentiation; lung development; and negative regulation of mesenchymal cell proliferation involved in lung development. Located in chromatin; cytoplasm; and nucleus. [provided by Alliance of Genome Resources, Mar 2025]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nPHF14, a member of the plant homeodomain (PHD) finger protein family, has emerged as an important regulator in several human cancers. Aberrant PHF14 expression promotes tumorigenesis by enhancing cell proliferation and cell cycle progression. In lung adenocarcinoma, PHF14 is highly expressed and, through its direct interaction with the nuclear motor protein KIF4A, ensures proper mitotic progression—its depletion leading to mitotic defects and prolonged M phase. Similarly, in gastrointestinal malignancies such as colorectal and gastric cancers, elevated PHF14 expression correlates with higher tumor grade and poor prognosis, while its knockdown triggers severe DNA damage signaling and downregulates key cell cycle regulators, ultimately inhibiting tumor growth."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "3"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nMechanistic studies further reveal that PHF14 functions through a network of protein–protein interactions. In lung cancer, its interaction with KIF4A is critical for maintaining efficient mitosis, while in breast cancer cells, PHF14 forms a coiled-coil complex with HMG20A that modulates the Hippo pathway via TEAD1, thereby influencing epithelial–mesenchymal plasticity. In esophageal squamous cell carcinoma, PHF14 acts as a transcriptional target of SP4, with SP4 binding to its promoter to drive PHF14 transcription, which in turn activates the Wnt/β-catenin signaling pathway to promote cell proliferation and inhibit apoptosis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}, {"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its roles in tumor cell proliferation and cell cycle regulation, genetic studies have implicated PHF14 in broader physiological processes. Specifically, variants in PHF14 have been significantly associated with hypertension, highlighting its potential impact on cardiovascular traits and suggesting a wider range of biological functions that may extend beyond oncogenesis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Lin Zhang, Qin Huang, Jiatao Lou, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A novel PHD-finger protein 14/KIF4A complex overexpressed in lung cancer is involved in cell mitosis regulation and tumorigenesis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncotarget (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/oncotarget.14962"}], "href": "https://doi.org/10.18632/oncotarget.14962"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28160558"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28160558"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Yuzu Zhao, Jiang He, Yongsen Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "PHF14 Promotes Cell Proliferation and Migration through the AKT and ERK1/2 Pathways in Gastric Cancer Cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biomed Res Int (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1155/2020/6507510"}], "href": "https://doi.org/10.1155/2020/6507510"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32596345"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32596345"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Guangzhao Pan, Kui Zhang, Shengjun Geng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "PHF14 knockdown causes apoptosis by inducing DNA damage and impairing the activity of the damage response complex in colorectal cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Lett (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.canlet.2022.01.002"}], "href": "https://doi.org/10.1016/j.canlet.2022.01.002"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35074497"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35074497"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Elena Gómez-Marín, Melanija Posavec-Marjanović, Laura Zarzuela, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The high mobility group protein HMG20A cooperates with the histone reader PHF14 to modulate TGFβ and Hippo pathways."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nucleic Acids Res (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/nar/gkac766"}], "href": "https://doi.org/10.1093/nar/gkac766"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36124662"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36124662"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Li Wei, Chaowei Deng, Bo Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "SP4 Facilitates Esophageal Squamous Cell Carcinoma Progression by Activating PHF14 Transcription and Wnt/Β-Catenin Signaling."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cancer Res (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/1541-7786.MCR-22-0835"}], "href": "https://doi.org/10.1158/1541-7786.MCR-22-0835"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "37768180"}], "href": "https://pubmed.ncbi.nlm.nih.gov/37768180"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Stefanie Friedrichs, Dörthe Malzahn, Elizabeth W Pugh, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Filtering genetic variants and placing informative priors based on putative biological function."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "BMC Genet (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12863-015-0313-x"}], "href": "https://doi.org/10.1186/s12863-015-0313-x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26866982"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26866982"}]}]}]}
Proteins	PHF14_HUMAN
NCBI Gene ID	9678
API
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Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

PHF14 has 7,146 functional associations with biological entities spanning 8 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA) extracted from 108 datasets.

Click the + buttons to view associations for PHF14 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

PHF14 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of PHF14 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of PHF14 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of PHF14 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of PHF14 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of PHF14 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of PHF14 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of PHF14 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of PHF14 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of PHF14 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of PHF14 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of PHF14 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with PHF14 protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with PHF14 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of PHF14 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of PHF14 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of PHF14 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of PHF14 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing PHF14 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing PHF14 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with PHF14 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of PHF14 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with PHF14 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with PHF14 gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with PHF14 gene/protein from the curated CTD Gene-Disease Associations dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by PHF14 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with PHF14 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with PHF14 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with PHF14 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with PHF14 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with PHF14 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at PHF14 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of PHF14 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of PHF14 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing PHF14 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GDSC Cell Line Gene Expression Profiles	cell lines with high or low expression of PHF14 gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset.
	GeneSigDB Published Gene Signatures	PubMedIDs of publications reporting gene signatures containing PHF14 from the GeneSigDB Published Gene Signatures dataset.
	GEO Signatures of Differentially Expressed Genes for Diseases	disease perturbations changing expression of PHF14 gene from the GEO Signatures of Differentially Expressed Genes for Diseases dataset.
	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	gene perturbations changing expression of PHF14 gene from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset.
	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	kinase perturbations changing expression of PHF14 gene from the GEO Signatures of Differentially Expressed Genes for Kinase Perturbations dataset.
	GEO Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of PHF14 gene from the GEO Signatures of Differentially Expressed Genes for Small Molecules dataset.