PIK3CB Gene

HGNC Family	C2 domain containing
Name	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta
Description	This gene encodes an isoform of the catalytic subunit of phosphoinositide 3-kinase (PI3K). These kinases are important in signaling pathways involving receptors on the outer membrane of eukaryotic cells and are named for their catalytic subunit. The encoded protein is the catalytic subunit for PI3Kbeta (PI3KB). PI3KB has been shown to be part of the activation pathway in neutrophils which have bound immune complexes at sites of injury or infection. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2011]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nPIK3CB encodes the p110β catalytic subunit of class IA phosphoinositide 3‐kinases, which has emerged as a critical mediator of oncogenic signaling especially in contexts where the tumor suppressor PTEN is lost. Multiple studies have demonstrated that in PTEN‐deficient cancers p110β’s lipid kinase activity is indispensable for sustaining aberrant PI3K pathway signaling that drives cell growth, survival, and tumor progression. In addition, oncogenic alterations—including gene fusions and point mutations such as E633K and D1067Y—have been shown to enhance p110β’s basal activity by promoting its membrane association, thereby increasing downstream Akt activation and conferring resistance to PI3K‐targeted therapies."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "4"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nDistinct from its p110α counterpart, p110β exhibits unique regulatory characteristics: it is less stringently inhibited by the p85 regulatory subunit and notably couples with guanine nucleotide–binding protein–coupled receptor (GPCR) signals via interactions with Gβγ subunits. This specialized regulation enables p110β to mediate diverse signaling outputs—including Akt activation in immune cells (such as neutrophils) and endothelial cells—and to modulate processes like cell migration and inflammatory responses. Moreover, in prostate cancer cells, p110β contributes to androgen receptor transactivation and promotes proliferation and metastasis, further reinforcing its multifaceted role in tumor biology."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "5", "end_ref": "9"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nFurthermore, targeted inhibition or gene silencing of PIK3CB has been shown to disrupt oncogenic PI3K signaling and impair tumor cell survival, establishing p110β as an attractive therapeutic target. Its regulatory versatility even extends to the modulation of nuclear processes, highlighting cross‐talk with additional cellular cascades that govern cell cycle progression and apoptosis. These collective findings underscore that PIK3CB functions as a central molecular hub integrating signals from receptor tyrosine kinases and GPCRs, orchestrating diverse processes in cancer and immune cell physiology."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "10"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Susan Wee, Dmitri Wiederschain, Sauveur-Michel Maira, et al. "}, {"type": "b", "children": [{"type": "t", "text": "PTEN-deficient cancers depend on PIK3CB."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.0802655105"}], "href": "https://doi.org/10.1073/pnas.0802655105"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18755892"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18755892"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Jean J Zhao, Zhenning Liu, Li Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The oncogenic properties of mutant p110alpha and p110beta phosphatidylinositol 3-kinases in human mammary epithelial cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.0508988102"}], "href": "https://doi.org/10.1073/pnas.0508988102"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16339315"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16339315"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Hashem A Dbouk, Bassem D Khalil, Haiyan Wu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Characterization of a tumor-associated activating mutation of the p110β PI 3-kinase."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0063833"}], "href": "https://doi.org/10.1371/journal.pone.0063833"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23734178"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23734178"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Yoshito Nakanishi, Kimberly Walter, Jill M Spoerke, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Activating Mutations in PIK3CB Confer Resistance to PI3K Inhibition and Define a Novel Oncogenic Role for p110β."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Res (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/0008-5472.CAN-15-2201"}], "href": "https://doi.org/10.1158/0008-5472.CAN-15-2201"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26759240"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26759240"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Suhasini Kulkarni, Cassian Sitaru, Zoltan Jakus, et al. "}, {"type": "b", "children": [{"type": "t", "text": "PI3Kβ plays a critical role in neutrophil activation by immune complexes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Signal (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1126/scisignal.2001617"}], "href": "https://doi.org/10.1126/scisignal.2001617"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21487106"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21487106"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Hashem A Dbouk, Oscar Vadas, Aliaksei Shymanets, et al. "}, {"type": "b", "children": [{"type": "t", "text": "G protein-coupled receptor-mediated activation of p110β by Gβγ is required for cellular transformation and invasiveness."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Signal (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1126/scisignal.2003264"}], "href": "https://doi.org/10.1126/scisignal.2003264"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23211529"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23211529"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Q Zhu, H Youn, J Tang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Phosphoinositide 3-OH kinase p85alpha and p110beta are essential for androgen receptor transactivation and tumor progression in prostate cancers."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncogene (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/onc.2008.91"}], "href": "https://doi.org/10.1038/onc.2008.91"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18372911"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18372911"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Bassem D Khalil, Christine Hsueh, Yanyan Cao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "GPCR Signaling Mediates Tumor Metastasis via PI3Kβ."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Res (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/0008-5472.CAN-15-1675"}], "href": "https://doi.org/10.1158/0008-5472.CAN-15-1675"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27013201"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27013201"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Mitsuyoshi Utsugi, Kunio Dobashi, Akihiro Ono, et al. "}, {"type": "b", "children": [{"type": "t", "text": "PI3K p110beta positively regulates lipopolysaccharide-induced IL-12 production in human macrophages and dendritic cells and JNK1 plays a novel role."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Immunol (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4049/jimmunol.0801352"}], "href": "https://doi.org/10.4049/jimmunol.0801352"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19380768"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19380768"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Hiroshi Kubo, Kaoru Hazeki, Shunsuke Takasuga, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Specific role for p85/p110beta in GTP-binding-protein-mediated activation of Akt."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem J (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1042/BJ20050671"}], "href": "https://doi.org/10.1042/BJ20050671"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16091017"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16091017"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Amit Kumar, Javier Redondo-Muñoz, Vicente Perez-García, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Nuclear but not cytosolic phosphoinositide 3-kinase beta has an essential function in cell survival."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Biol (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/MCB.01313-10"}], "href": "https://doi.org/10.1128/MCB.01313-10"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21383062"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21383062"}]}]}]}
Synonyms	PIK3C1, PI3KBETA, P110BETA
Proteins	PK3CB_HUMAN
NCBI Gene ID	5291
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

PIK3CB has 15,173 functional associations with biological entities spanning 9 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 130 datasets.

Click the + buttons to view associations for PIK3CB from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

PIK3CB Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Achilles Cell Line Gene Essentiality Profiles	cell lines with fitness changed by PIK3CB gene knockdown relative to other cell lines from the Achilles Cell Line Gene Essentiality Profiles dataset.
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of PIK3CB gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of PIK3CB gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of PIK3CB gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of PIK3CB gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of PIK3CB gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of PIK3CB gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of PIK3CB gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of PIK3CB gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of PIK3CB gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of PIK3CB gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of PIK3CB gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of PIK3CB gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Gene Mutation Profiles	cell lines with PIK3CB gene mutations from the CCLE Cell Line Gene Mutation Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with PIK3CB protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with PIK3CB gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of PIK3CB gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of PIK3CB gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of PIK3CB gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of PIK3CB gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing PIK3CB protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing PIK3CB protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with PIK3CB protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with PIK3CB protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of PIK3CB gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with PIK3CB gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with PIK3CB gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with PIK3CB gene/protein from the curated CTD Gene-Disease Associations dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by PIK3CB gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with PIK3CB gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with PIK3CB gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with PIK3CB gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with PIK3CB gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	DrugBank Drug Targets	interacting drugs for PIK3CB protein from the curated DrugBank Drug Targets dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at PIK3CB gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of PIK3CB gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of PIK3CB gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing PIK3CB from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GAD Gene-Disease Associations	diseases associated with PIK3CB gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.
	GAD High Level Gene-Disease Associations	diseases associated with PIK3CB gene in GWAS and other genetic association datasets from the GAD High Level Gene-Disease Associations dataset.