{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nPIMREG (PICALM interacting mitotic regulator) has emerged as a key modulator in cancer biology. In breast cancer, PIMREG contributes to the sustained activation of nuclear factor‑kappa B (NF‑κB) signaling—a pathway critically implicated in tumor initiation, progression, and therapy resistance—thus promoting cell survival and proliferation. This role in maintaining persistent NF‑κB activation suggests that PIMREG may serve as an important facilitator of the oncogenic process in breast cancer."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn hepatocellular carcinoma, PIMREG is transcriptionally up-regulated by the transcription factor HOXB13. This upregulation enhances DNA damage repair and accelerates the cell cycle by modulating key regulators: it elevates the expression of factors such as RAD51, BRCA1, CDC25A, CDC25B, and CDC25C, while down-regulating HIPK2. Consequently, the increased DNA repair capacity and rapid cell cycle progression contribute to chemoresistance and tumor progression, emphasizing the functional importance of PIMREG in facilitating the aggressive phenotype of hepatocellular carcinoma."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Lili Jiang, Liangliang Ren, Xiaolan Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Overexpression of PIMREG promotes breast cancer aggressiveness via constitutive activation of NF-κB signaling."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "EBioMedicine (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ebiom.2019.04.001"}], "href": "https://doi.org/10.1016/j.ebiom.2019.04.001"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30979686"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30979686"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Cui Tang, Shixiong Qiu, Wenying Mou, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Excessive activation of HOXB13/PIMREG axis promotes hepatocellular carcinoma progression and drug resistance."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2022.07.066"}], "href": "https://doi.org/10.1016/j.bbrc.2022.07.066"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35878427"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35878427"}]}]}]}