PLAGL1 Gene

HGNC Family	Zinc fingers
Name	pleiomorphic adenoma gene-like 1
Description	This gene encodes a C2H2 zinc finger protein that functions as a suppressor of cell growth. This gene is often deleted or methylated and silenced in cancer cells. In addition, overexpression of this gene during fetal development is thought to be the causal factor for transient neonatal diabetes mellitus (TNDM). Alternative splicing and the use of alternative promoters results in multiple transcript variants encoding two different protein isoforms. The P1 downstream promoter of this gene is imprinted, with preferential expression from the paternal allele in many tissues. [provided by RefSeq, Nov 2015]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nPLAGL1 (also known as ZAC or LOT1) is an imprinted zinc‐finger transcription factor that has emerged as a critical regulator of metabolic homeostasis and endocrine pancreas development. Studies in human tissues and mouse models have shown that PLAGL1 is expressed exclusively from the paternal allele and that its overexpression is tightly associated with transient neonatal diabetes mellitus (TNDM), in part by modulating the transcription of genes involved in insulin secretion and beta‐cell differentiation. This dysregulation appears to compromise the developmental program of the pancreatic islets and disrupt insulin release, underscoring a key role for PLAGL1 in metabolic control and neonatal endocrine function."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "3"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nAt the molecular level, PLAGL1 functions dually as a transcriptional activator and repressor to coordinate cell cycle arrest, apoptosis, and growth inhibition. Its ability to bind GC‐rich regulatory regions allows it to control the expression of key cell cycle regulators—including p21, p57, and PPARγ—via interactions with coactivators (such as p300 and PCAF) and corepressors (like HDAC1). Loss of PLAGL1 expression through epigenetic modifications (for example, promoter hypermethylation and loss of heterozygosity) has been documented in a range of malignancies (including breast, ovarian, colorectal, renal, and various soft tissue and neural tumors), highlighting its pivotal tumor suppressor role. In several cancer models, down‐regulation of PLAGL1 is coupled with impaired transcriptional control and unchecked cellular proliferation, suggesting that normal PLAGL1 function is essential to maintain growth control and genomic stability."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "4", "end_ref": "13"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its roles in metabolism and tumor suppression, PLAGL1 is integral to the orchestration of genomic imprinting and developmental regulation. It contributes to the fine‐tuning of imprinted gene networks that control processes such as placental vasculature formation, fetal growth, and tissue differentiation by binding to key regulatory elements (for instance, those governing the H19/IGF2 locus). Aberrant methylation and altered imprinting of PLAGL1 have been implicated in a spectrum of developmental anomalies—including congenital heart defects and growth dysregulation—as well as in pediatric central nervous system tumors that harbor recurrent PLAGL1 gene fusions. Collectively, these findings designate PLAGL1 as a master regulator whose precise epigenetic control is essential for normal development, and whose dysregulation may lead to diverse pathological outcomes."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "14", "end_ref": "23"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "M Kamiya, H Judson, Y Okazaki, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The cell cycle control gene ZAC/PLAGL1 is imprinted--a strong candidate gene for transient neonatal diabetes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hum Mol Genet (2000)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/hmg/9.3.453"}], "href": "https://doi.org/10.1093/hmg/9.3.453"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "10655556"}], "href": "https://pubmed.ncbi.nlm.nih.gov/10655556"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "D J G Mackay, A-M Coupe, J P H Shield, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Relaxation of imprinted expression of ZAC and HYMAI in a patient with transient neonatal diabetes mellitus."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hum Genet (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s00439-001-0671-5"}], "href": "https://doi.org/10.1007/s00439-001-0671-5"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "11935319"}], "href": "https://pubmed.ncbi.nlm.nih.gov/11935319"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Dan Ma, Julian P H Shield, Wendy Dean, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Impaired glucose homeostasis in transgenic mice expressing the human transient neonatal diabetes mellitus locus, TNDM."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Clin Invest (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1172/JCI19876"}], "href": "https://doi.org/10.1172/JCI19876"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15286800"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15286800"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Abbas Abdollahi, Debra Pisarcik, David Roberts, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LOT1 (PLAGL1/ZAC1), the candidate tumor suppressor gene at chromosome 6q24-25, is epigenetically regulated in cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M210361200"}], "href": "https://doi.org/10.1074/jbc.M210361200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12473647"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12473647"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Anke Hoffmann, Elisabetta Ciani, Joel Boeckardt, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Transcriptional activities of the zinc finger protein Zac are differentially controlled by DNA binding."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Biol (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/MCB.23.3.988-1003.2003"}], "href": "https://doi.org/10.1128/MCB.23.3.988-1003.2003"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12529403"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12529403"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Dusica Cvetkovic, Debra Pisarcik, Chan Lee, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Altered expression and loss of heterozygosity of the LOT1 gene in ovarian cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Gynecol Oncol (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ygyno.2004.08.051"}], "href": "https://doi.org/10.1016/j.ygyno.2004.08.051"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15581945"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15581945"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Takahiro Arima, Tetsuya Kamikihara, Toshirou Hayashida, et al. "}, {"type": "b", "children": [{"type": "t", "text": "ZAC, LIT1 (KCNQ1OT1) and p57KIP2 (CDKN1C) are in an imprinted gene network that may play a role in Beckwith-Wiedemann syndrome."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nucleic Acids Res (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/nar/gki555"}], "href": "https://doi.org/10.1093/nar/gki555"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15888726"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15888726"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Hugo Poulin, Yves Labelle "}, {"type": "b", "children": [{"type": "t", "text": "The PLAGL1 gene is down-regulated in human extraskeletal myxoid chondrosarcoma tumors."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Lett (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.canlet.2004.12.007"}], "href": "https://doi.org/10.1016/j.canlet.2004.12.007"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16112421"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16112421"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Eugenia Basyuk, Vincent Coulon, Anne Le Digarcher, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The candidate tumor suppressor gene ZAC is involved in keratinocyte differentiation and its expression is lost in basal cell carcinomas."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cancer Res (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/1541-7786.MCR-05-0019"}], "href": "https://doi.org/10.1158/1541-7786.MCR-05-0019"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16179495"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16179495"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Sebsebe Lemeta, Kaisa Salmenkivi, Lea Pylkkänen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Frequent loss of heterozygosity at 6q in pheochromocytoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hum Pathol (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.humpath.2006.02.002"}], "href": "https://doi.org/10.1016/j.humpath.2006.02.002"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16733217"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16733217"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Elizabeth M Valleley, Sarah F Cordery, David T Bonthron "}, {"type": "b", "children": [{"type": "t", "text": "Tissue-specific imprinting of the ZAC/PLAGL1 tumour suppressor gene results from variable utilization of monoallelic and biallelic promoters."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hum Mol Genet (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/hmg/ddm041"}], "href": "https://doi.org/10.1093/hmg/ddm041"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17341487"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17341487"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Sonata Jarmalaite, Aida Laurinaviciene, Justina Tverkuviene, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Tumor suppressor gene ZAC/PLAGL1: altered expression and loss of the nonimprinted allele in pheochromocytomas."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Genet (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.cancergen.2011.07.002"}], "href": "https://doi.org/10.1016/j.cancergen.2011.07.002"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21872827"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21872827"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Zhi Li, Yi Ding, Yunliang Zhu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Both gene deletion and promoter hyper-methylation contribute to the down-regulation of ZAC/PLAGL1 gene in gastric adenocarcinomas: a case control study."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Clin Res Hepatol Gastroenterol (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.clinre.2013.06.007"}], "href": "https://doi.org/10.1016/j.clinre.2013.06.007"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25091631"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25091631"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Elizabeth M A Valleley, Sarah F Cordery, Ian M Carr, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Loss of expression of ZAC/PLAGL1 in diffuse large B-cell lymphoma is independent of promoter hypermethylation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Genes Chromosomes Cancer (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/gcc.20758"}], "href": "https://doi.org/10.1002/gcc.20758"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20175198"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20175198"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Chao Xuan, Bin-Bin Wang, Ge Gao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A novel variation of PLAGL1 in Chinese patients with isolated ventricular septal defect."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Genet Test Mol Biomarkers (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1089/gtmb.2012.0003"}], "href": "https://doi.org/10.1089/gtmb.2012.0003"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22784302"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22784302"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Isabel Iglesias-Platas, Franck Court, Cristina Camprubi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Imprinting at the PLAGL1 domain is contained within a 70-kb CTCF/cohesin-mediated non-allelic chromatin loop."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nucleic Acids Res (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/nar/gks1355"}], "href": "https://doi.org/10.1093/nar/gks1355"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23295672"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23295672"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Salah Azzi, Theo C J Sas, Yves Koudou, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Degree of methylation of ZAC1 (PLAGL1) is associated with prenatal and post-natal growth in healthy infants of the EDEN mother child cohort."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Epigenetics (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4161/epi.27387"}], "href": "https://doi.org/10.4161/epi.27387"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24316753"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24316753"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Rebecca N Vincent, Luke D Gooding, Kenny Louie, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Altered DNA methylation and expression of PLAGL1 in cord blood from assisted reproductive technology pregnancies compared with natural conceptions."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Fertil Steril (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.fertnstert.2016.04.036"}], "href": "https://doi.org/10.1016/j.fertnstert.2016.04.036"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27178226"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27178226"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Annie Varrault, Christelle Dantec, Anne Le Digarcher, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of Plagl1/Zac1 binding sites and target genes establishes its role in the regulation of extracellular matrix genes and the imprinted gene network."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nucleic Acids Res (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/nar/gkx672"}], "href": "https://doi.org/10.1093/nar/gkx672"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28985358"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28985358"}]}, {"type": "r", "ref": 20, "children": [{"type": "t", "text": "Livio Provenzi, Pietro De Carli, Monica Fumagalli, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Very preterm birth is associated with PLAGL1 gene hypomethylation at birth and discharge."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Epigenomics (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.2217/epi-2017-0123"}], "href": "https://doi.org/10.2217/epi-2017-0123"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30070601"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30070601"}]}, {"type": "r", "ref": 21, "children": [{"type": "t", "text": "Xiaolei Zhao, Shaoyan Chang, Xinli Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Imprinting aberrations of SNRPN, ZAC1 and INPP5F genes involved in the pathogenesis of congenital heart disease with extracardiac malformations."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Mol Med (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/jcmm.15584"}], "href": "https://doi.org/10.1111/jcmm.15584"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32693431"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32693431"}]}, {"type": "r", "ref": 22, "children": [{"type": "t", "text": "Rebekah R Starks, Rabab Abu Alhasan, Haninder Kaur, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Transcription Factor PLAGL1 Is Associated with Angiogenic Gene Expression in the Placenta."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Mol Sci (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3390/ijms21218317"}], "href": "https://doi.org/10.3390/ijms21218317"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33171905"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33171905"}]}, {"type": "r", "ref": 23, "children": [{"type": "t", "text": "Michaela-Kristina Keck, Martin Sill, Andrea Wittmann, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Amplification of the PLAG-family genes-PLAGL1 and PLAGL2-is a key feature of the novel tumor type CNS embryonal tumor with PLAGL amplification."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Acta Neuropathol (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s00401-022-02516-2"}], "href": "https://doi.org/10.1007/s00401-022-02516-2"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36437415"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36437415"}]}]}]}
Synonyms	ZAC, ZAC1, LOT1
Proteins	PLAL1_HUMAN
NCBI Gene ID	5325
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

PLAGL1 has 9,335 functional associations with biological entities spanning 9 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 118 datasets.

Click the + buttons to view associations for PLAGL1 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

PLAGL1 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Achilles Cell Line Gene Essentiality Profiles	cell lines with fitness changed by PLAGL1 gene knockdown relative to other cell lines from the Achilles Cell Line Gene Essentiality Profiles dataset.
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of PLAGL1 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of PLAGL1 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of PLAGL1 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of PLAGL1 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of PLAGL1 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of PLAGL1 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of PLAGL1 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of PLAGL1 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of PLAGL1 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of PLAGL1 gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of PLAGL1 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of PLAGL1 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with PLAGL1 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of PLAGL1 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of PLAGL1 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of PLAGL1 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of PLAGL1 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing PLAGL1 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing PLAGL1 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	cellular components containing PLAGL1 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with PLAGL1 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with PLAGL1 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with PLAGL1 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with PLAGL1 gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with PLAGL1 gene/protein from the curated CTD Gene-Disease Associations dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by PLAGL1 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Curated Gene-Disease Association Evidence Scores 2025	diseases involving PLAGL1 gene from the DISEASES Curated Gene-Disease Association Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with PLAGL1 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with PLAGL1 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with PLAGL1 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with PLAGL1 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at PLAGL1 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of PLAGL1 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of PLAGL1 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing PLAGL1 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GAD Gene-Disease Associations	diseases associated with PLAGL1 gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.
	GAD High Level Gene-Disease Associations	diseases associated with PLAGL1 gene in GWAS and other genetic association datasets from the GAD High Level Gene-Disease Associations dataset.
	GDSC Cell Line Gene Expression Profiles	cell lines with high or low expression of PLAGL1 gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset.
	GeneRIF Biological Term Annotations	biological terms co-occuring with PLAGL1 gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.