POLR1G Gene

Name RNA polymerase I subunit G
Description Enables RNA binding activity. Involved in transcription initiation at RNA polymerase I promoter. Located in cytosol; mitochondrion; and nuclear lumen. Part of RNA polymerase I complex. Implicated in multiple myeloma. [provided by Alliance of Genome Resources, Mar 2025]
Summary
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nPOLR1G is an integral subunit of RNA polymerase I that plays a central role in driving the transcription of ribosomal RNA (rRNA), a process essential for ribosome biogenesis and thus protein synthesis and cellular proliferation. By supporting rRNA synthesis, POLR1G contributes not only to the basic machinery of cell growth but also to the maintenance of cellular homeostasis and stress responses. Its proper function is critical for normal cell division, and alterations in its activity can disrupt ribosomal production—a change that may subsequently affect cell-cycle regulation and overall cell survival."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "In the context of cancer biology, recent evidence indicates that genetic variation within POLR1G may modify individual susceptibility to lung cancer. In particular, interactions between POLR1G and inflammatory mediators such as interleukin‑1β (IL1B) have been observed; these interactions could influence the output of the Pol I transcriptional machinery, thereby linking the regulation of rRNA synthesis to cellular pathways that control inflammation, apoptosis, and tumorigenesis. Such gene–gene and gene–environment interactions highlight how POLR1G may serve as a nodal point integrating signals from multiple pathways involved in cancer development."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Jiaoyang Yin, Chunhong Wang, Ulla Vogel, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Common variants of pro-inflammatory gene IL1B and interactions with PPP1R13L and POLR1G in relation to lung cancer among Northeast Chinese."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41598-023-34069-z"}], "href": "https://doi.org/10.1038/s41598-023-34069-z"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "37147350"}], "href": "https://pubmed.ncbi.nlm.nih.gov/37147350"}]}]}]}
NCBI Gene ID 10849
API
Download Associations
Predicted Functions View POLR1G's ARCHS4 Predicted Functions.
Co-expressed Genes View POLR1G's ARCHS4 Predicted Functions.
Expression in Tissues and Cell Lines View POLR1G's ARCHS4 Predicted Functions.

Functional Associations

POLR1G has 1,514 functional associations with biological entities spanning 5 categories (chemical, disease, phenotype or trait, functional term, phrase or reference, cell line, cell type or tissue, gene, protein or microRNA) extracted from 41 datasets.

Click the + buttons to view associations for POLR1G from the datasets below.

If available, associations are ranked by standardized value

Dataset Summary
Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles tissue samples with high or low expression of POLR1G gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
Carcinogenome Chemical Perturbation Carcinogenicity Signatures small molecule perturbations changing expression of POLR1G gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
CCLE Cell Line Proteomics Cell lines associated with POLR1G protein from the CCLE Cell Line Proteomics dataset.
CellMarker Gene-Cell Type Associations cell types associated with POLR1G gene from the CellMarker Gene-Cell Type Associations dataset.
ClinVar Gene-Phenotype Associations 2025 phenotypes associated with POLR1G gene from the curated ClinVar Gene-Phenotype Associations 2025 dataset.
CM4AI KOLF21J CRISPRi Gene Perturbation Atlas gene perturbations changing expression of POLR1G gene from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas dataset.
CM4AI U2OS Cell Map Protein Localization Assemblies assemblies containing POLR1G protein from integrated AP-MS and IF data from the CM4AI U2OS Cell Map Protein Localization Assemblies dataset.
COMPARTMENTS Curated Protein Localization Evidence Scores 2025 cellular components containing POLR1G protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 cellular components containing POLR1G protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 dataset.
COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 cellular components co-occuring with POLR1G protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
DGIdb Drug Targets 2026 interacting drugs for POLR1G protein from the DGIdb Drug Targets 2026 dataset.
DisGeNET Gene-Disease Associations diseases associated with POLR1G gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
DisGeNET Gene-Phenotype Associations phenotypes associated with POLR1G gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
GO Biological Process Annotations 2023 biological processes involving POLR1G gene from the curated GO Biological Process Annotations 2023 dataset.
GO Biological Process Annotations 2025 biological processes involving POLR1G gene from the curated GO Biological Process Annotations2025 dataset.
GO Cellular Component Annotations 2023 cellular components containing POLR1G protein from the curated GO Cellular Component Annotations 2023 dataset.
GO Cellular Component Annotations 2025 cellular components containing POLR1G protein from the curated GO Cellular Component Annotations 2025 dataset.
GO Molecular Function Annotations 2023 molecular functions performed by POLR1G gene from the curated GO Molecular Function Annotations 2023 dataset.
GTEx Tissue Gene Expression Profiles 2023 tissues with high or low expression of POLR1G gene relative to other tissues from the GTEx Tissue Gene Expression Profiles 2023 dataset.
GWAS Catalog SNP-Phenotype Associations 2025 phenotypes associated with POLR1G gene in GWAS datasets from the GWAS Catalog SNP-Phenotype Associations 2025 dataset.
IMPC Knockout Mouse Phenotypes phenotypes of mice caused by POLR1G gene knockout from the IMPC Knockout Mouse Phenotypes dataset.
JASPAR Predicted Human Transcription Factor Targets 2025 transcription factors regulating expression of POLR1G gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Human Transcription Factor Targets dataset.
JASPAR Predicted Mouse Transcription Factor Targets 2025 transcription factors regulating expression of POLR1G gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Mouse Transcription Factor Targets 2025 dataset.
KEGG Pathways 2026 pathways involving POLR1G protein from the KEGG Pathways 2026 dataset.
Kinase Library Tyrosine Kinome Atlas kinases that phosphorylate POLR1G protein from the Kinase Library Tyrosine Kinome Atlas dataset.
MGI Mouse Phenotype Associations 2023 phenotypes of transgenic mice caused by POLR1G gene mutations from the MGI Mouse Phenotype Associations 2023 dataset.
MoTrPAC Rat Endurance Exercise Training tissue samples with high or low expression of POLR1G gene relative to other tissue samples from the MoTrPAC Rat Endurance Exercise Training dataset.
PFOCR Pathway Figure Associations 2023 pathways involving POLR1G protein from the PFOCR Pathway Figure Associations 2023 dataset.
Reactome Pathways 2024 pathways involving POLR1G protein from the Reactome Pathways 2024 dataset.
Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures gene perturbations changing expression of POLR1G gene from the Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures dataset.
Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures gene perturbations changing expression of POLR1G gene from the Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures dataset.
Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures gene perturbations changing expression of POLR1G gene from the Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures dataset.
Rummagene Transcription Factor Associations 2026 transcription factors regulating expression of POLR1G gene from the Rummagene Transcription Factor Associations 2026 dataset.
RummaGEO Drug Perturbation Signatures drug perturbations changing expression of POLR1G gene from the RummaGEO Drug Perturbation Signatures dataset.
RummaGEO Gene Perturbation Signatures gene perturbations changing expression of POLR1G gene from the RummaGEO Gene Perturbation Signatures dataset.
Sanger Dependency Map Cancer Cell Line Proteomics cell lines associated with POLR1G protein from the Sanger Dependency Map Cancer Cell Line Proteomics dataset.
Sci-Plex Drug Perturbation Signatures drug perturbations changing expression of POLR1G gene from the Sci-Plex Drug Perturbation Signatures dataset.
TISSUES Curated Tissue Protein Expression Evidence Scores 2025 tissues with high expression of POLR1G protein from the TISSUES Curated Tissue Protein Expression Evidence Scores 2025 dataset.
TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 tissues with high expression of POLR1G protein in proteomics datasets from the TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 dataset.
TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 tissues co-occuring with POLR1G protein in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 dataset.
WikiPathways Pathways 2024 pathways involving POLR1G protein from the WikiPathways Pathways 2024 dataset.