{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nAlthough the query mentions POT1‑AS1, the provided abstracts do not discuss POT1‑AS1 but instead detail the roles of the TANC family proteins. In one study, TANC1 was shown to be a PSD‑95–interacting synaptic scaffold that is essential for maintaining dendritic spines and excitatory synapses. Overexpression of TANC1 in cultured neurons increased spine density, and TANC1‑deficient mice exhibited reduced spine density in the CA3 region of the hippocampus along with impaired spatial memory, underscoring its importance in synaptic organization and cognitive function."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n \nDis primis, a second study expanded on this functional picture by highlighting that both TANC1 and its homolog TANC2 interact with Myo18a. This interaction, mediated by the TPR domains of TANC proteins and the coiled‑coil extension of Myo18a, is predominantly driven by charge–charge interactions and can undergo liquid‑liquid phase separation. Such phase separation may offer a biochemical basis for dynamic assembly of synaptic scaffolds necessary for modulating synapse strength and proper neurodevelopment."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n \nFusce class lectus fringilla commodo sit amet, these collective findings indicate that TANC proteins are pivotal regulators of synaptic structure and function. Their ability to orchestrate dendritic spine maintenance, synapse strength, and interactions with other synaptic components positions them as key players in neural connectivity and potentially in the pathogenesis of neurodevelopmental disorders."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Seungnam Han, Jungyong Nam, Yan Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Regulation of dendritic spines, spatial memory, and embryonic development by the TANC family of PSD-95-interacting proteins."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Neurosci (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1523/JNEUROSCI.3128-10.2010"}], "href": "https://doi.org/10.1523/JNEUROSCI.3128-10.2010"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21068316"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21068316"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Qingqing Yang, Haiyang Liu, Dengqin Zhong, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Tanc1/2 TPR domain interacts with Myo18a C-terminus and undergoes liquid-liquid phase separation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochim Biophys Acta Mol Cell Res (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbamcr.2023.119650"}], "href": "https://doi.org/10.1016/j.bbamcr.2023.119650"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "38092135"}], "href": "https://pubmed.ncbi.nlm.nih.gov/38092135"}]}]}]}