{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nPOTEE is a member of a primate‐specific gene family that encodes cancer testis antigens with distinctive structural features including ankyrin repeats and spectrin‐like helices. Its expression in normal human tissues is highly restricted – being detectable in embryonic stem cells as well as a few adult tissues such as testis and ovary – yet aberrant expression is frequently observed in cancer. In HeLa cell studies, for example, specific isoforms such as POTE‑2α–actin localize to actin filaments and can trigger apoptosis via a mitochondrial‐dependent pathway, while whole‐genome profiling in breast tumors identified POTEE as one of the key genes correlated with disease progression."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "3"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn addition to these cell‐intrinsic roles, POTEE has been implicated in modulating the tumor microenvironment. Studies of immune cell models have demonstrated that, although POTEE is generally not expressed in most lymphoid cells, its expression in certain macrophage populations – particularly those acquiring tumor-associated properties – facilitates interactions with proteins such as mTOR, RICTOR, and Rad51. These interactions appear to support enhanced cell survival and invasive behavior, suggesting a role for POTEE in the regulation of the tumor-supportive microenvironment."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn several malignancies, POTEE functions as an oncogene. In colorectal cancer, elevated POTEE levels promote tumor progression by enhancing cell growth, accelerating cell-cycle progression, inhibiting apoptosis, and facilitating migration and invasion – effects that are mediated in part by activation of signaling cascades such as the SPHK1/p65 axis and by stimulation of epithelial–mesenchymal transition via Rac1 and Cdc42. Similarly, in pancreatic cancer, high POTEE expression is associated with advanced tumor stage, larger tumor size, and poorer prognoses; mechanistic studies point to its role in activating the PI3K/Akt/GSK-3β/β-catenin signaling pathway."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "5", "end_ref": "7"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Tapan K Bera, Ashley Saint Fleur, Duc Ha, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Selective POTE paralogs on chromosome 2 are expressed in human embryonic stem cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Stem Cells Dev (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1089/scd.2007.0079"}], "href": "https://doi.org/10.1089/scd.2007.0079"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18447647"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18447647"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Xiu Fen Liu, Tapan K Bera, Lisa J Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A primate-specific POTE-actin fusion protein plays a role in apoptosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Apoptosis (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s10495-009-0392-0"}], "href": "https://doi.org/10.1007/s10495-009-0392-0"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19669888"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19669888"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Naci Cine, Ahmet Tarik Baykal, Deniz Sunnetci, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of ApoA1, HPX and POTEE genes by omic analysis in breast cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncol Rep (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/or.2014.3277"}], "href": "https://doi.org/10.3892/or.2014.3277"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24969553"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24969553"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Umeshkumar Vekariya, Kavita Rawat, Reshu Saxena, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of MΦ specific POTEE expression: Its role in mTORC2 activation via protein-protein interaction in TAMs."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Immunol (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.cellimm.2018.10.010"}], "href": "https://doi.org/10.1016/j.cellimm.2018.10.010"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30420269"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30420269"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Zhiyong Shen, Xiaochuang Feng, Yuan Fang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "POTEE drives colorectal cancer development via regulating SPHK1/p65 signaling."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Death Dis (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41419-019-2046-7"}], "href": "https://doi.org/10.1038/s41419-019-2046-7"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31723122"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31723122"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Qiong Xu, Jianxiong Chen, Man Peng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "POTEE promotes colorectal carcinoma progression via activating the Rac1/Cdc42 pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Exp Cell Res (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.yexcr.2020.111933"}], "href": "https://doi.org/10.1016/j.yexcr.2020.111933"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32142855"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32142855"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Qingya Hao, Lihua Gao, Wenyang Niu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "POTEE stimulates the proliferation of pancreatic cancer by activating the PI3K/Akt/GSK-3β/β-catenin signaling."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biofactors (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/biof.1640"}], "href": "https://doi.org/10.1002/biof.1640"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32589786"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32589786"}]}]}]}