{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRecent findings have identified POU2AF2 (renamed from COLCA2 as OCA-T1) as a critical transcriptional coactivator in the tuft cell lineage. Functioning as part of the POU2F3–OCA‐T complex, POU2AF2 binds in concert with the lineage‐specific transcription factor POU2F3 via a conserved peptide that interacts with class II POU domains and the DNA octamer motif. This partnership orchestrates the gene expression program that defines tuft cell identity in mucosal tissues and is essential for the survival and function of tuft‐cell‐like small‐cell lung cancer, representing a molecular vulnerability in these tumors."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Xiaoli S Wu, Xue-Yan He, Jonathan J Ipsaro, et al. "}, {"type": "b", "children": [{"type": "t", "text": "OCA-T1 and OCA-T2 are coactivators of POU2F3 in the tuft cell lineage."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nature (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41586-022-04842-7"}], "href": "https://doi.org/10.1038/s41586-022-04842-7"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35576971"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35576971"}]}]}]}