| HGNC Family | Homeoboxes |
| Name | POU class 4 homeobox 1 |
| Description | This gene encodes a member of the POU-IV class of neural transcription factors. This protein is expressed in a subset of retinal ganglion cells and may be involved in the developing sensory nervous system. This protein may also promote the growth of cervical tumors. A translocation of this gene is associated with some adult acute myeloid leukemias. [provided by RefSeq, Mar 2012] |
| Summary |
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nPOU4F1, also known as Brn3a, is a POU domain transcription factor originally recognized for its key role in neuronal differentiation and survival. However, its dysregulation has emerged as a common theme in several human cancers. In breast cancer, aberrant DNA methylation of POU4F1 has been identified as an early and frequent epigenetic alteration, suggesting its potential as a biomarker for tumor diagnosis. Likewise, studies in melanoma and prostate cancer have demonstrated that POU4F1 not only supports tumor cell viability but also modulates cellular responses such as cell cycle arrest and apoptosis. In Ewing’s sarcoma, its interaction with oncogenic fusion proteins contributes to altered differentiation and enhanced anti‑apoptotic signaling, while in cervical cancer, increased POU4F1 (Brn3a) levels correlate with enhanced transcription of viral oncogenes and disease progression. Notably, its transcription is subject to complex regulation through alternative promoter usage and epigenetic modifications, as evidenced by differential regulation in various tissues."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "11"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn cancer settings, POU4F1 has been implicated in driving therapy resistance and promoting aggressive tumor phenotypes. In melanoma, overexpression of POU4F1 re‑activates the MAPK/ERK pathway through transcriptional upregulation of MEK, thereby contributing to resistance against BRAF inhibitors. Similarly, in HER2‑positive breast cancer, elevated POU4F1 levels in trastuzumab‑resistant tumors are associated with enhanced cell proliferation, invasiveness, and ERK signaling. Moreover, its dysregulation has also been linked with altered cell cycle progression in basal‑like breast cancer through direct transcriptional activation of CDK2 and Cyclin D1 and repression of estrogen receptor expression, as well as being associated with aggressive thyroid cancers. In the context of Ewing’s sarcoma, POU4F1 is not only highly expressed but also appears to alter neuronal differentiation programs, thereby contributing to a distinctive transcriptional signature."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "12", "end_ref": "17"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its oncogenic roles, POU4F1 is essential for normal neuronal development and function. It is involved in the differentiation of retinal ganglion cells, and genetic studies have revealed that heterozygous loss‑of‑function mutations in POU4F1 result in a novel ataxia syndrome accompanied by cerebellar and olivary abnormalities. These findings underscore the dual importance of POU4F1 in both maintaining proper neuronal development and, when dysregulated, in contributing to tumor progression and therapy resistance."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "18"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Marta Faryna, Carolin Konermann, Sebastian Aulmann, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Genome-wide methylation screen in low-grade breast cancer identifies novel epigenetically altered genes as potential biomarkers for tumor diagnosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "FASEB J (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1096/fj.12-209502"}], "href": "https://doi.org/10.1096/fj.12-209502"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22930747"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22930747"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Tobias Hohenauer, Carola Berking, Andreas Schmidt, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The neural crest transcription factor Brn3a is expressed in melanoma and required for cell cycle progression and survival."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "EMBO Mol Med (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/emmm.201201862"}], "href": "https://doi.org/10.1002/emmm.201201862"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23666755"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23666755"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Duncan M Gascoyne, G Ruth Thomas, David S Latchman "}, {"type": "b", "children": [{"type": "t", "text": "The effects of Brn-3a on neuronal differentiation and apoptosis are differentially modulated by EWS and its oncogenic derivative EWS/Fli-1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncogene (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/sj.onc.1207497"}], "href": "https://doi.org/10.1038/sj.onc.1207497"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15021903"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15021903"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "J K J Diss, D J Faulkes, M M Walker, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Brn-3a neuronal transcription factor functional expression in human prostate cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Prostate Cancer Prostatic Dis (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/sj.pcan.4500837"}], "href": "https://doi.org/10.1038/sj.pcan.4500837"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16276351"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16276351"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "J M Fortier, J E Payton, P Cahan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "POU4F1 is associated with t(8;21) acute myeloid leukemia and contributes directly to its unique transcriptional signature."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Leukemia (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/leu.2010.61"}], "href": "https://doi.org/10.1038/leu.2010.61"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20376082"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20376082"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Michael Sindos, Daniel Ndisang, Narendra Pisal, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Measurement of Brn-3a levels in Pap smears provides a novel diagnostic marker for the detection of cervical neoplasia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Gynecol Oncol (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/s0090-8258(03)00261-0"}], "href": "https://doi.org/10.1016/s0090-8258(03"}, {"type": "t", "text": "00261-0) PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12893201"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12893201"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "D Ndisang, D J Faulkes, D Gascoyne, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Differential regulation of different human papilloma virus variants by the POU family transcription factor Brn-3a."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncogene (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/sj.onc.1209006"}], "href": "https://doi.org/10.1038/sj.onc.1209006"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16247485"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16247485"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Beate Frass, Lothar Vassen, Tarik Möröy "}, {"type": "b", "children": [{"type": "t", "text": "Gene expression of the POU factor Brn-3a is regulated by two different promoters."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochim Biophys Acta (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/s0167-4781(02)00540-7"}], "href": "https://doi.org/10.1016/s0167-4781(02"}, {"type": "t", "text": "00540-7) PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12427558"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12427558"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Biswa Pratim Das Purkayastha, Jagat Kumar Roy "}, {"type": "b", "children": [{"type": "t", "text": "Molecular analysis of oncogenicity of the transcription factor, BRN3A, in cervical cancer cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cancer Res Clin Oncol (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s00432-011-1059-0"}], "href": "https://doi.org/10.1007/s00432-011-1059-0"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21928122"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21928122"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "M Sindos, D Ndisang, N Pisal, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Detection of cervical neoplasia using measurement of Brn-3a in cervical smears with persistent minor abnormality."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Gynecol Cancer (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1046/j.1525-1438.2003.13303.x"}], "href": "https://doi.org/10.1046/j.1525-1438.2003.13303.x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12911730"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12911730"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Markus V Heppt, Anja Wessely, Eva Hornig, et al. "}, {"type": "b", "children": [{"type": "t", "text": "HDAC2 Is Involved in the Regulation of BRN3A in Melanocytes and Melanoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Mol Sci (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3390/ijms23020849"}], "href": "https://doi.org/10.3390/ijms23020849"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35055045"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35055045"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Lin Liu, Qiao Yue, Jingjing Ma, et al. "}, {"type": "b", "children": [{"type": "t", "text": "POU4F1 promotes the resistance of melanoma to BRAF inhibitors through MEK/ERK pathway activation and MITF up-regulation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Death Dis (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41419-020-2662-2"}], "href": "https://doi.org/10.1038/s41419-020-2662-2"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32532957"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32532957"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Di Wu, Hong-Yao Jia, Na Wei, et al. "}, {"type": "b", "children": [{"type": "t", "text": "POU4F1 confers trastuzumab resistance in HER2-positive breast cancer through regulating ERK1/2 signaling pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2020.09.003"}], "href": "https://doi.org/10.1016/j.bbrc.2020.09.003"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32988584"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32988584"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Seung-Nam Jung, Yea Eun Kang, Gun Ho Lee, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Brn3a/Pou4f1 Functions as a Tumor Suppressor by Targeting c-MET/STAT3 Signaling in Thyroid Cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Clin Endocrinol Metab (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1210/clinem/dgaa316"}], "href": "https://doi.org/10.1210/clinem/dgaa316"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32474599"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32474599"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "L V Spirina, S Yu Chizhevskaya, I V Kondakova, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Reception of Sex Steroid Hormones in Thyroid Papillary Cancer Tissue and Relationship with Expression and Content of Transcription Factors Brn-3α and TRIM16."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Bull Exp Biol Med (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s10517-018-4322-4"}], "href": "https://doi.org/10.1007/s10517-018-4322-4"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30488195"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30488195"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "D M Gascoyne, J Dunne, S Behjati, et al. "}, {"type": "b", "children": [{"type": "t", "text": "EWS/ETS proteins promote expression and regulate function of the homeodomain transcription factor BRN3A."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncogene (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/onc.2010.72"}], "href": "https://doi.org/10.1038/onc.2010.72"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20348952"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20348952"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Jiahui Zhang, Nanyan Miao, Liyan Lao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Activation of Bivalent Gene POU4F1 Promotes and Maintains Basal-like Breast Cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Adv Sci (Weinh) (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/advs.202307660"}], "href": "https://doi.org/10.1002/advs.202307660"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "38491910"}], "href": "https://pubmed.ncbi.nlm.nih.gov/38491910"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Jee-Soo Lee, Jin Wook Jeoung, Sohee Oh, et al. "}, {"type": "b", "children": [{"type": "t", "text": "No association between "}, {"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "POU4F1, POU4F2, ISL1"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": " polymorphisms and normal-tension glaucoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Ophthalmic Genet (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/13816810.2020.1783690"}], "href": "https://doi.org/10.1080/13816810.2020.1783690"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32597291"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32597291"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Bryn D Webb, Anthony Evans, Thomas P Naidich, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Haploinsufficiency of POU4F1 causes an ataxia syndrome with hypotonia and intention tremor."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hum Mutat (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/humu.24201"}], "href": "https://doi.org/10.1002/humu.24201"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33783914"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33783914"}]}]}]}
|
| Synonyms | BRN-3A, RDC-1, BRN3A, OCT-T1 |
| Proteins | PO4F1_HUMAN |
| NCBI Gene ID | 5457 |
| API | |
| Download Associations | |
| Predicted Functions |
 |
| Co-expressed Genes |
|
| Expression in Tissues and Cell Lines |
|
POU4F1 has 5,502 functional associations with biological entities spanning 9 categories (molecular profile, organism, chemical, disease, phenotype or trait, functional term, phrase or reference, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 101 datasets.
Click the + buttons to view associations for POU4F1 from the datasets below.
If available, associations are ranked by standardized value
| Dataset | Summary | |
|---|---|---|
| Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles | tissues with high or low expression of POU4F1 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset. | |
| Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles | tissues with high or low expression of POU4F1 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset. | |
| Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles | tissue samples with high or low expression of POU4F1 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset. | |
| Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray | tissue samples with high or low expression of POU4F1 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset. | |
| Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles | tissues with high or low expression of POU4F1 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset. | |
| BioGPS Cell Line Gene Expression Profiles | cell lines with high or low expression of POU4F1 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset. | |
| BioGPS Human Cell Type and Tissue Gene Expression Profiles | cell types and tissues with high or low expression of POU4F1 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset. | |
| BioGPS Mouse Cell Type and Tissue Gene Expression Profiles | cell types and tissues with high or low expression of POU4F1 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset. | |
| Carcinogenome Chemical Perturbation Carcinogenicity Signatures | small molecule perturbations changing expression of POU4F1 gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset. | |
| CCLE Cell Line Gene CNV Profiles | cell lines with high or low copy number of POU4F1 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset. | |
| CCLE Cell Line Gene Expression Profiles | cell lines with high or low expression of POU4F1 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset. | |
| CellMarker Gene-Cell Type Associations | cell types associated with POU4F1 gene from the CellMarker Gene-Cell Type Associations dataset. | |
| ChEA Transcription Factor Binding Site Profiles | transcription factor binding site profiles with transcription factor binding evidence at the promoter of POU4F1 gene from the CHEA Transcription Factor Binding Site Profiles dataset. | |
| ChEA Transcription Factor Targets | transcription factors binding the promoter of POU4F1 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset. | |
| ChEA Transcription Factor Targets 2022 | transcription factors binding the promoter of POU4F1 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset. | |
| ClinVar Gene-Phenotype Associations 2025 | phenotypes associated with POU4F1 gene from the curated ClinVar Gene-Phenotype Associations 2025 dataset. | |
| CMAP Signatures of Differentially Expressed Genes for Small Molecules | small molecule perturbations changing expression of POU4F1 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset. | |
| COMPARTMENTS Curated Protein Localization Evidence Scores | cellular components containing POU4F1 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset. | |
| COMPARTMENTS Text-mining Protein Localization Evidence Scores | cellular components co-occuring with POU4F1 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset. | |
| COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 | cellular components co-occuring with POU4F1 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset. | |
| COSMIC Cell Line Gene CNV Profiles | cell lines with high or low copy number of POU4F1 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset. | |
| COSMIC Cell Line Gene Mutation Profiles | cell lines with POU4F1 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset. | |
| CTD Gene-Chemical Interactions | chemicals interacting with POU4F1 gene/protein from the curated CTD Gene-Chemical Interactions dataset. | |
| CTD Gene-Disease Associations | diseases associated with POU4F1 gene/protein from the curated CTD Gene-Disease Associations dataset. | |
| DepMap CRISPR Gene Dependency | cell lines with fitness changed by POU4F1 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset. | |
| DISEASES Text-mining Gene-Disease Association Evidence Scores | diseases co-occuring with POU4F1 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset. | |
| DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 | diseases co-occuring with POU4F1 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset. | |
| DisGeNET Gene-Disease Associations | diseases associated with POU4F1 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset. | |
| DisGeNET Gene-Phenotype Associations | phenotypes associated with POU4F1 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset. | |
| ENCODE Histone Modification Site Profiles | histone modification site profiles with high histone modification abundance at POU4F1 gene from the ENCODE Histone Modification Site Profiles dataset. | |
| ENCODE Transcription Factor Binding Site Profiles | transcription factor binding site profiles with transcription factor binding evidence at the promoter of POU4F1 gene from the ENCODE Transcription Factor Binding Site Profiles dataset. | |
| ENCODE Transcription Factor Targets | transcription factors binding the promoter of POU4F1 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset. | |
| ESCAPE Omics Signatures of Genes and Proteins for Stem Cells | PubMedIDs of publications reporting gene signatures containing POU4F1 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset. | |
| GDSC Cell Line Gene Expression Profiles | cell lines with high or low expression of POU4F1 gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset. | |
| GeneRIF Biological Term Annotations | biological terms co-occuring with POU4F1 gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset. | |
| GeneSigDB Published Gene Signatures | PubMedIDs of publications reporting gene signatures containing POU4F1 from the GeneSigDB Published Gene Signatures dataset. | |
| GEO Signatures of Differentially Expressed Genes for Diseases | disease perturbations changing expression of POU4F1 gene from the GEO Signatures of Differentially Expressed Genes for Diseases dataset. | |
| GEO Signatures of Differentially Expressed Genes for Gene Perturbations | gene perturbations changing expression of POU4F1 gene from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset. | |
| GEO Signatures of Differentially Expressed Genes for Kinase Perturbations | kinase perturbations changing expression of POU4F1 gene from the GEO Signatures of Differentially Expressed Genes for Kinase Perturbations dataset. | |
| GEO Signatures of Differentially Expressed Genes for Small Molecules | small molecule perturbations changing expression of POU4F1 gene from the GEO Signatures of Differentially Expressed Genes for Small Molecules dataset. | |
| GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations | transcription factor perturbations changing expression of POU4F1 gene from the GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations dataset. | |
| GEO Signatures of Differentially Expressed Genes for Viral Infections | virus perturbations changing expression of POU4F1 gene from the GEO Signatures of Differentially Expressed Genes for Viral Infections dataset. | |
| GO Biological Process Annotations 2015 | biological processes involving POU4F1 gene from the curated GO Biological Process Annotations 2015 dataset. | |
| GO Biological Process Annotations 2023 | biological processes involving POU4F1 gene from the curated GO Biological Process Annotations 2023 dataset. | |
| GO Biological Process Annotations 2025 | biological processes involving POU4F1 gene from the curated GO Biological Process Annotations2025 dataset. | |
| GO Cellular Component Annotations 2015 | cellular components containing POU4F1 protein from the curated GO Cellular Component Annotations 2015 dataset. | |
| GO Cellular Component Annotations 2023 | cellular components containing POU4F1 protein from the curated GO Cellular Component Annotations 2023 dataset. | |
| GO Cellular Component Annotations 2025 | cellular components containing POU4F1 protein from the curated GO Cellular Component Annotations 2025 dataset. | |
| GO Molecular Function Annotations 2015 | molecular functions performed by POU4F1 gene from the curated GO Molecular Function Annotations 2015 dataset. | |
| GO Molecular Function Annotations 2023 | molecular functions performed by POU4F1 gene from the curated GO Molecular Function Annotations 2023 dataset. | |
| GO Molecular Function Annotations 2025 | molecular functions performed by POU4F1 gene from the curated GO Molecular Function Annotations 2025 dataset. | |
| GTEx eQTL 2025 | SNPs regulating expression of POU4F1 gene from the GTEx eQTL 2025 dataset. | |
| GTEx Tissue Gene Expression Profiles | tissues with high or low expression of POU4F1 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles dataset. | |
| GTEx Tissue Sample Gene Expression Profiles | tissue samples with high or low expression of POU4F1 gene relative to other tissue samples from the GTEx Tissue Sample Gene Expression Profiles dataset. | |
| GWAS Catalog SNP-Phenotype Associations 2025 | phenotypes associated with POU4F1 gene in GWAS datasets from the GWAS Catalog SNP-Phenotype Associations 2025 dataset. | |
| Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles | cell lines with high or low expression of POU4F1 gene relative to other cell lines from the Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles dataset. | |
| HPA Cell Line Gene Expression Profiles | cell lines with high or low expression of POU4F1 gene relative to other cell lines from the HPA Cell Line Gene Expression Profiles dataset. | |
| HPA Tissue Gene Expression Profiles | tissues with high or low expression of POU4F1 gene relative to other tissues from the HPA Tissue Gene Expression Profiles dataset. | |
| HPA Tissue Sample Gene Expression Profiles | tissue samples with high or low expression of POU4F1 gene relative to other tissue samples from the HPA Tissue Sample Gene Expression Profiles dataset. | |
| Hub Proteins Protein-Protein Interactions | interacting hub proteins for POU4F1 from the curated Hub Proteins Protein-Protein Interactions dataset. | |
| HuBMAP ASCT+B Annotations | cell types associated with POU4F1 gene from the HuBMAP ASCT+B dataset. | |
| HuBMAP ASCT+B Augmented with RNA-seq Coexpression | cell types associated with POU4F1 gene from the HuBMAP ASCT+B Augmented with RNA-seq Coexpression dataset. | |
| InterPro Predicted Protein Domain Annotations | protein domains predicted for POU4F1 protein from the InterPro Predicted Protein Domain Annotations dataset. | |
| JASPAR Predicted Human Transcription Factor Targets 2025 | transcription factors regulating expression of POU4F1 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Human Transcription Factor Targets dataset. | |
| JASPAR Predicted Mouse Transcription Factor Targets 2025 | transcription factors regulating expression of POU4F1 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Mouse Transcription Factor Targets 2025 dataset. | |
| JASPAR Predicted Transcription Factor Targets | transcription factors regulating expression of POU4F1 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset. | |
| Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles | cell lines with high or low copy number of POU4F1 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset. | |
| Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles | cell lines with POU4F1 gene mutations from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles dataset. | |
| KnockTF Gene Expression Profiles with Transcription Factor Perturbations | transcription factor perturbations changing expression of POU4F1 gene from the KnockTF Gene Expression Profiles with Transcription Factor Perturbations dataset. | |
| LINCS L1000 CMAP Chemical Perturbation Consensus Signatures | small molecule perturbations changing expression of POU4F1 gene from the LINCS L1000 CMAP Chemical Perturbations Consensus Signatures dataset. | |
| LINCS L1000 CMAP CRISPR Knockout Consensus Signatures | gene perturbations changing expression of POU4F1 gene from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset. | |
| LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules | small molecule perturbations changing expression of POU4F1 gene from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset. | |
| LOCATE Predicted Protein Localization Annotations | cellular components predicted to contain POU4F1 protein from the LOCATE Predicted Protein Localization Annotations dataset. | |
| MGI Mouse Phenotype Associations 2023 | phenotypes of transgenic mice caused by POU4F1 gene mutations from the MGI Mouse Phenotype Associations 2023 dataset. | |
| MiRTarBase microRNA Targets | microRNAs targeting POU4F1 gene in low- or high-throughput microRNA targeting studies from the MiRTarBase microRNA Targets dataset. | |
| MotifMap Predicted Transcription Factor Targets | transcription factors regulating expression of POU4F1 gene predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset. | |
| MPO Gene-Phenotype Associations | phenotypes of transgenic mice caused by POU4F1 gene mutations from the MPO Gene-Phenotype Associations dataset. | |
| MSigDB Cancer Gene Co-expression Modules | co-expressed genes for POU4F1 from the MSigDB Cancer Gene Co-expression Modules dataset. | |
| Pathway Commons Protein-Protein Interactions | interacting proteins for POU4F1 from the Pathway Commons Protein-Protein Interactions dataset. | |
| PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations | gene perturbations changing expression of POU4F1 gene from the PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations dataset. | |
| PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations | gene perturbations changing expression of POU4F1 gene from the PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations dataset. | |
| PFOCR Pathway Figure Associations 2023 | pathways involving POU4F1 protein from the PFOCR Pathway Figure Associations 2023 dataset. | |
| PFOCR Pathway Figure Associations 2024 | pathways involving POU4F1 protein from the Wikipathways PFOCR 2024 dataset. | |
| Phosphosite Textmining Biological Term Annotations | biological terms co-occuring with POU4F1 protein in abstracts of publications describing phosphosites from the Phosphosite Textmining Biological Term Annotations dataset. | |
| PID Pathways | pathways involving POU4F1 protein from the PID Pathways dataset. | |
| Reactome Pathways 2024 | pathways involving POU4F1 protein from the Reactome Pathways 2024 dataset. | |
| Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures | gene perturbations changing expression of POU4F1 gene from the Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures dataset. | |
| Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures | gene perturbations changing expression of POU4F1 gene from the Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures dataset. | |
| Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles | cell types and tissues with high or low DNA methylation of POU4F1 gene relative to other cell types and tissues from the Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles dataset. | |
| Roadmap Epigenomics Histone Modification Site Profiles | histone modification site profiles with high histone modification abundance at POU4F1 gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset. | |
| RummaGEO Drug Perturbation Signatures | drug perturbations changing expression of POU4F1 gene from the RummaGEO Drug Perturbation Signatures dataset. | |
| RummaGEO Gene Perturbation Signatures | gene perturbations changing expression of POU4F1 gene from the RummaGEO Gene Perturbation Signatures dataset. | |
| Tabula Sapiens Gene-Cell Associations | cell types with high or low expression of POU4F1 gene relative to other cell types from the Tabula Sapiens Gene-Cell Associations dataset. | |
| TargetScan Predicted Conserved microRNA Targets | microRNAs regulating expression of POU4F1 gene predicted using conserved miRNA seed sequences from the TargetScan Predicted Conserved microRNA Targets dataset. | |
| TargetScan Predicted Nonconserved microRNA Targets | microRNAs regulating expression of POU4F1 gene predicted using nonconserved miRNA seed sequences from the TargetScan Predicted Nonconserved microRNA Targets dataset. | |
| TCGA Signatures of Differentially Expressed Genes for Tumors | tissue samples with high or low expression of POU4F1 gene relative to other tissue samples from the TCGA Signatures of Differentially Expressed Genes for Tumors dataset. | |
| TISSUES Curated Tissue Protein Expression Evidence Scores | tissues with high expression of POU4F1 protein from the TISSUES Curated Tissue Protein Expression Evidence Scores dataset. | |
| TISSUES Curated Tissue Protein Expression Evidence Scores 2025 | tissues with high expression of POU4F1 protein from the TISSUES Curated Tissue Protein Expression Evidence Scores 2025 dataset. | |
| TISSUES Text-mining Tissue Protein Expression Evidence Scores | tissues co-occuring with POU4F1 protein in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores dataset. | |
| TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 | tissues co-occuring with POU4F1 protein in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 dataset. | |
| WikiPathways Pathways 2024 | pathways involving POU4F1 protein from the WikiPathways Pathways 2024 dataset. | |
