| HGNC Family | Homeoboxes |
| Name | POU class 5 homeobox 1 pseudogene 4 |
| Description | Predicted to enable DNA binding activity and DNA-binding transcription factor activity, RNA polymerase II-specific. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Mar 2025] |
| Summary |
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRecent studies have revealed that POU5F1P4 (also designated as OCT4‐pg4) plays an oncogenic role in hepatocellular carcinoma (HCC) by acting as a natural microRNA sponge. Specifically, OCT4‐pg4 sequesters the tumor‐suppressive miR‐145, thereby protecting OCT4 transcripts from miRNA-mediated inhibition. This post-transcriptional regulation results in increased OCT4 protein levels, which in turn enhances tumor cell growth and tumorigenicity and is associated with poor prognosis in HCC patients."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "In parallel, other studies have explored distinct molecular mechanisms that govern tissue repair and tumor resistance. For example, overexpression of PTEN in renal proximal tubular cells has been shown to alleviate maladaptive repair after ischemia/reperfusion injury by upregulating CHMP2A, an autophagy‐related protein. This upregulation assists in phagosome closure and improves autophagy flux, reducing cell damage, apoptosis, and subsequent renal fibrosis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "Similarly, CHMP2A has also been implicated in the intrinsic resistance programs of tumors to natural killer (NK) cell-mediated cytotoxicity. Genetic screens have identified CHMP2A as a mediator of tumor escape mechanisms, underscoring the protein’s multifaceted role in cancer biology and highlighting its potential as a therapeutic target to enhance antitumor immune responses."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Lei Wang, Zhang-Yan Guo, Rui Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Pseudogene OCT4-pg4 functions as a natural micro RNA sponge to regulate OCT4 expression by competing for miR-145 in hepatocellular carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Carcinogenesis (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/carcin/bgt139"}], "href": "https://doi.org/10.1093/carcin/bgt139"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23615404"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23615404"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Huizhen Wang, Yifan Wang, Xin Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "PTEN alleviates maladaptive repair of renal tubular epithelial cells by restoring CHMP2A-mediated phagosome closure."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Death Dis (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41419-021-04372-6"}], "href": "https://doi.org/10.1038/s41419-021-04372-6"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34789720"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34789720"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Jiyoung Yun, Robert Saddawi-Konefka, Benjamin Goldenson, et al. "}, {"type": "b", "children": [{"type": "t", "text": "CHMP2A regulates broad immune cell-mediated antitumor activity in an immunocompetent in vivo head and neck squamous cell carcinoma model."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Immunother Cancer (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1136/jitc-2023-007187"}], "href": "https://doi.org/10.1136/jitc-2023-007187"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "38702144"}], "href": "https://pubmed.ncbi.nlm.nih.gov/38702144"}]}]}]}
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| Synonyms | POU5FLC1, OCT4-PG4 |
| NCBI Gene ID | 645682 |
| API | |
| Download Associations | |
| Predicted Functions |
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| Co-expressed Genes |
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| Expression in Tissues and Cell Lines |
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POU5F1P4 has 550 functional associations with biological entities spanning 7 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, cell line, cell type or tissue, gene, protein or microRNA) extracted from 27 datasets.
Click the + buttons to view associations for POU5F1P4 from the datasets below.
If available, associations are ranked by standardized value
| Dataset | Summary | |
|---|---|---|
| BioGPS Cell Line Gene Expression Profiles | cell lines with high or low expression of POU5F1P4 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset. | |
| BioGPS Human Cell Type and Tissue Gene Expression Profiles | cell types and tissues with high or low expression of POU5F1P4 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset. | |
| CCLE Cell Line Gene CNV Profiles | cell lines with high or low copy number of POU5F1P4 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset. | |
| CCLE Cell Line Gene Expression Profiles | cell lines with high or low expression of POU5F1P4 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset. | |
| ChEA Transcription Factor Binding Site Profiles | transcription factor binding site profiles with transcription factor binding evidence at the promoter of POU5F1P4 gene from the CHEA Transcription Factor Binding Site Profiles dataset. | |
| ChEA Transcription Factor Targets | transcription factors binding the promoter of POU5F1P4 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset. | |
| CMAP Signatures of Differentially Expressed Genes for Small Molecules | small molecule perturbations changing expression of POU5F1P4 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset. | |
| COSMIC Cell Line Gene CNV Profiles | cell lines with high or low copy number of POU5F1P4 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset. | |
| ENCODE Histone Modification Site Profiles | histone modification site profiles with high histone modification abundance at POU5F1P4 gene from the ENCODE Histone Modification Site Profiles dataset. | |
| ENCODE Transcription Factor Binding Site Profiles | transcription factor binding site profiles with transcription factor binding evidence at the promoter of POU5F1P4 gene from the ENCODE Transcription Factor Binding Site Profiles dataset. | |
| ENCODE Transcription Factor Targets | transcription factors binding the promoter of POU5F1P4 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset. | |
| GeneRIF Biological Term Annotations | biological terms co-occuring with POU5F1P4 gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset. | |
| GeneSigDB Published Gene Signatures | PubMedIDs of publications reporting gene signatures containing POU5F1P4 from the GeneSigDB Published Gene Signatures dataset. | |
| GEO Signatures of Differentially Expressed Genes for Diseases | disease perturbations changing expression of POU5F1P4 gene from the GEO Signatures of Differentially Expressed Genes for Diseases dataset. | |
| GEO Signatures of Differentially Expressed Genes for Gene Perturbations | gene perturbations changing expression of POU5F1P4 gene from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset. | |
| GEO Signatures of Differentially Expressed Genes for Small Molecules | small molecule perturbations changing expression of POU5F1P4 gene from the GEO Signatures of Differentially Expressed Genes for Small Molecules dataset. | |
| GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations | transcription factor perturbations changing expression of POU5F1P4 gene from the GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations dataset. | |
| GEO Signatures of Differentially Expressed Genes for Viral Infections | virus perturbations changing expression of POU5F1P4 gene from the GEO Signatures of Differentially Expressed Genes for Viral Infections dataset. | |
| GTEx Tissue Gene Expression Profiles | tissues with high or low expression of POU5F1P4 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles dataset. | |
| GTEx Tissue Sample Gene Expression Profiles | tissue samples with high or low expression of POU5F1P4 gene relative to other tissue samples from the GTEx Tissue Sample Gene Expression Profiles dataset. | |
| JASPAR Predicted Transcription Factor Targets | transcription factors regulating expression of POU5F1P4 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset. | |
| Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles | cell lines with high or low copy number of POU5F1P4 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset. | |
| KnockTF Gene Expression Profiles with Transcription Factor Perturbations | transcription factor perturbations changing expression of POU5F1P4 gene from the KnockTF Gene Expression Profiles with Transcription Factor Perturbations dataset. | |
| LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules | small molecule perturbations changing expression of POU5F1P4 gene from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset. | |
| LOCATE Predicted Protein Localization Annotations | cellular components predicted to contain POU5F1P4 protein from the LOCATE Predicted Protein Localization Annotations dataset. | |
| MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations | gene perturbations changing expression of POU5F1P4 gene from the MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations dataset. | |
| Roadmap Epigenomics Histone Modification Site Profiles | histone modification site profiles with high histone modification abundance at POU5F1P4 gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset. | |
