PPP2R5C Gene

HGNC Family	Protein phosphatase 2 regulatory subunits (PPP2R)
Name	protein phosphatase 2, regulatory subunit B', gamma
Description	The product of this gene belongs to the phosphatase 2A regulatory subunit B family. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes a gamma isoform of the regulatory subunit B56 subfamily. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nPPP2R5C encodes a regulatory B56‐subunit of protein phosphatase 2A (PP2A) that plays a pivotal role in modulating cell cycle progression and tumor‐suppressive signaling. Several studies have shown that specific isoforms of PP2A–B56 complexes (often referred to as B56γ) promote dephosphorylation of key substrates such as p53—specifically at Thr55—which in turn triggers p53 stabilization, activation of its transcriptional targets (e.g., p21) and cell cycle arrest. In addition, defects in substrate binding and mutations within critical regions of PPP2R5C have been linked to impaired p53‐dependent and p53‐independent tumor suppression in various cancers, including leukemias, overgrowth syndromes and lung adenocarcinoma. Altered PPP2R5C expression or mutations, for example in the context of childhood T-cell leukemia, further underscore its role in restraining proliferation and transformation."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "11"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nPPP2R5C and its encoded B56γ variants also underpin diverse cellular signaling processes outside of classical tumor suppression. In hepatocytes, PPP2R5C modulates postprandial carbohydrate and lipid homeostasis by influencing AMPK and SREBP-1 activity—such that its inactivation increases glucose uptake and de novo lipogenesis. In cardiac myocytes, distinct PPP2R5C isoforms display differential subcellular distribution—affecting contractile function as well as nuclear events (for example, regulation of p27 phosphorylation and cell cycle control). Moreover, PPP2R5C-containing PP2A complexes have been implicated in immune signaling by negatively regulating NF-κB activation in T cells, in the maintenance of mitotic fidelity through control of spindle-associated phosphorylation events, and even in the intimate interplay with viral integrase complexes during HTLV-1 integration. Complementary studies further highlight a role for PPP2R5C in governing cell motility via interactions with scaffolding factors such as liprin-α1, as well as in serving as an epigenetic marker in colorectal cancer screening."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "12", "end_ref": "24"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Heng-Hong Li, Xin Cai, Geoffrey P Shouse, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A specific PP2A regulatory subunit, B56gamma, mediates DNA damage-induced dephosphorylation of p53 at Thr55."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "EMBO J (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/sj.emboj.7601519"}], "href": "https://doi.org/10.1038/sj.emboj.7601519"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17245430"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17245430"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Geoffrey P Shouse, Xin Cai, Xuan Liu "}, {"type": "b", "children": [{"type": "t", "text": "Serine 15 phosphorylation of p53 directs its interaction with B56gamma and the tumor suppressor activity of B56gamma-specific protein phosphatase 2A."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Biol (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/MCB.00983-07"}], "href": "https://doi.org/10.1128/MCB.00983-07"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17967874"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17967874"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "G P Shouse, Y Nobumori, X Liu "}, {"type": "b", "children": [{"type": "t", "text": "A B56gamma mutation in lung cancer disrupts the p53-dependent tumor-suppressor function of protein phosphatase 2A."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncogene (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/onc.2010.161"}], "href": "https://doi.org/10.1038/onc.2010.161"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20473327"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20473327"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "G P Shouse, Y Nobumori, M J Panowicz, et al. "}, {"type": "b", "children": [{"type": "t", "text": "ATM-mediated phosphorylation activates the tumor-suppressive function of B56γ-PP2A."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncogene (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/onc.2011.95"}], "href": "https://doi.org/10.1038/onc.2011.95"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21460856"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21460856"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Haitao Zheng, Yu Chen, Shaohua Chen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Expression and distribution of PPP2R5C gene in leukemia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Hematol Oncol (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/1756-8722-4-21"}], "href": "https://doi.org/10.1186/1756-8722-4-21"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21548944"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21548944"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Yumiko Nobumori, Geoffrey P Shouse, Li Fan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "HEAT repeat 1 motif is required for B56γ-containing protein phosphatase 2A (B56γ-PP2A) holoenzyme assembly and tumor-suppressive function."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M111.334094"}], "href": "https://doi.org/10.1074/jbc.M111.334094"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22315229"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22315229"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Yumiko Nobumori, Geoffrey P Shouse, Yong Wu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "B56γ tumor-associated mutations provide new mechanisms for B56γ-PP2A tumor suppressor activity."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cancer Res (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/1541-7786.MCR-12-0633"}], "href": "https://doi.org/10.1158/1541-7786.MCR-12-0633"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23723076"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23723076"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Yu Chen, Sichu Liu, Qi Shen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Differential gene expression profiles of PPP2R5C-siRNA-treated malignant T cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "DNA Cell Biol (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1089/dna.2013.2138"}], "href": "https://doi.org/10.1089/dna.2013.2138"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23941244"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23941244"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Chey Loveday, Katrina Tatton-Brown, Matthew Clarke, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Mutations in the PP2A regulatory subunit B family genes PPP2R5B, PPP2R5C and PPP2R5D cause human overgrowth."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hum Mol Genet (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/hmg/ddv182"}], "href": "https://doi.org/10.1093/hmg/ddv182"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25972378"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25972378"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Tomoko Ito, Satoru Ozaki, Rachanee Chanasong, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Activation of ERK/IER3/PP2A-B56γ-positive feedback loop in lung adenocarcinoma by allelic deletion of B56γ gene."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncol Rep (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/or.2016.4677"}], "href": "https://doi.org/10.3892/or.2016.4677"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26986830"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26986830"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Lei Liu, Hai-Tao Li, Hua-Yue Zheng, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "Dihydroxyphenylethanol induces apoptosis by activating serine/threonine protein phosphatase PP2A and promotes the endoplasmic reticulum stress response in human colon carcinoma cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Carcinogenesis (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/carcin/bgl009"}], "href": "https://doi.org/10.1093/carcin/bgl009"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16524888"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16524888"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Xing Wang Zhou, Malkanthi Mudannayake, Mariah Green, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "The B56gamma3 regulatory subunit of protein phosphatase 2A (PP2A) regulates S phase-specific nuclear accumulation of PP2A and the G1 to S transition."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M109.094953"}], "href": "https://doi.org/10.1074/jbc.M109.094953"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20448040"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20448040"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Ricardo Nunes Bastos, Michael J Cundell, Francis A Barr "}, {"type": "b", "children": [{"type": "t", "text": "KIF4A and PP2A-B56 form a spatially restricted feedback loop opposing Aurora B at the anaphase central spindle."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Biol (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1083/jcb.201409129"}], "href": "https://doi.org/10.1083/jcb.201409129"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25512391"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25512391"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Xiucui Luo, Jing Pan, Leilei Wang, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "Alteration of gene expression profile following PPP2R5C knockdown may be associated with proliferation suppression and increased apoptosis of K562 cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Hematol Oncol (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s13045-015-0125-5"}], "href": "https://doi.org/10.1186/s13045-015-0125-5"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25888193"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25888193"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Yong-Sheng Cheng, Oksana Seibert, Nora Klöting, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "Cryo-EM structure of the deltaretroviral intasome in complex with the PP2A regulatory subunit B56γ."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Commun (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41467-020-18874-y"}], "href": "https://doi.org/10.1038/s41467-020-18874-y"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33028863"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33028863"}]}, {"type": "r", "ref": 23, "children": [{"type": "t", "text": "Marta Ripamonti, Andrea Lamarca, Norman E Davey, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A functional interaction between liprin-α1 and B56γ regulatory subunit of protein phosphatase 2A supports tumor cell motility."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Commun Biol (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s42003-022-03989-3"}], "href": "https://doi.org/10.1038/s42003-022-03989-3"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36171301"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36171301"}]}, {"type": "r", "ref": 24, "children": [{"type": "t", "text": "Ben Li, Shanglong Liu, Yuan Gao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Combined detection of SDC2/ADHFE1/PPP2R5C methylation in stool DNA for colorectal cancer screening."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cancer Res Clin Oncol (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s00432-023-04943-4"}], "href": "https://doi.org/10.1007/s00432-023-04943-4"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "37270460"}], "href": "https://pubmed.ncbi.nlm.nih.gov/37270460"}]}]}]}
Synonyms	B56gamma, PR61G, B56G
Proteins	2A5G_HUMAN
NCBI Gene ID	5527
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

PPP2R5C has 6,401 functional associations with biological entities spanning 9 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 124 datasets.

Click the + buttons to view associations for PPP2R5C from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

PPP2R5C Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of PPP2R5C gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of PPP2R5C gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of PPP2R5C gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of PPP2R5C gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of PPP2R5C gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of PPP2R5C gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of PPP2R5C gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of PPP2R5C gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of PPP2R5C gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with PPP2R5C protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with PPP2R5C gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of PPP2R5C gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of PPP2R5C gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of PPP2R5C gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of PPP2R5C gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing PPP2R5C protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing PPP2R5C protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores	cellular components containing PPP2R5C protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	cellular components containing PPP2R5C protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with PPP2R5C protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with PPP2R5C protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of PPP2R5C gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with PPP2R5C gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with PPP2R5C gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with PPP2R5C gene/protein from the curated CTD Gene-Disease Associations dataset.
	dbGAP Gene-Trait Associations	traits associated with PPP2R5C gene in GWAS and other genetic association datasets from the dbGAP Gene-Trait Associations dataset.
	DeepCoverMOA Drug Mechanisms of Action	small molecule perturbations with high or low expression of PPP2R5C protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by PPP2R5C gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores	diseases associated with PPP2R5C gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with PPP2R5C gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with PPP2R5C gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with PPP2R5C gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with PPP2R5C gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with PPP2R5C gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	DrugBank Drug Targets	interacting drugs for PPP2R5C protein from the curated DrugBank Drug Targets dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at PPP2R5C gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of PPP2R5C gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of PPP2R5C gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing PPP2R5C from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GAD Gene-Disease Associations	diseases associated with PPP2R5C gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.