PRAMEF4 Gene

HGNC Family	PRAME family (PRAMEF)
Name	PRAME family member 4
Proteins	PRAM4_HUMAN
NCBI Gene ID	400735
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Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

PRAMEF4 has 436 functional associations with biological entities spanning 4 categories (molecular profile, functional term, phrase or reference, cell line, cell type or tissue, gene, protein or microRNA) extracted from 21 datasets.

Click the + buttons to view associations for PRAMEF4 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

PRAMEF4 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of PRAMEF4 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of PRAMEF4 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of PRAMEF4 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with PRAMEF4 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by PRAMEF4 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at PRAMEF4 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of PRAMEF4 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of PRAMEF4 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	GeneSigDB Published Gene Signatures	PubMedIDs of publications reporting gene signatures containing PRAMEF4 from the GeneSigDB Published Gene Signatures dataset.
	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	gene perturbations changing expression of PRAMEF4 gene from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset.
	GO Biological Process Annotations 2025	biological processes involving PRAMEF4 gene from the curated GO Biological Process Annotations2025 dataset.
	GO Cellular Component Annotations 2025	cellular components containing PRAMEF4 protein from the curated GO Cellular Component Annotations 2025 dataset.
	GO Molecular Function Annotations 2025	molecular functions performed by PRAMEF4 gene from the curated GO Molecular Function Annotations 2025 dataset.
	GTEx Tissue Gene Expression Profiles	tissues with high or low expression of PRAMEF4 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles dataset.
	JASPAR Predicted Transcription Factor Targets	transcription factors regulating expression of PRAMEF4 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset.
	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	cell lines with high or low copy number of PRAMEF4 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset.
	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	transcription factor perturbations changing expression of PRAMEF4 gene from the KnockTF Gene Expression Profiles with Transcription Factor Perturbations dataset.
	LOCATE Predicted Protein Localization Annotations	cellular components predicted to contain PRAMEF4 protein from the LOCATE Predicted Protein Localization Annotations dataset.
	Roadmap Epigenomics Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at PRAMEF4 gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset.
	TargetScan Predicted Nonconserved microRNA Targets	microRNAs regulating expression of PRAMEF4 gene predicted using nonconserved miRNA seed sequences from the TargetScan Predicted Nonconserved microRNA Targets dataset.
	TCGA Signatures of Differentially Expressed Genes for Tumors	tissue samples with high or low expression of PRAMEF4 gene relative to other tissue samples from the TCGA Signatures of Differentially Expressed Genes for Tumors dataset.