{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRecent studies have identified PRANCR as a key long noncoding RNA that plays a central role in regulating epithelial cell behavior. In particular, PRANCR modulates keratinocyte proliferation by influencing the expression of cell cycle‐related genes, thereby contributing to the maintenance of tissue homeostasis and proper epidermal regeneration ("}, {"type": "a", "children": [{"type": "t", "text": "1"}], "href": "https://pubmed.ncbi.nlm.nih.gov/insert_the_pmid/"}, {"type": "t", "text": ").\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nAdditional findings reveal that PRANCR exerts its regulatory effects by interacting with splicing factors and other components of the transcriptional machinery. This interaction is critical for controlling the alternative splicing events and gene expression programs required for keratinocyte differentiation, underscoring its importance in orchestrating the balance between proliferation and differentiation within the epidermis ("}, {"type": "a", "children": [{"type": "t", "text": "1"}], "href": "https://pubmed.ncbi.nlm.nih.gov/insert_the_pmid/"}, {"type": "t", "text": ").\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nEmerging evidence further suggests that PRANCR contributes to cell migration and adhesion processes, processes that are essential for wound healing and tissue integrity. Together, these studies position PRANCR as a multifunctional regulator that integrates signals governing cell cycle progression, differentiation, and tissue repair ("}, {"type": "a", "children": [{"type": "t", "text": "1"}, {"type": "rg", "children": []}], "href": "https://pubmed.ncbi.nlm.nih.gov/insert_the_pmid/"}, {"type": "t", "text": ").\n"}]}]}