PRC1 Gene

Name protein regulator of cytokinesis 1
Description This gene encodes a protein that is involved in cytokinesis. The protein is present at high levels during the S and G2/M phases of mitosis but its levels drop dramatically when the cell exits mitosis and enters the G1 phase. It is located in the nucleus during interphase, becomes associated with mitotic spindles in a highly dynamic manner during mitosis, and localizes to the cell mid-body during cytokinesis. This protein has been shown to be a substrate of several cyclin-dependent kinases (CDKs). It is necessary for polarizing parallel microtubules and concentrating the factors responsible for contractile ring assembly. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2012]
Summary
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nProtein Regulator of Cytokinesis 1 (PRC1) is a pivotal microtubule‐associated protein that orchestrates the organization and bundling of antiparallel microtubules to form a stable spindle midzone, thereby ensuring faithful chromosome segregation and successful cytokinesis. In mammalian cells, PRC1 directly binds and bundles microtubules during late mitosis, and its spatial distribution is precisely controlled by interactions with key mitotic motors—including KIF4, MKLP1, and CENP‐E—and by cell cycle–dependent phosphorylation events. Through these interactions, PRC1 establishes a platform for the recruitment of additional regulators such as Ect2 and CLASP1 that stabilize midzone microtubules and coordinate cleavage furrow positioning. Moreover, structural studies have revealed that PRC1 possesses distinct domains required for microtubule binding versus midbody localization, and its end‐tagging of microtubule plus ends may be tuned by filament length, reflecting a sophisticated mechanism for integrating motor-driven sliding forces during spindle elongation and cytokinesis."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "17"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nThe precise activity of PRC1 is further modulated by phosphorylation events and interactions with cell cycle regulators. For example, inhibitory phosphorylation by Cdk1 during early mitosis maintains PRC1 in an inactive state, whereas dephosphorylation at the metaphase‐to‐anaphase transition unleashes its bundling activity. In addition, oncogenic stress and tumor suppressor pathways can regulate PRC1 at the transcriptional and post‐translational levels—for instance, p53 has been shown to directly repress PRC1 transcription, and atypical kinases such as CDK16 phosphorylate PRC1 to influence its localization—thus adding additional layers to its temporal control during cell division."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "18"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nAberrant regulation of PRC1 has been implicated in tumorigenesis across multiple cancer types. Overexpression or mis‐localization of PRC1 can lead to defects in cytokinesis, promoting chromosomal instability, aneuploidy, and the emergence of aggressive tumor phenotypes. In several studies, elevated PRC1 expression correlated with poor clinical outcomes in hepatocellular, breast, ovarian, oral, and prostate cancers, and experimental downregulation of PRC1 in tumor models has been associated with cell cycle arrest, reduced invasive capacity, and inhibited tumor growth. These findings underscore its potential as both a prognostic biomarker and a therapeutic target in cancer."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "20", "end_ref": "28"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn addition to its role in mitosis, a distinct complex also designated PRC1—namely, the Polycomb Repressive Complex 1—is involved in epigenetic gene silencing through histone H2A monoubiquitination. This complex, composed of subunits with multiple paralogs, plays a central role in maintaining transcriptional repression during development and in various disease contexts. Notably, several studies have dissected the modular organization of PRC1 variants, their recruitment by long noncoding RNAs like XIST, and their interactions with complementary proteins that coordinate chromatin compaction and heritable epigenetic memory. Such insights highlight the versatility of the “PRC1” designation in regulating both cell division and chromatin state."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "29", "end_ref": "35"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Cristiana Mollinari, Jean-Philippe Kleman, Wei Jiang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "PRC1 is a microtubule binding and bundling protein essential to maintain the mitotic spindle midzone."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Biol (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1083/jcb.200111052"}], "href": "https://doi.org/10.1083/jcb.200111052"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12082078"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12082078"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Yasuhiro Kurasawa, William C Earnshaw, Yuko Mochizuki, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Essential roles of KIF4 and its binding partner PRC1 in organized central spindle midzone formation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "EMBO J (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/sj.emboj.7600347"}], "href": "https://doi.org/10.1038/sj.emboj.7600347"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15297875"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15297875"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Changjun Zhu, Wei Jiang "}, {"type": "b", "children": [{"type": "t", "text": "Cell cycle-dependent translocation of PRC1 on the spindle by Kif4 is essential for midzone formation and cytokinesis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.0408438102"}], "href": "https://doi.org/10.1073/pnas.0408438102"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15625105"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15625105"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Ulrike Gruneberg, Rüdiger Neef, Xiuling Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "KIF14 and citron kinase act together to promote efficient cytokinesis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Biol (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1083/jcb.200511061"}], "href": "https://doi.org/10.1083/jcb.200511061"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16431929"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16431929"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Rüdiger Neef, Ulrike Gruneberg, Robert Kopajtich, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Choice of Plk1 docking partners during mitosis and cytokinesis is controlled by the activation state of Cdk1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Cell Biol (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ncb1557"}], "href": "https://doi.org/10.1038/ncb1557"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17351640"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17351640"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Radhika Subramanian, Elizabeth M Wilson-Kubalek, Christopher P Arthur, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Insights into antiparallel microtubule crosslinking by PRC1, a conserved nonmotor microtubule binding protein."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.cell.2010.07.012"}], "href": "https://doi.org/10.1016/j.cell.2010.07.012"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20691902"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20691902"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Benjamin A Wolfe, Tohru Takaki, Mark Petronczki, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Polo-like kinase 1 directs assembly of the HsCyk-4 RhoGAP/Ect2 RhoGEF complex to initiate cleavage furrow formation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS Biol (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pbio.1000110"}], "href": "https://doi.org/10.1371/journal.pbio.1000110"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19468300"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19468300"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Changjun Zhu, Eric Lau, Robert Schwarzenbacher, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Spatiotemporal control of spindle midzone formation by PRC1 in human cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.0506926103"}], "href": "https://doi.org/10.1073/pnas.0506926103"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16603632"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16603632"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Michael J Cundell, Ricardo Nunes Bastos, Tongli Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The BEG (PP2A-B55/ENSA/Greatwall) pathway ensures cytokinesis follows chromosome separation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.molcel.2013.09.005"}], "href": "https://doi.org/10.1016/j.molcel.2013.09.005"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24120663"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24120663"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Radhika Subramanian, Shih-Chieh Ti, Lei Tan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Marking and measuring single microtubules by PRC1 and kinesin-4."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.cell.2013.06.021"}], "href": "https://doi.org/10.1016/j.cell.2013.06.021"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23870126"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23870126"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Antoine Campagne, Ming-Kang Lee, Dina Zielinski, et al. "}, {"type": "b", "children": [{"type": "t", "text": "BAP1 complex promotes transcription by opposing PRC1-mediated H2A ubiquitylation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Commun (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41467-018-08255-x"}], "href": "https://doi.org/10.1038/s41467-018-08255-x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30664650"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30664650"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Jing Liu, Zhikai Wang, Kai Jiang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "PRC1 cooperates with CLASP1 to organize central spindle plasticity in mitosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M109.009670"}], "href": "https://doi.org/10.1074/jbc.M109.009670"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19561070"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19561070"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Sanjay Shrestha, Lori Jo Wilmeth, Jarrett Eyer, et al. "}, {"type": "b", "children": [{"type": "t", "text": "PRC1 controls spindle polarization and recruitment of cytokinetic factors during monopolar cytokinesis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Biol Cell (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1091/mbc.E11-12-1008"}], "href": "https://doi.org/10.1091/mbc.E11-12-1008"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22323288"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22323288"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Xu Liu, Leilei Xu, Junying Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Mitotic motor CENP-E cooperates with PRC1 in temporal control of central spindle assembly."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Mol Cell Biol (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/jmcb/mjz051"}], "href": "https://doi.org/10.1093/jmcb/mjz051"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31174204"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31174204"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Sithara Wijeratne, Radhika Subramanian "}, {"type": "b", "children": [{"type": "t", "text": "Geometry of antiparallel microtubule bundles regulates relative sliding and stalling by PRC1 and Kif4A."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Elife (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.7554/eLife.32595"}], "href": "https://doi.org/10.7554/eLife.32595"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30353849"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30353849"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Sara Hernández-Ortega, Abril Sánchez-Botet, Eva Quandt, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Phosphoregulation of the oncogenic protein regulator of cytokinesis 1 (PRC1) by the atypical CDK16/CCNY complex."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Exp Mol Med (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s12276-019-0242-2"}], "href": "https://doi.org/10.1038/s12276-019-0242-2"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30992425"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30992425"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Kruno Vukušić, Ivana Ponjavić, Renata Buđa, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Microtubule-sliding modules based on kinesins EG5 and PRC1-dependent KIF4A drive human spindle elongation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Dev Cell (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.devcel.2021.04.005"}], "href": "https://doi.org/10.1016/j.devcel.2021.04.005"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33910056"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33910056"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Cong Li, Meihong Lin, Jingwen Liu "}, {"type": "b", "children": [{"type": "t", "text": "Identification of PRC1 as the p53 target gene uncovers a novel function of p53 in the regulation of cytokinesis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncogene (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/sj.onc.1208114"}], "href": "https://doi.org/10.1038/sj.onc.1208114"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15531928"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15531928"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Ignas Gaska, Mason E Armstrong, April Alfieri, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The Mitotic Crosslinking Protein PRC1 Acts Like a Mechanical Dashpot to Resist Microtubule Sliding."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Dev Cell (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.devcel.2020.06.017"}], "href": "https://doi.org/10.1016/j.devcel.2020.06.017"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32640202"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32640202"}]}, {"type": "r", "ref": 20, "children": [{"type": "t", "text": "Jianxiang Chen, Muthukumar Rajasekaran, Hongping Xia, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The microtubule-associated protein PRC1 promotes early recurrence of hepatocellular carcinoma in association with the Wnt/β-catenin signalling pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Gut (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1136/gutjnl-2015-310625"}], "href": "https://doi.org/10.1136/gutjnl-2015-310625"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26941395"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26941395"}]}, {"type": "r", "ref": 21, "children": [{"type": "t", "text": "Rui Guo, Yuchen Zhang, Mingxiang Teng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "DNA methylation enzymes and PRC1 restrict B-cell Epstein-Barr virus oncoprotein expression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Microbiol (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41564-020-0724-y"}], "href": "https://doi.org/10.1038/s41564-020-0724-y"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32424339"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32424339"}]}, {"type": "r", "ref": 22, "children": [{"type": "t", "text": "Xinran Liu, Yangkai Li, Lijing Meng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Reducing protein regulator of cytokinesis 1 as a prospective therapy for hepatocellular carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Death Dis (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41419-018-0555-4"}], "href": "https://doi.org/10.1038/s41419-018-0555-4"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29748662"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29748662"}]}, {"type": "r", "ref": 23, "children": [{"type": "t", "text": "Fanglong Wu, Xueke Shi, Rui Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Regulation of proliferation and cell cycle by protein regulator of cytokinesis 1 in oral squamous cell carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Death Dis (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41419-018-0618-6"}], "href": "https://doi.org/10.1038/s41419-018-0618-6"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29752448"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29752448"}]}, {"type": "r", "ref": 24, "children": [{"type": "t", "text": "Hualei Bu, Yingwei Li, Chengjuan Jin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Overexpression of PRC1 indicates a poor prognosis in ovarian cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Oncol (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/ijo.2020.4959"}], "href": "https://doi.org/10.3892/ijo.2020.4959"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31922238"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31922238"}]}, {"type": "r", "ref": 25, "children": [{"type": "t", "text": "Hong-Wei Luo, Qing-Biao Chen, Yue-Ping Wan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Protein regulator of cytokinesis 1 overexpression predicts biochemical recurrence in men with prostate cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biomed Pharmacother (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.biopha.2016.01.004"}], "href": "https://doi.org/10.1016/j.biopha.2016.01.004"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26898432"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26898432"}]}, {"type": "r", "ref": 26, "children": [{"type": "t", "text": "Veronika Brynychova, Marie Ehrlichova, Viktor Hlavac, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Genetic and functional analyses do not explain the association of high PRC1 expression with poor survival of breast carcinoma patients."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biomed Pharmacother (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.biopha.2016.07.047"}], "href": "https://doi.org/10.1016/j.biopha.2016.07.047"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27505863"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27505863"}]}, {"type": "r", "ref": 27, "children": [{"type": "t", "text": "Jing Li, Marlene Dallmayer, Thomas Kirchner, et al. "}, {"type": "b", "children": [{"type": "t", "text": "PRC1: Linking Cytokinesis, Chromosomal Instability, and Cancer Evolution."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Trends Cancer (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.trecan.2017.11.002"}], "href": "https://doi.org/10.1016/j.trecan.2017.11.002"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29413422"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29413422"}]}, {"type": "r", "ref": 28, "children": [{"type": "t", "text": "Bin Zhang, Xiaoting Shi, Guifang Xu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Elevated PRC1 in gastric carcinoma exerts oncogenic function and is targeted by piperlongumine in a p53-dependent manner."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Mol Med (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/jcmm.13063"}], "href": "https://doi.org/10.1111/jcmm.13063"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28190297"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28190297"}]}, {"type": "r", "ref": 29, "children": [{"type": "t", "text": "Andrea Piunti, Ali Shilatifard "}, {"type": "b", "children": [{"type": "t", "text": "The roles of Polycomb repressive complexes in mammalian development and cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Rev Mol Cell Biol (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41580-021-00341-1"}], "href": "https://doi.org/10.1038/s41580-021-00341-1"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33723438"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33723438"}]}, {"type": "r", "ref": 30, "children": [{"type": "t", "text": "Keith Wheaton, Feroz Sarkari, Beena Stanly Johns, et al. "}, {"type": "b", "children": [{"type": "t", "text": "UbE2E1/UBCH6 Is a Critical "}, {"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "in Vivo"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": " E2 for the PRC1-catalyzed Ubiquitination of H2A at Lys-119."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M116.749564"}], "href": "https://doi.org/10.1074/jbc.M116.749564"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28073915"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28073915"}]}, {"type": "r", "ref": 31, "children": [{"type": "t", "text": "Adhikarimayum Lakhikumar Sharma, Joseph Hokello, Shilpa Sonti, et al. "}, {"type": "b", "children": [{"type": "t", "text": "CBF-1 Promotes the Establishment and Maintenance of HIV Latency by Recruiting Polycomb Repressive Complexes, PRC1 and PRC2, at HIV LTR."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Viruses (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3390/v12091040"}], "href": "https://doi.org/10.3390/v12091040"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32961937"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32961937"}]}, {"type": "r", "ref": 32, "children": [{"type": "t", "text": "Thomas Dixon-McDougall, Carolyn J Brown "}, {"type": "b", "children": [{"type": "t", "text": "Independent domains for recruitment of PRC1 and PRC2 by human XIST."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS Genet (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pgen.1009123"}], "href": "https://doi.org/10.1371/journal.pgen.1009123"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33750950"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33750950"}]}, {"type": "r", "ref": 33, "children": [{"type": "t", "text": "Jing Li, Shunya Ohmura, Aruna Marchetto, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Therapeutic targeting of the PLK1-PRC1-axis triggers cell death in genomically silent childhood cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Commun (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41467-021-25553-z"}], "href": "https://doi.org/10.1038/s41467-021-25553-z"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34531368"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34531368"}]}, {"type": "r", "ref": 34, "children": [{"type": "t", "text": "Jorine M Eeftens, Manya Kapoor, Davide Michieletto, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Polycomb condensates can promote epigenetic marks but are not required for sustained chromatin compaction."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Commun (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41467-021-26147-5"}], "href": "https://doi.org/10.1038/s41467-021-26147-5"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34620850"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34620850"}]}, {"type": "r", "ref": 35, "children": [{"type": "t", "text": "Pamela Völkel, Perrine Le Faou, Julien Vandamme, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A human Polycomb isoform lacking the Pc box does not participate to PRC1 complexes but forms protein assemblies and represses transcription."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Epigenetics (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4161/epi.19741"}], "href": "https://doi.org/10.4161/epi.19741"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22419124"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22419124"}]}]}]}
Synonyms ASE1
Proteins PRC1_HUMAN
NCBI Gene ID 9055
API
Download Associations
Predicted Functions View PRC1's ARCHS4 Predicted Functions.
Co-expressed Genes View PRC1's ARCHS4 Predicted Functions.
Expression in Tissues and Cell Lines View PRC1's ARCHS4 Predicted Functions.

Functional Associations

PRC1 has 10,622 functional associations with biological entities spanning 8 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA) extracted from 128 datasets.

Click the + buttons to view associations for PRC1 from the datasets below.

If available, associations are ranked by standardized value

Dataset Summary
Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles tissues with high or low expression of PRC1 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles tissues with high or low expression of PRC1 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray tissue samples with high or low expression of PRC1 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq tissue samples with high or low expression of PRC1 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles tissues with high or low expression of PRC1 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
BioGPS Cell Line Gene Expression Profiles cell lines with high or low expression of PRC1 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
BioGPS Human Cell Type and Tissue Gene Expression Profiles cell types and tissues with high or low expression of PRC1 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
BioGPS Mouse Cell Type and Tissue Gene Expression Profiles cell types and tissues with high or low expression of PRC1 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
CCLE Cell Line Gene CNV Profiles cell lines with high or low copy number of PRC1 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
CCLE Cell Line Gene Expression Profiles cell lines with high or low expression of PRC1 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
CCLE Cell Line Proteomics Cell lines associated with PRC1 protein from the CCLE Cell Line Proteomics dataset.
CellMarker Gene-Cell Type Associations cell types associated with PRC1 gene from the CellMarker Gene-Cell Type Associations dataset.
ChEA Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of PRC1 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
ChEA Transcription Factor Targets transcription factors binding the promoter of PRC1 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
ChEA Transcription Factor Targets 2022 transcription factors binding the promoter of PRC1 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
CMAP Signatures of Differentially Expressed Genes for Small Molecules small molecule perturbations changing expression of PRC1 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
COMPARTMENTS Curated Protein Localization Evidence Scores cellular components containing PRC1 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
COMPARTMENTS Curated Protein Localization Evidence Scores 2025 cellular components containing PRC1 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
COMPARTMENTS Experimental Protein Localization Evidence Scores cellular components containing PRC1 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores dataset.
COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 cellular components containing PRC1 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 dataset.
COMPARTMENTS Text-mining Protein Localization Evidence Scores cellular components co-occuring with PRC1 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 cellular components co-occuring with PRC1 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
COSMIC Cell Line Gene CNV Profiles cell lines with high or low copy number of PRC1 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
COSMIC Cell Line Gene Mutation Profiles cell lines with PRC1 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
CTD Gene-Chemical Interactions chemicals interacting with PRC1 gene/protein from the curated CTD Gene-Chemical Interactions dataset.
CTD Gene-Disease Associations diseases associated with PRC1 gene/protein from the curated CTD Gene-Disease Associations dataset.
dbGAP Gene-Trait Associations traits associated with PRC1 gene in GWAS and other genetic association datasets from the dbGAP Gene-Trait Associations dataset.
DeepCoverMOA Drug Mechanisms of Action small molecule perturbations with high or low expression of PRC1 protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
DISEASES Curated Gene-Disease Association Evidence Scores 2025 diseases involving PRC1 gene from the DISEASES Curated Gene-Disease Association Evidence Scores 2025 dataset.
DISEASES Experimental Gene-Disease Association Evidence Scores diseases associated with PRC1 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores dataset.
DISEASES Experimental Gene-Disease Association Evidence Scores 2025 diseases associated with PRC1 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
DISEASES Text-mining Gene-Disease Association Evidence Scores diseases co-occuring with PRC1 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 diseases co-occuring with PRC1 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
DisGeNET Gene-Disease Associations diseases associated with PRC1 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
DisGeNET Gene-Phenotype Associations phenotypes associated with PRC1 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
ENCODE Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at PRC1 gene from the ENCODE Histone Modification Site Profiles dataset.
ENCODE Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of PRC1 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
ENCODE Transcription Factor Targets transcription factors binding the promoter of PRC1 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
ESCAPE Omics Signatures of Genes and Proteins for Stem Cells PubMedIDs of publications reporting gene signatures containing PRC1 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
GAD Gene-Disease Associations diseases associated with PRC1 gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.
GAD High Level Gene-Disease Associations diseases associated with PRC1 gene in GWAS and other genetic association datasets from the GAD High Level Gene-Disease Associations dataset.
GDSC Cell Line Gene Expression Profiles cell lines with high or low expression of PRC1 gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset.
GeneRIF Biological Term Annotations biological terms co-occuring with PRC1 gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.
GeneSigDB Published Gene Signatures PubMedIDs of publications reporting gene signatures containing PRC1 from the GeneSigDB Published Gene Signatures dataset.
GEO Signatures of Differentially Expressed Genes for Diseases disease perturbations changing expression of PRC1 gene from the GEO Signatures of Differentially Expressed Genes for Diseases dataset.
GEO Signatures of Differentially Expressed Genes for Gene Perturbations gene perturbations changing expression of PRC1 gene from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset.
GEO Signatures of Differentially Expressed Genes for Kinase Perturbations kinase perturbations changing expression of PRC1 gene from the GEO Signatures of Differentially Expressed Genes for Kinase Perturbations dataset.
GEO Signatures of Differentially Expressed Genes for Small Molecules small molecule perturbations changing expression of PRC1 gene from the GEO Signatures of Differentially Expressed Genes for Small Molecules dataset.
GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations transcription factor perturbations changing expression of PRC1 gene from the GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations dataset.
GEO Signatures of Differentially Expressed Genes for Viral Infections virus perturbations changing expression of PRC1 gene from the GEO Signatures of Differentially Expressed Genes for Viral Infections dataset.
GO Biological Process Annotations 2015 biological processes involving PRC1 gene from the curated GO Biological Process Annotations 2015 dataset.
GO Biological Process Annotations 2023 biological processes involving PRC1 gene from the curated GO Biological Process Annotations 2023 dataset.
GO Biological Process Annotations 2025 biological processes involving PRC1 gene from the curated GO Biological Process Annotations2025 dataset.
GO Cellular Component Annotations 2015 cellular components containing PRC1 protein from the curated GO Cellular Component Annotations 2015 dataset.
GO Cellular Component Annotations 2023 cellular components containing PRC1 protein from the curated GO Cellular Component Annotations 2023 dataset.
GO Cellular Component Annotations 2025 cellular components containing PRC1 protein from the curated GO Cellular Component Annotations 2025 dataset.
GO Molecular Function Annotations 2015 molecular functions performed by PRC1 gene from the curated GO Molecular Function Annotations 2015 dataset.
GO Molecular Function Annotations 2023 molecular functions performed by PRC1 gene from the curated GO Molecular Function Annotations 2023 dataset.
GO Molecular Function Annotations 2025 molecular functions performed by PRC1 gene from the curated GO Molecular Function Annotations 2025 dataset.
GTEx Tissue Gene Expression Profiles tissues with high or low expression of PRC1 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles dataset.
GTEx Tissue Gene Expression Profiles 2023 tissues with high or low expression of PRC1 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles 2023 dataset.
GTEx Tissue Sample Gene Expression Profiles tissue samples with high or low expression of PRC1 gene relative to other tissue samples from the GTEx Tissue Sample Gene Expression Profiles dataset.
GTEx Tissue-Specific Aging Signatures tissue samples with high or low expression of PRC1 gene relative to other tissue samples from the GTEx Tissue-Specific Aging Signatures dataset.
GWASdb SNP-Disease Associations diseases associated with PRC1 gene in GWAS and other genetic association datasets from the GWASdb SNP-Disease Associations dataset.
GWASdb SNP-Phenotype Associations phenotypes associated with PRC1 gene in GWAS datasets from the GWASdb SNP-Phenotype Associations dataset.
Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles cell lines with high or low expression of PRC1 gene relative to other cell lines from the Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles dataset.
HPA Cell Line Gene Expression Profiles cell lines with high or low expression of PRC1 gene relative to other cell lines from the HPA Cell Line Gene Expression Profiles dataset.
HPA Tissue Gene Expression Profiles tissues with high or low expression of PRC1 gene relative to other tissues from the HPA Tissue Gene Expression Profiles dataset.
HPA Tissue Protein Expression Profiles tissues with high or low expression of PRC1 protein relative to other tissues from the HPA Tissue Protein Expression Profiles dataset.
HPA Tissue Sample Gene Expression Profiles tissue samples with high or low expression of PRC1 gene relative to other tissue samples from the HPA Tissue Sample Gene Expression Profiles dataset.
HPM Cell Type and Tissue Protein Expression Profiles cell types and tissues with high or low expression of PRC1 protein relative to other cell types and tissues from the HPM Cell Type and Tissue Protein Expression Profiles dataset.
Hub Proteins Protein-Protein Interactions interacting hub proteins for PRC1 from the curated Hub Proteins Protein-Protein Interactions dataset.
HuBMAP Azimuth Cell Type Annotations cell types associated with PRC1 gene from the HuBMAP Azimuth Cell Type Annotations dataset.
HuGE Navigator Gene-Phenotype Associations phenotypes associated with PRC1 gene by text-mining GWAS publications from the HuGE Navigator Gene-Phenotype Associations dataset.
IMPC Knockout Mouse Phenotypes phenotypes of mice caused by PRC1 gene knockout from the IMPC Knockout Mouse Phenotypes dataset.
InterPro Predicted Protein Domain Annotations protein domains predicted for PRC1 protein from the InterPro Predicted Protein Domain Annotations dataset.
JASPAR Predicted Transcription Factor Targets transcription factors regulating expression of PRC1 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset.
KEA Substrates of Kinases kinases that phosphorylate PRC1 protein from the curated KEA Substrates of Kinases dataset.
Kinase Library Serine Threonine Kinome Atlas kinases that phosphorylate PRC1 protein from the Kinase Library Serine Threonine Atlas dataset.
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles cell lines with high or low copy number of PRC1 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset.
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles cell lines with high or low expression of PRC1 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles dataset.
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles cell lines with PRC1 gene mutations from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles dataset.
KnockTF Gene Expression Profiles with Transcription Factor Perturbations transcription factor perturbations changing expression of PRC1 gene from the KnockTF Gene Expression Profiles with Transcription Factor Perturbations dataset.
LINCS L1000 CMAP Chemical Perturbation Consensus Signatures small molecule perturbations changing expression of PRC1 gene from the LINCS L1000 CMAP Chemical Perturbations Consensus Signatures dataset.
LINCS L1000 CMAP CRISPR Knockout Consensus Signatures gene perturbations changing expression of PRC1 gene from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset.
LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules small molecule perturbations changing expression of PRC1 gene from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
LOCATE Curated Protein Localization Annotations cellular components containing PRC1 protein in low- or high-throughput protein localization assays from the LOCATE Curated Protein Localization Annotations dataset.
LOCATE Predicted Protein Localization Annotations cellular components predicted to contain PRC1 protein from the LOCATE Predicted Protein Localization Annotations dataset.
MGI Mouse Phenotype Associations 2023 phenotypes of transgenic mice caused by PRC1 gene mutations from the MGI Mouse Phenotype Associations 2023 dataset.
MiRTarBase microRNA Targets microRNAs targeting PRC1 gene in low- or high-throughput microRNA targeting studies from the MiRTarBase microRNA Targets dataset.
MotifMap Predicted Transcription Factor Targets transcription factors regulating expression of PRC1 gene predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset.
MoTrPAC Rat Endurance Exercise Training tissue samples with high or low expression of PRC1 gene relative to other tissue samples from the MoTrPAC Rat Endurance Exercise Training dataset.
MPO Gene-Phenotype Associations phenotypes of transgenic mice caused by PRC1 gene mutations from the MPO Gene-Phenotype Associations dataset.
MSigDB Cancer Gene Co-expression Modules co-expressed genes for PRC1 from the MSigDB Cancer Gene Co-expression Modules dataset.
MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations gene perturbations changing expression of PRC1 gene from the MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations dataset.
NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles drug perturbations changing expression of PRC1 gene from the NIBR DRUG-seq U2OS MoA Box dataset.
NURSA Protein Complexes protein complexs containing PRC1 protein recovered by IP-MS from the NURSA Protein Complexes dataset.
NURSA Protein-Protein Interactions interacting proteins for PRC1 from the NURSA Protein-Protein Interactions dataset.
Pathway Commons Protein-Protein Interactions interacting proteins for PRC1 from the Pathway Commons Protein-Protein Interactions dataset.
PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations gene perturbations changing expression of PRC1 gene from the PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations dataset.
PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations gene perturbations changing expression of PRC1 gene from the PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations dataset.
PFOCR Pathway Figure Associations 2023 pathways involving PRC1 protein from the PFOCR Pathway Figure Associations 2023 dataset.
PFOCR Pathway Figure Associations 2024 pathways involving PRC1 protein from the Wikipathways PFOCR 2024 dataset.
Phosphosite Textmining Biological Term Annotations biological terms co-occuring with PRC1 protein in abstracts of publications describing phosphosites from the Phosphosite Textmining Biological Term Annotations dataset.
PhosphoSitePlus Substrates of Kinases kinases that phosphorylate PRC1 protein from the curated PhosphoSitePlus Substrates of Kinases dataset.
Reactome Pathways 2024 pathways involving PRC1 protein from the Reactome Pathways 2024 dataset.
Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures gene perturbations changing expression of PRC1 gene from the Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures dataset.
Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures gene perturbations changing expression of PRC1 gene from the Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures dataset.
Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures gene perturbations changing expression of PRC1 gene from the Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures dataset.
Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles cell types and tissues with high or low DNA methylation of PRC1 gene relative to other cell types and tissues from the Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles dataset.
Roadmap Epigenomics Cell and Tissue Gene Expression Profiles cell types and tissues with high or low expression of PRC1 gene relative to other cell types and tissues from the Roadmap Epigenomics Cell and Tissue Gene Expression Profiles dataset.
Roadmap Epigenomics Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at PRC1 gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset.
RummaGEO Drug Perturbation Signatures drug perturbations changing expression of PRC1 gene from the RummaGEO Drug Perturbation Signatures dataset.
RummaGEO Gene Perturbation Signatures gene perturbations changing expression of PRC1 gene from the RummaGEO Gene Perturbation Signatures dataset.
Sanger Dependency Map Cancer Cell Line Proteomics cell lines associated with PRC1 protein from the Sanger Dependency Map Cancer Cell Line Proteomics dataset.
SILAC Phosphoproteomics Signatures of Differentially Phosphorylated Proteins for Drugs drug perturbations changing phosphorylation of PRC1 protein from the SILAC Phosphoproteomics Signatures of Differentially Phosphorylated Proteins for Drugs dataset.
SILAC Phosphoproteomics Signatures of Differentially Phosphorylated Proteins for Protein Ligands ligand (protein) perturbations changing phosphorylation of PRC1 protein from the SILAC Phosphoproteomics Signatures of Differentially Phosphorylated Proteins for Protein Ligands dataset.
Tabula Sapiens Gene-Cell Associations cell types with high or low expression of PRC1 gene relative to other cell types from the Tabula Sapiens Gene-Cell Associations dataset.
Tahoe Therapeutics Tahoe 100M Perturbation Atlas drug perturbations changing expression of PRC1 gene from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
TargetScan Predicted Conserved microRNA Targets microRNAs regulating expression of PRC1 gene predicted using conserved miRNA seed sequences from the TargetScan Predicted Conserved microRNA Targets dataset.
TargetScan Predicted Nonconserved microRNA Targets microRNAs regulating expression of PRC1 gene predicted using nonconserved miRNA seed sequences from the TargetScan Predicted Nonconserved microRNA Targets dataset.
TCGA Signatures of Differentially Expressed Genes for Tumors tissue samples with high or low expression of PRC1 gene relative to other tissue samples from the TCGA Signatures of Differentially Expressed Genes for Tumors dataset.
TISSUES Curated Tissue Protein Expression Evidence Scores tissues with high expression of PRC1 protein from the TISSUES Curated Tissue Protein Expression Evidence Scores dataset.
TISSUES Curated Tissue Protein Expression Evidence Scores 2025 tissues with high expression of PRC1 protein from the TISSUES Curated Tissue Protein Expression Evidence Scores 2025 dataset.
TISSUES Experimental Tissue Protein Expression Evidence Scores tissues with high expression of PRC1 protein in proteomics datasets from the TISSUES Experimental Tissue Protein Expression Evidence Scores dataset.
TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 tissues with high expression of PRC1 protein in proteomics datasets from the TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 dataset.
TISSUES Text-mining Tissue Protein Expression Evidence Scores tissues co-occuring with PRC1 protein in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores dataset.
TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 tissues co-occuring with PRC1 protein in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 dataset.