{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRecent investigations into systemic lupus erythematosus (SLE) have implicated long non-coding RNAs (lncRNAs) as key modulators in the disease’s pathogenesis. In this context, PRDX6-AS1 is emerging as a potential candidate that may influence immune regulation, possibly by altering the transcriptional or epigenetic control of genes involved in autoantibody production—a hallmark feature of SLE. The dysregulation of lncRNAs like PRDX6-AS1 could therefore contribute to the breakdown of self-tolerance and promote susceptibility to SLE."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nFurther genetic analysis of lncRNA coding genes is beginning to uncover how variations or aberrant expression of PRDX6-AS1 might serve as a pivotal factor in the autoimmune cascade underlying SLE. These insights not only enhance our molecular understanding of the disease but also suggest that PRDX6-AS1 could be a promising biomarker or therapeutic target, thereby paving the way for personalized approaches in managing and predicting SLE onset."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Xiao-Xue Zhang, Jun-Peng You, Xin-Ran Liu, et al. "}, {"type": "b", "children": [{"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "PRDX6"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": " "}, {"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "AS1"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": " gene polymorphisms and SLE susceptibility in Chinese populations."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Front Immunol (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3389/fimmu.2022.987385"}], "href": "https://doi.org/10.3389/fimmu.2022.987385"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36311744"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36311744"}]}]}]}