{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nLINC00346 is an emerging long non‐coding RNA that has been implicated in the development and progression of several human malignancies as well as other disorders. Studies have shown that its aberrant expression is associated with aggressive tumor properties in cancers such as bladder cancer"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ", non‐small cell lung cancer"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": ", pancreatic cancer"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": ", and hepatocellular carcinoma."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": " In addition, its upregulation has been observed in glioma"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": ", while altered expression is also noted in neuropsychiatric conditions such as schizophrenia"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "8"}]}, {"type": "t", "text": "and developmental disorders like Hirschsprung's disease."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "9"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn cutaneous squamous cell carcinoma, LINC00346 has been specifically characterized and renamed PRECSIT (p53‐regulated carcinoma‐associated STAT3‐activating long intergenic non‐protein coding transcript). This study demonstrated that p53 negatively regulates PRECSIT and that its overexpression enhances tumor progression by activating STAT3 signaling and upregulating matrix metalloproteinases (MMP-1, MMP-3, MMP-10, and MMP-13), thereby promoting cancer cell invasion and xenograft tumor growth."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "10"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Tingyu Ye, Wei Ding, Nanxiong Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long noncoding RNA linc00346 promotes the malignant phenotypes of bladder cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2017.07.045"}], "href": "https://doi.org/10.1016/j.bbrc.2017.07.045"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28705739"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28705739"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "F Wang, J-G Chen, L-L Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Up-regulation of LINC00346 inhibits proliferation of non-small cell lung cancer cells through mediating JAK-STAT3 signaling pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur Rev Med Pharmacol Sci (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.26355/eurrev_201711_13830"}], "href": "https://doi.org/10.26355/eurrev_201711_13830"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29228425"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29228425"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Weidong Shi, Chenyue Zhang, Zhouyu Ning, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long non-coding RNA LINC00346 promotes pancreatic cancer growth and gemcitabine resistance by sponging miR-188-3p to derepress BRD4 expression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Exp Clin Cancer Res (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s13046-019-1055-9"}], "href": "https://doi.org/10.1186/s13046-019-1055-9"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30728036"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30728036"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Yun-Zhi Yin, Wei-Hua Zheng, Xin Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LINC00346 promotes hepatocellular carcinoma progression via activating the JAK-STAT3 signaling pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Biochem (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jcb.29319"}], "href": "https://doi.org/10.1002/jcb.29319"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31478228"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31478228"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Nuobei Zhang, Xin Chen "}, {"type": "b", "children": [{"type": "t", "text": "A positive feedback loop involving the LINC00346/β-catenin/MYC axis promotes hepatocellular carcinoma development."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Oncol (Dordr) (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s13402-019-00478-4"}], "href": "https://doi.org/10.1007/s13402-019-00478-4"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31691159"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31691159"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Y-B Geng, C-C Pan, C Xu, et al. 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